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Journal of Geriatric Cardiology 2020年第6期17卷 313-320页

作者： Maciej Kubala alexis Hermida Otilia Buiciuc Pierre-Marc Lallemand Geneviève Bertaina Frédéric Anselme Didier Klug Momar Diouf Jean-Sylvain Hermida Centre Hospitalier Universitaire AmiensFrance Centre Hospitalier Régional Universitaire RouenFrance Centre Hospitalier Régional Universitaire LilleFrance

Background Several liver function tests have been identified as predictors of hospitalization for heart failure(HF) and death in patients with chronic HF. The relationship between serum γ-glutamyltranferase(GGT) and albumin(SA) levels with the response to cardiac resynchronization therapy(CRT) has not been reliably determined. The aim of the study was to evaluate the impact of liver function tests on the results of CRT in the elderly. Methods Baseline GGT and SA were assessed before CRT device implantation in the elderly(> 70-year-old) patients. The endpoints were:(1) CRT response defined as > 5% left ventricular ejection fraction improvement and no hospitalization for HF or cardiovascular death;(2) hospitalizations;and(3) mortality. Results Eighty of 138(58%) included patients were responders at nine months. compared to responders, the SA levels were not significantly different(35.1 ± 5.4 vs. 33.6 ± 5.5 g/L, P = 0.103);but the GGT levels, higher(81.6 ± 69.3 vs. 54.7 ± 49.6 U/L, P = 0.013) in non-responders to CRT. GGT level was independently associated with non-response to CRT(P conclusions Higher level of GGT is an independent predictor of non-response to CRT in patients over age 70 years and is associated with higher risk of hospitalization for AF. Baseline serum levels of albumin and GGT and have no impact on mortality in elderly patients undergoing CRT.

关键词： Cardiac resynchronization therapy Heart failure Liver enzymes The elderly

Application of MODIS satellite products to the air pollution research in Beijing

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Science China Earth Sciences 2005年第z2期48卷 209-219页

作者： alexis K.H.Lau Center for coastal and Atmospheric Research The Hong Kong University of Science and TechnologyClear Water BayHong KongChina

The direct correlation between NASA MODIS aerosol optical depth (AOD) products and the air pollution index (API) in Beijing was found relatively low based on the long-term comparison analysis. The correlation improved to some extent after taking account of the seasonal variation of scale height and the vertical distribution of aerosols. The correlation coefficient further improved significantly after considering the influencing factor of Relative Humidity (RH). This study concluded that satellite remote-sensing could serve as an efficient tool for monitoring the spatial distribution of particulate pollutants on the ground-level, as long as corrections have been made in the two aforementioned processes. Taking advantage of the MODIS information, we analyzed a pollution episode occurring in October 2004 in Beijing. It indicated that satellite remote-sensing could describe the formation process of the ground-level pollution episode in detail, and showed that regional transport and the topography were crucial factors to air quality in Beijing. The annual averaged distribution in the urban area of Beijing and its surroundings could be also obtained from the high-resolution retrieval results, implicating that high-resolution satellite remote-sensing might be potential in monitoring the source distribution of particulate pollutants.

关键词： particulate pollution, MODIS, aerosol.

Substrate selection and seasonal variation in abundance and size composition of isopod Lirceus fontinalis in Ontario streams, Canada

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Chinese Journal of Oceanology and Limnology 2007年第2期25卷 215-220页

作者： ZHAO Xiaoxia Michael G FOX David C. LASENBY alexis C. ARMIT Dolly N. KOTHAWALA Watershed Ecosystems Graduate Program Trent University Peterborough Ontario K9J 7B8 Canada Environmental ＆ Resource Studies Program and Department of Biology Trent University Peterborough ON K9J 7B8 Canada Department of Biology Trent University Peterborough ON K9J 7B8 Canada

The abundance and size composition of stream isopods Lirceusfontinalis were investigated from April 2001 to August 2002 in 3 streams in southem Ontario, Canada. Effects of current speed was released from the analysis by choosing slow flowing water. The effects of substrate, season and water depth on the abundance, distribution and size composition of the isopods were analyzed. It was found that substrate and season influence isopods the most. The rocky substrate with attached filamentous macro-algae contains an isopod abundance 7.05 times that of bare rock substrate and 14.6 times that of free-sand and mud substrate. There was a large variation with respect to seasonali .ty in both abundance and size composition of the isopods, with the highest abundance occumng in summer and the lowest in winter and spring; individual isopods also tend to be larger in the winter and spring. In all substrates, shallow areas tend to support higher densities of isopods than deeper areas.

