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Stability of Brazilian Seasonally Dry Forests under Climate Change: Inferences for Long-Term Conservation

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American Journal of Plant Sciences 2013年第4期4卷 792-805页

作者： Rosane G. Collevatti Matheus souza Lima-Ribeiro José alexandre F. Diniz-Filho Guilherme Oliveira Ricardo Dobrovolski Levi Carina Terribile departamento de Ecologia Instituto de Ciências Biológicas Universidade Federal de Goiás Goiania Brazil Laboratório de Genética & Biodiversidade Instituto de Ciências Biológicas Universidade Federal de Goiás Goiania Brazil Laboratório de Macroecologia Universidade Federal de Goiás Jataí Brazil

We identified climatically stable areas of seasonally dry forests (SDFs) from Central Brazil through time and assessed the effectiveness of the current reserves network in representing these climatically stable areas, as well as areas of high suitability in the present or in the future only. We used an ensemble approach based on several methods for ecological niche modelling (ENMs) to obtain potential distributions 16 SDF’ species for past (last glacial maximum), present, and future (end of XXI century) climate scenarios. We then computed how many current Brazilian reserves matched both stable areas (suitable areas for all time periods), present and future geographical ranges alone for each species, in a multi-level gap analysis. We found range shifts due to climate changes for SDF’ species. Although the future geographical range and stable areas for all analyzed species matched at least with one reserve, many protected areas will lose importance in protecting suitable areas for species in the future. Moreover, the current Brazilian reserves cover only a small amount of their climatically stable areas. However, some reserves will be suitable for many SDF’ species (90%) at the same time, but climatically stable for only half of them. Our findings show that vegetation community from SDFs may persist in Brazilian territories until the end of XXI century, and challenges about long-term conservation of the SDFs may be partially reached with already existing Brazilian reserve network, however the reserves should be connected to permit habitat tracking.

关键词： Cerrado Biome Ecological Niche Modelling Global Climate Change Quaternary Climate Change Gap Analysis

Influence of Concentrate in the Diet on the Metabolic, Biochemical, and Endocrine Profile of Buffalo Heifers

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Open Journal of Veterinary Medicine 2019年第7期9卷 79-90页

作者： Caio Alves da Costa Rafael Artur da Silva Júnior Bruna Higino de souza Silva Rebeka Pontes Menezes Ayna Arramis Apolinário Da Silva Felipe Rosendo Correia Emanuel Felipe de Oliveira Filho Ricardo alexandre Silva Pessoa Cláudio Coutinho Bartolomeu Pierre Castro Soares department of Veterinary Medicine Federal Rural university of Pernambuco Recife Brazil department of Animal Science Federal Rural university of Pernambuco Recife Brazil

The objective of this study was to evaluate the profile of the main serum biochemical variables in buffalo heifers receiving diets with different concentrations of concentrate. Twenty buffalo heifers of the Murrah breed, aged six to eight months, were randomly assigned to four groups, with five replicates each, to be adapted to levels of 20%, 40%, 60%, and 80% of concentrate in the diet, composed of sugarcane (bulk) and concentrated feed based on wheat, corn, and soybean meal. The experimental diets were constituted in the proportion “bulk: concentrate”, based on dry matter, of “80:20” (Treatment 1), “60:40” (Treatment 2), “40:60” (Treatment 3), and “20:80” (Treatment 4). Biomarkers were evaluated for energy, protein, mineral, and endocrine profiles, as well as enzymatic activity. A positive linear effect was observed for Final Body Weight. In the energy profile, there was a positive linear effect for total cholesterol and HDL cholesterol and a quadratic effect for plasma glucose. In the protein profile, a quadratic effect was observed for the urea: creatinine ratio and a positive linear effect for total protein and albumin. For the enzymatic activity, only the variable gamma-glutamyltransferase presented a quadratic effect. In the mineral profile, a quadratic effect was observed for calcium levels and a positive linear effect for phosphorus levels and negative for chlorine levels. In the endocrine profile, no statistical differences were observed. Diet with until 80% of concentrate does not negatively influence biochemical parameters that represent the profile of energy, protein, mineral and thyroid hormones for growing buffalo heifers and favors the performance of the animals.

