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Neural regeneration research 2022年第10期17卷 2208-2210页

作者： alexandre f.r.stewart Hsiao-Huei Chen Department of Biochemistry Microbiology and ImmunologyUniversity of Ottawaand University of Ottawa Heart InstituteOttawaONCanada Centre for Infection Immunity and InflammationOttawaONCanada Medicine Cellular and Molecular MedicineUniversity of Ottawa Brain and Mind InstituteOttawa Hospital Research InstituteOttawaONCanada

Glutamate is the main exc i tatory neurotransmitter in the brain and binds to two major classes of receptors,theα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid(AMPA)and the N-methyl-D-aspartate(NMDA)*** AMPA receptors that are immediately activated by glutamate release,NMDA receptors are blocked by magnesium and can only be activated by glutamate after membrane ***,NMDA receptors are only activated after repeated AMPA receptor activation by *** receptors are,for the most part,calcium-permeable *** influx through NMDA receptors modulates synaptic transmission in neurons based on prior history of excitation,and provides a means of scaling the strength of synapses required for Hebbian plasticity.

关键词： PTP1B aspartate NMDA

Activation of tyrosine phosphatases in the progression of Alzheimer’s disease

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Neural regeneration research 2020年第12期15卷 2245-2246页

作者： alexandre f.r.stewart Hsiao-Huei Chen University of Ottawa Heart Institute OttawaCanada Ottawa Hospital research Institute OttawaCanada

Patients with Alzheimer’s disease(AD)have progressive memory loss,inability to reason,and display anxiety that accelerates disease *** points to two deficits:1)the brain fails to respond to insulin that regulates the formation of neuron connections required to store memories,and 2)deficits arise in the brain’s endogenous cannabinoid signaling that regulates mood and prevents anxiety(Aso and ferrer,2014).In addition,leptin signaling,important in regulating hypothalamic synaptic plasticity and cognitive function is also affected in AD(McGregor and Harvey,2018).

关键词： Alzheimer endogenous arise

Neuronal protein-tyrosine phosphatase 1B hinders sensory-motor functional recovery and causes affective disorders in two different focal ischemic stroke models

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Neural regeneration research 2021年第1期16卷 129-136页

作者： Shelly A.Cruz Zhaohong Qin Konrad M.ricke alexandre f.r.stewart Hsiao-Huei Chen Ottawa Hospital research Institute Neuroscience ProgramUniversity of OttawaOttawaONCanada Brain and Mind Institute University of OttawaOttawaONCanada Department of Biochemistry Microbiology and ImmunologyUniversity of OttawaOttawaONCanada Cellular and Molecular Medicine University of OttawaOttawaONCanada Department of Medicine University of OttawaOttawaONCanada Centre for Infection Immunity and InflammationUniversity of OttawaOttawaONCanada University of Ottawa Heart Institute OttawaONCanada

Ischemic brain injury causes neuronal death and *** activates protein-tyrosine phosphatase 1B(PTP1B).Here,we tested the significance of PTP1B activation in glutamatergic projection neurons on functional recovery in two models of stroke:by photothrombosis,focal ischemic lesions were induced in the sensorimotor cortex(SM stroke)or in the peri-prefrontal cortex(peri-PfC stroke).Elevated PTP1B expression was detected at 4 days and up to 6 weeks after *** ablation of PTP1B in neurons of neuronal knockout(NKO)mice had no effect on the volume or resorption of ischemic lesions,markedly different effects on functional recovery were *** stroke caused severe sensory and motor deficits(adhesive removal test)in wild type and NKO mice at 4 days,but NKO mice showed drastically improved sensory and motor functional recovery at 8 *** addition,peri-PfC stroke caused anxiety-like behaviors(elevated plus maze and open field tests),and depression-like behaviors(forced swimming and tail suspension tests)in wild type mice 9 and 28 days after stroke,respectively,with minimal effect on sensory and motor ***-PfC stroke-induced affective disorders were associated with fewer active(fosB+)neurons in the PfC and nucleus accumbens but more fosB+neurons in the basolateral amygdala,compared to sham-operated *** contrast,mice with neuronal ablation of PTP1B were protected from anxiety-like and depression-like behaviors and showed no change in fosB+neurons after peri-PfC *** together,our study identifies neuronal PTP1B as a key component that hinders sensory and motor functional recovery and also contributes to the development of anxiety-like and depression-like behaviors after ***,PTP1B may represent a novel therapeutic target to improve stroke *** procedures for animal use were approved by the Animal Care and Use Committee of the University of Ottawa Animal Care and Veterinary Service(protocol 1806)on July 27,2018.

