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International Journal of Minerals,Metallurgy and Materials 2016年第2期23卷 127-136页

作者： Gustavo Urbano Isabel Lázaro Israel Rodríguez Juan Luis Reyes Roxana Larios Roel cruz Instituto de Metalurgia Universidad Autonotrla de San Luis PotosiAvSierra Leona 550Lomas 2a SeccionSan Luis PotosiS.L.P.78210Mexico Industrial Minera Mexico S.A.de C.V. San Luis PotosiS.L.P.Mexico Centro Universitario de Ciencias Exactas e Ingenierias Universidad de GuadalajaraGuadalajaraJaliscoMexico

Comparative voltammetry and differential double-layer capacitance studies were performed to evaluate interfacial interactions between cnalcopyrite（CuFeS2） and n-isopropyl xanthate（X） in the presence of ammonium bisulfite/39wt%SO2 and caustic starch at different pH *** spectroscopy,Fourier transform infrared（FTIR） spectroscopy,contact angle measurements,and microflotation tests were used to establish the type and extent of xanthate adsorption as well as the species involved under different mineral surface conditions in this *** results demonstrate that the species that favor a greater hydrophobicity of chalcopyrite are primarily CuX and S^0,whereas oxides and hydroxides of Cu and Fe as well as an excess of starch decrease the hydrophobicity.A conditioning of the mineral surface with ammonium bisulfite/39wt%SO2 at pH 6 promotes the activation of surface and enhances the xanthate ***,this effect is diminished at pH ≥ 8,when an excess of starch is added during the preconditioning step.

关键词： sulfide minerals chalcopyrite xanthates flotation interfacial reactions electrochemistry spectroscopy

When a general morphology allows many habitat uses

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Integrative Zoology 2016年第6期11卷 483-499页

作者： María J.TULLI Félix B.cruz Tiana KOHLSDORF Virginia ABDALA Unidad Ejecutora Lillo(CONICET)Instituto de Herpetología Fundación Miguel LilloTucumánArgentina Instituto de Investigaciones en Biodiversidad y Medioambiente(INIBIOMA)CONICET-UNCOMA BarilocheRío NegroArgentina Departamento de Biologia-FFCLRP Universidade de São PauloRibeirão PretoBrazil Instituto de Biodiversidad Neotropical UNT-CONICETCátedra de Biología GeneralFacultad de Ciencias Naturales e IMLTucumánArgentina

During the last decades the study of functional morphology received more attention incorporating more detailed data corresponding to the internal anatomy that together contribute for a better understanding of the functional basis in *** we focus on 2 lizard families,Tropiduridae and Liolaemidae,and use information related to muscle-tendinous and external morphology traits of hind *** investigate whether the value of the traits analyzed tend to exhibit a reduced phenotypic variation produced by stabilizing selection,and whether species showing specialization in their habitat use will also exhibit special morphological features related to *** a result,we identified that evolution of hind limb traits is mainly explained by the Ornstein-Uhlenbeck model,suggesting stabilizing *** and tropidurids show clear ecomorphological trends in the variables considered,with sand lizards presenting the most specialized morphological *** ecomorphological trends differ between the 2 lineages,and traits of internal morphology tend to be more flexible than those of external morphology,restricting the ability to identify ecomorphs shared between these 2 *** traits of external morphology likely explain such restriction,as ecomorphs have been historically defined in other lizard clades based on variation of external morphology.

关键词： external morphology Lioalemidae muscles tendon Tropiduridae

Optopharmacological control of TRPC channels by coumarin-caged lipids is associated with a phototoxic membrane effect

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Science China(Life Sciences) 2016年第8期59卷 802-810页

作者： Oleksandra Tiapko Bernadett Bacsa Gema Guedes de la cruz Toma Glasnov Klaus Groschner Institute of Biophysics Medical University of GrazBio Tech Med-GrazHarrachgasse 21Graz 8010Austria Institute of Chemistry University of GrazNAWI GrazBio Tech Med-GrazHeinrichstrasse 28Graz 8010Austria

