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Operational Protocol for Detection of Contamination by Actinides U,Pu and Am in Urine Using Calixarene Columns:From Mineralization to ICP-MS Measurement

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American Journal of Analytical Chemistry 2017年第5期8卷 317-333页

作者： Celine Bouvier-Capely alexandre legrand Aurelie Sylvain Annabelle Manoury Francois Rebiere Laboratoire de Radiochimie Service de Dosimetrie InternePRP-HOMInstitut de Radioprotection et Surete Nucleaire(IRSN)Fontenay-aux-RosesFrance

Individual monitoring of workers exposed to the risk of intake of actinides requires suitable methods for measuring low level of excreted activity. The current protocols used for actinides analysis in bioassay are usually complicated and highly time consuming. In this work, a protocol based on the microwave digestion of urines followed by the separation of actinides using calix[6]arene-based chromatography columns and their measurement by a quadrupole ICP-MS is developed and validated, for the first time, on urine samples containing the three actinides, U, Pu and Am. With this protocol, the total analysis time is about 2 days, including the mineralization of urine and the chromatographic separation of actinides. Detection limits of actinides in urine are determined and compared to those obtained after “dilute and shoot” ICP-MS analysis or after alpha spectrometry measurement.

关键词： Actinides Urine CalixArene Analysis ICP-MS

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Accuracy of Medical Oxygen Flowmeters: A Multicentric Field Study

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Health 2014年第15期6卷 1978-1983页

作者： Frédéric Duprez Maria Barile Thierry Bonus Grégory Cuvelier Sandra Ollieuz Shahram Mashayekhi alexandre legrand Department of Physiology and Pharmacology University of Mons Mons Belgium Intensive Care Unit Centre Hospitalier Epicura Hornu Belgium Laboratory of Motion Haute Ecole Condorcet Tournai Belgium

The accuracy of 476 oxygen flowmeters was investigated using a thermal mass flowmeter in eight hospitals in France and Belgium. Different oxygen flow rates (2 to 15 l/min) were evaluated at the patient’s bed. When the sample was considered as a whole, the accuracy of delivered flow was acceptable but precision was poor. The variability of the delivered flow between devices was greater when a low flow rate was required. Compensated-pressure oxygen flowmeters for these low rates were more accurate than their non-compensated counterparts. This study emphasizes the need to individually adapt the oxygen flow rate each time a patient has to move from one flowmeter to another.

关键词： Medical Device Accuracy Oxygen Therapy Flowmeter

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Validation and Comparison of Two Calibration Methods for the Measurement of Stable Iodine in the Urinary Matrix by ICP-MS:Standard Addition *** Calibration

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American Journal of Analytical Chemistry 2017年第4期8卷 245-263页

作者： Geraldine Landon Celine Bouvier-Capely alexandre legrand Thibaud Sontag Gregory Finance Mailie Saint-Hilaire Francois Rebiere Xavier Millot Valerie Renaud-Salis Michelle Agarande Institute for Radiological Protection and Nuclear Safety(IRSN) Fontenay-aux-RosesFrance The French Alternative Energies and Atomic Energy Commission(CEA) Gif-sur-YvetteFrance

Background: In the context of a nuclear reactor accident, thyroid is the main target organ of radioactive iodines. To avoid as much as possible thyroid disorders or even cancer development, it is recommended to administer a single dose of potassium iodide to people at risk of exposure. Nevertheless, the Fukushima Dai-ichi disaster has pointed out many questions about the conditions of stable iodine prophylaxis implementation highlighting the need for reflection further revision of the actual “iodine doctrine”. Therefore, providing useful data is required notably through the implementation of animal experiments to strengthen current knowledge and to edit new recommendations. Methods: Urinary iodine constitutes a very good indicator to investigate the function of thyroid, its interpretation demands reliable analyses. Prior to perform animal experiments, two calibration methods were designed by our lab and compared together (standard addition and external calibration) to assess the urinary concentration of stable iodine in urine by ICP-MS. They were validated based on several key parameters especially linearity, accuracy and limits of detection (LOD) and quantification (LOQ). Results: The results were nicely satisfying. Indeed, both calibration methods have indicated very good coefficients of correlations, accuracies with low expanded relative uncertainties were obtained. The estimated LOD in the sample for standard addition method and external calibration were fully acceptable, 0.39 μg·L-1 and 0.35 μg·L-1, respectively. All performance criteria have been thus fulfilled successfully. The established methods were proven to be accurate, robust and sensitive. Once validated, both calibration methods were applied to rat urine samples and the results of z-score and Wilcoxon W test concluded that there were no statistically significant differences between both methods.

关键词： Stable Iodine Urine Standard Addition External Calibration Validation

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