关键词： adhesive removal test anxiety depression elevated plus maze forced swimming test Iba1 interleukin-1β microglia open field test tail suspension test tumor necrosis factor-α

Assimilation of GOES-r Geostationary Lightning Mapper flash Extent Density Data in GSI 3DVar, EnKf, and Hybrid En3DVar for the Analysis and Short-Term forecast of a Supercell Storm Case

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Advances in Atmospheric Sciences 2024年第2期41卷 263-277页

作者： rong KONG Ming XUE Edward r.MANSELL Chengsi LIU alexandre O.fIErrO Center for Analysis and Prediction of Storms Norman Oklahoma 73072U.S.A University of Oklahoma Norman Oklahoma 73072U.S.A NOAA/National Severe Storms Laboratory NormanOklahoma 73072U.S A.4Zentralanstalt für Meteorologie und Geodynamik Department of Forecasting Models-ZAMGVienna 1190Austria

Capabilities to assimilate Geostationary Operational Environmental Satellite “r-series ”(GOES-r) Geostationary Lightning Mapper(GLM) flash extent density(fED) data within the operational Gridpoint Statistical Interpolation ensemble Kalman filter(GSI-EnKf) framework were previously developed and tested with a mesoscale convective system(MCS) case. In this study, such capabilities are further developed to assimilate GOES GLM fED data within the GSI ensemble-variational(EnVar) hybrid data assimilation(DA) framework. The results of assimilating the GLM fED data using 3DVar, and pure En3DVar(PEn3DVar, using 100% ensemble covariance and no static covariance) are compared with those of EnKf/DfEnKf for a supercell storm case. The focus of this study is to validate the correctness and evaluate the performance of the new implementation rather than comparing the performance of fED DA among different DA schemes. Only the results of 3DVar and pEn3DVar are examined and compared with EnKf/DfEnKf. Assimilation of a single fED observation shows that the magnitude and horizontal extent of the analysis increments from PEn3DVar are generally larger than from EnKf, which is mainly caused by using different localization strategies in EnfK/DfEnKf and PEn3DVar as well as the integration limits of the graupel mass in the observation operator. Overall, the forecast performance of PEn3DVar is comparable to EnKf/DfEnKf, suggesting correct implementation.

关键词： GOES-r lightning data assimilation EnKf EnVar

Influence of manufacturing process-induced geometrical defects on the energy absorption capacity of polymer lattice structures

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Defence Technology（防务技术） 2024年第5期35卷 47-59页

作者： alexandre riot Enrico Panettieri Antonio Cosculluela Marco Montemurro Universite de Bordeaux Arts et Metiers Institute of TechnologyCNRSINRABordeaux INPHESAM UniversiteI2M UMR 5295F-33405 TalenceFrance french Atomic Energy Commission Route des GargailsCedexF-33114Le BarpFrance

Modern additive manufacturing processes enable fabricating architected cellular materials of complex shape,which can be used for different *** them,lattice structures are increasingly used in applications requiring a compromise among lightness and suited mechanical properties,like improved energy absorption capacity and specific stiffness-to-weight and strength-to-weight ratios.A dedicated modeling strategy to assess the energy absorption capacity of lattice structures under uni-axial compression loading is presented in this *** numerical model is developed in a non-linear framework accounting for the strain rate effect on the mechanical responses of the lattice *** geometries,i.e.,cubic body centered cell,octet cell,rhombic-dodecahedron and truncated cuboctahedron 2+,are ***,the influence of the relative density of the representative volume element of each geometry,the strain-rate dependency of the bulk material and of the presence of the manufacturing process-induced geometrical imperfections on the energy absorption capacity of the lattice structure is *** main outcome of this study points out the importance of correctly integrating geometrical imperfections into the modeling strategy when shock absorption applications are aimed for.

