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Cerebral and muscle tissue oxygenation during exercise in healthy adults: A systematic review

Journal of Sport and Health Science 2024年第4期13卷 459-471,F0003页

作者： Diego Orcioli-Silva Victor Spiandor Beretta Paulo Cezar Rocha Santos Felipe Marroni Rasteiro Anita Brum Marostegan Rodrigo Vitorio Claudio alexandre Gobatto Fulvia barros Manchado-Gobatto Laboratory of Applied Sport Physiology(LAFAE) School of Applied Sciences(FCA)University of Campinas(UNICAMP)Limeira 13484-350Brazil Posture and Gait Studies Laboratory(LEPLO) Institute of BiosciencesSao Paulo State University(UNESP)Rio Claro 13506-900Brazil Physical Education Department School of Technology and SciencesSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Computer Science&Applied Mathematics Weizmann Institute of ScienceRehovot 7610001Israel Center of Advanced Technologies in Rehabilitation Sheba Medical CenterRamat Gan 5265601Israel Department of Sport Exercise and RehabilitationNorthumbria UniversityNewcastle upon Tyne NE18STUK

Background:Near-infrared spectroscopy(NIRS)technology has allowed for the measurement of cerebral and skeletal muscle oxygenation simultaneously during *** this technology has been growing and is now successfully used in laboratory and sports settings,this systematic review aimed to synthesize the evidence and enhance an integrative understanding of bloodﬂow adjustments and oxygen(O_(2))changes(i.e.,the balance between O_(2) delivery and O_(2) consumption)within the cerebral and muscle systems during ***:A systematic review was conducted using PubMed,Embase,Scopus,and Web of Science databases to search for relevant studies that simultaneously investigated cerebral and muscle hemodynamic changes using the near-infrared spectroscopy system during *** review considered manuscripts written in English and available before February 9,*** step of screening involved evaluation by 2 inde-pendent authors,with disagreements resolved by a third *** Joanna Briggs Institute Critical Appraisal Checklist was used to assess the methodological quality of the ***:Twenty studies were included,of which 80%had good methodological quality,and involved 290 young or middle-aged *** types of exercises were used to assess cerebral and muscle hemodynamic changes,such as cycling(n=11),treadmill(n=1),knee extension(n=5),isometric contraction of biceps brachii(n=3),and duet swim routines(n=1).The cerebral hemodynamics anal-ysis was focused on the frontal cortex(n=20),while in the muscle,the analysis involved vastus lateralis(n=18),gastrocnemius(n=3),biceps brachii(n=5),deltoid(n=1),and intercostal muscle(n=1).Overall,muscle deoxygenation increases during exercise,reaching a plateau in voluntary exhaustion,while in the brain,oxyhemoglobin concentration increases with exercise intensity,reaching a plateau or declining at the exhaustion ***:Muscle and cerebral oxygenation respond differently to exercise,with muscle

关键词： Near-infrared spectroscopy Hemodynamic Blood flow Brain Muscle metabolism

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Effects on Cell Viability and on Apoptosis in Tumoral(MCF-7)and in Normal(MCF10A)Epithelial Breast Cells after Human Chorionic Gonadotropin and Derivated-Angiotensin Peptides Treatments

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Journal of Cancer Therapy 2013年第7期4卷 65-69页

作者： Silvana Aparecida Alves Correa de Noronha Werica Bernardo alexandre jesus barros Clovis Ryuichi Nakaie Suma Imura Shimuta Ismael Dale Cotrim Guerreiro da Silva Samuel Marcos Ribeiro de Noronha Laboratorio de Cirurgia Translacional Departamento de CirurgiaUniversidade Federal De Sao Paulo/Escola Paulista De MedicinaSao PauloBrazil Laboratorio de Ginecologia Molecular Universidade Federal de Sao PauloSao PauloBrazil Departamento de Biofísica Universidade Federal de Sao PauloSao PauloBrazil

