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Factors associated with success of telaprevir-and boceprevir-based triple therapy for hepatitis C virus infection

World Journal of Hepatology 2017年第11期9卷 551-561页

作者： Kian Bichoupan Neeta Tandon Valerie Martel-Laferriere Neal M Patel David Sachs Michel Ng Emily A Schonfeld alexis pappas James Crismale Alicia Stivala Viktoriya Khaitova Donald Gardenier Michael Linderman William Olson Ponni V Perumalswami Thomas D Schiano Joseph A Odin Lawrence U Liu Douglas T Dieterich Andrea D Branch Division of Liver Diseases Icahn School of Medicine at Mount Sinai Icahn Medical Instititute Janssen Pharmaceuticals Com-panies Division of Janssen Scientific Affairs Inc. Genetics and Genomics Icahn School of Medicine at Mount Sinai

To evaluate new therapies for hepatitis C virus (HCV), data about real-world outcomes are needed. METHODSOutcomes of 223 patients with genotype 1 HCV who started telaprevir- or boceprevir-based triple therapy (May 2011-March 2012) at the Mount Sinai Medical Center were analyzed. Human immunodeficiency virus-positive patients and patients who received a liver transplant were excluded. Factors associated with sustained virological response (SVR24) and relapse were analyzed by univariable and multivariable logistic regression as well as classification and regression trees. Fast virological response (FVR) was defined as undetectable HCV RNA at week-4 (telaprevir) or week-8 (boceprevir). RESULTSThe median age was 57 years, 18% were black, 44% had advanced fibrosis/cirrhosis (FIB-4 ≥ 3.25). Only 42% (94/223) of patients achieved SVR24 on an intention-to-treat basis. In a model that included platelets, SVR24 was associated with white race [odds ratio (OR) = 5.92, 95% confidence interval (CI): 2.34-14.96], HCV sub-genotype 1b (OR = 2.81, 95%CI: 1.45-5.44), platelet count (OR = 1.10, per x 104 cells/μL, 95%CI: 1.05-1.16), and IL28B CC genotype (OR = 3.54, 95%CI: 1.19-10.53). Platelet counts > 135 x 103/μL were the strongest predictor of SVR by classification and regression tree. Relapse occurred in 25% (27/104) of patients with an end-of-treatment response and was associated with non-FVR (OR = 4.77, 95%CI: 1.68-13.56), HCV sub-genotype 1a (OR = 5.20; 95%CI: 1.40-18.97), and FIB-4 ≥ 3.25 (OR = 2.77; 95%CI: 1.07-7.22). CONCLUSIONThe SVR rate was 42% with telaprevir- or boceprevir-based triple therapy in real-world practice. Low platelets and advanced fibrosis were associated with treatment failure and relapse.

关键词： Sustained virologic response Hepatitis C virus Relapse Telaprevir Boceprevir Triple-therapy Classification and regression Adverse event Real-world

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Entropy Corrections for a Charged Black Hole of String Theory

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Communications in Theoretical Physics 2011年第1期55卷 72-74页

作者： alexis Larraaga National University of Colombia National Astronomical Observatory

We study the entropy of the Gibbons-Maeda-Garfinkle-Horowitz-Strominger （GMGHS） charged black hole, originated from the effective action that emerges in the low-energy of string theory, beyond semiclassical approxi- mations. Applying the properties of exact differentials for three variables to the first law thermodynamics we derive the quantum corrections to the entropy of the black hole. The leading （logarithmic） and non leading corrections to the area law are obtained.

关键词： quantum aspects of black holes thermodynamics strings and branes

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Understanding lateral root formation,one cell at a time

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Molecular Plant 2021年第8期14卷 1229-1231页

作者： Anamarija Primc alexis Maizel Center for Organismal Studies(COS) University of HeidelbergHeidelbergGermany

Formation of lateral roots shapes the architecture of plant root systems and con tributes to their *** Arabidopsis,lateral roots follow a well-described sequenee of events that lead to the emergence of a new root complete with its own meristem and a set of tissue and cell types very similar to the ones found in the primary *** are the different cell types established?In a recent study,Serrano-Ron et al.(2021)used single-cell RNA sequencing(scRNA-seq)to profile the diversity of cell types in the forming lateral roots and revealed a hitherto unknown role for camalexins in controlling lateral root patterning.

关键词： roots Arabidopsis cell

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On Thermodynamical Relation Between Rotating Charged BTZ Black Holes and Effective String Theory

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Communications in Theoretical Physics 2008年第12期50卷 1341-1344页

作者： alexis Larraaga National

In this paper we study the first law of thermodynamics for the （2＋1）-dimensional rotating charged BTZ black hole considering a pair of thermodynamical systems constructed with the two horizons of this solution. We show that these two systems are similar to the right and left movers of string theory and that the temperature associated with the black hole is the harmonic mean of the temperatures associated with these two systems.

关键词： quantum aspects of black holes thermodymics classical black holes strings and branes

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On Hawking Radiation from a Charged Black Hole of Heterotic String Theory

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Communications in Theoretical Physics 2014年第4期61卷 491-494页

作者： alexis Larraaga National Astronomical Observatory National University of Colombia

We investigate the Hawking radiation of a GMGHS charged black hole from the heterotic string scenario by the massive particles turmeling method. We consider the spacetime background to be dynamical, incorporate the self-gravitation effect of the emitted particles and show that the tunneling rate is related to the change of Bekenstein- Hawking entropy and the derived emission spectrum does not deviate from the pure thermal spectrum of Schwrzschild＇s black hole.