关键词： Lattice structures Architected cellular materials Dynamic simulation Energy absorption Geometrical imperfection Additive manufacturing

The impact of heterogeneity and pore network characteristics on single and multi-phase fluid propagation in complex porous media:An X-ray computed tomography study

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Petroleum Science 2024年第3期21卷 1719-1738页

作者： Shohreh Iraji Tales rodrigues De Almeida Eddy ruidiaz Munoz Mateus Basso alexandre Campane Vidal Department of Mechanical Engineering(fEM) State University of Campinas(UNICAMP)CampinasSP13083-860Brazil Department of Geology and Natural resources Geosciences Institute(IG)State University of Campinas(UNICAMP)CampinasSP.13083-855.Brazil LrAP/COPPE/COPPETEC/UfrJ Rua Moniz Aragao 360Bloco 4 Cidade UniversitariaRio de Janeiro21941-594Brazil Center of Energy and Petroleum Studies(CEPETrO) State University of Campinas(UNICAMP)CampinasSP13083-896Brazil

This study investigates the impact of pore network characteristics on fluid flow through complex and heterogeneous porous media,providing insights into the factors affecting fluid propagation in such ***,high-resolution or micro X-ray computed tomography(CT)imaging techniques were utilized to examine outcrop stromatolite samples of the Lagoa Salgada,considered flow analogous to the Brazilian Pre-salt carbonate *** petrophysical results comprised two distinct stromatolite depositional facies,the columnar and the fine-grained *** generating pore network model(PNM),the study quantified the relationship between key features of the porous system,including pore and throat radius,throat length,coordination number,shape factor,and pore *** study found that the less dense pore network of the columnar sample is typically characterized by larger pores and wider and longer throats but with a weaker connection of throats to *** facies exhibited less variability in the radius of the pores and throats in comparison to throat ***,a series of core flooding experiments coupled with medical CT scanning was designed and conducted in the plug samples to assess flow propagation and saturation *** study revealed that the heterogeneity and presence of disconnected or dead-end pores significantly impacted the flow patterns and ***-phase flow patterns and oil saturation distribution reveal a preferential and heterogeneous displacement that mainly swept displaced fluid in some regions of plugs and bypassed it in *** relation between saturation profiles,porosity profiles,and the number of fluid flow patterns for the samples was *** for the columnar plug sample was the enhancement in recovery factor after shifting to lower salinity water injection(SB)observed.

关键词： Pore network model Heterogeneous porous media flow patterns Dead-end pores

A novel saliva-based mirNA profile to diagnose and predict oral cancer

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International Journal of Oral Science 2024年第1期16卷 97-109页

作者： Jaikrishna Balakittnen Chameera Ekanayake Weeramange Daniel f.Wallace Pascal H.G.Duijf alexandre S.Cristino Gunter Hartel roberto A.Barrero Touraj Taheri Liz Kenny Sarju Vasani Martin Batstone Omar Breik Chamindie Punyadeera Saliva&Liquid Biopsy Translational Laboratory Griffith Institute for Drug DiscoveryGriffith UniversityNathanQLDAustralia Department of Medical Laboratory Sciences Faculty of Allied Health SciencesUniversity of JaffnaJaffnaSri Lanka Menzies Health Institute Griffith UniversityGold CoastQLDAustralia School of Biomedical Sciences Faculty of HealthQueensland University of TechnologyBrisbaneQLDAustralia Centre for Cancer Biology Clinical and Health SciencesUniversity of South Australia&SA PathologyAdelaideSAAustralia Institute of Clinical Medicine Faculty of MedicineUniversity of OsloOsloNorway Department of Medical Genetics Oslo University HospitalOsloNorway Griffith Institute for Drug Discovery Griffith UniversityNathanQLDAustralia QIMr Berghofer Medical research Institute Statistics UnitBrisbaneQLDAustralia School of Public Health The University of QueenslandBrisbaneQLDAustralia School of Nursing Queensland University of TechnologyBrisbaneQLDAustralia eresearch Research InfrastructureAcademic DivisionQueensland University of TechnologyBrisbaneQLDAustralia Department of Anatomical Pathology Royal Brisbane and Women’s HospitalHerstonQLDAustralia faculty of Medicine The University of QueenslandBrisbaneQLDAustralia royal Brisbane and Women’s Hospital Cancer Care ServicesHerstonQLDAustralia Department of Otolaryngology Royal Brisbane and Women’s HospitalHerstonQLDAustralia Department of Oral and Maxillofacial Surgery Royal Brisbane and Women’s HospitalHerstonQLDAustralia

