检索结果-南通市图书馆

Brain dysfunctions and neurotoxicity induced by psychostimulants in experimental models and humans:an overview of recent findings

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第9期19卷 1908-1918页

作者： Marcello Serra Nicola Simola alexia E.Pollack Giulia Costa Department of Biomedical Sciences Section of NeuroscienceUniversity of CagliariCagliariItaly Department of Biology University of Massachusetts-BostonBostonMAUSA

Preclinical and clinical studies indicate that psychostimulants,in addition to having abuse potential,may elicit brain dysfunctions and/or neurotoxic *** toxicity induced by psychostimulants may pose serious health risks since the recreational use of these substances is on the rise among young people and *** present review provides an overview of recent research,conducted between 2018 and 2023,focusing on brain dysfunctions and neurotoxic effects elicited in experimental models and humans by amphetamine,cocaine,methamphetamine,3,4-methylenedioxymethamphetamine,methylphenidate,caffeine,and *** elucidation of factors and mechanisms that underlie psychostimulant-induced brain dysfunction and neurotoxicity is crucial for understanding the acute and enduring noxious brain effects that may occur in individuals who use psychostimulants for recreational and/or therapeutic purposes.

关键词： 3,4-methylenedioxymethamphetamine amphetamine caffeine cell cultures cocaine methamphetamine methylphenidate neurotoxicity nicotine

Association of the immediate perioperative dynamics of circulating DNA levels and neutrophil extracellular traps formation in cancer patients

在线全文

学校读者我要写书评

暂无评论

Precision Clinical Medicine 2024年第2期7卷 93-108页

作者： Andrei Kudriavtsev Brice Pastor alexia Mirandola Ekaterina Pisareva Yann Gricourt Xavier Capdevila Alain R.Thierry Philippe Cuvillon Institut de Recherche en Cancerologie de Montpellier INSERM U1194Universite de MontpellierMontpellier 34298France Institut regional du Cancer de Montpellier Montpellier 34298France Department of Anaesthesiology and Pain Management Centre Hospitalo-Universitaire(CHU)CaremeauPlace du Professeur DebreNimes 30400France University of Montpellier Montpellier 34298France Division of Anaesthesia Intensive Care Pain and Emergency MedicineMontpellier University HospitalMontpellier 34090France Montpellier NeuroSciences Institute INSERMU1298University of MontpellierMontpellier 34295Franc

Objectives:Elevated circulating DNA(cirDNA)concentrations were found to be associated with trauma or tissue damage which suggests involvement of inflammation or cell death in post-operative cirDNA *** carried out the first prospective,multicenter study of the dynamics of cirDNA and neutrophil extracellular trap(NETs)markers during the perioperative period from 24 h before surgery up to 72 h after curative surgery in cancer ***:We examined the plasma levels of two NETs protein markers[myeloperoxidase(MPO)and neutrophil elastase(NE)],as well as levels of cirDNA of nuclear(cir-nDNA)and mitochondrial(cir-mtDNA)origin in 29 colon,prostate,and breast cancer patients and in 114 healthy individuals(HI).Results:The synergistic analytical information provided by these markers revealed that:(i)NETs formation contributes to post-surgery conditions;(i)post-surgery cir-nDNA levels were highly associated with NE and MPO in colon cancer[r=0.60(P<0.001)and r=0.53(P<0.01),respectivelyl,but not in prostate and breast cancer;(i)each tumor type shows a specific pattern of cir-nDNA and NETs marker dynamics,but overall the pre-and post-surgery median values of cir-nDNA,NE,and MPO were significantly higher in cancer patients than in ***:Taken as a whole,our work reveals the association of NETs formation with the elevated cir-nDNA release during a cancer patient's perioperative period,depending on surgical procedure or cancer *** contrast,cir-mtDNA is poorly associated with NETs formation in the studied perioperative period,which would appear to indicate a different mechanism of release or suggest mitochondrial dysfunction.

