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Endoscopic treatment of biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants: Lessons learned from single-balloon enteroscopy-assisted ERCP

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 509-514页

作者： Rodrigo garcés-Durán Laurent Monino Pierre H Deprez Hubert Piessevaux Tom g Moreels Department of gastroenterology and Hepatology Universitécatholique de LouvainCliniques Universitaires Saint-LucAvenue Hippocrates 101200 BrusselsBelgium

Background: Endoscopic treatment of biliopancreatic pathology is challenging due to surgically altered anatomy after Whipple's pancreaticoduodenectomy. This study aimed to evaluate the feasibility and safety of single-balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography(SBE-ERCP) to treat biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants. Methods: We retrospectively analyzed 106 SBE-ERCP procedures in 46 patients with Whipple's variants. Technical and clinical success rates and adverse events were evaluated. Results: Biliary SBE-ERCP was performed in 34 patients and pancreatic SBE-ERCP in 17, including 5 with both indications. From a total of 106 SBE-ERCP procedures, 76 were biliary indication with technical success rate of 68/76(90%) procedures and clinical success rate of 30/34(88%) patients. Mild adverse event rate was 8/76(11%), without serious adverse events. From a total of 106 SBE-ERCP procedures, 30 were pancreatic indication with technical success rate of 24/30(80%) procedures( P = 0.194 vs. biliary SBEERCP) and clinical success rate of 11/17(65%) patients( P = 0.016 vs. biliary SBE-ERCP). Mild adverse event rate was 6/30(20%)( P = 0.194 vs. biliary SBE-ERCP), without serious adverse events. After SBE-ERCP failure, endoscopic ultrasound-guided drainage, percutaneous drainage and redo surgery were alternative therapeutic options. Conclusions: Biliopancreatic pathology after Whipple's pancreaticoduodenectomy variants can be treated using SBE-ERCP without serious adverse events. Technical and clinical success rates are high for biliary indications, whereas clinical success rate of pancreatic indications is significantly lower. SBE-ERCP can be considered as first-line treatment option in this patient group with surgically altered anatomy.

关键词： Enteroscopy Endoscopic retrograde cholangiopancreatography Pancreaticoduodenectomy Surgically altered anatomy Whipple’s procedure

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Rodent management in Aotearoa New Zealand: approaches and challenges to landscape-scale control

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Integrative Zoology 2024年第1期19卷 8-26页

作者： John g.INNES grant NORBURY Araceli SAMANIEgO Susan WALKER Deborah J.WILSON Manaaki Whenua-Landcare Research HamiltonNew Zealand Manaaki Whenua-Landcare Research AlexandraNew Zealand Manaaki Whenua-Landcare Research AucklandNew Zealand Manaaki Whenua-Landcare Research DunedinNew Zealand

Aotearoa—New Zealand has only four rodent species,all *** order of arrival,they are Pacific rat Rattus exulans,brown rat ***,house mouse Mus musculus,and black rat *** management in New Zealand aims mainly to conserve indigenous biodiversity rather than to protect crops or manage diseases,as is usual *** describe four major“regimes”and one major vision for rodent control in New Zealand to meet ecological restoration *** challenges for island eradications are for large islands that are remote or populated by *** 1080 is the only large-scale(tens of thousands of hectares)option for black rat control,but its application requires adjustment to counter subsequent rapid black rat ***“ecosanctuaries”(mean 720 ha)use ground-based traps and poisons to target mainly black rats and face constant *** with mammal-resistant fences(up to 3500 ha)limit reinvasion and target more pest species and have enabled the return of previously extirpated taxa to the main *** Free 2050 aims to eradicate the rat species(but not mice)plus some other introduced mammals from New Zealand by *** vision is not attainable with current tools,but research and experimental management is exploring techniques and *** large scale(to 100000 ha)at which black rats are now targeted for control to extremely low abundance seems to be unique to New Zealand.