关键词： isopods Lirceusfontinalis, size abundance substrate seasonal variation Ontario

Use of Groundwater, Baseflow and SPEI to Evaluate Water Resources in Michigan, USA

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Journal of Water Resource and Protection 2024年第10期16卷 640-670页

作者： Sawyer Schnettler alexis Sonnemann Katherine Clancy college of Natural Resources University of Wisconsin at Stevens Point Stevens Point USA

Precipitation and evaporation are commonly used to assess and forecast droughts. However, surface and groundwater respond to both land surface processes, land use, and climatic variables, and should be integrated into water management decisions. Water trend analysis near the Great Lakes is limited due to fluctuating cycles and data scarcity. In this study, we examine daily discharge data from 46 surface water gauges with high baseflow contributions and groundwater elevation from 28 observation wells in Michigan. Using established hydrograph separation techniques, we determined baseflow and standardized both annual average baseflow levels (SDBF) and groundwater levels (SDGW) from 1960 to 2022. These results are compared to the widely used Standardized Precipitation-Evapotranspiration Index (SPEI). SPEI is a widely used drought indicator that integrates both precipitation and potential evapotranspiration, offering a more comprehensive measure of water balance. While the SPEI suggests that Michigan is becoming wetter, the SDBF shows a mix of both wet and dry conditions. Interpreting SDGW is more challenging due to incomplete records, but it indicates varying groundwater stability across the state. In some areas, SDGW mirrors the trends seen in SDBF, while in others, it takes 3 to 4 years for groundwater levels to reflect the same changes observed in baseflow. Overall, SDBF provides a better understanding of surface processes and responses to changing climatic variables.

关键词： SPEI Drought Groundwater Baseflow

Reproducing indolent B-cell lymphoma transformation with T-cell immunosuppression in LMP1/CD40-expressing mice

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Cellular & Molecular Immunology 2019年第4期16卷 412-414页

作者： Christelle Vincent-Fabert alexis Saintamand Amandine David Mehdi Alizadeh François Boyer Nicolas Arnaud Ursula Zimber-Strobl Jean Feuillard Nathalie Faumont CNRS-UMR 7276 INSERM U1262 CRIBL University of Limogesand Hematology Laboratory of Dupuytren Hospital University Center(CHU)of LimogesLimogesFrance INSERM U917 University of Rennes 1RennesFrance LNPRM EFS BretagneRennesFrance Research Unit Gene Vectors Helmholtz Center MunichGerman Research Center for Environmental Health GmbHMunichGermany

Indolent B-cell lymphomas are a group of incurable cancers of the elderly that encompass various entities,such as chronic lymphocytic leukemia(CLL),follicular lymphoma(FL),and marginal zone lymphoma(MZL).All indolent lymphomas may evolve towards aggressive transformation with an increased proliferation index and decreased tumor doubling *** transformation,which is called Richter’s syndrome in CLL,is associated with an aggressive clinical course and poor *** least in CLL,transformation of an indolent B-cell clone is molecularly different from that of de novo diffuse large B-cell lymphomas.1 Aging is known to be associated with immune decline,with increased inflammation,decreased immune surveillance and increased onset of malignancies among the consequences.2 Progression of indolent B-cell lymphomas is likely to be associated with escape from immune surveillance.

关键词： lymphoma Richter transformation

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风险投资中的二级市场

风险投资中的二级市场

作者： Moulinier alexis 上海交通大学

学位级别：硕士

中国的风险投资市场仍在不断发展,每年的投资额逐渐增高。尽管缺乏流动性是风险投资的风险之一,但市场上投资数量有增无减,与风投退出相关的交易(不管是IPO还是战略性股权转让)却逐渐减少,这使得风险投资退出的压力和风险大增。这种流... 详细信息

中国的风险投资市场仍在不断发展,每年的投资额逐渐增高。尽管缺乏流动性是风险投资的风险之一,但市场上投资数量有增无减,与风投退出相关的交易(不管是IPO还是战略性股权转让)却逐渐减少,这使得风险投资退出的压力和风险大增。这种流动性风险有可能扰乱风投周期并进一步阻碍初创企业的融资进程。本文分析了一种投资退出模式的可行性——一家风投把初创企业的股权转让给另一家风投。文章检验了这种交易模式在二级市场中带给买方和卖方的好处。随后,本文把该模式与其他一级市场的代表样本进行了比较。最后,通过分析以往的交易并运用多元回归,本文研究了决定风投IPO退出模式的主要决定因素。尽管我们发现二级市场中的表现不如一级市场,通过分析市场情况,本文构建了一个优于一级市场IPO的投资策略。我们认为当一级市场发育壮大并被中国政府的金融改革所支持的话,二级市场对风投基金会更有吸引力,更多新的投资策略会被开发出来。

关键词：风险投资投资策略二级市场

The Global Stability Analysis of a Mathematical Cellular Model of Hepatitis C Virus Infection with Non-Cytolytic Process

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Journal of Applied Mathematics and Physics 2019年第7期7卷 1531-1546页

作者： alexis Nangue Cyprien Fokoue Raoue Poumeni Department of Mathematics Higher Teachers’ Training College University of Maroua Maroua Cameroon Department of Mathematics and computer Science Faculty of Science University of Maroua Maroua Cameroon

The aim of this work is to analyse the global dynamics of an extended mathematical model of Hepatitis C virus (HCV) infection in vivo with cellular proliferation, spontaneous cure and hepatocyte homeostasis. We firstly prove the existence of local and global solutions of the model and establish some properties of this solution as positivity and asymptotic behaviour. Secondly we show, by the construction of appropriate Lyapunov functions, that the uninfected equilibrium and the unique infected equilibrium of the mathematical model of HCV are globally asymptotically stable respectively when the threshold number and when .