Photouncaging of second messengers has been successfully employed to gain mechanistic insight of cellular signaling path- ways. One of the most enigmatic processes of ion channel regulation is lipid recognition and lipid-gating of TRPC channels, which represents pivotal mechanisms of cellular Ca2＋ homeostasis. Recently, optopharmacological tools including caged lipid mediators became available, enabling an unprecedented level of temporal and spatial control of the activating lipid species within a cellular environment. Here we tested a commonly used caged ligand approach for suitability to investigate TRPC sig- naling at the level of membrane conductance and cellular Ca2＋ handling. We report a specific photouncaging artifact that is triggered by the cage structure coumarin at UV illumination. Electrophysiological characterization identified a light-dependent membrane effect of coumarin. UV light （340 nm） as used for photouncaging, initiated a membrane conductance specifically in the presence of coumarin as low as 30 pmol L-1 concentrations. This conductance masked the TRPC3 conductance evoked by photouncaging, while TRPC-mediated cellular Ca2＋ responses were largely preserved. The observed light-induced membrane effects of the released caging moiety may well interfere with certain cellular functions, and prompt caution in using couma- fin-caged second messengers in cellular studies.

关键词： caged diacylglycerols TRPC channels Ca2+ signaling optopharmacology

Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases

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Translational Neurodegeneration 2017年第1期6卷 187-196页

作者： Marcela cruz-Haces Jonathan Tang Glen Acosta Joseph Fernandez Riyi Shi Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteIN 47907USA Department of Basic Medical Sciences Purdue UniversityWest LafayetteUSA

Traumatic brain injury is among the most common causes of death and disability in youth and young *** addition to the acute risk of morbidity with moderate to severe injuries,traumatic brain injury is associated with a number of chronic neurological and neuropsychiatric sequelae including neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***,despite the high incidence of traumatic brain injuries and the established clinical correlation with neurodegeneration,the causative factors linking these processes have not yet been fully *** from removal from activity,few,if any prophylactic treatments against post-traumatic brain injury neurodegeneration ***,it is imperative to understand the pathophysiological mechanisms of traumatic brain injury and neurodegeneration in order to identify potential factors that initiate neurodegenerative *** stress,neuroinflammation,and glutamatergic excitotoxicity have previously been implicated in both secondary brain injury and *** particular,reactive oxygen species appear to be key in mediating molecular insult in neuroinflammation and *** such,it is likely that post injury oxidative stress is a key mechanism which links traumatic brain injury to increased risk of ***,reactive oxygen species and their subsequent byproducts may serve as novel fluid markers for identification and monitoring of cellular ***,these reactive species may further serve as a suitable therapeutic target to reduce the risk of post-injury neurodegeneration and provide long term quality of life improvements for those suffering from traumatic brain injury.

关键词： Traumatic brain injury Neurodegenerative diseases Alzheimer’s disease Parkinson’s disease Amyotrophic lateral sclerosis Oxidative stress Reactive oxygen species

Reporter gene systems for the identification and characterization of cancer stem cells

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World Journal of Stem Cells 2021年第7期13卷 861-876页

作者： NohemíSalinas-Jazmín Arely Rosas-cruz Marco Velasco-Velázquez Department of Pharmacology School of MedicineUniversidad Nacional Autónoma de MéxicoMexico City 04510Mexico

Cancer stem cells(CSCs)are tumor cells that share functional characteristics with normal and embryonic stem *** have increased tumor-initiating capacity and metastatic potential and lower sensitivity to chemo-and radiotherapy,with important roles in tumor progression and the response to ***,a current goal of cancer research is to eliminate CSCs,necessitating an adequate phenotypic and functional characterization of *** have been developed to identify,enrich,and track CSCs,many of which distinguish CSCs by evaluating the expression of surface markers,the initiation of specific signaling pathways,and the activation of master transcription factors that control stemness in normal *** review and discuss the use of reporter gene systems for identifying *** that are under the control of aldehyde dehydrogenase 1A1,CD133,Notch,Nanog homeobox,Sex-determining region Y-box 2,and POU class 5 homeobox can be used to identify CSCs in many tumor types,track cells in real time,and screen for ***,reporter gene systems,in combination with in vitro and in vivo functional assays,can assess changes in the CSCs *** present relevant examples of these systems in the evaluation of experimental CSCs-targeting therapeutics,demonstrating their value in CSCs research.

