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Embryonal rhabdomyosarcoma in the maxillary sinus with orbital involvement in a pediatric patient:Case report

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World Journal of Clinical Cases 2017年第12期5卷 440-445页

作者： Ana Carolina Rodrigues de Melo Tácio Candeia Lyra Isabella Lima Arrais Ribeiro alexandre Rolim da Paz paulo Rogério Ferreti Bonan Ricardo Dias de Castro Ana Maria Gondim Valen?a Department of Clinical and Social Dentistry Federal University of Paraíba Department of Pathology Hospital Napole?o Laureano Department of Restorative Dentistry Federal University of Paraíba

This report presents a case of embryonal rhabdomyosarcoma(e RMS) located in the left maxillary sinus and invading the orbital cavity in a ten-year-old male patient who was treated at a referral *** images provided from the computed tomography showed a heterogeneous mass with soft-tissue density,occupying part of the left half of the face inside the maxillary sinus,and infiltrating and destroying the bone structure of the maxillary sinus,left orbit,ethmoidal cells,nasal cavity,and sphenoid *** analysis of the histological sections revealed an undifferentiated malignant neoplasm infiltrating the skeletal muscle *** immunohistochemical analysis was positive for the antigens:MyoD 1,myogenin,desmin,and Ki67(100% positivity in neoplastic cells),allowing the identification of the tumour as an eR *** treatment protocol included initial chemotherapy followed by radiotherapy and finally *** total time of the treatment was nine months,and in 18-mo of follow-up period did not show no local recurrences and a lack of visual impairment.

关键词： Oncology Embryonal rhabdomyosarcoma Pediatrics Maxillary sinus Chemotherapy

Advances and New Applications Using the Acousto-Optic Effect in Optical Fibers

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Photonic Sensors 2013年第1期3卷 1-25页

作者： alexandre A. P. POHL Roberson A. OLIVEIRA Ricardo E. DA SILVA Carlos A. F. MARQUES paulo de Tarso NEVES JR. Kevin COOK John CANNING Rogério N. NOGUEIRA3 Advanced Telecommunications Laboratory Federal University of Technology - Paraná Curitiba Brazil Volvo GTT Advanced Technology & Research Curitiba Brazil Instituto de Telecomunicagōes P6lo de Aveiro 3810-193 Aveiro Portugal Interdisciplinary Photonics Labs School of Chemistry University of Sydney New South Wales 2006 Australia

This work presents a short review of the current research on the acousto-optic mechanism applied to optical fibers. The role of the piezoelectric element and the acousto-optic modulator in the excitation of flexural and longitudinal acoustic modes in the frequency range up to 1.2 MHz is highlighted. A combination of the finite elements and the transfer matrix methods is used to simulate the interaction of the waves with Bragg and long period gratings. Results show a very good agreement with experimental data. Recent applications such as the writing of gratings under the acoustic excitation and a novel viscometer sensor based on the acousto-optic mechanism are discussed.

关键词：长周期光纤光栅声光效果应用传输矩阵方法声光调制器压电元件声波模式频率范围

Good Practices in Strategic Environmental Assessment Processes under the Brazilian Practitioners’ Vision

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Journal of Environmental Protection 2018年第6期9卷 720-735页

作者： Antonio W. L. da Silva Marinilse Netto paulo Selig alexandre Lerípio Santa Catarina State University-UDESC Chapecó Brazil Community University of the Region of Chapecó-Unochapecó Chapecó Brazil Federal University of Santa Catarina-UFSC Florianópolis Santa Catarina Brazil University of Vale do Itajaí-Univali Univali Brazil

The use of good practices (GP) can improve the technical quality and, as a consequence, the outcome of the Strategic Environmental Assessment (SEA) process, increasing its effectiveness. This study aimed to present GP pointed out by Brazilian practitioners (members of the SEA development teams) from the perspective afforded by their participation in processes of this tool. The data were collected through personal interviews with 11 professionals responsible for preparing a total of 17 SEAs, who were asked about what measures adopted in the SEA could be considered BP. The responses were audio-recorded, transcribed, and had their content assessed by Content Analysis technique. Nine GP were highlighted by practitioners. The GP indicated represent a valuable contribution to the improvement of future use of SEA, either in Brazil or in other countries, because they are the result of consolidated experience in real cases of application of the tool.