关键词： circulating DNA perioperative period neutrophil extracellular traps neutrophil elastase myeloperoxidase minimal residualdisease

Determination of critical state line(CSL)for silty-sandy iron ore tailings subjected to low-high confining pressures

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1684-1695页

作者： Nilo Cesar Consoli João Vítor de Azambuja Carvalho alexia Cindy Wagner Hugo Carlos Scheuermann Filho Inácio Carvalho Pedro Pazzoto Cacciari João Paulo de Sousa Silva Civil Engineering Universidade Federal do Rio Grande do SulPorto AlegreRS90035-190Brazil Exploration and Mineral Projects-Mineral Development Centre VALE S.A.Santa LuziaMG33040-900Brazil Department of Civil Geological and Mining EngineeringPolytechnique MontrealQuebecH3C 3A7Canada

The disposal of filtered tailings in high dry stacks can induce particle breakage,changing the material's behaviour during the structure's *** grading changes influence material properties at the critical state,and this is not mature for intermediate artificial soils(tailings)in a broad range of confining *** this paper,it aims to describe the behaviour of iron ore tailings in a spectrum of confining pressures broader than the reported in previous studies.A series of consolidated drained(CD)triaxial tests was carried out with confining pressures ranging from 0.075 MPa to 120 *** results show that the amount of breakage plays an essential role in the response of iron ore *** existence of curved critical state line(CSL)in both specific volume(ν)-logarithm of mean effective stress(p′)and deviatoric stress(q)-mean effective stress(p′)planes,and different responses in the deviatoric stress-axial strain-volumetric strain curves were *** inverse S-shaped equation was proposed to represent the silty-sandy tailings'behaviour up to high pressures onν-lnp′*** proposed equation provides a basis for enhancing constitutive models and considers the evolution of the grading up to severe loading *** adjustment considered three regions with different responses associated with particle breakage at different pressure levels.

关键词： Tailings Iron ore tailings dry stacking Silty-sandy material Critical state soil mechanics High confining pressures Particle breakage

Prenatal and postnatal drug exposure:focus on persistent central effects

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第8期18卷 1697-1702页

作者： Giulia Costa alexia E.Pollack Department of Biomedical Sciences Section of NeuroscienceUniversity of CagliariCagliariItaly Department of Biology University of Massachusetts-BostonBostonMAUSA

Clinical studies indicate significant use of prescription,nonprescription and social/recreational drugs by women during pregnancy;however,limited knowledge exists about the detrimental effects that this practice may have on the developing central nervous system of the ***,few experimental and clinical data are available on how gestational exposure could exacerbate the effects of the same or a different drug consumed by the offspring later in *** present review summarizes recent findings on the central toxicity elicited by several classes of drugs,administered prenatally and postnatally in experimental animals and humans,focusing on prescription and nonprescription analgesics,anti-inflammatory agents,alcohol and nicotine.

关键词： 3 4-methylenedioxymethamphetamine acetaminophen alcohol chlorpyrifos dexamethasone ibuprofen methadone neuroinflammation neurotoxicity nicotine

Cancer cells evade ferroptosis: sex hormone-driven membrane-bound O-acyltransferase domain-containing 1 and 2 (MBOAT1/2) expression

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第10期8卷 4424-4425页

作者： alexia Belavgeni Wulf Tonnus Andreas Linkermann Division of Nephrology Department of Internal Medicine IUniversity Hospital Carl Gustav Carus at the Technische Universitat DresdenDresdenGermany Division of Nephrology Department of MedicineAlbert Einstein College of MedicineBronxNYUSA

In a recent manuscript published in Cell,Liang et *** novel ferroptosis regulators,membrane-bound O-acyltransferase domain-containing 1 and 2(MBOAT1/2).1 These findings may have implications for ferroptosis-based canc... 详细信息

关键词： al. T1/2 Cancer

Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第11期36卷 1327-1343页

作者： alexia Duveau Eleonore Bertin Eric Boue-Grabot Universite de Bordeaux Institut des Maladies NeurodegenerativesUMR 529333000 BordeauxFrance CNRS Institut des Maladies NeurodegenerativesUMR 529333000 BordeauxFrance

The P2X4 receptor(P2X4)is an ATP-gated cation channel that is highly permeable to Ca2+and widely expressed in neuronal and glial cell types throughout the central nervous system(CNS).A growing body of evidence indicates that P2X4 plays key roles in numerous central disorders.P2X4 trafficking is highly regulated and consequently in normal situations,P2X4 is present on the plasma membrane at low density and found mostly within intracellular endosomal/lysosomal *** increase in the de novo expression and/or surface density of P2X4 has been observed in microglia and/or neurons during pathological *** review aims to summarize knowledge on P2X4 functions in CNS disorders and provide some insights into the relative contributions of neuronal and glial P2X4 in pathological ***,determination of the cell-specific functions of P2X4 along with its intracellular and cell surface roles remain to be elucidated before its potential as a therapeutic target in multiple disorders can be defined.

