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Higher incidence of steroid-induced ocular hypertension in keratoconus

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Eye and Vision 2016年第1期3卷 29-36页

作者： Anastasios John Kanellopoulos Emerson M.cruz Robert Edward T.Ang George Asimellis Laservision.gr Clinical and Research Eye Institute 17 Tsocha StreetAthens Postal Code:11521Greece NYU Medical School New YorkNYUSA Asian Eye Institute MakatiPhilippines

Background:To compare intraocular pressure(IOP)changes following topical dexamethasone administration for 1 month in keratoconic versus normal ***:This is a retrospective,single-center,non-randomized case series evaluation of 350 *** groups were formed:normal/control Group A(n_(A)=73),eyes that underwent excimer laser photorefractive keratectomy;and keratoconic(KCN)Group B(n_(B)=277),eyes that were subjected to partial laser photorefractive keratectomy combined with collagen cross-linking(The Athens Protocol).All eyes received the same post-operative regimen of topical dexamethasone 0.1%for at least 1 *** applanation tonometry IOP readings and central corneal thickness(CCT)measurements were *** with induced ocular hypertension(OHT,defined as post-operative IOP higher than 21 mmHg),were identified and correlated to refractive procedure,gender,and corneal ***:At 4 weeks postoperatively,OHT was noted on 27.4%(20/73 eyes)in Group A,and 43.7%(121/277 eyes)in KCN Group B,(p<0.01).Six months post-operatively(following 5-months of discontinuing topical dexamethasone treatment and commencing treatment of IOP-lowering medications),OHT rate was 1.8%in Group A and 3.9%in the KCN Group ***:This study demonstrates a potentially significant pre-disposition of keratoconic eyes to the development of steroid-induced OHT.

关键词： Keratoconus Intraocular pressure Corticosteroid induced ocular hypertension IOP spike Corneal collagen cross-linking CXL The Athens protocol Topography-guided Photorefractive keratectomy Dexamethasone topical ophthalmic solution

Exploring alternative treatments for Helicobacter pylori infection

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World Journal of Gastroenterology 2014年第6期20卷 1450-1469页

作者： Guadalupe Ayala Wendy Itzel Escobedo-Hinojosa Carlos Felipe de la cruz-Herrera Irma Romero Centro de Investigación sobre Enfermedades Infecciosas Instituto Nacional de Salud Pública INSP Departamen-to de Bioquímica Facultad de Medicina Universidad Nacional Autónoma de México

Helicobacter pylori(H. pylori) is a successful pathogen that can persist in the stomach of an infected person for their entire life. It provokes chronic gastric inflammation that leads to the development of serious gastric diseases such as peptic ulcers, gastric cancer and Mucosa associated lymphoid tissue lymphoma. It is known that these ailments can be avoided if the infection by the bacteria can be prevented or eradicated. Currently, numerous antibiotic-based therapies are available. However, these therapies have several inherent problems, including the appearance of resistance to the antibiotics used and associated adverse effects, the risk of re-infection and the high cost of antibiotic therapy. The delay in developing a vaccine to prevent or eradicate the infection has furthered research into new therapeutic approaches. This review summarises the most relevant recent studies on vaccine development and new treatments using natural resources such as plants, probiotics and nutraceuticals. In addition, novel alternatives based on microorganisms, peptides, polysaccharides, and intragastric violet light irradiation are presented. Alternative therapies have not been effective in eradicating the bacteria but have been shown to maintain low bacterial levels. Nevertheless, some of them are useful in preventing the adverse effects of antibiotics, modulating the immune response, gastroprotection, and the general promotion of health. Therefore, those agents can be used as adjuvants of allopathic anti-H. pylori eradication therapy.