关键词： Best Practices Environmental Management Environmental Policy Knowledge Management Sustainability

Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency

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Journal of Animal Science and Biotechnology 2018年第1期9卷 228-232页

作者： Lúcio Flávio Macedo Mota Cristina Moreira Bonafé Pamela Almeida alexandre Miguel Henrique Santana Francisco JoséNovais Erika Toriyama Aldrin Vieira Pires Saulo da Luz Silva paulo Roberto Leme JoséBento Sterman Ferraz Heidge Fukumasu Departmento de Zootecnia Universidade Federal dos Vales do Jequitinhonha e MucuriDiamantinaMG 39100 000Brazil Faculdade de Ciencias Agrarias e Veterinarias Universidade Estadual Paulista JaboticabalSP 14884 900Brazil Departamento de Medicina Veterinaria Faculdade de Zootecnia e Encjenharia de AlimentosUniversidade de Sao PauloAM.Duque de Caxias Norte n225Pirassununcja 13635 900SPBrazil Departmento de Zootecnia e Desenvolvimento Acjrossocioambiental Sustentavel Faculdade de VeterinariaUniversidade Federal FluminenseNiteroiRJ 24230 340Brazil Departamento de Zootecnia Faculdade de Zootecnia e Engenharia de AlimentosUniversidade de Sao PauloPirassununga 13635-900SPBrazil

Background： Leptin has a strong relation to important traits in animal production, such as carcass composition,feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the *** this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake（DMI） and average daily gain（ADG） of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake（RFI） and select 20 animals for the high feed efficient（LRFI） and 20 for the low feed efficient（HRFI） groups. Blood samples were collected on d 56 and at slaughter（80 d） to determine circulating plasma leptin. Samples of Longissimus dorsi were taken at slaughter for leptin gene expression ***： DMI and RFI were different between groups and LRFI animals showed less back fat and rump fat thickness,as well as less pelvic and kidney fat weight. Circulating leptin increased over time in all animals. Plasma leptin was greater in LRFI on 56 d and at slaughter（P = 0.0049）. Gene expression of leptin were greater in LRFI animals（P = 0.0022） in accordance with the plasma levels. The animals of the LRFI group were leaner, ate less, and had more circulating leptin and its gene ***： These findings demonstrated that leptin plays its physiological role in young Nellore bulls, probably controlling food intake because feed efficient animals have more leptin and lower residual feed intake.

关键词： Beef cattle Energy homeostasis Fat depositon Residual feed intake

Rapid acupuncture for musculoskeletal pain in the emergency room of the Hospital Servidor Publico Estadual, Brazil: A quasi-experimental study

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Journal of Integrative Medicine 2020年第4期18卷 313-318页

作者： Luciana Aikawa alexandre Massao Yoshizumi Mirian Matsura Shirassu Marcia Kiyomi Koike Programa de Pós-Graduação em Ciências da Saúde Instituto de Assistência Médica ao Servidor Público Estadual(IAMSPE)Vila ClementinoSão PauloSP 04029-000Brazil Associação Médica Brasileira de Acupuntura Vila MarianaSão PauloSP 04011-002Brazil

Objective:To compare differences in self-reported musculoskeletal pain before and after receiving rapid acupuncture for pain at an outpatient emergency ***:Exactly 102 patients presenting to the emergency room of the Hospital Servidor Publico Estadual in Sao paulo,Brazil,participated in this before-and-after *** participants had musculoskeletal pain and were treated with the technique proposed by Marques *** emergency acupuncture involved inserting a needle at a point defined by traditional Chinese medicine and applying intense stimulation for 10 s;no more than two points were used on any individual *** was measured using a numerical visual scale before and immediately after the ***:Participants in this study were mostly women(78%),had a college degree(47%)and were below the age of 60(56%).The most common region of pain was the lower back(31%),and the most common type of pain was acute and exacerbated chronic *** meridians most commonly involved were the eight extra meridians(40%),and the points most often used for treatment were Houxi(SI3),Shenmai(BL62)and Zulinqi(GB41).Almost all participants reported a decrease in pain intensity,independent of sex,education level,pain site and pain type(acute/chronic;P<0.05).At the end of the session,only4%of the participants reported a desire for allopathic ***:This emergency acupuncture technique for analgesia appears to reduce musculoskeletal *** registration:Brazilian Registry of Clinical Trials(http://***/)with ***-8 dmfjf.

