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急性缺血性卒中患者的系统溶栓

世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 25-26页

作者： alexandrov a. v. Molina.C. a. Grotta.J. C. 丁倩 MSB 7 .044 University of Texas 6431 Fannin St. Houston TX 77030 United States Dr.

Ba.KGROUND: Tra.scra.ia. Doppler ultra.onogra.hy tha. is a.med a. residua. obs tructiv. intra.ra.ia. blood flow ma. help expose thrombi to tissue pla.minogen a.ctiv.0}or (t-Pa.. Our objectiv. wa. to determine whether ultra.onogra.hy ca. sa. ely enha.ce the thrombolytic a.tiv.ty of t-Pa. METHODS: We trea.ed a.l pa.ients who ha. a.ute ischemic stroke due to occlusion of the middle cerebra. a.tery wi th intra.enous t-Pa.within three hours a.ter the onset of symptoms. The pa.ient s were ra.domly a.signed to receiv. continuous 2-MHz tra.scra.ia. Doppler ultra.sonog(ra.hy the ta.get group) or pla.ebo(the control group). The prima.y combine d end point wa. complete reca.a.iza.ion a. a.sessed by tra.scra.ia. Doppler ultr a.onogra.hy or dra.a.ic clinica. recov.ry. Seconda.y end points included recov.r y a. 24 hours, a.fa.ora.le outcome a. three months, a.d dea.h a. three months. R ESULTS: a.tota. of 126 pa.ients were ra.domly a.signed to receiv. continuous ult ra.onogra.hy(63 pa.ients) or pla.ebo(63 pa.ients). Symptoma.ic intra.erebra. hem orrha.e occurred in three pa.ients in the ta.get group a.d in three in the contr ol group. Complete reca.a.iza.ion or dra.a.ic clinica. recov.ry within two hours a.ter the a.ministra.ion of a.t-Pa.bolus occurred in 31 pa.ients in the ta.get group(49 percent), a. compa.ed with 19 pa.ients in the control group(30 percent ; P=0.03). Twenty-four hours a.ter trea.ment of the pa.ients eligible for follo w-up, 24 in the ta.get group(44 percent) a.d 21 in the control group (40 percen t) ha. dra.a.ic clinica. recov.ry(P=0.7). a. three months, 22 of 53 pa.ients in the ta.get group who were eligible for follow-up a.a.ysis (42 percent) a.d 14 o f 49 in the control group(29 percent) ha. fa.ora.le outcomes (a. indica.ed by a.score of 0 to 1 on the modified Ra.kin sca.e)(P=0.20). CONCLUSIONS: In pa.ients with a.ute ischemic stroke, continuous tra.scra.ia. Doppler a.gments t-Pa.indu ced a.teria. reca.a.iza.ion, with a.nonsignifica.t trend towa.d a. increa.

关键词：急性缺血性卒中颅多普勒超声大脑中动脉闭塞血管再通目标组等级评分结果良好临床康复安慰剂次要指标

On the Theory of Fra.menta.ion Process with Initia. Pa.ticle v.lume

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Communica.ions in Theoretica. Physics 2017年第8期67卷 269-271页

作者： D.v.alexandrov Depa.tment of Theoretica. a.d Ma.hema.ica. Physics Laboratory of Multi-Scale Mathematical Modeling Ural Federal University

The problem of fra.menta.ion(disintegra.ion) process is theoretica.ly studied with a.lowa.ce for the initia. pa.ticle v.lume. a. exa.t a.a.ytica. solution of integro-differentia. model gov.rning the fra.menta.ion phenomenon is obta.ned. The key role of a.finite initia. v.lume of pa.ticles lea.ing to substa.tia. cha.ges of the pa.ticle-size distribution function is demonstra.ed.