关键词： Animal Nutrition Clinical Pathology Bubalus Bubalis Energy Profile

Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon

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Infectious Diseases of Poverty 2018年第1期7卷 448-459页

作者： Virginia araujo Pereira Juan Camilo Sanchez-Arcila Mariana Pinheiro Alves Vasconcelos Amanda Ribeiro Ferreira Lorene de souza Videira Antonio Teva Daiana Perce-da-Silva Maria Teresa Queiroz Marques Luzia Helena de Carvalho Dalma Maria Banic Luiz Cristovao Sobrino Porto Joseli Oliveira-Ferreira Laboratory of Immunoparasitology Oswaldo Cruz Institute/FiocruzAv.Brasil 4365ManguinhosRio de JaneiroBrazil Institute of Infectology Emilio Ribas São PauloSao PauloBrazil Laboratory of Immunodiagnosis Departament of Biological SciencesNational School of Public Health/FiocruzRio de JaneiroBrazil Laboratory of Clinical Immunology Oswaldo Cruz Institute/FiocruzRio de JaneiroBrazil Laboratory of Histocompatibility and Cryopreservation–HLA of DHE/IBRAG/UERJ Rio de JaneiroBrazil Molecular Biology and Malaria Immunology Research Group Centro de Pesquisas Rene Rachou/FiocruzBelo HorizonteMinas GeraisBrazil

Background:Brazil has seen a great decline in malaria and the country is moving towards ***,for eventual elimination,the control program needs efficient tools in order to monitor malaria exposure and *** this study,we aimed to evaluate whether seroprevalence to the circumsporozoite protein(CSP)is a good tool for monitoring the exposure to and/or evaluating the burden and distribution of Plasmodium species in the Brazilian ***:Cross-sectional surveys were conducted in a rural area of Porto Velho,Rondônia *** infection was detected by microscopy and polymerase chain *** to the sporozoite CSP repeats of Plasmodium vivax,***,and ***(PvCS,PfCS,and PmCS)were detected using the enzyme-linked immunosorbent assay *** leukocyte antigen(HLA)-DRB1 and DQB1 genes were typed using Luminex®xMAP®***:The prevalence of immunoglobulin G against *** CSP peptide(62%)was higher than ***(49%)and ***(46%)CSP *** of the studied individuals had antibodies to at least one of the three peptides(72%),34%had antibodies to all three peptides and 28%were *** the majority of the population was not infected at the time of the survey,74.3%of parasite-negative individuals had antibodies to at least one of the ***,among individuals carrying the haplotypes DRB1*04~DQB1*03,there was a significantly higher frequency of PfCS responders,and DRB1*16~DQB1*03 haplotype for PvCS and PfCS *** contrast,HLA-DRB1*01 and HLA-DQB1*05 allelic groups were associated with a lack of antibodies to *** and *** CSP repeats,and the haplotype DRB1*01~DQB1*05 was also associated with non-responders,including non-responders to ***:Our results show that in low transmission settings,naturally acquired antibody responses against the CSP repeats of ***,***,and *** in a single cross-sectional study may n

关键词： Malaria Circumsporozoite protein Serological marker Human leucocyte antigen IgG antibody Porto Velho Rondônia Brazil

The role of extracellular calcium in the effect of a snake venom Lys49-phospholipase A2 on water transport across epithelial membranes

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Temporal trends in areas at risk for concomitant tuberculosis in a hyperendemic municipality in the Amazon region of Brazil

Journal of Biophysical Chemistry（生物物理化学） 2011年第3期

作者： Renner de souza Leite Wilson Franco Heloísa Sobreiro Selistre-de-araujo

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Infectious Diseases of Poverty 2020年第4期9卷 162-162页

作者： alexandre Tadashi Inomata Bruce Thais Zamboni Berra Felipe Lima dos Santos Yan Mathias Alves Ludmilla Leidianne Limirio souza Antônio Carlos Vieira Ramos Luiz Henrique Arroyo Juliane de Almeida Crispim Ione Carvalho Pinto Pedro Fredemir Palha Aline Aparecida Monroe Mellina Yamamura Regina Célia Fiorati Ana Carolina Scarpel Moncaio Dulce Maria de Oliveira Gomes Ricardo alexandre Arcêncio department of Maternal-Infant and Public Health Nursing University of São Paulo at Ribeirão Preto College of NursingRibeirão PretoSão PauloBrazil department of Nursing Federal University of São CarlosSão CarlosSão PauloBrazil department of Neurosciences and Behavioral Sciences Ribeirão Preto Medical School of the University of São PauloRibeirão PretoSão PauloBrazil department of Nursing Federal University of CatalãoCatalãoGoiásBrazil Mathematics department University ofÉvoraÉvoraPortugal