关键词： HCV Model Global Solutions Non-Cytolytic Process Invariant Set Lyapunov Functions Basic Reproduction Number Equilibrium Points

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土著旅游与社会变迁

旅游学刊 2013年第12期28卷 4-6页

作者： alexis Celeste Bunten Intellectual Property in Cultural Heritage Simon Fraser University Burnaby British ColumbiaCanada

土著民族自他们初次招待探索性游客和早期殖民者始, 就已经被卷入旅游中。作者和格雷本把土著旅游定义为至少部分地由土著群体拥有或经营且与外来客人产生交换的任何服务或产品。最近, 借助旨在通过旅游刺激经济而专门设计的行业走向与... 详细信息

土著民族自他们初次招待探索性游客和早期殖民者始, 就已经被卷入旅游中。作者和格雷本把土著旅游定义为至少部分地由土著群体拥有或经营且与外来客人产生交换的任何服务或产品。最近, 借助旨在通过旅游刺激经济而专门设计的行业走向与行业政策和对土著资源的开发, 由土著拥有和经营的旅游已经不断扩大且蓬勃发展。旅游已经开辟了对外界表述的新领地, 创造了社会运动扎根与成长的康庄大道。

关键词：土著民族旅游社会变迁行业政策刺激经济社会运动殖民者经营

TOWARDS A BETTER FORECAST FOR RESERVOIR SLOPE SLIDING

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International Journal of Sediment Research 2003年第4期18卷 278-289页

作者： Didier MAROT,Alain alexis,Pierre THOMAS Doctor IUT de Saint Nazaire Laboratolre Génie Civil Nantes-Saint Nazaire. BP 420 44606 SAINT NAZAIRE cedex Doctor-Engineer IUT de Saint Nazaire Laboratoire Génie Civil Nantes-Saint Nazaire. BP 420 44606 SAINT NAZAIRE cedex Professor IUT de Saint Nazaire Laboratoire Génie Civil Nantes-Saint Nazaire. BP 420 44606 SAINT NAZAIRE cedex

The siltation of reservoir causes many problems of management and environmental disturbances that are important to minimize. Solving these problems requires in particular a good knowledge of mud bank instabilities. In partnership with the Laboratoire National d'Hydraulique (LNH), a subsidiary of Electricite de France (E.D.F.), authors realize a study of soft soils sliding entailed by reservoir emptying. Using a geotechnical flat sliding mechanism, the theoretical formulation of the safety factor can be established when the sediment mass is submerged and emergent. The measurement campaign carried out makes it possible to obtain bathymetric and topographic surveys and a geotechnical characterization of the soil for the whole reservoir of Grangent dam, located on the Loire (France). The proposed model appears to agree satisfactorily with the instability of the zones emerged because of the emptying and with the stability of the profile after emptying. The use of this model within the framework of forecasts

关键词： Soft soils Mud Bank Sliding Dam reservoir Emptying

Neglected Rural Public Health Issue:The Case of Intestinal Roundworms

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China & World Economy 2013年第3期21卷 25-43页

作者： Linxiu Zhang Yingping Cai Xiaobing Wang Xiaochen Ma alexis Medina D.Scott Smith Scott Rozelle Center for Chinese Agricultural Policy Institute for Geographical Sciences and Natural Resource ResearchChinese Academy of Sciences University of Chinese Academy of Sciences Department of Agricultural and Resource Economics University of California Freeman Spogli Institute for International Studies Stanford University

Despite increasing institutional and financial support, certain public health issues are still neglected by the Chinese Government. The present paper examines the soil-transmitted helminth （STH） infection and reinfection rates by conducting a survey on 1724 children in Guizhou Province, China. Our results indicate that 37.5 percent of children had been infected with one or more of the three types of tested STH. However, only 50.4 percent of children reported having taken deworming medicine during the 18-month period before the survey. Of those who reported being dewormed, 34.6 percent tested positive for STH infections. Poverty and number of siblings are significantly and positively correlated with infection and reinfection, and parental education is significantly and negatively correlated with infection and reinfection. Given the ineffectiveness of treatment in these areas to date, for anthelminthic campaigns to actually succeed, China must pay more attention to local- level incentives to improve children＇s health.

关键词： deworming intestinal roundworms poor reinfection