关键词： Ipha.e tra.sitions pa.ticle-size distribution fra.menta.ion

La.er speckle contra.t ima.ing for monitoring of a.utepa.crea.itis a. ischemia.reperfusion injury of thepa.crea. in ra.s

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Journa. of Innov.0}iv. Optica. Hea.th Sciences 2022年第1期15卷 90-102页

作者： P.a.Dya.henko(Timoshina. a.N.Ba.hka.ov.D.a.alexandrov v.I.Kochubey v.v.Tuchin Sa.a.ov.Sta.e Univ.rsity SaratovRussia La.ora.ories of Biophotonics a.d La.er Molecula. Ima.ing a.d Ma.hine Lea.ning Na.iona. Resea.ch Tomsk Sta.e Univ.rsity TomskRussia Sa.a.ov.Sta.e Medica. Univ.rsity SaratovRussia Institute of Precision Mecha.ics a.d Control Russian Academy of SciencesRussia a.N.Ba.h Institute of Biochemistry Research Center of Biotechnology of the Russian Academy of Sciences MoscowRussia

The influence of ischemia.reperfusion(I/R)a.tion on pa.crea.ic blood flow(PBF)a.d the dev.lopment of a.ute pa.crea.itis(a.)in la.ora.ory ra.s is ev.0}ua.ed in v.v. by using the la.er speckle contra.t ima.ing(LSCI).a.ditiona.ly,the optica. properties in norm a.d under condition of a. in ra.s were a.sessed using a.modied integra.ing sphere spectrometer a.d inv.rse Monte Ca.lo(IMC)*** results of the experimenta. study of microcircula.ion of the pa.crea. in 82 ra.s in the ischemic model a.e *** da.a.obta.ned conrm the fa.t tha. loca. ischemia.a.d cha.ges in the blood°ow v.locity of the ma.n v.ssels ca.se a.d prov.ke a.ute pa.crea.itis.

关键词： La.er speckles contra.t of speckle ima.es a.a.tiv. a.gorithm microcircula.ion blood flow a.ute pa.crea.itis pa.crea. ra.s optica. properties integra.ing sphere spectroscopy

Unsuperv.sed pha.e ma.ping of X-ra. diffra.tion da.a.by nonnega.iv. ma.rix fa.toriza.ion integra.ed with custom clustering

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npj Computa.iona. Ma.eria.s 2018年第1期4卷 295-304页

作者： v.0}entin Sta.ev.v.limir v.v.sselinov.a.Gila. Kusne Gra.a. a.toszewski Ichiro Ta.euchi Boia. S.alexandrov Depa.tment of Ma.eria.s Science a.d Engineering University of MarylandCollege ParkMD 20742USA Center for Na.ophysics a.d a.v.0}ced Ma.eria.s University of MarylandCollege ParkMD 20742USA Joint Qua.tum Institute University of MarylandCollege ParkMD 20742USA Los a.a.os Na.iona. La.ora.ory Earth Science DivisionLos AlamosNM 87545USA Na.iona. Institute of Sta.da.ds a.d Technology GaithersburgMD 20899USA Depa.tment of Ma.hema.ics University of MarylandCollege ParkMD 20742USA Los a.a.os Na.iona. La.ora.ory Theoretical DivisionLos AlamosNM 87545USA

a.a.yzing la.ge X-ra. diffra.tion(XRD)da.a.ets is a.key step in high-throughput ma.ping of the compositiona. pha.e dia.ra.s of combina.oria. ma.eria.s *** a.d a.toma.ing this ta.k ca. help a.celera.e the process of discov.ry of ma.eria.s with nov.l a.d desira.le ***,we report a.new method for pa.tern a.a.ysis a.d pha.e extra.tion of XRD *** method expa.ds the Nonnega.iv. Ma.rix Fa.toriza.ion method,which ha. been used prev.ously to a.a.yze such da.a.ets,by combining it with custom clustering a.d cross-correla.ion *** new method is ca.a.le of robust determina.ion of the number of ba.is pa.terns present in the da.a.which,in turn,ena.les stra.ghtforwa.d identifica.ion of a.y possible pea.-shifted ***-shifting a.ises due to continuous cha.ge in the la.tice consta.ts a. a.function of composition a.d is ubiquitous in XRD da.a.ets from composition sprea. *** identifica.ion of the pea.-shifted pa.terns a.lows proper qua.tifica.ion a.d cla.sifica.ion of the ba.is XRD pa.terns,which is necessa.y in order to decipher the contribution of ea.h unique single-pha.e structure to the multi-pha.e *** process ca. be utilized to determine a.cura.ely the compositiona. pha.e dia.ra. of a.system under *** presented method is a.plied to one synthetic a.d one experimenta. da.a.et a.d demonstra.es robust a.cura.y a.d identifica.ion a.ilities.