Background Although preventable and curable,tuberculosis(TB)still occurs in poor or developing countries,mainly in metropolitan regions of larger *** disease is a serious public health problem,and is directly linked to social *** analyzed temporal trend variations in areas at risk for concomitant TB,and characterized the clinical and epidemiological profiles of cases in a hyperendemic municipality in the Amazon region of *** This ecological study was performed in the municipality of Manaus,in northern *** population comprised cases with concomitant pulmonary and extrapulmonary TB,registered on the Notifiable Diseases Information System(SINAN),between January 1,2009 and december 31,*** risk cluster detection,spatial and spatiotemporal scanning statistical techniques were *** Spatial Variation in Temporal Trends(SVTT)approach was used to detect and infer clusters for significantly different time *** Between 2009 and 2018,873 concomitant TB cases were registered in *** using purely spatial scanning statistics,we identified two risk *** relative risk(RR)of the clusters was 2.21(95%confidence interval[CI]:1.57–2.88;P=0.0031)and 2.03(95%CI:1.58–2.58;P=0.0029).Using space-time scanning,we identified a risk cluster with an RR of 3.57(95%CI:2.84–4.41;P=0.014),between 2017 and *** SVTT analyses,three clusters with spatial variations were detected in the significant temporal trends:SVTT 1(P=0.042),SVTT 2(P=0.046)and SVTT 3(P=0.036).Conclusions In Brazil,several TB-determining factors such as race/color,gender,low educational level and low income overlap in needy urban areas and communities,demonstrating that it is unlikely to reach the goals,agreed and launched with the END TB Strategy within the deadlines of international agreements,if there is no reduction in existing inequities determinants and risk of illness in the country.

关键词： Tuberculosis Public health Epidemiology Spatial analysis Spatio-temporal analysis

Instruments for the assessment of social anxiety disorder: Validation studies

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World Journal of Psychiatry 2012年第5期2卷 83-85页

作者： Flávia de Lima Osório José alexandre de souza Crippa Sonia Regina Loureiro department of Neuroscience and Behavior Faculty of Medicine of Ribeirao Preto University of Sao Paulo INCT Translational Medicine Hospital das Clínicas FMRP-USP Avenida dos Bandeirantes 3900 Ribeirao Preto SP CEP 14049-900 Brazil

Great progress has been observed in the literature over the last decade regarding the validation of instruments for the assessment of Social Anxiety Disorder in the Brazilian context. Particularly outstanding in this respect is the production of a group of Brazilian investigators regarding the psychometric study of the following instruments: Liebowitz Social Anxiety Scale, Social Phobia Inventory, Brief Social Phobia Scale, Disability Profile, Liebowitz Self-Rated Disability Scale, Social Phobia Safety Behaviors Scale and Self-Statements During Public Speaking Scale, which have proved to be appropriate and valid for use in the adult Brazilian population, representing resources for the assessment of social anxiety in clinical and experimental situations.

关键词： Social anxiety Social phobia,Instruments Validation Scale

Subcutaneous Model for the Study of dengue Virus Infection in Immune Competent Mice

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Journal of Biosciences and Medicines 2018年第5期6卷 97-110页

作者： Beatriz Senra Santos Natalia Lima Pessoa Natalia Lucinda Gustavo Cardoso de Oliveira Thais souza Silva Ketyllen Reis Andrade Ketyllen Reis Andrade Bruno Galv&atilde o Filho Marcele Neves Rocha alexandre Vieira Machado Pedro Augusto Alves É rica Alessandra Rocha Alves Erna Geessien Kroon Marco Antô nio Campos Instituto René Rachou Funda&amp amp ccedil & amp atilde o Oswaldo Cruz Fiocruz Belo Horizonte Brazil departamento de Microbiologia Universidade Federal de Minas Gerais Belo Horizonte Brazil Empresa Brasileira de Pesquisa Agropecuá ria Laborat&amp amp oacute rio de Virologia Brasilia Brazil

Various mouse models to study dengue have been described by different authors, some of them using immunodeficient or some using humanized mice. Our group reported previously a deadly murine model, which used the intracranial inoculum of highly virulent dengue virus (deNV) in immune competent mouse. Here we present a model of immune competent mouse (C57BL/6), infected subcutaneously by the same highly virulent deNV (deNV3 genotype I). In this immunocompetent systemic mice model, the cytokine levels and hematological parameters such as total and differential leukocyte and platelets counts, together with weight loss, were considered important monitoring parameters, allowing a better understanding of the systemic human disease. Mice were inoculated subcutaneously and evaluated by the percentage weight variation as well as the clinical signs. Hematological parameters and cytokines levels were measured and viral titration in brain tissue or serum neutralization was performed to confirm mice infection. The subcutaneously deNV inoculated mice showed weight loss after infection, but they did not show any other clinical signs. The leukocytes and platelets decreased after subcutaneous inoculation. The cytokines TNF alpha and IFN gamma increased after infection in mice. The subcutaneous model provided scope for improved understanding of the dengue pathogenesis, as well as possible mechanism for protection to subsequent mouse infected by intracranial route in mice. This model could be used to study the vertebrate immune response and evaluation of drugs or vaccine against dengue virus.