关键词： Cancer Gene reporter systems Cancer stem cells Pluripotency transcription factors Anticancer drugs Preclinical analysis Cancer stem cells marker

Mobile Alert and Warning in the United States and Japan:Confronting the Challenges of International Harmonization

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International Journal of Disaster Risk Science 2021年第6期12卷 928-934页

作者： Hamilton Bean Ana Maria cruz Mika Shimizu Keri K.Stephens Matthew McGlone Sharon Strover Department of Communication University of ColoradoDenver.CO 80204USA Disaster Prevention Research Institute(DPRI).Kyoto University Kyoto 611-0011Japan Graduate School of Advanced Integrated Studies in Human Survivability Kyoto UniversityKyoto 606-8501Japan Department of Communication Studies The University of Texas at AustinAustinTX 78712USA School of Journalism and Media The University of Texas at AustinAustinTX 78712USA

A U.S.-Japan expert workshop on mobile alert and warning was held online 8–10 September *** by the Japan Foundation’s Center for Global Partnership(CGP)and responding to the Sendai Framework for Disaster Risk Reduction 2015–2030,the workshop compared *** Japanese mobile alert and warning contexts,systems,policies,and messages to investigate possibilities for international harmonization of mobile device-based early *** workshop’s sessions revealed two interrelated issues that repeatedly surfaced among workshop participants:culture and *** workshop illuminated several possibilities and problems confronting U.S.,Japanese,and global stakeholders as they develop,deploy,and seek to improve the effectiveness of mobile alert and warning systems and messages.

关键词： Alerts Disasters Warning Japan Mobile technology United States

Horizontally Solidified Al-3 wt%Cu-(0.5 wt%Mg)Alloys:Tailoring Thermal Parameters,Microstructure,Microhardness,and Corrosion Behavior

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Acta Metallurgica Sinica(English Letters) 2019年第6期32卷 695-709页

作者： Andre Barros Clarissa cruz Adrina P.Silva Noe Cheung Amauri Garcia Otavio Rocha Antonio Moreira Institute of Technology Federal University of Para-UFPABelemPA 66075-110Brazil Federal Institute of Education Science and Technology of Para-IFPABelemPA 66093-020Brazil Department of Manufacturing and Materials Engineering University of Campinas-UNICAMPCampinasSP 13083-860Brazil

In the present experimental investigation,Al–3 wt%Cu and Al–3 wt%Cu–0.5 wt%Mg alloys castings are produced by a horizontal solidification technique with a view to examining the interrelationship among growth rate(GR),cooling rate(CR),secondary dendrite arm spacing(λ2),Vickers microhardness(HV),and corrosion behavior in a 0.5 M NaCl *** intermetallic phases of the as-solidified microstructures,that is,h-Al2Cu,S–Al2CuMg,and x-Al7Cu2 Fe,are subjected to a comprehensive characterization by using calculations provided by computational thermodynamics software,optical microscopy,and scanning electron microscopy/energy-dispersive ***,electrochemical impedance spectroscopy and potentiodynamic polarization tests have been applied to analyze the corrosion performance of samples of both alloys ***–Petch-type equations are proposed to represent the HV dependence onλ*** is shown that the addition of Mg to the Al–Cu alloy has led to a considerable increase in HV;however,the Al–Cu binary alloy is shown to have lower corrosion current density(icorr)as well as higher polarization resistance as compared to the corresponding results of the Al–Cu–Mg ternary alloy.