Angiotensin-(1 - 7) [Ang-(1 - 7)] is an endogenous heptapeptide hormone of the renin-angiotensin system that has antiproliferative properties. The aim of this work was to evaluate the anti-proliferative and pro-apoptotic properties of Ang-(1 - 7) and of Ang-(1 - 7)-substituents 9-fluorenylmethyloxycarbonyl (Fmoc) e Ang II-derivatives containing the TOAC (2,2,6,6-tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid) in normal (MCF10A) and in tumoral (MCF7) epithelial mammary cell lines. Both cell lines received an hCG and angiotensin peptides 24-hour treatment, in combination or alone followed by cell viability, apoptosis and cell cycle assays performed by flow cytometer (GUAVA). After hCG, Ang-(1 - 7), hCG + Ang-(1 - 7) and hCG + Ang-(1 - 7)-Fmoc treatments, MCF7 displayed cell viability decrease and mid-apoptosis increase. We also observed cell viability decrease in MCF10A after Ang-(1 - 7), Ang-(1 - 7) Fmoc and hCG + AngII Toac treatments. These cells had an increase in late apoptosis and necrosis after AngII Toac, hCG + Ang-(1 - 7) and hCG + Ang-(1 - 7)-Fmoc treatments. Regarding the cell cycle analysis, we did not observed any changes in cell cycle phases. In summary, cell viability was decreased and apoptosis (initial, mid and late) was increased after hCG and/or Ang-(1 - 7) peptides treatments. These results point out hCG and Ang-(1 - 7) as effective compounds to inhibit cell proliferation, since they decrease cell viability and increase apoptosis in both normal and in tumoral breast cells, being the effect more pronounced in the tumoral cell line. Our results support the idea of investigating more closely the putative use of these compounds as novel therapeutic agents for breast cancer.

关键词： Angiotensin II Angiotensin 1-7 Angiotensin II Type 1 Receptor(AT1R) Breast Cancer Apoptosis Human Chorionic Gonadotropin

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Angiotensin-(1-7)and Human Chorionic Gonadotropin(hCG)Modulate the Nuclear Transcription Factors or Nuclear Receptors Genes in the Tumorigenic Undifferentiated Breast Cancer Cell Line SKBR3

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Journal of Cancer Therapy 2013年第7期4卷 70-74页

作者： Isidoro Binda Neto Samuel Marcos Ribeiro de Noronha Silvana Aparecida Alves Correa de Noronha Maria Del Carmen Garcia Molina Wolgien alexandre jesus barros Clovis Ryiuchi Nakaie Suma Imura Shimuta Gil Facina Ismael Dale Cotrim Guerreiro da Silva Laboratorio de Ginecologia Molecular Universidade Federal de Sao PauloSao PauloBrazil Universidade Federal do Estado do Rio de Janeiro Rio de JaneiroBrazil Laboratorio de Cirurgia Translacional Departamento de CirurgiaUNIFESP/EPMSao PauloBrazil Departamento de Biofísica Universidade Federal de Sao PauloSao PauloBrazil

Breast cancer is the most common cancer among women. Angiotensin-(1 - 7) [Ang-(1 - 7)] has been correlated with cancer antiproliferative and apoptotic effects, similar properties of the human Chorionic Gonadotrofin (hCG). The aims of this work are to evaluate the role of Ang-(1 - 7) and of hCG in modulating the expression of Nuclear Receptors and Coregulators related genes in the tumorigenic breast cell line SK-BR3. Three experimental groups were created: control, hCG and hCG + Ang-(1 - 7). Cells were treated for 11 days and then had their RNA extracted. Samples were loaded into PCR Array plates containing 84 genes relate to Nuclear Receptors and Coregulators pathways. Gene expression data were used to construct canonical pathways (MetacoreTM). hCG and hCG + Ang-(1 - 7) treatments markedly modulate the expression of Nuclear Receptors and Coregulators related genes. hCG differentially expressed 17% of the genes, being 29% upregulated and 71% downregulated. Meanwhile, hCG + Ang-(1 - 7) changed the expression of 30% of the genes on the plate, among these genes 56% were upregulated and 44% downregulated. Among these differentially expressed genes, we highlight Esr1, Nr2f2, and Nr2f1, Esr1, Hdac5, and Nr4A1 (>4 fold). Finally MetaCore analysis based on Gene Ontology (GO) generated six networks for hCG and ten networks for the combined treatment. All generated networks are related to regulation of apoptosis or to Programmed Cell Death processes. In summary, our results herein demonstrate that the modulation of sexual hormones and of other nuclear factor genes expression might underlie the tumorigenic protection effect and the induction of cell differentiation caused by the hormones hCG and Ang-(1 - 7), especially in Cancer Stem Cells.

