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Neural Regeneration Research 2025年第6期20卷 1713-1714页

作者： alexei Verkhratsky Alexey Semyanov Faculty of biology Medicine and HealthThe University of ManchesterManchesterUK Department of Neurosciences University of the Basque Country UPV/EHU and CIBERNEDLeioaSpain Department of Forensic Analytical Toxicology School of Forensic MedicineChina Medical UniversityShenyangLiaoning ProvinceChina Department of Stem Cell biology State Research Institute Centre for Innovative MedicineVilniusLithuania International Collaborative Center on big Science Plan for Purinergic Signalling Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina Department of Physiology Jiaxing University College of MedicineJiaxingZhejiang ProvinceChina

“Last scene of all that ends this strange,eventful history,is second childishness and mere oblivion.I am sans teeth,sans eyes,sans taste,sans everything.”William Shakespeare‘As You Like It'Act 2,Sc.7,l.139Aging of the human brain is characterized by a progressive decline of its functional capacity;this decline however varies widely,and cognitive longevity differs substantially between individuals.

关键词： aging teeth progressive

Nanoparticle meta-grid for enhanced light extraction from light-emitting devices

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Light(Science & Applications) 2020年第1期9卷 842-852页

作者： Debabrata Sikdar John b.Pendry alexei A.Kornyshev Department of Chemistry Molecular Sciences Research HubImperial College LondonWhite CityLondon W120BZUK Department of Electronics and Electrical Engineering Indian Institute of Technology GuwahatiGuwahati 781039India The blackett Laboratory Department of PhysicsImperial College LondonLondon SW72AZUK Thomas Young Centre for Theory and Simulation of Materials Imperial College LondonLondon SW72AZUK

based on a developed theory,we show that introducing a meta-grid of sub-wavelength-sized plasmonic nanoparticles(NPs)into existing semiconductor light-emitting-devices(LEDs)can lead to enhanced transmission of light across the LED-chip/encapsulant *** results from destructive interference between light reflected from the chip/encapsulant interface and light reflected by the NP meta-grid,which conspicuously increase the efficiency of light extraction from ***“meta-grid”,should be inserted on top of a conventional LED chip within its usual encapsulating *** described by the theory,the nanoparticle composition,size,interparticle spacing,and distance from the LED-chip surface can be tailored to facilitate maximal transmission of light emitted from the chip into its encapsulating layer by reducing the Fresnel *** analysis shows that transmission across a typical LEDchip/encapsulant interface at the peak emission wavelength can be boosted up to ~99%,which is otherwise mere~84% at normal *** scheme could provide improved transmission within the photon escape cone over the entire emission spectrum of an *** would benefit energy saving,in addition to increasing the lifetime of LEDs by reducing ***,the scheme will be easy to implement and adopt into existing semiconductor-device technologies,and it can be used separately or in conjunction with other methods for mitigating the critical angle loss in LEDs.

关键词： light particle reflected

Glial calcium signaling in physiology and pathophysiology

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Acta Pharmacologica Sinica 2006年第7期27卷 773-780页

作者： alexei VERKHRATSKY Faculty of Life Sciences the University of Manchester UK

Neuronal-glial circuits underlie integrative processes in the nervous ***-tion of glial syncytium is,to a very large extent,regulated by the intracellularcalcium signaling *** calcium signals are triggered by activation ofmultiple receptors,expressed in glial membrane,which regulate both Ca2+entryand Ca2+release from the endoplasmic *** endoplasmic reticulum alsoendows glial cells with intracellular excitable media,which is able to produce andmaintain long-ranging signaling in a form of propagating Ca2+*** patho-logical conditions,calcium signals regulate glial response to injury,which mighthave both protective and detrimental effects on the nervous tissue.

关键词： calcium signaling neuronal-glial interactions brain ischemia Alzheimer’s disease epilepsy spreading depression

Variation of Small Scale Magnetic Fields Over a Century using Ca-K Images as Proxy

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Research in Astronomy and Astrophysics 2023年第4期23卷 172-183页

作者： Jagdev Singh Muthu Priyal b.Ravindra Luca bertello alexei Pevtsov Indian Institute of Astrophysics II BlockKoramangalaBengaluru–560034India National Solar Observatory 3365 Discovery DriveThird FloorBoulderCO 80303USA

A combined uniform and long-time series of Ca-K images from the Kodaikanal Observatory,Mount Wilson Observatory and Mauna Loa Solar Observatory was used to identify and study the Ca-K small-scale features and their solar cycle variations over a *** small scale features are classified into three distinct categories:enhanced network,active network and quiet *** these features show that their areas vary according to the11 yr solar *** relative amplitude of the Ca-K network variations agrees with that of the sunspot *** total area of these small-scale features varies from about 5%during the minimum phase of the solar cycle to about20%during its maximum phase.

关键词： Sun activity-Sun chromosphere-(Sun:)sunspots

Antiproton-nucleus reactions at intermediate energies

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Nuclear Science and Techniques 2015年第2期26卷 104-110页

作者： alexei borisovich Larionov Frankfurt Institute for Advanced Studies National Research Centre Kurchatov Institute

Antiproton-induced reactions on nuclei at the beam energies from hundreds Me V up to several Ge V provide an excellent opportunity to study interactions between the antiproton and secondary particles(mesons, baryons and antibaryons) with nucleons. The antiproton projectile is unique in the sense that most of the annihilation particles are relatively slow in the target nucleus frame. Hence, the prehadronic effects do not much influence their interactions with the nucleons of the nuclear residue. Moreover, the particles with momenta less than about 1 Ge V/c are sensitive to nuclear mean field potentials. This paper discusses the microscopic transport calculations of the antiproton-nucleus reactions and is focused on three related problems:(i) antiproton potential determination,(ii) possible formation of strongly bound antiproton-nucleus systems, and(iii) strangeness production.

