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Chinese Chemical Letters 2010年第5期21卷 550-553页

作者： A.Davoodnia S.Allameh A.r.Fakhari N.Tavakoli-Hoseini Department of Chemistry Faculty of SciencesIslamic Azad UniversityMashhad BranchMashhad 91735-413Iran

A simple and efficient procedure for the synthesis of 2-arylquinazolin-4（3H）-ones has been developed through cyclocondensation of 2-aminobenzamide with aromatic aldehydes using tetrabutylammonium bromide（TBAB） as novel neutral ionic liquid catalyst in the presence of copper（Ⅱ） chloride（CuCl;） as oxidizing agent under solvent-free conditions at 100℃.In the absence of CuCl;and under a nitrogen atmosphere,the unoxidized intermediates,2-aryl-2,3-dihydroquinazolin-4（1H）-ones,were isolated. Treatment of these intermediates with CuCl;in TBAB media gave the oxidized products 2-arylquinazolin-4（3H）-*** the other hand,cyclocondensation of 2-aminobenzamide with aromatic aldehydes in TBAB under microwave irradiation directly gave 2- arylquinazolin-4（3H）-ones.

关键词： Quinazolinones Aromatic aldehydes Tetrabutylammonium bromide(TBAB) Copper(Ⅱ) chloride(CuCl2) Microwave irradiation

Single Positive Core Prostate Cancer Has Less Aggressive Pathologic Features than Multiple Positive Core Prostate Cancer but Should It Still Be Considered an Indolent Tumor?

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Open Journal of Urology 2014年第6期4卷 71-77页

作者： ricardo Kupka Marcos Francisco Dall’Oglio alexandre Crippa José Pontes Aguinel José Bastian Júnior Luís Felipe Piovesan Willian Nahas Miguel Srougi Division of Uro-Oncology University of Sao Paulo Medical School Sao Paulo SP Brazil

Introduction: A single positive core (SPC) in a prostate biopsy is usually associated with indolent prostate cancer (PCa), and is considered one active surveillance criteria. To determine if a SPC should qualify a patient for surveillance, we compared the pathological findings for SPC and multiple positive core in a matched population who underwent radical prostatectomy (rP). Material and Methods: We evaluated 373 SPC patients who underwent rP (Group 1) and 375 consecutive cases with multiple positive core (Group 2) who were matched according to age, prostate weight, PSA level and clinical stage. In addition to preoperative data and epidemiological characteristics, we compared the rates of positive surgical margins (PSMs), extraprostatic extension (EPE) and seminal vesicle invasion (SVI) according to the Gleason scores (GSs) of the biopsies. results: Both groups were similar according age, PSA level, prostate weight and clinical stage. Group 1 had a lower PSM rate (20.9% vs 37.6%, p rates increased with increasing GS in both groups. In Group 1, a patient with a GS ≥ 8 was 3.5 times more likely to have a PSM than a patient with a GS ≤ 6 (p = 0.03);with no difference in Group 2 (p = 0.162). There were no correlations between the EPE and SVI rates and the GS in Group 1 (p = 0.273 and p = 0.95, respectively). However, in Group 2, we observed a higher rate of EPE among GS 7 than among GS ≤ 6, Or = 3.1 (p rved a higher rate of SVI among GS 7 than among GS ≤ 6 in Group 2, Or = 3.1 (p = 0.004). Conclusion: SPC PCa have reduced rates of PSM, EPE and SVI relative to multiple positive core. However, these pathologic findings were observed in 6.0% - 20.9% of SPC, especially in undifferentiated tumors. These results led us to conclude that active treatment instead of active surveillance should be considered and must be evaluated individually for SPC patients, e

关键词： Prostate Cancer Active Surveillance radical Prostatectomy Prostate Biopsy

Predicting synthesizable multi-functional edge reconstructions in two-dimensional transition metal dichalcogenides

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npj Computational Materials 2020年第1期6卷 1314-1322页

作者： Guoxiang Hu Victor Fung Xiahan Sang raymond r.Unocic P.Ganesh Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA

Two-dimensional(2D)transition metal dichalcogenides(TMDCs)have attracted tremendous interest as functional materials due to their exceptionally diverse and tunable properties,especially in their *** addition to the conventional armchair and zigzag edges common to hexagonal 2D materials,more complex edge reconstructions can be realized through careful control over the synthesis ***,the whole family of synthesizable,reconstructed edges remains poorly ***,we develop a computational approach integrating ensemble-generation,force-relaxation,and electronic-structure calculations to systematically and efficiently discover additional reconstructed edges and screen their functional properties.