关键词： Breast Stem Cancer Cells SK-BR3 hCG Angiotensin-(1-7)

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Understanding the corrosion of Mg alloys in in vitro urinary tract conditions: A step forward towards a biodegradable metallic ureteral stent

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Journal of Magnesium and Alloys 2023年第11期11卷 4301-4324页

作者： Margarida Pacheco Ivo M.Aroso Joana M.Silva Sviatlana V.Lamaka Jan Bohlen Maria Nienaber Dietmar Letzig Estêvão Lima alexandre A.barros Rui L.Reis 3B’s Research Group-Research Institute on Biomaterials Biodegradables and BiomimeticsUniversity of MinhoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal Institute of Surface Science Helmholtz-Zentrum hereon GmbHGermany Institute of Material and Process Design Helmholtz-Zentrum hereon GmbHGermany School of Health Sciences Life and Health Sciences Research Institute(ICVS)University of MinhoBragaPortugal

Ureteral stents play a fundamental role in modern time urology. However, following the deployment, stent-related symptoms are frequent and affect patient health and quality of life. Using biodegradable metals as ureteral stent materials have emerged as a promising strategy, mainly due to the improved radial force and slower degradation rate expected. Therefore, this study aimed to characterize different biodegradable metals in urinary tract environment to understand their propensity for future utilization as base materials for ureteral stents. The corrosion of 5 Mg alloys - AZ31, Mg-1Zn, Mg-1Y, pure Mg, and Mg-4Ag - under simulated urinary tract conditions was accessed. The corrosion layer of the different alloys presented common elements, such as Mg(OH)_(2), MgO, and phosphate-containing products, but slight variations in their chemical compositions were detected. The corrosion rate of the different metals varied, which was expected given the differences in the corrosion layers. On top of this, the findings of this study highlighted the significant differences in the samples' corrosion and corrosion layers when in stagnant and flowing conditions. With the results of this study, we concluded that Mg-1Zn and Mg-4Ag presented a higher propensity for localized corrosion, probably due to a less protective corrosion layer;Mg-4Ag corroded faster than all the other four alloys,and Mg-1Y stood out due to its distinct corrosion pattern, that showed to be more homogeneous than all the other four samples, making this one more attractive for the future studies on biodegradable metals.

关键词： Biodegradable metals Magnesium alloys Localized corrosion Biodegradable metallic ureteral stent

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Mapping Between Charge-Dyon and Position-Dependent Mass Systems

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Communications in Theoretical Physics 2019年第10期71卷 1261-1266页

作者： Anderson L.de jesus alexandre G.M.Schmidt Departamento de Fisica de Volta Redonda Instituto de Ciencias Exatas—Universidade Federal Fluminense

The primary purpose of this work is to reproduce the scenario composed of a charge-dyon system utilizing position-dependent effective mass(PDM) background in the non-relativistic and in the relativistic regimes. In the nonrelativistic case we substitute the exact charge-dyon eigenfunction into PDM Schr?dinger equation, in the Zhu-Kroemer parametrization, and then solve it for the mass distribution considering M = M(r). Analogously, in the relativistic case we study the Klein-Gordon equation for a position-dependent mass, and in this case, we are able to analytically solve the equation for M = M(r, θ).

关键词： position-dependent mass Schrodinger equation Klein-Gordon equation dyon

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Non-exhaustive double effort test is reliable and estimates the firs ventilatory threshold intensity in running exercise

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Journal of Sport and Health Science 2018年第2期7卷 197-203页

作者： Lucas Dantas Maia Forte Fúlvia barros Manchado-Gobatto Roberta Cunha Matheus Rodrigues Maria Ceclia Gallani Claudio alexandre Gobatto School of Applied Science University of Campinas School of Nursing University of Campinas Faculty of Nursing Laval University

