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Interferon regulatory factor 2 binding protein 2:a new player of the innate immune response for stroke recovery

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Neural Regeneration Research 2017年第11期12卷 1762-1764页

作者： Hsiao-Huei Chen alexandre E R.Stewart Ottawa Hospital Research Institute OttawaCanada University of Ottawa Heart Institute OttawaCanada

Ischemic brain injury triggers an inflammatory response. tissue but can also exacerbate brain injury. Microglia are This response is necessary to clear damaged brain the innate immune cells of the brain that execute this critical function. In healthy brain, microglia perform a housekeeping function, pruning unused syn- apses between neurons. However, microglia become activated to an inflammatory phenotype upon brain injury. Interferon regulatory factors modulate microglial activation and their production of inflammatory cytokines. This review briefly discusses recent findings pertaining to these regulatory mechanisms in the context of stroke recovery.

关键词： interferon regulatory factors interferon beta protein 2 stroke inflammation synaptie pruning anxiety microglia interferon regulatory factor 2 binding

instaGraminoid,a Novel Colorimetric Method to Assess Herbicide Resistance,Identifies Patterns of Cross-Resistance in Annual Ryegrass

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Plant Phenomics 2019年第1期1卷 185-197页

作者： Jefferson F.Paril alexandre J.Fournier-Level School of Biosciences University of MelbourneParkvilleVICAustralia

Herbicide resistance in agricultural weeds is a global problem with an increasing understanding that it is caused by multiple genes leading to quantitative *** quantitative patterns of resistance are not easy to decipher withmortality assays alone,and there is a need for straightforward and unbiased protocols to accurately assess quantitative herbicide ***—a computer vision and statistical analysis package—was developed as an automated and scalable method for quantifying herbicide *** package was tested in rigid ryegrass(Lolium rigidum),the most noxious and highly resistant weed in Australia and theMediterranean *** method provides quantitative measures of the degree of chlorosis and necrosis of individual plants which was shown to accurately reflect herbicide *** were able to reliably characterise resistance to four herbicides with different sites of action(glyphosate,sulfometuron,terbuthylazine,and trifluralin)in two *** populations from Southeast ***-validation of themethod across populations and herbicide treatments showed high repeatability and *** positive correlations in resistance of individual plants were observed across herbicides,which suggest either the accumulation of herbicide-specific resistance alleles in single genotypes(multiple stacked resistance)or the presence of general broad-effects resistance alleles(cross-resistance).We used these quantitative estimates of cross-resistance to simulate howresistance development under an herbicide rotation strategy is likely to be higher than expected.

关键词： straight likely Australia

WNT/β-catenin pathway and circadian rhythms in obsessive-compulsive disorder

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Neural Regeneration Research 2022年第10期17卷 2126-2130页

作者： alexandre Vallée Yves Lecarpentier Jean-Noël Vallée Department of Clinical Research and Innovation(DRCI) Foch HospitalSuresnesFrance Centre de Recherche Clinique Grand Hôpital de l’Est Francilien(GHEF)MeauxFrance Laboratoire de Mathématiques et Applications(LMA) Universitéde PoitiersPoitiersFrance Centre Hospitalier Universitaire(CHU)Amiens Picardie UniversitéPicardie Jules Verne(UPJV)AmiensFrance

The neuropsychiatric disease named obsessive-compulsive disorder is composed by obsessions and/or ***-compulsive disorder etiologies are ***,numerous mechanisms in several localizations are *** studies showed that both glutamate,inflammatory factors and oxidative stress could have main functions in obsessive-compulsive *** synthase kinase-3β,the major negative controller of the WNT/β-catenin pathway is upregulated in obsessive-compulsive *** obsessive-compulsive disorder,some studies presented the actions of the different circadian clock ***/β-catenin pathway and circadian clock genes appear to be ***,this review focuses on the interaction between circadian clock genes and the WNT/β-catenin pathway in obsessive-compulsive disorder.

关键词： circadian rhythms glutamatergic pathway inflammation obsessive-compulsive disorder oxidative stress WNT/β-catenin pathway

Structural and optical properties of pillared Eu^(3+)-containing layered double hydroxides intercalated by 2-to 12-carbon aliphatic dicarboxylates

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Journal of Rare Earths 2022年第2期40卷 260-267,I0003页

作者： alexandre Candido Teixeira Ivan Guide Nunes Silva Alysson Ferreira Morais Danilo Mustafa Physics Institute.University of Sao Paulo 05508-090Sao PauloSPBrazil