关键词： functional dimensional integrating

recognizing by Spectrum for the Automorphism Groups of Sporadic Simple Groups

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Communications in Mathematics and Statistics 2015年第4期3卷 491-496页

作者： V.D.Mazurov A.r.Moghaddamfar Sobolev Institute of Mathematics Novosibirsk State UniversityNovosibirsk 630090Russia Faculty of Mathematics K.N.Toosi University of TechnologyP.O.Box 16315-1618TehranIran

The spectrum of a finite group is the set of its element orders,and two groups are said to be isospectral if they have the same spectra.A finite group G is said to be recognizable by spectrum,if every finite group isospectral with G is isomorphic to *** prove that if S is one of the sporadic simple groups M^(c)L,M_(12),M_(22),He,Suz and O'N,then Aut(S)is recognizable by *** finishes the proof of the recognizability by spectrum of the automorphism groups of all sporadic simple groups,except J_(2).

关键词： Automorphism groups of sporadic simple groups Prime graph recognizable by spectrum

Summer egg diapause in a matchstick grasshopper synchronizes the life cycle and buffers thermal extremes

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Integrative Zoology 2018年第4期13卷 437-449页

作者： Michael r.KEArNEY John DEUTSCHEr Jacinta D.KONG Ary A.HOFFMANN School of BioSciences The University of MelbourneParkvilleAustralia

The phenological response is among the most important traits affecting a species’sensitivity to *** insects,strongly seasonal environments often select for a univoltine life cycle such that one seasonal extreme is avoided as an inactive *** understanding the underlying mechanisms for univoltinism,and the consequences of its failure,we can better predict insect responses to climate *** we combine empirical data and simulation studies to investigate the consequences of an unusual diapause mechanism in a parthenogenetic matchstick grasshopper,Warramaba virgo,from arid southern *** field body temperature measurements indicate that this species is a thermoconformer and our laboratory studies of the thermal response of feeding rate imply strong constraints on winter ***,the species exhibits no obligate winter diapause,and eggs can develop in 1 month under constant temperatures approximating the mean soil temperature at the time of oviposition(summer).We show that diurnal temperature cycles exceeding a peak of 36℃ inhibit egg development in summer,and that this is sufficient to prevent autumnal hatching of *** is also strongly retarded below 24℃.Microclimate-driven simulation studies of egg development show that these thermal responses provide robust maintenance of a univoltine life cycle,thereby resulting in survival of heat stress as an egg(due to limited developmental state)and avoidance of cold stress as a nymph and adult(due to overwintering in the soil as an egg).

关键词： egg diapause life cycle matchstick grasshopper phenology thermal extremes thermoregulation

Control of PHErES1 Imprinting in Arabidopsis by Direct Tandem repeats

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Molecular Plant 2009年第4期2卷 654-660页

作者： Corina Belle r. Villar Aleksandra Erilova Grigory Makarevich raphael Trosch Claudia Kohler Department of Biology and Zurich-Basel Plant Science Center Swiss Federal Institute of Technology ETH Centre CH-8092 Zurich Switzerland

Genomic imprinting is an epigenetic phenomenon that causes monoallelic expression of specific genes dependent on the parent-of-origin. Imprinting of the Arabidopsis gene PHErES1 requires the function of the FErTILIZATION INDEPENDENT SEED （FIS） Polycomb group complex as well as a distally located methylated region containing a tandem triple repeat sequence. In this study, we investigated the regulation of the close PHErES1 homolog PHErES2. We found that PHErES2 is also a direct target gene of the FIS Polycomb group complex, but, in contrast to PHErES1, PHErES2 is equally expressed from maternal and paternal alleles. Thus, PHErES2 is not regulated by genomic imprinting, correlating with the lack of tandem repeats at PHErES2. Eliminating tandem repeats from the PHErES1 locus abolishes PHErES1 imprinting, demonstrating that tandem repeats are essential forPHErES1 imprinting. Taking these results together, our study shows that the recently duplicated genes PHErES1 and PHErES2 are both target genes of the FIS Polycomb group complex but only PHErES1 is regulated by genomic imprinting, which is likely caused by the presence of repeat sequences in the proximity of the PHErES1 locus.

关键词： Chromatin structure and remodeling epigenetics gene regulation gene silencing gametogenesis and fertilization.