Purpose: The present study aimed to investigate the reliability of the non-exhaustive double effort(NEDE) test in running exercise and its associations with the ventilatory thresholds(VT_1 and VT_2) and the maximal lactate steady state(MLSS).Methods: Ten healthy male adults(age: 23 ± 4 years, height: 176.6 ± 6.4 cm, body mass: 76.6 ± 10.7 kg) performed 4 procedures:(1) a ramp test for VT_1 and VT_2 determinations measured by ratio of expired ventilation to O_2 uptake(VE/VO_2) and expired ventilation to CO_2 output(VE/VCO_2) equivalents, respectively;(2) the NEDE test measured by blood lactate concentration(NEDE_(LAC)) and heart rate responses(NEDE_(HR));(3) a retest of NEDE for reliability analysis; and(4) continuous efforts to determine the MLSS intensity. The NEDE test consisted of4 sessions at different running intensities. Each session was characterized by double efforts at the same running velocity(E1 and E2, 180 s), separated by a passive recovery period(90 s rest). LAC and HR values after E1 and E2(in 4 sessions) were used to estimate the intensity equivalent to"null delta" by linear fit. This parameter represents, theoretically, the intensity equivalent to maximal aerobic ***: The intraclass correlation coefficient indicated significant reliability for NEDE_(LAC)(0.93) and NEDE_(HR)(0.79)(both p < 0.05). There were significant correlations, no differences, and strong agreement with the intensities predicted by NEDE_(LAC)(10.1 ± 1.9 km/h) and NEDE_(HR)(9.8 ± 2.0 km/h) to VT_1(10.2 ± 1.1 km/h). In addition, despite significantly lower MLSS intensity(12.2 ± 1.2 km/h), NEDE_(LAC) and NEDE_(HR) intensities were highly correlated with this parameter(0.90 and 0.88, respectively).Conclusion: The NEDE test applied to running exercise is reliable and estimates the VT_1 intensity. Additionally, NEDE intensities were lower but still correlated with VT_2 and MLSS.

关键词： Aerobic exercise Anaerobic threshold Maximal lactate steady state Non-exhaustive protocol Training prescription Ventilatory threshold

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Interaction between Equatorial Plasma Bubbles and a Medium-Scale Traveling Ionospheric Disturbance,observed by OI 630 nm airglow imaging at Bom jesus de Lapa,Brazil

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Earth and Planetary Physics 2021年第5期5卷 397-406页

作者： Cristiano Max Wrasse Cosme alexandre Oliveira barros Figueiredo Diego barros Hisao Takahashi Alexander JoséCarrasco Luiz Fillip Rodrigues Vital Láysa Cristina Araujo Resende Fábio Egito Geângelo de Matos Rosa Antonio Hélder Rodrigues Sampaio Space Weather Division National Institute for Space Research(INPE)São Josédos CamposBrazil University of Los Andes(ULA) MéridaVenezuela State Key Laboratory of Space Weather Beijing 100190China Federal University of Campina Grande(UFCG) Campina GrandeBrazil Federal Institute for Education Science and Technology Baiano(IF Baiano)Bom Jesus da LapaBrazil

OI 630.0 nm airglow observations,from a new observatory at Bom jesus de Lapa,were used to study the interaction between EPBs(Equatorial Plasma Bubbles)and the MSTID(Medium-Scale Traveling Ionospheric Disturbance)over the Northeast region in *** the night of September 16 to 17,2020,an EPB was observed propagating eastward,in an apparent fossil stage,until it interacted with a dark band electrified MSTID(e MSTID).After the interaction,four EPBs merged,followed by an abrupt southward development and *** of the data suggests that an eastward polarization electric field,induced by the dark band e MSTID,forced the EPB into an upward drift,growing latitudinally along the magnetic field lines and then bifurcating.

关键词： Equatorial Plasma Bubbles Medium-Scale Traveling Ionospheric Disturbance ionosphere thermosphere EPB and MSTID interaction

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World Journal of Clinical Cases 2021年第17期9卷 4123-4132页

作者： Rodrigo Nascimento Pinheiro Samantha Mucci Renato Morato Zanatto Olavo Magalhães Picanço Junior alexandre Ferreira Oliveira Gaspar de jesus Lopes Filho Surgical Oncology Service Surgical Oncology Residency and Academic League of OncologyFederal District Base HospitalBrasília 70330-150Distrito FederalBrazil Department of Psychiatry Federal University of São PauloPaulista School of Medicine(UNIFESP-EPM)São Paulo 04024-002São PauloBrazil Department of Surgical Oncology Amaral Carvalho Cancer HospitalJaú17210-070São PauloBrazil Department of Surgical Oncology Federal University of AmapáMacapá68900-073AmapáBrazil Department of Surgery Juiz de Fora Federal UniversityJuiz de Fora 36036-110Minas GeraisBrazil Postgraduate Program in Interdisciplinary Surgical Science Federal University of São PauloPaulista School of Medicine(UNIFESP-EPM)São Paulo 04024-002São PauloBrazil