关键词： black rat brown rat eradication house mouse rodent control

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Combination treatment of inflammatory bowel disease:Present status and future perspectives

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World Journal of gastroenterology 2024年第15期30卷 2068-2080页

作者： John K Triantafillidis Constantinos g Zografos Manousos M Konstadoulakis Apostolos E Papalois Inflammatory Bowel Disease Unit "Metropolitan General"HospitalHolargos 15562AtticaGreece Hellenic Society for gastrointestinal Oncology 354 Iera OdosChaidari 12461AtticaGreece The 2^(nd)Department of Surgery University of AthensSchool of MedicineAretaieion HospitalAthens 11528Greece Unit of Surgical Research and Training The 2^(nd)Department of SurgeryUniversity of AthensSchool of MedicineAretaieion HospitalAthens 11528Greece

The treatment of patients with inflammatory bowel disease(IBD),especially those with severe or refractory disease,represents an important challenge for the clinical *** seems to be no exaggeration to say that in these patients,not only the scientific background of the gastroenterologist is tested,but also the abundance of“gifts”that he should possess(insight,intuition,determ-ination,ability to take initiative,etc.)for the successful outcome of the *** daily clinical practice,depending on the severity of the attack,IBD is treated with one or a combination of two or more pharmaceutical *** combin-ations include not only the first-line drugs(e.g.,mesalazine,corticosteroids,antibiotics,etc)but also second-and third-line drugs(immunosuppressants and biologic agents).It is a fact that despite the significant therapeutic advances there is still a significant percentage of patients who do not satisfactorily respond to the treatment ***,a part of these patients are going to *** recent years,several small-size clinical studies,reviews,and case reports have been published combining not only biological agents with other drugs(e.g.,immunosuppressants or corticosteroids)but also the combination of two biologi-cal agents simultaneously,especially in severe *** our opinion,it is at least a strange(and largely unexplained)fact that we often use combinations of drugs in a given patient although studies comparing the simultaneous administration of two or more drugs with monotherapy are very *** mentioned above,there is a timid tendency in the literature to combine two biological agents in severe cases unresponsive to the applied treatment or patients with severe extraintestinal *** appropriate dosage,the duration of the administration,the suitable timing for checking the clinical and laboratory outcome,as well as the treatment side-effects,should be the subject of intense clinical research *** this

关键词： Biologics for immune-mediated conditions Dual-targeted treatment Combination treatment Inflammatory bowel disease Crohn’s

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Heterogeneous Catalysis with Metal-Containing Crystalline Porous Materials:Element-and Site-Specific Insights

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CCS Chemistry 2024年第5期6卷 1110-1129页

作者： Yan Li Andrew g.Walsh Peng Zhang Tianjun Zhang State Key Laboratory of New Pharmaceutical Preparations and Excipients College of Chemistry and Materials ScienceHebei UniversityBaoding 071002 Department of Chemistry Dalhousie UniversityHalifaxNova Scotia B3H 4R2

Metal-containing crystalline porous materials(CPMs)are gaining popularity in heterogeneous catalysis because of their highly crystalline and porous systems,and their excellent chemical *** of the metal species and framework structure permits them to have greater activity,selectivity,and stability over other *** in-depth understanding of the complex nature of metal active sites in CPMs is essential for revealing the structure-performance relationships and directing the rational design of such *** to conventional characterization techniques,the rapid development of X-ray absorption spectroscopy(XAS)has provided element-and site-specific deep insights into the electronic and structural information of metal species in *** such,this review begins by summarizing novel XAS techniques and analysis methods in accurately obtaining such ***,the combination of XAS with other high-level characterization methods into disclosing the configuration of active sites in metalcontaining CPMs is ***,the utilization of theory-assisted XAS data analysis in examining complex metal-containing CPM catalysts is ***,advanced in-situ/operando XAS studies into revealing the working sites in metal-containing CPMs under catalytic conditions are *** conclude by outlining the future challenges and prospects of XAS measurements,data analyses,and in-situ/operando setups in advancing the study of metal-in-CPM catalysts.

关键词： X-ray absorption spectroscopy in-situ metal species crystalline porous materials heterogeneous catalysis

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Carcinoembryonic antigen in the diagnosis,treatment,and follow-up of focal liver lesions

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World Journal of gastrointestinal Surgery 2024年第4期16卷 999-1007页

作者： Osman Nuri Dilek Dilaraİrem Arslan Kahraman gökhan Kahraman Department of Surgery İzmir Katip Celebi UniversitySchool of Medicineİzmir 35150Turkey Department of Patology Merzifon KMP State HospitalAmasya 5300Turkey Department of Radiology Suluova State HospitalAmasya 5500Turkey