Oral cancer (OC) is the most common form of head and neck cancer. Despite the high incidence and unfavourable patient outcomes, currently, there are no biomarkers for the early detection of OC. This study aims to discover, develop, and validate a novel saliva-based microrNA signature for early diagnosis and prediction of OC risk in oral potentially malignant disorders (OPMD).The Cancer Genome Atlas (TCGA) mirNA sequencing data and small rNA sequencing data of saliva samples were used to discover differentially expressed mirNAs. Identified mirNAs were validated in saliva samples of OC (n=50), OPMD (n=52), and controls(n=60) using quantitative real-time PCr. Eight differentially expressed mirNAs (mir-7-5p, mir-10b-5p, mir-182-5p, mir-215-5p,mir-431-5p, mir-486-3p, mir-3614-5p, and mir-4707-3p) were identified in the discovery phase and were validated. The efficiency of our eight-mirNA signature to discriminate OC and controls was:area under curve (AUC):0.954, sensitivity:86%, specificity:90%,positive predictive value (PPV):87.8%and negative predictive value (NPV):88.5%whereas between OC and OPMD was:AUC:0.911,sensitivity:90%, specificity:82.7%, PPV:74.2%and NPV:89.6%. We have developed a risk probability score to predict the presence or risk of OC in OPMD patients. We established a salivary mirNA signature that can aid in diagnosing and predicting OC,revolutionising the management of patients with OPMD. Together, our results shed new light on the management of OC by salivary mirNAs to the clinical utility of using mirNAs derived from saliva samples.

关键词： specificity salivary diagnosis

Cerebral and muscle tissue oxygenation during exercise in healthy adults: A systematic review

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Journal of Sport and Health Science 2024年第4期13卷 459-471,F0003页

作者： Diego Orcioli-Silva Victor Spiandor Beretta Paulo Cezar rocha Santos felipe Marroni rasteiro Anita Brum Marostegan rodrigo Vitorio Claudio alexandre Gobatto fulvia Barros Manchado-Gobatto Laboratory of Applied Sport Physiology(LAfAE) School of Applied Sciences(FCA)University of Campinas(UNICAMP)Limeira 13484-350Brazil Posture and Gait Studies Laboratory(LEPLO) Institute of BiosciencesSao Paulo State University(UNESP)Rio Claro 13506-900Brazil Physical Education Department School of Technology and SciencesSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Computer Science&Applied Mathematics Weizmann Institute of ScienceRehovot 7610001Israel Center of Advanced Technologies in rehabilitation Sheba Medical CenterRamat Gan 5265601Israel Department of Sport Exercise and RehabilitationNorthumbria UniversityNewcastle upon Tyne NE18STUK

Background:Near-infrared spectroscopy(NIrS)technology has allowed for the measurement of cerebral and skeletal muscle oxygenation simultaneously during *** this technology has been growing and is now successfully used in laboratory and sports settings,this systematic review aimed to synthesize the evidence and enhance an integrative understanding of bloodﬂow adjustments and oxygen(O_(2))changes(i.e.,the balance between O_(2) delivery and O_(2) consumption)within the cerebral and muscle systems during ***:A systematic review was conducted using PubMed,Embase,Scopus,and Web of Science databases to search for relevant studies that simultaneously investigated cerebral and muscle hemodynamic changes using the near-infrared spectroscopy system during *** review considered manuscripts written in English and available before february 9,*** step of screening involved evaluation by 2 inde-pendent authors,with disagreements resolved by a third *** Joanna Briggs Institute Critical Appraisal Checklist was used to assess the methodological quality of the ***:Twenty studies were included,of which 80%had good methodological quality,and involved 290 young or middle-aged *** types of exercises were used to assess cerebral and muscle hemodynamic changes,such as cycling(n=11),treadmill(n=1),knee extension(n=5),isometric contraction of biceps brachii(n=3),and duet swim routines(n=1).The cerebral hemodynamics anal-ysis was focused on the frontal cortex(n=20),while in the muscle,the analysis involved vastus lateralis(n=18),gastrocnemius(n=3),biceps brachii(n=5),deltoid(n=1),and intercostal muscle(n=1).Overall,muscle deoxygenation increases during exercise,reaching a plateau in voluntary exhaustion,while in the brain,oxyhemoglobin concentration increases with exercise intensity,reaching a plateau or declining at the exhaustion ***:Muscle and cerebral oxygenation respond differently to exercise,with muscle