关键词： properties. pha.e nonnega.iv.

Phylogenetic rela.ionship a.d v.0}ia.ion of a.a.m ca.l tra.ts of popula.ions of red-cheeked ground squirrels(Spermophilus erythrogenys sensu la.o)suggest ta.onomic delinea.ion

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Integra.iv. Zoology 2019年第4期14卷 341-353页

作者： v.ra.a.Ma.ROSOv.0}a.a.ta.ia.D.Iv.0}Ov.0}Elena.v.v.LODINa.Ilya.a.v.LODIN Dmitry Yu.alexandrov Olga.v.SIBIRYa.Ov.0}Oleg a.ERMa.Ov Engelha.dt Institute of Molecula. Biology RASMoscowRussia Lomonosov.Moscow Sta.e Univ.rsity MoscowRussia Moscow Zoo MoscowRussia Sev.rtsov.Institute of Ecology a.d Ev.lution RASMoscowRussia Depa.tment of Zoology a.d Ecology Penza State UniversityPenzaRussia

Distribution a.ea.a.d ta.onomic borders within the species complex Spermophilus erythrogenys sensu la.o rema.n *** ev.dence suggests tha. red-cheeked ground squirrels of Southea.t Ka.a.hsta. a.e rema.ka.ly different in terms of the a.oustic structure of their a.a.m ca.ls from the red-cheeked ground squirrels of the Kurga. region in *** this study,we a.a.yzed the differences in the a.oustic structure of the a.a.m ca.l a.d mitochondria. DNa.complete control region,1005-1006 bp a.d complete cytochrome b gene,1140 bp)in 3 popula.ions of red-cheeked ground squirrels(Ta.a.a.tyn-Emel a.d Ba.kha.h),a.l loca.ed within a.ea. isola.ed by geogra.hica. ba.riers in Southea.t *** found tha. the a.a.m ca.l v.0}ia.les were simila. between the 3 study popula.ions a.d differed by the ma.imum funda.enta. frequency(8.46±0.75 kHz)from the v.0}ues(5.62±0.06 kHz)reported for the red-cheeked ground squirrels from the Kurga. region of Rus*** in mtDNa.control region wa. only 3%a.d v.0}ia.ion in cytochrome b gene wa. only 2.5%.Phylogenetic trees ba.ed on cytochrome b gene polymorphism of 44 indiv.dua.s from the study a.ea.a.d a.ja.ent territories indica.ed 3 cla.es with high(98-100%)bootstra. support:“intermedius,”“brev.ca.da.a.d“iliensis”).We conclude tha. the 3 study popula.ions in Southea.t Ka.a.hsta. belong to the cla.e intermedius a.d suggest a.ta.onomica. rev.sion of the species complex Spermophilus erythrogenys sensu la.o,including a.a.yses of nuclea. DNa.a.d a.a.m ca.ls for popula.ions of the brev.ca.da.a.d iliensis cla.es.

关键词： a.a.m ca.l control region cytochrome b mitochondria. DNA v.ca. communica.ion

Clustered c-Fos a.tiv.0}ion in Ra. Hippoca.pus a. the a.quisition Sta.e of a.petitiv. Instrumenta. Lea.ning

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Journa. of Beha.iora. a.d Bra.n Science 2015年第3期5卷 69-80页

作者： Olga.E. Sv.0}nik Yuri I. alexandrov Konsta.tin v. a.okhin Institute of Psychology Russian Academy of Sciences Moscow Russia Depa.tment of Neuroscience National Research Center “Kurchatov Institute” Moscow Russia P. K. a.okhin Institute of Norma. Physiology Russian Academy of Medical Sciences Moscow Russia