Dermoid cyst in a domestic shorthair cat

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Asian Pacific Journal of Tropical Biomedicine 2012年第3期2卷 247-249页

作者： Akhtardanesh B Kheirandish r Azari O Department of Clinical Sciences Faculty of Veterinary MedicineShahid Bahonar University of Kerman Department of Pathobiology Faculty of Veterinary MedicineShahid Bahonar University of Kerman

A S-year-old neutered male domestic shorthair cat was presented for examination of a subcutaneous mass in his *** mass was firm,non-painful,oval,and approximately 2.5×3.5 cm. Surgical exploration revealed a well-circumscribed,encapsulated *** mass was removed and sectioned for histopathological *** gross section,it was filled with numerous dark *** the mass was consisted of haired skin with dermal cystic structures lined by stratified squamous *** cyst lumen contained squamous debris and filled with keratinous *** hair shafts were extended from the wall of the *** sebaceous and apocrine gland adnexal structures were also observed which confirmed the diagnosis of dermoid *** tumor recurrence was observed after surgery in fallowing *** or subcutaneous cysts of all types are considered rare in cats and to our knowledge this is the third reported case of cutaneous dermoid cyst of cats in veterinary literature which is different from the other cases because it occurred in dorsal midline in tail area whereas other's occurred in flank area.

关键词： Cutaneous dermoid cyst Cat Feline medicine Shorthair cat Dermoid cyst Histopathology

Effects of sodium-dependent glucose transporter 2 inhibitors in patients with type 2 diabetes mellitus and asymptomatic heart failure

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World Journal of Cardiology 2024年第11期16卷 665-668页

作者： Mohamed H Laimoud Ismail r raslan Department of Cardiovascular Critical Care Prince Sultan Cardiac CenterRiyadh 12611Saudi Arabia Critical Care Medicine Cairo UniversityCairo 12613Egypt Department of Cardiac Sciences King Saud UniversityRiyadh 11362Saudi Arabia Department of Adult Cardiology Prince Sultan Cardiac CenterRiyadh 12611Saudi Arabia

Sodium-dependent glucose transporter 2 inhibitors(SGLT2i)have been increa-singly used with proven efficacy in patients with heart failure(HF),regardless of diabetes ***ćrotkvićet al recently published an observational study on SGLT2i therapy in patients with type 2 diabetes mellitus and asymptomatic *** found that the use of SGLT2i led to reduced cardiac load and improved cardiovascular performance,reinforcing the evolving paradigm that SGLT2i are not merely glucose-lowering agents but are integral to the broader management of cardiovascular risk in patients with type 2 diabetes *** study by Grubićrotkvićet al contributes to the growing body of literature supporting the early use of SGLT2i in patients with diabetic cardiomyopathy,offering a potential strategy to mitigate the progression of *** larger studies should be con-ducted to confirm these findings,and explore the long-term cardiovascular bene-fits of SGLT2i,particularly in asymptomatic patients at risk of developing HF.

关键词： Heart failure Cardiovascular risk Diabetes mellitus Mortality Sodiumdependent glucose transporter 2 inhibitors

Λ■ production in p collis

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Chinese Physics C 2010年第9期34卷 1462-1464页

作者： P.G.Ortega D.r.Entem F.Fernández Grupo de ísica Nuclear and IUFFyM Universidad de Salamanca

We describe the production of Λ Λ in pp collisions using a constituent quark model which has been successfully applied to the N N system.

关键词： non-relativistic quark model hyperon-antihyperon production

Brown marine algae turbinaria conoides as biosorbent for Malachite green removal:Equilibrium and kinetic modeling

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Frontiers of Environmental Science & Engineering 2010年第1期4卷 116-122页

作者： r.rAJESH KANNAN M.rAJASIMMAN N.rAJAMOHAN B.SIVAPrAKASH Environmental Engineering Laboratory Department of Chemical EngineeringAnnamalai UniversityAnnamalai Nagar-608002Tamil NaduIndia

In this study,the biosorption of Malachite green(MG)onto Turbinaria conoides,brown marine algae,was studied with respect to initial pH,temperature,initial dye concentration,and sorbent *** optimum initial pH and temperature values for MG removal were found to be 8.0 and 30℃,*** dosage was found to strongly influence the removal of *** studies were carried out to test the validity of the Langmuir(q_(max)=66.6 mg/g and b=0.526 mL mol/L)and the Freundlich(n=1.826 and K=3.751 mg/g)*** kinetic studies indicated the validity of the pseudo first-order and second-order equation.

关键词： Malachite green(MG) Turbinaria conoides marine algae equilibrium studies biosorption