检索结果-南通市图书馆

Rare dentin defects:Understanding the pathophysiological mechanisms of COLXVA1 mutations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 1-5页

作者： Isaac Maximiliano Bugueno Tristan Rey alexandra Jimenez-Armijo Marzena Kawczynski Naji Kharouf Marie-Cecile Maniere Yann Herault Agnes Bloch-Zupan Virginie HaushalterLaugel Institute of Genetics and Molecular and Cellular Biology(IGBMC) CNRS-UMR7104INSERM U1258Universitede StrasbourgIllkirch 67400France Faculty of Dentistry Universitede StrasbourgStrasbourg 67000France Institute of Advanced Studies(USIAS) Universitede StrasbourgStrasbourg 67045France Reference Center for Rare Oral and Dental Diseases(CRMR-O-Rares) Oral Medicine and Surgery DepartmentHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Rare Diseases Health Network“TETE COU”&European Reference Network ERN CRANIO Strasbourg 67000France “Institut de Genetique Medicale d’Alsace” Laboratory of Genetic DiagnosticHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Biomaterials and Bioengineering Laboratory Inserm UMR_S 1121Strasbourg 67000France Orofacial Development and Regeneration Faculty of MedicineInstitute of Oral BiologyCentre of Dental MedicineUniversity of ZurichZurich 8032Switzerland

Dentin is a mineralized tissue with a chemical composition similar to bone but with a higher mineralized density and *** constitutes the central structure of the tooth between the internal pulp and external enamel toward the oral cavity or cementum toward the underlying *** dentin defects occur in a variety of rare genetic *** can manifest as“isolated”occurrences such as in dentinogenesis imperfecta(DI)or dentin dysplasia(DD)or can be associated with other symptoms in diseases such as osteogenesis imperfecta,Goldblatt syndrome,microcephalic osteodysplastic primordial dwarfism type Ⅱ,among others.

关键词： diseases den rigidity

Innate IgM antibodies to mannose in patients with gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2024年第3期21卷 193-197页

作者： Maxim Petrovich Nikulin Nadezhda Vladimirovna Shilova Alexander Dmitrievich Lipatnikov Ivan Sokratovich Stilidi alexandra Vladimirovna Semyanikhina Nikolai Vladimirovich Bovin Nikolai Nikolaevich Tupitsyn Federal State Budgetary Institution"National Medical Research Center for Oncology Named After N.N.Blokhin"of the Ministry of Health of Russia MoscowRussia State Research Center"Institute of Bioorganic Chemistry Named After Academicians M.M.Shemyakin and Yu.A.Ovchinnikov"of the Russian Academy of Sciences MoscowRussia National Medical Research Center for Obstetrics Gynecology and Perinatology Named After Academician VI.Kulakov of the Ministry of Health of Russian FederationMoscowRussia

Gastric cancer(GC) remains one of the most common lethal diseases. Every year, about 1 million people fall ill and almost 800 thousand people die worldwide~1. Surgical treatment has reached its limit. The current advances in immunology and detection of epidermal growth factor molecules(EGFR) in gastric cancer cells allowed to improve the treatment results;however, the metastatic form of this disease is still incurable.

关键词： Gastric cancer gastric

Prognostic and predictive role of immune microenvironment in colorectal cancer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第3期16卷 643-652页

作者： Olesya Kuznetsova mikhail Fedyanin Larisa Zavalishina Larisa Moskvina Olga Kuznetsova alexandra Lebedeva Alexey Tryakin Galina Kireeva Gleb Borshchev Sergei Tjulandin Ekaterina Ignatova Department of Chemotherapy Federal State Budgetary Institution(N.N.Blokhin National Medical Research Center of Oncology)of the Ministry of Health of the Russian FederationMoscow 115478Russia Department of Pathology Russian Medical Academy of Continuous Professional EducationMoscow 123242Russia OncoAtlas LCC Moscow 115478Russia Federal State Budgetary Institution“National Medical and Surgical Center named after N.I.Pirogov”of the Ministry of Health of the Russian Federation Moscow 105203Russia STOONCO:Science and Technology in Oncology Moscow 115478Russia