In Brazil,gastric cancer is the third most common type of cancer among men and fifth among women,with an estimated 13360 new cases among men and 7870 among women each year during the 2020-2022 *** study presents reflections and attempts to add knowledge to the theme of quality of life(QoL)in patients with gastric adenocarcinoma and describes some of its characteristics in three regions of Brazil,with an evaluation of the disease’s impacts in various dimensions of life,as reported by the patients *** performed a narrative review of the literature and a data analysis of studies on QoL in Brazilian patients treated for gastric adenocarcinoma from three different cities in three geographic regions:Brasília(the midwest),Jaú(the southeast),and Macapá(the north).

关键词： Quality of life Gastric cancer Gastrectomy Stomach cancer Stomach neoplasms Gastric neoplasms

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Evaluation and Comparison of Medicine Students’ Knowledge about HPV

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Health 2023年第8期15卷 908-916页

作者： Clara Vitória Braz Lima de Oliveira Carla Patrícia Alves Barbosa alexandre Salomão de barros Oliveira Ana Paula Portela Andrade Maria Eduarda Dantas Donald Arthur Carmo da Silva Iva Sampaio Bisneta Francisco Expedito Aguiar Sampaio alexandre Salomão de Braz Oliveira Elizabeth Bacha Tiradentes University Center (UNIT) Maceió Brazil Chesf Foundation for Assistance and Social Security (FACHESF) Aracaju Brazil Tiradentes University Center (UNIT) Aracaju Brazil Department of Medicine University of Pernambuco (UPE) Recife Brazil

The Human Papillomavirus (HPV) is responsible for almost 99% of cervical cancers. Cervical cancer is a public health problem, being the fourth most common type of tumor among women worldwide and the third most common cancer among women in Brazil. It is known that cervical cancer is one of the most easily preventable forms of cancer, as there is a highly effective vaccine against HPV, however, morbidity and mortality rates related to human papillomavirus are still frightening, especially in less developed countries. Low vaccination adherence rates, especially the second dose, are probably a reflection of the lack of knowledge about this virus, its clinical repercussions, and the vaccine. A clinical trial was carried out in a higher education institution in Alagoas (Brazil), with students of the medical course to whom a validated questionnaire was applied on HPV in the virtual environment (google forms). Data collection was carried out throughout the month of May of the year 2023. It was shown that the knowledge of medical students about the human papillomavirus was less than what would be desired for future doctors. The alert for the acute need to assess health illiteracy is clear, especially regarding cancer that can be prevented by a highly effective vaccine.

关键词： Health Education HPV Health Literacy Cervical Cancer

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Job and housework during radiotherapy: Comparisons between leaving out activities and disease treatment

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Health 2013年第6期5卷 1062-1068页

作者： Cristiane Helena Gallasch Neusa Maria Costa alexandre Sergio Carlos barros Esteves Faculty of Nursing State University of CampinasSao PauloBrazil Department of Tocogynecology CAISM Hospital of Women Dr.Jose Aristodemo PinottiState University of CampinasSao PauloBrazil

Background: Researches about work limitations related to cancer treatment and survival are recent. This study describes the characteristics of patients who keep their work and house work activities during radiotherapy, and comparison between some disease data and leaving out those activities. Methods: Data were collected from medical records of patients admitted in a Brazilian Radiotherapy Private Health Service. Descriptive statistical analysis was performed, as hypotheses texts, Chi-square and Fisher’s exact test. Results: Data of 111 individuals were presented;being 65.77% of workers of paid activities and 34.34% of careers of home. Between employees, 50.7% kept their job activities, and 92.1% between house workers. The association between absence from work activities and tumor type (primary or metastasis) and between absence and KPS (p < 0.05) were observed. Discussion: It is observed that breast, brain and lung tumors significantly affect employees’ performance, causing the withdrawal of workers from their activities. Data from the literature review clearly demonstrated the importance of work activities in social support of the worker, but his overall performance may be impaired. Implications for cancer survivors: The study indicates the need for assessment of the individual, work or activity environment and required as well as the continuity research aiming at the development and validation of evaluation tools such as questionnaires or scales.

关键词： Radiation Therapy Cancer Survivorship Return to Work Occupational Health Nursing

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