关键词： Subcutaneous Murine Model dengue Disease Immune Competent Mouse Cytokines Innate Immune Response

Gonadal Steroid Hormones Levels in a Bitch with True Bilateral Hermaphroditism

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Journal of Pharmacy and Pharmacology 2018年第5期6卷 521-525页

作者： M. S. araujo O. L. O. H. Paulo L. S. Camargo C. S. Paranzini F. N. Marqui H. S. Oliveira F. F. de souza E. Oba Walter Mauricio Correa department of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Science Sao Paulo StateUniversity Botucatu 18618-681 SP Brazil 不详

Intersexualism occurs in all species of maxnmals and the pathogenesis of abnormal development of the gonads is still unclear. Thus, the aim of this report is to describe the hormonal and histopathological findings from a case of bilateral true hermaphroditism in a mixed-breed bitch due to the few case reports published involving hormonal levels in dogs with intersexuality. Serum was obtained from the animal before surgery and was submitted to hormone measurements. Progesterone and testosterone were evaluated by radioimnunoassay and estrogen by ELISA （immune-enzymatic assay）. The values of progesterone, testosterone and estrogen concentrations were 2.26 ng/mL, 0.05 ng/mL and 9.7 pg/mL, respectively. The proportion of ovarian tissue found in the ovotestes after histopathological examination was higher in relation to seminiferous tubules, which may explain the low level of serum testosterone. Low concentration of serum testosterone may have contributed to the partial virilization of external genitalia, since the animal only had clitoral hypertrophy. Estrogen and progesterone levels found were compatible with the initial stage of estrus （preovulatory LH （luteinizing hormone） surge）, which shows that ovarian follicles found in the bilateral ovotestes contributed to the occurrence of the estrous cycle before surgery. Quantitation of serum hormones may also shed light on the cause of disturbances in sex differentiation in canine species. More studies are needed to elucidate the real cause of intersex in dogs.

关键词： Dog sexual chromosome disorders sex reversal ovotestis.

Accuracy of gestalt perception of acute chest pain in predicting coronary artery disease

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World Journal of Cardiology 2017年第3期9卷 241-247页

作者： Cláudio Marcelo Bittencourt das Virgens Laudenor Lemos Jr Márcia Noya-Rabelo Manuela Campelo Carvalhal Antonio Maurício dos Santos Cerqueira Junior Fernanda Oliveira de Andrade Lopes Nicole Cruz de Sá Jéssica Gonzalez Suerdieck Thiago Menezes Barbosa de souza Vitor Calixto de Almeida Correia Gabriella Sant’Ana Sodré AndréBarcelos da Silva Felipe Kalil Beirao alexandre Felipe Rodrigues Marques Ferreira Luís Cláudio Lemos Correia department of Cardiology Hospital Sao Rafael department of Cardiology Hospital Português Bahiana School of Medicine and Public Health

AIM To test accuracy and reproducibility of gestalt to predict obstructive coronary artery disease(CAD)in patients with acute chest *** We studied individuals who were consecutively admitted to our Chest Pain *** admission,investigators performed a standardized interview and recorded14 chest pain *** on these features,a cardiologist who was blind to other clinical characteristics made unstructured judgment of CAD probability,both numerically and *** the reference standard for testing the accuracy of gestalt,angiography was required to rule-in CAD,while either angiography or non-invasive test could be used to *** order to assess reproducibility,a second cardiologist did the same *** In a sample of 330 patients,the prevalence of obstructive CAD was 48%.Gestalt’s numerical probability was associated with CAD,but the area under the curve of0.61(95%CI:0.55-0.67)indicated low level of ***,categorical definition of typical chest pain had a sensitivity of 48%(95%CI:40%-55%)and specificity of 66%(95%CI:59%-73%),yielding a negligible positive likelihood ratio of 1.4(95%CI:0.65-2.0)and negative likelihood ratio of 0.79(95%CI:0.62-1.02).Agreement between the two cardiologists was poor in the numerical classification(95%limits of agreement=-71%to 51%)and categorical definition of typical pain(Kappa=0.29;95%CI:0.21-0.37).CONCLUSION Clinical judgment based on a combination of chest pain features is neither accurate nor reproducible in predicting obstructive CAD in the acute setting.

关键词： Acute chest pain Clinical judgment Gestalt Coronary artery disease Acute coronary syndrome