Colorectal cancer(CRC)represents a molecularly heterogeneous disease and one of the most frequent causes of cancer-related death *** traditional classification of CRC is based on pathomorphological and molecular character-istics of tumor cells(mucinous,ring-cell carcinomas,etc.),analysis of mechanisms of carcinogenesis involved(chromosomal instability,microsatellite instability,CpG island methylator phenotype)and mutational statuses of commonly altered genes(KRAS,NRAS,BRAF,APC,etc.),as well as expression signatures(CMS 1-4).It is also suggested that the tumor microenvironment is a key player in tumor progression and metastasis in *** to the latest data,the immune microenvironment can also be predictive of the response to immune checkpoint *** this review,we highlight how the immune environment influences CRC prognosis and sensitivity to systemic therapy.

关键词： Immunoscore Immune microenvironment Colorectal cancer Gastrointestinal cancers Predictive biomarkers Digital pathology

Successful cetuximab rechallenge in metastatic colorectal cancer:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第9期15卷 1232-1238页

作者： alexandra Guedes Sandra Silva Sandra Custódio Andreia Capela Department of Medical Oncology Centro Hospitalar Gaia/EspinhoVila Nova de Gaia 4434-502Portugal

BACKGROUND Metastatic colorectal cancer(mCRC)treatment has been evolving and increasingly driven by tumor biology and gene expression *** with epidermal growth factor receptor(EGFR)inhibitors(anti-EGFR)represents a promising strategy for patients with RAS wild-type(RAS-wt)mCRC and circulating tumor DNA has emerged as a potential selection ***,we report the case of a RAS-wt mCRC patient who had a successful response to cetuximab *** SUMMARY Our patient was diagnosed with stage IV RAS-wt,microsatellite-stable rectosigmoid junction *** was started on first-line treatment with FOLFIRI and cetuximab and achieved partial response,allowing for a left hepatectomy(R0),followed by post-operative chemotherapy and an anterior resection;progression-free survival(PFS)of 16 months was *** to hepatic and nodal relapse,second-line treatment with FOLFOX and bevacizumab was started with partial response;metastasectomy was performed(R0),achieving a PFS of 11 *** a 15 months anti-EGFR-free interval,FOLFIRI and cetuximab were reintroduced upon disease progression,again with partial response and a PFS of 16 *** extensive hepatic relapse,cetuximab was reintroduced and a marked clinical and analytical improvement was seen,after only one *** status was confirmed on circulating tumor *** patient’s overall survival exceeded 5 *** Our case provides real-world data to support cetuximab rechallenge in later lines of RAS-wt mCRC treatment.

关键词： Metastatic colorectal cancer RAS mutation RAS wild type Anti-epidermal growth factor receptor Cetuximab Rechallenge Case report

Direct anterior compared to posterior approach for hip hemiarthroplasty following femoral neck fractures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2024年第6期15卷 605-607页

作者： Kevin A Wu alexandra N Krez Albert T Anastasio Department of Orthopaedic Surgery Duke University HospitalDurhamNC 27710United States Department of Orthopaedic Surgery Duke University School of MedicineDurhamNC 27710United States

The differences in complication rates between the direct anterior and posterior approaches for hemiarthroplasty in elderly patients with femoral neck fractures are not yet fully ***,a severe complication associated with increased mortality and often requiring additional surgery,may occur less frequently with the direct anterior approach compared to the posterior *** consideration of patient demographics is essential when planning the surgical *** research in this area should focus on robust randomized controlled trials involving elderly patients recovering from femoral neck fractures.