关键词： Near-infrared spectroscopy Hemodynamic Blood flow Brain Muscle metabolism

Interferon regulatory factor 2 binding protein 2:a new player of the innate immune response for stroke recovery

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Neural regeneration research 2017年第11期12卷 1762-1764页

作者： Hsiao-Huei Chen alexandre E r.stewart Ottawa Hospital research Institute OttawaCanada University of Ottawa Heart Institute OttawaCanada

Ischemic brain injury triggers an inflammatory response. tissue but can also exacerbate brain injury. Microglia are This response is necessary to clear damaged brain the innate immune cells of the brain that execute this critical function. In healthy brain, microglia perform a housekeeping function, pruning unused syn- apses between neurons. However, microglia become activated to an inflammatory phenotype upon brain injury. Interferon regulatory factors modulate microglial activation and their production of inflammatory cytokines. This review briefly discusses recent findings pertaining to these regulatory mechanisms in the context of stroke recovery.

关键词： interferon regulatory factors interferon beta protein 2 stroke inflammation synaptie pruning anxiety microglia interferon regulatory factor 2 binding

Bacteriological Profile of Infections Encountered in a Pneumology Service in a Moderate-Income Country [Pneumology Department of CHU Cocody (Côte d’Ivoire)]

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Open Journal of respiratory Diseases 2024年第1期14卷 1-11页

作者： Brou Jean Marcel Ahui Alitonde Eudoxie Djegbeton Alima Kone Marc-Olivier Koffi Kouame Clarisse Elogne Mobio Nancy Hermine Benjamin Kouraogo Erick Akouatia Constante Virginie Brou-Gode Kigninlman Horo Boko alexandre Kouassi Ngoran Koffi Pneumology Service Teaching Hospital of Cocody Abidjan C&#244te d’Ivoire Medical School of Abidjan University Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire Pasteur Institute of Cô te d’Ivoire Abidjan C&#244te d’Ivoire

Introduction: Infections represent a real public health problem aggravating the morbidity and mortality of hospitalized patients. Methods: This was a retrospective study with descriptive purposes over a period of 05 years, in the Pneumology Department of the University Hospital of Cocody. results: The average age in our population was 42 years. We observed a male predo- minance of 64.5%, with a sex ratio of 1.8. Medical history was dominated by HIV infection (23.5%), followed by tuberculosis (15.6%). Concerning lifestyle, smoking was found in 38% of cases. Symptoms progressed chronically in 80% of cases. An infectious syndrome was found in 75% of cases. Microbial culture was positive in 42% of cases. Pseudomonas aeruginosa and Klebsiella pneumoniae were encountered in 26.4% of cases each, followed by Echerichia coli in 10.4% of cases. Klebsiella pneumoniae in the first three years topped the list, but gradually. Pseudomonas aeruginosa maintained its leadership over the last three years. Pseudomonas aeruginosa isolates expressed a resistance rate of 9.8% to ceftazidime and 8.1% to imipenem;to aztreonam (36%), ticarcillin (33.3%) and levofloxacin. These strains were susceptible to fosfomycin (100%), mero- penem (96.6%) and amikacin (96%). for isolated strains of Entero- bacteria- ceae, resistance was observed about ticarcillin (83.3%) and amoxicillin clavula- nic acid (71.2%). Streptococcaceae showed resistance to tetracycline (69.2%) and erythromycin (50%). Over the years there has been an increase in re- sistance to amoxicillin-clavulanic acid ceftriaxone. The death rate was 14%. Conclusion: The bacterial profile of infections is dominated by germs respon- sible for nosocomial infection with significant mortality.

关键词： Bacterial Pleural Pneumonia Nosocomial Infection Sub-Saharan Africa Antibiotic Therapy