关键词：原子核反应反质子能量相互作用次级粒子核平均场核系统 iii

Understanding the epidemiology and outcomes of out-of-hospital cardiac arrest in the former Union of Soviet Socialist Republics:Observations from the Crimean peninsula

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World Journal of Emergency Medicine 2022年第1期13卷 67-68页

作者： alexei birkun Department of Anesthesiology Resuscitation and Emergency MedicineMedical Academy named after S.I.Georgievsky of V.I.Vernadsky Crimean Federal UniversitySimferopol 295051Russian Federation

Out-of-hospital cardiac arrest(OHCA)is widely recognized as a global health ***,little is known about OHCA epidemiology in the former Union of Soviet Socialist Republics(USSR)territories.[1,2]The15 post-Soviet states ... 详细信息

关键词： occupy Republic cardiac

Alterations of protein homeostasis in Alzheimer's disease:beyond Procrustean bed of endoplasmic reticulum stress and unfolded protein response

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Neural Regeneration Research 2024年第8期19卷 1645-1646页

作者： Dmitry Lim alexei Verkhratsky Department of Pharmaceutical Sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly Faculty of biology Medicine and HealthThe University of ManchesterManchesterUK Achucarro Center for Neuroscience IKERBASQUEBasque Foundation for ScienceBilbaoSpain&Department of NeurosciencesUniversity of the Basque Country UPV/EHU and CIBERNEDLeioaSpain Department of Stem Cell biology State Research Institute Centre for Innovative MedicineVilniusLithuania Department of Forensic Analytical Toxicology School of Forensic MedicineChina Medical UniversityShenyangLiaoning ProvinceChina

Alzheimer’s disease(AD)is a major age-related form of dementia with a number of cases exponentially growing,causing enormous social and economic impact on individuals and *** hallmarks of AD,evident in postmortem AD brains,include a massive loss of the grey matter in the neocortex,extracellular deposition of amyloid-β(Aβ)in the form of senile plaques and cerebrovascular amyloid angiopathy,and intra-neuronal accumulation of neurofibrillary tangles,formed by hyper-phosphorylated tau protein.

关键词： Alzheimer homeostasis cortex

Palaeoclimate background of the diverse Eocene floras of South China

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Science bulletin 2017年第22期62卷 1501-1503页

作者： Jian-Hua Jin alexei b. Herman Robert A. Spicer Tatiana M. Kodrul State Key Laboratory of biocontrol and Guangdong Provincial Key Laboratory of Plant Resources School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Geological Institute Russian Academy of SciencesMoscow 119017Russia School of Environment Earth and Ecosystem SciencesThe Open UniversityMilton Keynes MK7 6AAUK

Hainan and Guangdong provinces,located in north tropical area and south subtropical area of China respectively,bear one of the highest levels of biodiversity in *** modern floras of Hainan and Guangdong are dominated by pantropical and tropical-subtropical taxa and many of their representative families appeared as early as in the Eocene[1].The Eocene,therefore,represents a crucial stage in the formation of the extant ***,previously the Eocene floras and vegetation were largely studied in mid-

关键词： Palaeoclimate background of the diverse Eocene floras of South China

Store-operated calcium entry in neuroglia

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Neuroscience bulletin 2014年第1期30卷 125-133页

作者： alexei Verkhratsky Vladimir Parpura Faculty of Life Sciences The University of Manchester Achucarro Center for Neuroscience IKERBASQUE Basque Foundation for Science 48011 Bilbao Spain and Department of Neurosciences University of the Basque Country UPV/EHU Department of Neurobiology Center for Glial Biology in Medicine Atomic Force Microscopy & Nanotechnology aboratories Civitan International Research Center Evelyn F. McKnight Brain Institute University of Alabama Department of biotechnology University or Rijeka

Neuroglial cells are homeostatic neural cells. Generally, they are electrically non-excitable and their activation is associated with the generation of complex intracellular Ca^2＋ signals that define the ＂Ca^2＋ excitability＂ of glia. In mammalian glial cells the major source of Ca^2＋ for this excitability is the lumen of the endoplasmic reticulum （ER）, which is ultimately （re）filled from the extracellular space. This occurs via store-operated Ca^2＋ entry （SOCE） which is supported by a specific signaling system connecting the ER with plasmalemmal Ca^2＋ entry. Here, emptying of the ER Ca^2＋ store is necessary and sufficient for the activation of SOCE, and without Ca^2＋ influx via SOCE the ER store cannot be refilled. The molecular arrangements underlying SOCE are relatively complex and include plasmalemmal channels, ER Ca^2＋ sensors, such as stromal interaction molecule, and possibly ER Ca^2＋ pumps （of the SERCA type）. There are at least two sets of plasmalemmal channels mediating SOCE, the Ca2＊-release activated channels, Orai, and transient receptor potential （TRP） channels. The molecular identity of neuroglial SOCE has not been yet identified unequivocally. However, it seems that Orai is predominantly expressed in microglia, whereas astrocytes and oligodendrocytes rely more on TRP channels to produce SOCE. In physiological conditions the SOCE pathway is instrumental for the sustained phase of the Ca^2＋ signal observed following stimulation of metabotropic receptors on glial cells.

关键词： calcium signaling astrocyte oligodendrocyte microglia store-operated calcium entry TRP STIM Orai