In this editorial review,we comment on the article published in the recent issue of the World Journal of gastrointestinal *** antigen(CEA)is a fetal glycoprotein and can be secreted in very small amounts from healthy adults after *** is widely used not only for diagnostic tumor markers but also importantly for the management of some gastrointestinal *** most common clinical use is surveillance for the monitoring of colorectal ***,CEA can become elevated in several malign or benign characterized *** CEA level may vary depending on the location of the lesion,whether it metastasizes or not,and its histopathological *** has been determined that cases with high preoperative CEA have a more aggressive course and the risk of metastasis to the lymph tissue and liver *** this editorial review,we focused on evaluating the role of CEA in clinical practice with a holistic approach,including the diagnostic and prognostic significance of CEA in patients with focal liver lesions,the role of CEA in follow-up after definitive surgery,and also hepatic resection for metastasis,and the management of all patients with raised CEA.

关键词： Carcinoembriyonic antigen Liver Focal liver lesions Metastasis Surgery Prognosis Surveillance

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Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

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Changes in acute and late toxicity and patient-reported health-related quality of life following radiotherapy in women with breast cancer:A 1-year longitudinal study

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Journal of Integrative Nursing 2024年第1期6卷 15-21页

作者： gonca Hanedan USLU Aydanur AYDIN Ayla gÜRSOY Department of Radiation Oncology Faculty of MedicineRecep Tayyip Erdogan UniversityRizeTurkey Department of Nursing Antalya Bilim UniversityFaculty of Health SciencesGumushane UniversityGumushaneTurkey Department of Nursing Faculty of Health SciencesAntalya Bilim UniversityAntalyaTurkey

Objective:The objective of this study was to investigate the frequency of acute and late toxicities,as well as changes in the quality of life(QOL)for breast cancer patients following radiotherapy(RT).Materials and Methods:A total of 108 breast cancer women were recruited for this prospective *** were collected at various intervals;prior to,and 1,3,6 months,and 1 year after radiation *** primary outcomes were toxicity radiation therapy oncology group/European Organization for Research and Treatment of Cancer(EORTC)*** secondary outcome was QOL,measured using EORTC QLQ-C30 and Edmonton Symptom Assessment *** employed Friedman’s two-way analysis to evaluate the changes in QOL over the course of 1 ***:The early toxicities that are most commonly experienced include pharyngeal,skin,and mucous membrane *** toxicities frequently involve skin and submucosal *** measure patient functionality,all functional subscale scores except for the patient’s emotional state increased over time compared to *** of the patients,which were included in the QOL symptom scale,decreased during the follow-up period,except for fatigue;however,changes in pain,insomnia,and loss of appetite did not significantly *** identified the analogous symptom profiles in *** patients’overall health scores declined in the 1st and 3rd months after radiotherapy(RT),they rebounded at 6 and 12 ***:For breast cancer patients,RT did not adversely affect functional capacity or exacerbate symptoms,but persistent fatigue did increase during the observation ***-care professionals ought to devise strategies to assist patients with skin toxicity and fatigue.

关键词： Breast cancer health‑related quality of life radiotherapy toxicity

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High Power Microwave Treatment Impacts on Microbes in Rough Rice

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Rice science 2024年第2期31卷 139-141,I0020,I0021页

作者： Faith OUMA Luthra KAUSHIK Boreddy SREENIVASULA Oduola ABASS griffiths g.ATUNgULU Department of Food Science University of Arkansas Division of AgricultureFayetteville 72704USA Department of Processing and Food Engineering Dr.NTR College of Agricultural EngineeringBapatla 522101India

As rice consumption increases,ensuring its safety has become a priority for the food *** address this concern,the industry is exploring a single-pass microbial inactivation treatment at the rough rice *** this study,a long-grain rice variety,RT7321[21.2%wet basis(WB)and a 20 mm bed thickness]was exposed to microwave radiation(915 MHz frequency)at powers of 16,18,and 20 kW for durations of 1,2,and 3 *** found that the highest microwave power(20 kW)and the longest exposure duration(3 min)produced the greatest reduction in total aerobic count and total fungal count,reducing them by up to 1.21 and 5.01 log(CFU/g),*** findings provided insights into the used to high-power,shortduration 915 MHz microwave technology for decontamination purposes in rough rice to help improve the microbial safety of *** aim is to develop a single-pass drying approach for microbial inactivation in rice processing facilities while ensuring that the yield and quality is not compromised.