关键词： Helicobacter pylori Treatment Natural products Probiotics Nutraceuticals

Infuence of Process Parameters on the RF Sputtered GaP Thin Films

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Journal of Materials Science & Technology 2013年第9期29卷 821-829页

作者： D.A.Mota G.Hema Chandra J.Ventura A.Guedes J.Pérez de la cruz INESC TEC Rua do Campo Alegre n°687 IFIMUP-IN Rua do Campo Alegre n°687 Thin Film Laboratory Material Physics Division VIT University Geology Department Faculty of Science University of Porto Rua do Campo Alegre n°687

In this work, gallium phosphide thin films were deposited on glass substrates by radio frequency （RF） magnetron sputtering technique under different depositions conditions. The X-ray diffraction analysis showed a diversity of states： from amorphous in the films deposited at 175 ~C to a nearly stoichiometric and polycrystalline films, exhibiting cubic phase with preferred orientation along （220）, in the films deposited at temperatures higher than 250 ~C. Scanning electron microscopy images revealed that all films were uniform with a smooth surface, while the energy-dispersive spectroscopy （EDS） analysis showed that there was a visible dependence on the Ga/P ratio in the deposition conditions and confirmed that a residual Ga metallic phase was presented in the surface of all the films. The Raman analysis showed the structural evolution of the GaP films was strongly dependent on the deposition conditions. The conductivity of the films was slightly dependent on the argon pressure and the rf power, but strongly dependent on the deposition temperature, mainly above 200 ~C. The optical transmission and absorption analyses of the GaP films revealed an indirect band gap of ~ 1.70 eV in the films deposited at temperatures less than 200 ~C, which transited to a band gap of 2.26 eV as the deposition temperature was close to 300 ~C.

关键词： Gallium phosphide Thin films Sputtering Amorphous Band gap

Intelligent collision risk detection in medium-sized cities of developing countries,using naturalistic driving:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第6期9卷 912-929页

作者： Juan Jose Paredes Santiago Felipe Yepes Ricardo Salazar-Cabrera Alvaro Pachon dela cruz Juan Manuel Madrid Molina Telematics Engineering Research Group(GIT) Telematics DepartmentUniversidad Del CaucaPopayanColombia Information Technology and Telecommunications Research Group(12T) Universidad IcesiCaliColombia

Traffic accidents are one of the most serious problems worldwide,being one of the leading causes of death and economic loss in the ***-and middle-income countries,mainly their medium-sized cities,are among the most affected by this problem.93%of traffic accidents occur in low and middle-income countries,even though these countries have approximately 60%of the world’s *** occurs mainly because in these types of countries,especially in medium-sized cities(target context),there are no ideal conditions for driving,such as adequate road infrastructure,good condition of vehicles,and rigorous safety *** data analysis techniques including machine learning(ML)have increasingly been used to solve this *** driving(ND)can be applied as a data collection method that provides information on traffic *** commonly uses a vehicle’s kinematic data to detect high-risk driving behaviors that could cause an *** objectives of this document are to present a review of different alternatives that help in data collection and creation of intelligent solutions related to detection of possible traffic accidents,principally using ND;and to propose an intelligent collision risk detection system(ICRDS)for identification of areas with a high probability of TA in the target *** the review,it was possible to analyze and evaluate the devices,variables and algorithms that help characterize a risk event in driving,considering the target *** development of a prototype of an ICRDS for a medium-sized city in a developing country is considered viable,considering the identified components,with the aim of identifying risk events in driving,and areas of high probability of accidents in the city.

关键词： Naturalistic driving Near-crash Traffic accident Vehicle data collection

Determination of Cusp Number and Occlusal Groove Pattern in Mandibular Molars:A Preliminary Epidemiological Study in an Indian Population

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Journal of Forensic Science and Medicine 2016年第2期2卷 98-101页

作者： Urvashi Ashwin Shetty Pushparaja Shetty Audrey Madonna D’cruz Departments of Oral Pathology and Microbiology and 1Public Health Dentistry A.B.Shetty Memorial Institute of Dental ScienceNitte UniversityMangaloreKarnatakaIndia