关键词： quantum aspects of black holes thermodynamics strings and branes

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A novel strategy for ionomer coating of Ag nanoparticles used for the electrochemical reduction of CO2 to CO in a membrane electrode assembly

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National Science Review 2024年第2期11卷 94-95页

作者： alexis T.Bell Department of Chemical and Biomolecular Engineering University of California

The electrochemical reduction of the CO2reaction （CO2RR） offers an attractive means for converting the carbon content of CO2, released from a stationary source or the atmosphere, into fuels and chemicals [1]. Utiliz...

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Hydrodeoxygenation of vegetable oil in batch reactor:Experimental considerations

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Chinese Journal of Chemical Engineering 2020年第6期28卷 1670-1683页

作者： alexis K.Noriega alexis Tirado Cecilia Méndez Gustavo Marroquín Jorge Ancheyta Instituto Politécnico Nacional Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada Unidad LegariaLegaria 694Col.Irrigación 11500Mexico Instituto Mexicano del Petróleo Eje Central Lázaro Cárdenas Norte 152San Bartolo Atepehuacan 07730Mexico

The generation of reliable experimental data in any experimental scale requires proper procedures not only for the reaction step but also for the feed preparation,separation,and characterization of products as well as calculations of conversion and product *** reactor is the most used experimental setup for carrying out exploratory studies for catalyst screening and *** work is focused on describing and discussing a step-by-step methodology for conducting experiments for catalytic hydrotreating of vegetable oils in batch *** proposed methodology considers literature and own experiences on advantages and disadvantages of different feed types,catalysts,experimental setup and procedures,effect of reaction parameters,separation and characterization of products,and calculations.

关键词： Vegetable oils Hydrotreating Batch reactor

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Surgical management of necrotizing pancreatitis:An overview

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World Journal of Gastroenterology 2014年第43期20卷 16106-16112页

作者： George Kokosis Alexander Perez Theodore N pappas Department of Surgery Duke University Medical CenterDurhamNC 27705United States

Necrotizing pancreatitis is an uncommon yet serious complication of acute pancreatitis with mortality rates reported up to 15%that reach 30%in case of *** open surgical debridement was the only tool in our disposal to manage this serious clinical *** approach is however associated with poor *** has now shifted away from open surgical debridement to a more conservative management and minimally invasive *** approach to patients with necrotizing pancreatitis and/or infectious pancreatitis is summarized in the 3Ds:Delay,Drain and *** can be managed in the intensive care unit and any intervention should be *** drainage can be utilized first and early in the course of the disease,followed by endoscopic drainage or video assisted retroperitoneoscopic drainage if necrosectomy is deemed *** surgery is now less frequently performed and should be reserved for cases refractory to any other *** management of necrotizing pancreatitis therefore requires a multidisciplinary dynamic model of approach rather than being a surgical disease.

关键词： Necrotizing pancreatitis Severe acute pancreatitis Debridement Necrosectomy Infected necrosis Endoscopic necrosectomy Video-assisted retroperitoneal debridement Percutaneous catheter drainage

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Advancements in the development of liquid organic hydrogen carrier systems and their applications in the hydrogen economy

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Progress in Natural Science:Materials International 2024年第5期34卷 825-839页

作者： alexis Munyentwali Khai Chen Tan Teng He Dalian Institute of Chemical Physics Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

The transition towards sustainable and clean energy systems has become a significant concern in the modern world. Hydrogen has the potential to meet the growing energy demands while addressing greenhouse gas emissions. However, one major obstacle in utilizing hydrogen as a fuel is the lack of efficient and cost-effective storage methods. In this regard, liquid organic hydrogen carriers(LOHCs) offer several advantages, including high hydrogen storage capacity, improved safety compared to traditional storage methods, and the ability to transport hydrogen using existing liquid fuels' infrastructure. This review summarizes advancements in the development of LOHC systems for hydrogen storage, with a focus on the latest and innovative systems such as those based on dehydrogenative coupling reactions, renewable LOHCs from lignocellulosic biomass, and the development of LOHCs from plastic waste recycling. In addition to the material aspect, this contribution also discusses various applications of LOHCs in the broader context of the hydrogen economy, including a recently proposed concept of mixed gas hydrogenation of LOHCs for realizing hydrogen purification and storage in a single process step. By highlighting the main advantages and challenges of each LOHC system and providing future directions in the development of efficient LOHC systems, this review aims to contribute to an extensive understanding and advancement of LOHCs in the evolving hydrogen-based economy.

关键词： Hydrogen storage Liquid organic hydrogen carriers (LOHCs) Hydrogen economy Hydrogenation Dehydrogenation

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Porous Medium Flow with Both a Fractional Potential Pressure and Fractional Time Derivative

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Chinese Annals of Mathematics,Series B 2017年第1期38卷 45-82页

作者： Mark ALLEN Luis CAFFARELLI alexis VASSEUR Department of Mathematics The University of Texas at AustinAustinTX 78712USA

The authors study a porous medium equation with a right-hand side. The operator has nonlocal diffusion effects given by an inverse fractional Laplacian *** derivative in time is also fractional and is of Caputo-type, which takes into account"memory". The precise model isD_t~αu- div(u(-Δ)^(-σ)u) = f, 0 < σ <1/*** paper poses the problem over {t ∈ R^+, x ∈ R^n} with nonnegative initial data u(0, x) ≥0 as well as the right-hand side f ≥ 0. The existence for weak solutions when f, u(0, x)have exponential decay at infinity is proved. The main result is H¨older continuity for such weak solutions.

关键词： Caputo derivative Marchaud derivative Porous medium equation Hlder continuity Nonlocal diffusion

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