关键词： Aluminum alloys Solidification Dendritic microstructure Intermetallic phases Microhardness Corrosion resistance

Pillararene-based supramolecular systems for theranostics and bioapplications

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Science China Chemistry 2021年第5期64卷 688-700页

作者： Huangtianzhi Zhu Qi Li Laila E.Khalil-cruz Niveen M.Khashab Guocan Yu Feihe Huang State Key Laboratory of Chemical Engineering Key Laboratory of Excited-State Materials of Zhejiang ProvinceDepartment of ChemistryZhejiang UniversityHangzhou 310027China Smart Hybrid Materials Laboratory(SHMs) Advanced Membranes and Porous Materials CenterKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China

As an emerging type of important macrocycles for supramolecular chemistry,pillararenes and their derivatives have been widely studied and applied in numerous fields,which intensively promotes the development of chemistry,materials science and ***-based theranostic systems are of special interest in the biological and medical areas as they have shown very promising *** to easy preparation,reliable guest affinity,good biocompatibility and stability,pillararenes are frequently used to construct functional *** one hand,pillararenes can either be used individually or form diversiform self-assemblies such as micelles,nanoparticles and vesicles to increase water solubility and biocompatibility of *** the other hand,it is promising to modify solid materials like framework materials,silica nanoparticles and graphene oxides with pillararene derivatives to enhance their functions and *** this review,we summarize recent endeavors of pillararene-based supramolecular systems with theranostics and other biological applications comprising drug delivery/chemotherapy,photodynamic/photothermal therapy,antimicrobials,bioimaging,*** introducing several typical examples,the design principles,preparation strategies,identifications and bio-applications of these pillararene-based supramolecular systems are *** challenges and directions of this field are also outlined.

关键词： pillararenes self-assembly theranostics drug delivery supra-amphiphiles

Biodiesel Production Based in Microalgae: A Biorefinery Approach

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Natural Science 2015年第7期7卷 358-369页

作者： Lauren Espinosa González Gisel Chenard Díaz Donato alexandre Gomes Aranda Yordanka Reyes cruz Mariana Monteiro Fortes Greentec Laboratory School of Chemistry Federal University of Rio de Janeiro Rio de Janeiro Brazil Grand Valle Bio Energy Ltd. Biodiesel Factory Porto Real Rio de Janeiro Brazil

It is of great knowledge nowadays that the use of fossil fuels is responsible for the emission of gases that intensify the greenhouse effect, which threatens the survival of the humankind. The gravity of this fact could be mitigated through the indirect use of solar energy for fuels derived from vegetable that can be planted and cultivated by the world of renewable and non-polisher. Microalgae play an important role in this regard, as they have promising characteristics as potential raw material for the production of biofuels, able to absorb large amounts of CO2. Chlorophyll organisms convert these simple substances in the atmosphere, absorbing sunlight into chemical energy stored, that is, compounds with high energy, biomass can also be used to obtain biocompounds human nutritional supplement and food animal, however, have been found an important number of difficulties to economically viable production like high cost of production of dry biomass and oil extraction. Here, we review the main approaches of biorefinery concept appearing as an alternative to achieve economic viability of the production of bio-diesel based on microalgae. The major points are the following: 1) use of re-residual water, 2) marketing of Carbon Credits, and 3) development of co-products resulting from high value added.

关键词： Biodiesel Biorefinery Microalgae

A local spatial decision support system for developing countries based on MCA,fuzzy sets and OWA–case study of a municipality in Cuba

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Geo-Spatial Information Science 2013年第2期16卷 120-129页

作者： Ricardo DELGADO TELLEZ ZHONG Ershun ZUHU Yang Arisleydis PEÑA DE LA cruz Graduate University of Chinese Academy of Sciences No.A19Yuquan RoadBeijing 100049China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchCASNo.A11Datun RoadBeijing 100101China International Business Division SuperMap Software Co.LtdNo.A10Jiuxianqiao North RoadBeijing 100015China Department of Applied Meteorology Cuban Institute of MeteorologyHavana 95100Cuba

This paper presents a Spatial Decision Support System for local governments of developing *** allows municipality government,enterprises,scientific community and civil society to address decision problems using *** framework is supported by four modules of information technologies:Environmental Decision Support Database,Data Manipulation,Decision Support,and Mapping.A case study is presented covering the implementation of this framework in one municipality of *** example of land suitability planning for coconut crops is used to evaluate the system performance and *** show local municipalities are able to use this framework to solve local decision problems using state of the art decision making even with low infrastructure development.

关键词： GIS Spatial Decision Support System MCA OWA developing countries