Teeth are excellent material in living and nonliving populations for anthropological,genetic,odontologic,and forensic *** present study aims to study the number of a number of cusps in the first and second mandibular molar and to assess the frequency and expression of different types of occlusal groove *** cross‑sectional study is carried *** hundred patients attending the Outpatient Department of the hospital were recruited for the study based on exclusion and inclusion *** examination was done,and the morphological details of the crown(the number of cusps)were *** casts of the mandibular teeth were *** occlusal grooves were highlighted by using Indian ink and observed under the 2×magnification for the groove pattern(+or y type).Descriptive statistics were carried out for the *** the case of mandibular first molar,the 5 cusp form was the most frequent occlusal configuration(82%)followed by 6 cusp variety(12%)and 4 cusp variety(4%)*** predominant occlusal groove pattern seen in mandibular first molar was“y”shape(65%)followed by“+”pattern(28%).Hence,the most frequent occlusal surface configuration in case of first mandibular molar was“y5”*** the case of mandibular second molar,the 4 cusp form was the most frequent occlusal configuration(86%),followed by 5 cusp type(12%)*** predominant occlusal groove pattern seen in mandibular second molar was a“+”shape(85%)followed by“y”pattern(11%).Hence,the most frequent occlusal surface configuration in case of mandibular second molar was“+4”*** study of dental morphological characteristics is important in forensic and anthropological research as it can provide information on the phylogenetic relationship between species,as well as variation and diversities within a population.

关键词： Anthropology cusp dentistry forensic occlusal groove teeth

3D extrusion of multi-biomaterial lattices using an environmentally informed workflow

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Frontiers of Architectural Research 2022年第4期11卷 691-708页

作者： Vasiliki Panagiotidou Andreas Koerner Marcos cruz Brenda Parker Bastian Beyer Sofoklis Giannakopoulos Bio-Integrated Design Lab The Bartlett School of ArchitectureUniversity College LondonLondonWC1E 6BTUnited Kingdom

The conventional building material palette has been proven limited in terms of adaptability to our current environmental challenges. Innovations in computational design and digital manufacturing have supported the broadening of biomaterial applications as an alternative. While biomaterials are characteristically responsive to stimuli such as temperature and humidity, their unpredictable behaviour is a hurdle to standardization and architectural utilisation. To examine the nexus between material formulation, computation and manufacturing, multi-biomaterial lattice structures were produced through an environmentally informed workflow. Customized biomaterial development resulted in three candidate biopolymer blends with varying levels of hydro-responsiveness and transparency. The computational strategy included a machine learning clustering algorithm to customise results and dictate material distribution outputs. To test the workflow, environmental data of solar radiation exposure and solar heat gain from a specific location was used to inform the material deposition via pneumatic extrusion for the design and digital fabrication of a deformation-controlled prototype of 350 mm × 350 mm. This led to a series of multi-biomaterial wall panel components that can be applied at architectural scale. In future, these techniques can support the incorporation of living elements to be embedded within the built environment for truly animate architecture.

关键词： Hydrogels Multi-biomaterials Hygroscopic properties Pneumatic extrusion Environmentally informed deposition Integrated workflows

Mitochondrial genotyping of cultured Piaractus brachypomus revealed low diversity and mutations in regions involved in metabolisms and proliferation

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Aquaculture and Fisheries 2023年第3期8卷 239-243页

作者： Alexis Felipe Rojas-cruz Carlos Ciceri-Coronado Alejandro Reyes-Bermúdez Programa de Biología Facultad de Ciencias B´asicasUniversidad de la AmazoniaFlorencia180001Colombia

In Amazonia,small-oriented family businesses or communities cultivate freshwater organisms as a source of *** effective management is fundamental for optimizing cultivated stocks,Amazonian aquaculture belittles the importance of genetic diversity,relying primarily on phenotypical characteristics during breeders’*** provide a“proof of concept”built on the premise that implementing modern technologies is crucial to optimizing fish stocks in rural Amazonian fish farms,we conducted a pilot study assessing genetic diversity on cultivated Piaractus brachypomus from Caquet´a,*** used mitochondrial control region(CR)sequences to evaluate *** data revealed low genetic diversity and suggested that most sampled individuals probably originated from a single maternal *** diversification resulted from discrete point mutations not associated with geographical *** accumulate in non-conserved CR regions,yet the most divergent haplotypes display mutations in conserved CR sequences with roles in mitochondrial metabolisms and ***,our results indicate a need in the local industry to design breeding strategies to enhance diversity to avoid deleterious effects caused by inbreeding and domestication.