While the versatile composition of layered double hydroxides(LDHs)allows the introduction of almost any polyvalent cation in their structure,the exchangeable negatively charged ions intercalated between the plates increase their vast range of *** we report on the preparation and optical properties of pillared Eu^(3+)-substituted ZnAl LDHs intercalated by aliphatic dicarboxylates:-OOC-(CH_(2))_(n-2)-COO-.The basal distance in these materials is dependent on the size and packing of the intercalated *** varying the number(n)of carbon atoms in the aliphatic chain from 2 to 12,the interlayer gallery of these ZnAlEu LDHs is considerably expanded from 0.9 to 2.1 *** the interlayer gallery,the aliphatic dicarboxylates form a monolayer,with the aliphatic chain inclined by an angleα≈63°with the hydroxide *** carbon atom in the COO-group is 0.43 nm far from the metal plane,showing that these carboxylates are not grafted in the brucite-like *** LDHs are thermally stable up to around 150℃,after which dehydroxylation of the hydroxide layers is *** Judd-Ofelt intensity parameters were obtained and compared to the Eu^(3+)-containing complexes with the same ligand series indicating a more symmetrical and less polarizable chemical environment around the rare earth ion.

关键词： Europium Layered double hydroxides Carboxylate ligands Luminescence Rare earths

Design and Manufacturing of A Ball Catcher’s Robot

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Design and Manufacturing of A Ball Catcher’s Robot

作者： CHEVALIER alexandre 东南大学

学位级别：硕士

The purpose of the thesis was to build an Arduino-based robot that is able to catch tennis balls on an unknown area without the help of its *** paper describes the whole project,from the design to the realization with the tests and *** functioning of the robot was inspired from the automated vacuum cleaners,and the ball catcher system from construction machine,It means the ball catcher system is easy to remove,and could be replaced by another tool in order to realize other *** and electrical studies were realized to choose the *** the algorithms,probabilities studies and simulations results were made to determine the best way to cover with efficiency a large area by moving *** develop the algorithm,some random walks path finding,such as random walk,spiral,snaking and wall follow algorithms were compared,and simulated on Webots to select the best one to *** mathematics results obtained on Wolfram Mathematica also describe more deeply the random walk algorithm,depending on the size of the *** theorical obtained results showed that a random walker will easily cover all the sites for a small *** is confirmed with the realized tests with our ***,the implemented algorithm is based on a random walk,using ultrasonic,choc and infrared sensors to get information on the *** a larger lattice,the results showed that the algorithm meet some issues to visit al the sites and is visiting some sites more than *** the tests,the reliability of the ball catcher system was *** chosen solution has evolved during the project but is still not completely *** study concludes that the random walk algorithm has a limited range to conserves a good *** larger areas,upgrades need to be conducted,such as adding encoders,or change the microcontroller for a more powerful one,in order to do execute image *** the ball catcher,a system that doesn’t need activation,but

关键词：接球机器人壁面跟踪随机游走器红外传感器

Adaptive Bayesian Inference for Discontinuous Inverse Problems,Application to Hyperbolic Conservation Laws

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Communications in Computational Physics 2014年第6期16卷 1-34页

作者： alexandre Birolleau Gaël Poëtte Didier Lucor CEA DAMDIFF-91297 ArpajonFrance. UPMC Univ Paris 06 UMR 7190Institut Jean Le Rond d’AlembertF-75005 ParisFrance. CNRS UMR 7190Institut Jean Le Rond d’AlembertF-75005 ParisFrance.

Various works from the literature aimed at accelerating Bayesian inference in inverse *** spectral methods have been recently proposed as surrogate approximations of the forward uncertainty propagation model over the support of the prior *** representations are efficient because they allow affordable simulation of a large number of samples from the posterior ***,they do not perform well when the forward model exhibits strong nonlinear behavior with respect to its *** this work,we first relate the fast(exponential)L2-convergence of the forward approximation to the fast(exponential)convergence(in terms of Kullback-Leibler divergence)of the approximate *** particular,we prove that in case the prior distribution is uniform,the posterior is at least twice as fast as the convergence rate of the forward model in those *** Bayesian inference strategy is developed in the framework of a stochastic spectral projection *** predicted convergence rates are then demonstrated for simple nonlinear inverse problems of varying *** then propose an efficient numerical approach for the Bayesian solution of inverse problems presenting strongly nonlinear or discontinuous system *** comes with the improvement of the forward model that is adaptively approximated by an iterative generalized Polynomial Chaos-based *** numerical approximations and predicted convergence rates of the former approach are compared to the new iterative numerical method for nonlinear time-dependent test cases of varying dimension and complexity,which are relevant regarding our hydrodynamics motivations and therefore regarding hyperbolic conservation laws and the apparition of discontinuities in finite time.

关键词： Stochastic inverse problems Bayesian inference iterative generalized Polynomial Chaos compressible gas dynamics.