关键词： Purinergic signaling P2X ATP Ligandgated ion channels Chronic pain Brain trauma Ischemia Neurodegenerative diseases Alcohol Neuropsychiatric disorders

Overexpression of the angiogenic tetrapeptide AcSDKP and the prolyl oligopeptidase(POP) is a common feature of cancer

在线全文

学校读者我要写书评

暂无评论

生物物理学报 2009年第S1期25卷 32-33页

作者： Jérme Bignon alexia Pinault Joanna Wdzieczak-Bakala Institut de Chimie des Substances Naturelles CNRS 91198 Gif-sur-Yvette France

Prolyl oligopeptidase (POP) is a cytosolic enzyme involved in the metabolism of many peptide hormones and neuropeptides (1). It was recently reported that POP is responsible

关键词： AcSDKP Overexpression of the angiogenic tetrapeptide AcSDKP and the prolyl oligopeptidase is a common feature of cancer POP

在线全文

学校读者我要写书评

暂无评论

终生年金制房产交易，法国房地产交易的未来

终生年金制房产交易，法国房地产交易的未来

作者：罗夏（alexia Pierrette sabine ROY）华中科技大学

学位级别：硕士

“终生年金制房产交易”是法国的一种房地产交易方式，买方可以通过这种交易而获得房产的继承权。交易定价由两部分组成。一部分是首先要支付给卖房人“购房费”，另一部分则是支付到卖房人去世前的定期养老金。而这两部分构成的购房成... 详细信息

“终生年金制房产交易”是法国的一种房地产交易方式，买方可以通过这种交易而获得房产的继承权。交易定价由两部分组成。一部分是首先要支付给卖房人“购房费”，另一部分则是支付到卖房人去世前的定期养老金。而这两部分构成的购房成本一般仅占总房价的20%，收益则根据通货膨胀的情况而定。本文讨论了卖房人所获得的一系列好处，其中之一是可以继续获得房屋的使用权同时改善自己的生活。而对于买房人而言，本文也详述了其受益情况。其中之一是，可以以更便宜的价格购房。 “终生年金制房产交易”曾经是交易方式中一种非常普遍的方式，特别是在十九世纪，当时还没有明显的保险和回报机制。而在二十世纪也是非常少见的。然而，自从在其流行起来的十年间，特别是从2005年到2008年，这个市场实现了翻倍。本文的主要目的是阐述这种“终生年金制房产交易”新的生机。本文由六个部分组成。首先会介绍“终生年金制房产交易”的多种方式和买卖双方的优劣势。然后，本文会深度剖析其计算机理以及专家如何运用这种交易方式。更进一步地，本文将会研究其进化方式和所产生的伦理争论。最后，本文将会讨论其在法国的交易前景。

关键词：终生年金制房产交易种群进化道德

The role of seaweed as a potential dietary supplementation for enteric methane mitigation in ruminants: Challenges and opportunities

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Animal Nutrition 2021年第4期7卷 1371-1387页

作者： Byeng R.Min David Parker David Brauer Heidi Waldrip Catherine Lockard Kristin Hales alexia Akbay Simona Augyte College of Agriculture Environment and Nutrition SciencesTuskegee UniversityTuskegeeAL 36088USA United States Department of Agriculture(USDA) Agriculture Research Service(ARS)2300 Experiment Station Dr.BushlandTX 79012USA Department of Animal and Food Sciences Texas Tech UniversityLubbockTX 79409USA Symbrosia Inc Kailua-KonaHI 96740USA

Seaweeds are macroalgae,which can be of many different morphologies,sizes,colors,and chemical *** include brown,red,and green *** seaweeds have been more investigated and exploited in comparison to other seaweed types for their use in animal feeding studies due to their large sizes and ease of *** in vitro and in vivo studies suggest that plant secondary compound-containing seaweeds(e.g.,halogenated compounds,phlorotannins,etc.)have the potential to mitigate enteric methane(CH_(4))emissions from ruminants when added to the diets of beef and dairy *** seaweeds including Asparagopsis *** rich in crude protein and halogenated compounds compared to brown and green *** halogenated-containing red seaweeds are used as the active ingredient in ruminant diets,bromoform concentration can be used as an indicator of antimethanogenic ***-containing brown seaweed has also the potential to decrease CH_(4) ***,numerous studies examined the possible anti-methanogenic effects of marine seaweeds with inconsistent *** work reviews existing data associated with seaweeds and in vitro and in vivo rumen fermentation,animal performance,and enteric CH4 emissions in *** understanding of the seaweed supplementation related to rumen fermentation and its effect on animal performance and CH_(4) emissions in ruminants may lead to novel strategies aimed at reducing greenhouse gas emissions while improving animal productivity.

关键词： Seaweed Bromoform Methane Phlorotannins Ruminant Cattle