关键词： Mitochondrial control region Amazonian fish farming Genetic diversity Freshwater

Flight performance and wing morphology in the bat Carollia perspicillata:biophysical models and energetics

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Integrative Zoology 2023年第5期18卷 876-890页

作者： Lucas de Oliveira CARNEIRO Breno MELLADO Marcelo Rodrigues NOGUEIRA Ariovaldo Pereira da cruz-NETO Leandro Rabello MONTEIRO Laboratório de Ciências Ambientais Centro de Biociências e BiotecnologiaUniversidade Estadual do Norte FluminenseCampos dos GoytacazesRio de JaneiroBrasil Departamento de Biodiversidade Universidade Estadual PaulistaRio ClaroSão PauloBrasil

Studies on functional performance are important to understand the processes responsible for the evolution of *** trait variation within species influences the energetic cost of locomotion and impacts life history traits,with ecological and evolutionary *** study examined wing morphology correlates of flight performance measured by energetic expenditure in the Seba’s short-tailed bat,Carollia *** the flight experiments,nature caught bats(59 females,57 males)were allowed to fly for 3 min in a *** each flight,thermographic images were taken to measure body temperature,and biophysical models were used to calculate sensible heat loss as a measure of energetic *** morphological traits were measured for each individual and associated with heat loss and power required to fly on performance *** morphological traits explained 7-10%of flight energetic cost,and morphologies with the best performance would save the energy equivalent to 9-30%of total daily *** optimal performance areas within the *** morphospace were consistent with predicted selection trends from the literature.A trade-off between demands for flight speed and maneuverability was *** loading and camber presented sexual *** morphological differences are likely associated with more economical but less maneuverable flight in females,leading them to fly more often in open areas along the forest *** findings demonstrate how small scale changes in wing morphology can affect life history strategies and fitness.

关键词： aerodynamics Chiroptera infrared thermography performance surfaces Phyllostomidae wing morphometrics

Physio-chemical modeling of the NO_(x)-O_(3) photochemical cycle and the air pollutants’ reactive dispersion around an isolated building

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Building Simulation 2023年第9期16卷 1735-1758页

作者： Yunfei Fu Xisheng Lin Xing Zheng Liangzhu Wang Chun-Ho Liu Xuelin Zhang cruz Y.Li K.T.Tse Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Future Cities Lab Global Singapore-ETH CentreSingapore 138602 Department of Building Civil and Environmental Engineering at Concordia UniversityMontrealQuebecCanada Department of Mechanical Engineering The University of Hong KongPok-fu-lam RoadHong KongChina Department of Civil Engineering Chongqing UniversityChongqingChina School of Atmospheric Sciences Sun Yat-sen UniversityZhuhaiChina

A numerical physio-chemical model of the NO_(x)-O_(3) photochemical cycle in the near-wake region of an isolated residential/office building has been presented in this *** investigation delves into the dispersion of reactive air pollutants through the lens of fluid phenomenology and its impact on chemical reactivity,formation,transport,deposition,and *** fluid dynamics(CFD)simulations were conducted for the ground-point-source(GES)and roof-pointsource(RES)*** show that the Damköhler number(Da),which quantifies pollutants’physio-chemical timescales,displays a strong inverse proportionality with the magnitude and spread of NO–increasing Da reduces human exposure to the toxic NO and NO_(2) *** different wind directions were considered,the dispersion range of NO exhibited varying shrinking directions as Da ***,as Da increases,the concentration ratio KNO_(2)/KNO_(x),which quantifies the production of NO_(2) resulting from NO depletion,forms sharp high-low gradients near emission *** GES,the dispersion pattern is governed by the fluid’s phenomenological *** RES,the intoxicated area emanates from the building’s leading-edge,with the lack of shielding inhibiting pollutant interactions in the near-wake,resulting in scant physio-chemical *** NO_(2)/NO_(x) distribution follows a self-similar,stratified pattern,exhibiting consistent layering gradients and attributing to the natural deposition of the already-reacted pollutants rather than in-situ *** the end,building design guidelines have been proposed to reduce pedestrian and resident exposure to NO_(x)-O_(3).

关键词： reactive pollutant dispersion NO_(x)-O_(3)cycle air pollution isolated building physio-chemical modelling