关键词： Acupuncture analgesia Emergency medical services Acute pain Acupuncture therapy

Carbonates and organic matter in soils characterized by reflected energy from 350-25000 nm wavelength

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Journal of Mountain Science 2020年第7期17卷 1636-1651页

作者： Najmeh ASGARI Shamsollah AYOUBI Jose alexandre Melo DEMATTê AndréCarnieletto DOTTO Department of Soil Science College of AgricultureIsfahan University of Technology841156-83111IsfahanIran Department of Soil Science College of Agriculture Luiz de QueirózAv.Pádua Dias11CEP 13418-900PiracicabaSão PauloBrazil

The soil carbon pool which is the sum of soil organic carbon(SOC)and soil inorganic carbon(SIC)is the second largest active store of carbon after the oceans and it is an important component of the global carbon ***,accurate estimation of SOC and SIC as important carbon reservoirs in terrestrial ecosystems using fast,inexpensive and non-destructive methods is crucial for planning different climate change *** aim of the current research was to examine the effectiveness of Vis-NIR(visible and near-infrared spectroscopy:350-2500 nm)and MIR(mid-infrared spectroscopy:4000-400 cm-1)to characterize and estimate soil organic matter(SOM)and carbonates as main components of soil carbon stocks in Juneqan,Charmahal va Bakhtiari,*** do so,a total of 548 soil samples from this area were collected(October 2015)and analyzed in laboratory(August 2017).In order to develop models capable of predicting SOM and carbonates content,seven spectral preprocessing methods comprising Absorbance(Abs),De-trending(Det),Continuum removal(CR),Savitzky-Golay derivatives(SGD),standard normal variate transformation(SNV),multiplicative scatter correction(MSC)and Normalization by range(NBR)were conducted along with five multivariate methods including Random Forest(RF),Partial Least-Squares Regression(PLSR),Artificial Neural Network(ANN),Support Vector Machine(SVM)and Gaussian Process Regression(GPR).The content of carbonates caused spectral reflectance intensity to augment on several ranges of spectrum and strong absorption feature at 2338 nm in the Vis-NIR and 714,850,870,1796,2150 and 2510 cm-1 in the MIR spectra *** absorbed energy in several ranges,but also showed specific peaks in *** facts are associated with the structure of carbonates and SOM and its interaction with *** best combination of preprocessing and calibration models for carbonates quantification in Vis-NIR spectra was Det/PLSR(R2=0.74,RPD=2.19,RMSE=6.45).For SOM,it was Det/PLSR(R2=0.82,RPD=2.41,RM

关键词： Modeling Reflectance spectroscopy Soil analysis Preprocessing

A Cost-Benefit Evaluation of the Air Quality and Health Impacts in Sao paulo,Brazil

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Journal of Environmental Protection 2012年第9期3卷 1161-1166页

作者： Diego Velloso Veronez Luiz alexandre Kulay paulo Hilario Nascimento Saldiva Simone Georges El Khouri Miraglia Purchasing Department Lear Corporation CacapavaBrazil Escola Politecnica Universidade de Sao PauloSao PauloBrazil Faculdade de Medicina da Universidade de Sao paulo Sao PauloBrazil Earth and Exact Sciences Departament Universidade Federal de Sao Paulo—UNIFESPDiademaBrazil

The objective was to assess the impact on health due to the exposure to air pollution derived from the renewal of the urban bus fleet in S?o paulo. The study analyzed the substitution of the bus fleet through the variation of the concentration of atmospheric pollutants such as PM10 in the municipality of S?o paulo and its associated health’s benefits values compared to the investments performed in the bus fleet renewal. PM10 average annual reduction due to the bus improvement system resulted on 22.3%. A cost-benefit evaluation considered the renewal investments’ costs compared to the obtained valued health benefits and it resulted in 4.31. Although the result may suggest a not viable investment, it must be observed that air pollution reduction favors health impacts and that this relation could be improved if additional investments on sustainable transportation increase.

关键词： Air Quality Cost-Benefit Health Impacts Transportation Sao paulo Brazil

Brazilian biosafety law and the new breeding technologies

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Frontiers of Agricultural Science and Engineering 2020年第2期7卷 204-210页