Strengthening nanocomposite magnetism through microemulsion synthesis

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Nano Research 2018年第8期11卷 4133-4141页

作者： Yijun xie alexandre H. Vincent Haeun Chang Jeffrey D. Rinehart Materials Science and Engineering Program University of California San Diego 9500 Gilman Drive La Jolla CA 92093 USA Department of Chemistry and Biochemistry University of Cafifomia San Diego 9500 Gilman Drive La Jolla CA 92093 USA

The magnetic strength and versatility of heterostructures generated via a simple microemulsion cluster-formation technique is demonstrated. This approach allows optimization of individual component magnetic nanoparticles prior to heterostructuring, expediting the discovery and optimization of hybrid magnetic materials. The efficacy of this method is validated through a magnetic study of nanoparticle clusters combining antiferromagnetic CoO and superparamagnetic CoFe204 nanoparticles with tunable particle ratio and size. An enhancement of coercivity compared with pure CoFe204 nanoparticles indicates that close interparticle contacts are achieved. Upon annealing, an exchange bias field of 0.32 T was observed--over twice that achieved in any other colloidally-synthesized system. Additionally, the unique microstructure is defined during cluster formation and thus protects magnetic coercivity during the annealing process. Overall, this work demonstrates a general approach for quickly exploring magnetic parameter space, designing interparticle functionality, and working towards the construction of high-value bulk magnets with low materials and processing cost.

关键词： nanoparticle cluster microemulsion exchange bias exchange interaction coercivity

Induction of desiccation tolerance in desiccation sensitive Citrus limon seeds

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Journal of Integrative Plant Biology 2019年第5期61卷 624-638页

作者： alexandre Marques Harm Nijveen Charles Somi Wilco Ligterink Henk Hilhorst Laboratory of Plant Physiology Wageningen University and ResearchWageningenThe Netherlands Bioinformatics Group Wageningen University and ResearchWageningenThe Netherlands

Many economically important perennial species bear recalcitrant seeds, including tea, coffee, cocoa, mango,citrus, rubber, oil palm and coconut. Orthodox seeds can be dried almost completely without losing viability, but so-called recalcitrant seeds have a very limited storage life and die upon drying below a higher critical moisture content than orthodox seeds. As a result, the development of longterm storage methods for recalcitrant seeds is *** this critical moisture content would be very valuable since dry seed storage is the safest, most convenient and cheapest method for conserving plant genetic ***, we have attempted to induce desiccation tolerance(DT) in the desiccation sensitive seeds of Citrus limon. We show that DT can be induced by paclobutrazol(an inhibitor of gibberellin biosynthesis) and we studied its associated transcriptome to delineate the molecular mechanisms underlying this induction of DT. Paclobutrazol not only interfered with gibberellin related gene expression but also caused extensive changes in expression of genes involved in the biosynthesis and signaling of other hormones. Paclobutrazol induced a transcriptomic switch encompassing suppression of biotic-and induction of abiotic *** hypothesize that this is the main driver of the induction of DT by paclobutrazol in C. limon seeds.

关键词： economically important recalcitrant seeds paclobutrazol in C.limon seeds

PLANNED LEAD TIME OPTIMIZATION IN MATERIAL REQUIREMENT PLANNING ENVIRONMENT FOR MULTILEVEL PRODUCTION SYSTEMS

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Journal of Systems Science and Systems Engineering 2008年第2期17卷 132-155页

作者： Faicel HNAIEN alexandre DOLGUI Mohamed-Aly OULD LOULY Industrial Engineering and Computer Science Centre(G2I)Ecole des Mines de St Etienne 158cours Fauriel42023 Saint EtienneFrance King Saud University College of Engineering-Industrial Engineering Department P.O.B 800 Riyadh 11421Kingdom of Saudi Arabia

This paper deals with the problem of planned lead time calculation in a Material Requirement Planning （MRP） environment under stochastic lead times. The objective is to minimize the sum of holding and backlogging costs. The proposed approach is based on discrete time inventory control where the decision variables are integer. Two types of systems are considered： multi-level serial-production and assembly systems. For the serial production systems （one type of component at each level）, a mathematical model is suggested. Then, it is proven that this model is equivalent to the well known discrete Newsboy Model. This directly provides the optimal values for the planned lead times. For multilevel assembly systems, a dedicated model is proposed and some properties of the decision variables and objective function are proven. These properties are used to calculate lower and upper limits on the decision variables and lower and upper bounds on the objective function. The obtained limits and bounds open the possibility to develop an efficient optimization algorithm using, for example, a Branch and Bound approach. The paper presents the proposed models in detail with corresponding proofs and se＇~eral numerical examples. Some advantages of the suggested models and perspectives of this research are discussed.

关键词： Multilevel assembly and production control model planned lead time optimization systems MRP random lead times discrete inventory