关键词： microwave insight facilities

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Tensile deformation of fine-grained Mg at 4K,78K and 298K

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Journal of Magnesium and Alloys 2024年第6期12卷 2534-2556页

作者： M.Walag A.Kula P.Noga T.Tokarski g.Cios M.Niewczas AgH University of Krakow Faculty of Non-Ferrous MetalsKrakowPoland AgH University of Krakow Academic Centre for Materials and NanotechnologyKrakowPoland Materials Science and Engineering McMaster UniversityHamiltonCanada

The impact of grain size,ranging from 0.9μm to 9μm,on the mechanical properties of commercially pure Mg is investigated at temperatures of 4K,78K,and *** mechanisms governing plastic flow are influenced by both grain size and *** 4K and 78K,dominant deformation modes in Mg involve dislocation glide and extension twinning,regardless of grain *** interactions between basal and non-basal dislocations and dislocations with grain boundaries promote an unusually high rate of work hardening in the plastic regime,leading to premature *** yield stress follows the Hall-Petch relationshipσ_(y)∼k/√d,with the slope k increasing with decreasing *** 298K,in addition to dislocation glide and twinning,grain boundary sliding(gBS)becomes significant in samples with grain sizes below 3μm,considerably enhancing the material’s *** activation provides an additional recovery mechanism for dislocations accumulating at grain boundaries,facilitating their absorption during sliding and *** ofσrelationship suggests that the basal slip is the dominant dislocation mode in Mg at *** grain size suppresses dislocation activity and twinning and increases gBS,resulting in lowerandσ*** conventional deformation modes coupled with enhanced gBS yields stress softening,breaking down the Hall-Petch relationship in Mg below 3μm grain size,leading to an inverse Hall-Petch *** work reports new data on the strength,ductility,work hardening and fracture behaviour,and their variations with Mg grain size across different temperature regimes.

关键词： Polycrystalline Mg Mechanical properties Deformation mechanisms Work-hardening Texture evolution Cryogenic temperatures Hall-Petch relationship

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The initial stages of Li_(2)O_(2) formation during oxygen reduction reaction in Li-O_(2) batteries:The significance of Li_(2)O_(2) in charge-transfer reactions within devices

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Journal of Energy Chemistry 2024年第1期88卷 223-231,I0006页

作者： Daniela M.Josepetti Bianca P.Sousa Simone A.J.Rodrigues Renato g.Freitas gustavo Doubek Advanced Energy Storage Division LABCenter for Innovation on New EnergiesSchool of Chemical EngineeringUniversity of CampinasAv Albert Einstein 50013083-852CampinasSPBrazil Institute of Physics&Department of Chemistry Laboratory of Computational MaterialsFederal University of Mato Grosso78060-900CuiabáMTBrazil

Lithium-oxygen batteries are a promising technology because they can greatly surpass the energy density of lithium-ion ***,this theoretical characteristic has not yet been converted into a real device with high *** with air contamination,metallic lithium reactivity,and complex discharge and charge reactions are the main issues for this technology.A fast and reversible oxygen reduction reaction(ORR)is crucial for good performance of secondary batteries',but the partial knowledge of its mechanisms,especially when devices are concerned,hinders further *** this perspective,the present work uses operando Raman experiments and electrochemical impedance spectroscopy(EIS)to assess the first stages of the discharge processes in porous carbon electrodes,following their changes cycle by cycle at initial operation.A growth kinetic formation of the discharge product signal(Li_(2)O_(2))was observed with operando Raman,indicating a first-order reaction and enabling an analysis by a microkinetic *** solution mechanism in the evaluated system was ascribed for an equivalent circuit with three time *** the time constant for the anode interface reveals to remain relatively constant after the first discharge,its surface seemed to be more *** model indicated that the reaction occurs at the Li_(2)O_(2) surface,decreasing the associated resistance during the initial discharge ***,the growth of Li_(2)O_(2) forms a hetero-phase between Li_(2)O_(2)/electrolyte,while creating a more compact and homogeneous on the Li_(2)O_(2)/cathode *** methodology here described thus offers a way of directly probing changes in surface chemistry evolution during cycling from a device through EIS analysis.

关键词： Li-O_(2)battery Operando Raman analysis Equivalent circuit modeling Time-constant distribution

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