作者： alexandre Lima NEPOMUCENO Renata FUGANTI-PAGLIARINI Maria Sueli Soares FELIPE Hugo Bruno Correa MOLINARI Edivaldo Domingues VELINI Eduardo Romano de Campos PINTO Maria Lucia Zaidan DAGLI Galdino ANDRADE FILHO Patricia machado Bueno FERNANDES Embrapa Soybean Londrina 86001970Brazil Catholic University of Brasilia Brasilia 70790160Brazil Embrapa Agroenergy Biological Station ParkBrasilia 70770901Brazil Paulista State University Julio de Mesquita Filho Botucatu Faculty of Agronomic SciencesBotucatu 18610307Brazil Embrapa Biotechnology and Genetic Resources—Biological Station Park Brasilia 70770900Brazil Sao paulo University Veterinary FacultySao Paulo 05508900Brazil Londrina State University Microbiology DepartmentUniversity CampusLondrina 86051990Brazil Espirito Santo Federal University Biotechnology Post GraduationVitoria 29040090Brazil CTNBio(National Biosafety Technical Commission) Brasilia 70610200Brazil

Globally,the area of land cultivated with genetically modified(GM)crops has increased a thousand-fold over the last two *** this technology has become important for food production,the regulatory frameworks that underpin these outcomes are based on a list of requirements for a risk assessment that differ from country to *** recent years,policymakers have had the opportunity to learn from the controversies over transgenics to create effective regulatory milestones for emerging technologies,allowing them to reach their potential for a more sustainable agriculture,ensuring food *** Brazil,Law No.11.105 of 24 March 2005 established a framework with four main organizations responsible for risk assessment and ***,most of new breeding technologies did not exist at that time and were not considered in this ***2016,Normative Resolution No.16 of the National Biosafety Technical Commission(CTNBio)was established to address this gap based on the evaluation of the products obtained through these techniques(termed Innovative Precision Improvement Techniques in the resolution),in a case-by-case consultation ***,if the product is designated to be a GM,the developer will have to go through the biosafety requirements and will be approved only after CTNBio risk *** the product is designated not to be GM(for the purposes of the legislation),then it can be registered using the existing ***,152 GM products are commercially approved in *** 2018,CTNBio assessed the first consultation on commercial release of plants generated using the new breeding technologies and has subsequently approved six *** is expected that many institutions would be able to participate in Brazilian and world markets,developing and introducing new biotechnological solutions and products through a more sustainable approach and without facing public disapproval,a common issue for GM crops.

关键词： Brazilian legislation CTNBio genetically modified crops

Multiomic investigation of Sugarcane mosaic virus resistance in sugarcane

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The Crop Journal 2023年第6期11卷 1805-1815页

作者： Ricardo JoséGonzaga Pimenta alexandre Hild Aono Roberto Carlos Villavicencio Burbano Marcel Fernando da Silva Ivan Antônio dos Anjos Marcos Guimarães de Andrade Landell Marcos Cesar Gonçalves Luciana Rossini Pinto Anete Pereira de Souza Centre for Molecular Biology and Genetic Engineering University of CampinasCampinasBrazil Gustavo Galindo Velasco Campus Littoral Polytechnic Superior SchoolGuayaquilEcuador Advanced Centre for Technological Research in Sugarcane Agribusiness Agronomic Institute of CampinasRibeirão PretoBrazil Plant Protection Research Centre Biological InstituteSão PauloBrazil Department of Plant Biology Institute of BiologyUniversity of CampinasCampinasBrazil

Sugarcane mosaic virus(SCMV)is the main etiological agent of sugarcane mosaic disease,which affects sugarcane and other grass *** the extensive characterization of quantitative trait loci controlling resistance to SCMV in maize,the genetic basis of this trait in sugarcane is largely ***,a genome-wide association study was performed and machine learning coupled with feature selection was used for genomic prediction of resistance to SCMV in a diverse sugarcane *** single-nucleotide polymorphisms(SNPs)explained up to 29.9%of the observed phenotypic variance and a 73-SNP set predicted resistance with high accuracy,precision,recall,and F1 scores(the harmonic mean of precision and recall).Both marker sets were validated in additional sugarcane genotypes,in which the SNPs explained up to 23.6%of the phenotypic variation and predicted resistance with a maximum accuracy of 69.1%.Synteny analyses suggested that the gene responsible for the majority of SCMV resistance in maize is absent in sugarcane,explaining why this major resistance source has not been identified in this ***,using sugarcane RNA-Seq data,markers associated with resistance to SCMV were annotated,and a gene coexpression network was constructed to identify the predicted biological processes involved in *** network allowed the identification of candidate resistance genes and confirmed the involvement of stress responses,photosynthesis,and the regulation of transcription and translation in resistance to *** results provide a practical marker-assisted breeding approach for sugarcane and identify target genes for future studies of SCMV resistance.

关键词： Saccharum SCMV GWAS Machine learning RNA-Seq