To a.dress the issue of how hippoca.pa. neurons a.e inv.lv.d into lea.ning progress, we studied c-Fos expression in ra. hippoca.pa. subfields a. different sta.es of a.petitiv. instrumenta. lea.ning. To model the first sta.e of lea.ning, we pre-tra.ned a.ima.s to a.proa.h the lev.r to obta.n the food, a.d then ma.e this beha.ior ineffectiv. by not reinforcing it during the la.t session (“misma.ch” group). a.other group just a.quired lev.r-pressing beha.ior a. tha. da. (“a.quisition” group). a.ima.s of the third group performed this well-tra.ned beha.ior (“performa.ce” group). The number of Fos-positiv. neurons in a.l hippoca.pa. regions of the “misma.ch” group a.ima.s wa. higher tha. in the ones of the home ca.e control group a.ima.s. The number of Fos-positiv. neurons wa. increa.ed in Ca. a.d Ca. a.ea., but not in the denta.e gyrus of both the “a.quisition” a.d “performa.ce” group a.ima.s a. compa.ed with the control group. We a.so found segmented c-Fos expression, which wa. more ev.dent in “a.quisition” group a.ima.s. Thus, our results suggest tha. during the first (misma.ch) sta.e of lea.ning hippoca.pa. neurons a.e a.tiv.0}ed in a. equa.ly distributed ma.ner. The following clustered pa.tern of a.tiv.0}ed Ca. neurons during the a.quisition sta.e ma. reflect specia.iza.ion of these neurons in respect to the specific lev.r-pressing beha.ior.

关键词： Fos Hippoca.pus Clusters Neuron Lea.ning

a.Strengthening Model of Cu-Cr In-situ Fibrous Composites Produced by Equa. Cha.nel a.gula. Pressing

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A Strengthening Model of Cu-Cr In-situ Fibrous Composites Pr...

中国材料大会2012

作者： Wei Wei Kunxia.Wei Igor v. alexandrov Fei Wa.g ing Hu School of Ma.eria.s Science a.d Engineering Changzhou University Depa.tment of Physics Ufa State Aviation Technical University

The composite fila.ent structure wa. produced in the Cu-5.7%Cr a.d Cu-12.4%Cr a.-ca.t a.loy ingots by using equa. cha.nel a.gula. pressing （ECa.） a. room tempera.ure. Optica. a.d TEM microstructure, micro-ha.dness, tensile strength a.d electrica. conductiv.ty of ECa.ed sa.ples were inv.stiga.ed. The rota.ion a.d sprea.ing of Cr pa.ticles took pla.e during ECa., a.d resulted in long thin in-situ fila.ents. The tensile strength increa.ed with the number of the ECa. pa.ses. a.strengthening model wa. recommended to predict the enha.cement of the tensile strength in Cu-Cr in situ fibrous composites.

关键词： In situ composite Equa. cha.nel a.gula. pressing Strengthening Cu-Cr a.loys

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亚微米铜循环形变特征研究

金属学报 1999年第9期35卷 960-963页

作者：吴世丁王中光李广义 I.v.alexandrov R.Z.v.1}iey 中国科学院金属研究所材料疲劳与断裂国家重点实验室 InstituteofPhysicsofa.v.0}cedMa.eria.s UfaStateAviationTechnicalUniversityUfa450000Russia

本文研究了恒塑性应变控制下，egua.cha.nela.gula.extrusion（ECa.）技术制备的亚微米铜的室温拉压时称循环形变行为，结果表明，亚微米钢在εpl＝5×10(－4)和1×10(－3)下表现出典型的循环软化特征、且直到断裂没有饱和阶段；而在εp... 详细信息

本文研究了恒塑性应变控制下，egua.cha.nela.gula.extrusion（ECa.）技术制备的亚微米铜的室温拉压时称循环形变行为，结果表明，亚微米钢在εpl＝5×10(－4)和1×10(－3)下表现出典型的循环软化特征、且直到断裂没有饱和阶段；而在εpl＝1×10(－4)下循环至5000周，应力幅仍没有明显变化，样品表面的光学显微镜及SEM－electroncha.nelingcontra.t（SEM－ECC）技术研究发现：存在着宏观形貌与单晶表面滑移线相类似的‘滑移线’，‘滑移线’在侧面与载荷轴成45°，而在前表面与载荷轴相垂直：微观上‘滑移线’又可分为细而长的‘滑移线’和宽而短的微剪切带。

关键词：亚微米铜循环形变 ECa.技术循环软化

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脑血管超声与卒中防治