关键词： Direct anterior approach Posterior approach Hemiarthroplasty Femoral neck fractures Arthroplasty Dislocation Surgical technique

Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第5期14卷 2349-2357页

作者： Rabea Voget Julian Breidenbach Tobias Claff alexandra Hingst Katharina Sylvester Christian Steinebach Lan Phuong Vu Renato H.Weiße Ulrike Bartz Norbert Sträter Christa E.Müller Michael Gütschow Pharmaceutical Institute Pharmaceutical&Medicinal ChemistryUniversity of BonnBonn 53121Germany Institute of Bioanalytical Chemistry Center for Biotechnology and BiomedicineLeipzig UniversityLeipzig 04103Germany Department of Natural Sciences University of Applied Sciences Bonn-Rhein-SiegRheinbach 53359Germany

A titrant for the SARS-CoV-2 main protease(M^(pro))was developed that enables,for the first time,the exact determination of the concentration of the enzymatically active M^(pro) by active-site *** covalent binding mode of the tetrapeptidic titrant was elucidated by the determination of the crystal structure of the enzyme–titrant *** fluorogenic substrates of M^(pro),including a prototypical,internally quenched Dabcyl-EDANS peptide,were compared in terms of solubility under typical assay *** exploiting the new titrant,key kinetic parameters for the M^(pro)-catalyzed cleavage of these substrates were determined.

关键词： COVID-19 SARS-CoV-2 Main protease Peptide nitriles Fluorogenic substrates Active-site titration X-ray crystallography Inner filter effect

Effect of vaccinations and school restrictions on the spread of COVID-19 in different age groups in Germany

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Disease Modelling 2024年第4期9卷 1250-1264页

作者： Christiane Dings Dominik Selzer Nicola Luigi Bragazzi Eva Mohler Markus Wenning Thomas Gehrke Ulf Richter alexandra Nonnenmacher Folke Brinkmann Tobias Rothoeft Michael Zemlin Thomas Lücke Thorsten Lehr Department of Clinical Pharmacy Saarland University66123SaarbrückenGermany Department of Child and Adolescent Psychiatry Saarland University Hospital66421HomburgGermany Medical Association Westfalen-Lippe48151MünsterGermany School of Education and Psychology Siegen University57072SiegenGermany University Children's Hospital Ruhr University44791BochumGermany University Children's Hospital Airway Research Center North(ARCN)German Center for Lung Research(DZL)LübeckGermany Department of General Pediatrics and Neonatology Saarland University Hospital66421HomburgGermany

With the emergence of SARS-CoV-2,various non-pharmaceutical interventions were adopted to control virus transmission,including school ***,the introduction of vaccines mitigated not only disease severity but also the spread of *** study leveraged an adapted SIR model and non-linear mixed-effects modeling to quantify the impact of remote learning,school holidays,the emergence of Variants of Concern(VOCs),and the role of vaccinations in controlling SARS-CoV-2 spread across 16 German federal states with an age-stratified *** highlight a significant inverse correlation(Spearman's ρ=0.92,p<0.001)between vaccination rates and peak incidence rates across all age ***-parameter estimation using the observed number of cases stratified by federal state and age allowed to assess the effects of school closure and holidays,considering adjustments for vaccinations and spread of VOCs over ***,modeling revealed significant(p<0.001)differences in the virus's spread among pre-school children(0-4),children(5-11),adolescents(12-17),adults(18-59),and the elderly(60+).The transition to remote learning emerged as a critical measure in significantly reducing infection rates among children and adolescents(p<0.001),whereas an increased infection risk was noted among the elderly during these periods,suggesting a shift in infection networks due to altered caregiving ***,during school holiday periods,infection rates among adolescents mirrored those observed when schools were *** exercises based on the model provided evidence that COVID-19 vaccinations might serve a dual purpose:they protect the vaccinated individuals and contribute to the broader community's safety.

关键词： COVID-19 Vaccination Non-pharmaceutical interventions Age Mathematical modeling

The Impact of Psychosocial Influences on Chronic Wound Healing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Medical Psychology 2024年第3期13卷 39-57页

作者： Kelly Frasier Vivian Li Sara Christoforides Kathleen Daly alexandra Loperfito Karina Stech Milena Dragovic Nuvance Health/Vassar Brothers Medical Center Poughkeepsie NY USA Lake Erie College of Osteopathic Medicine New York NY USA Medical College of Georgia Augusta University Augusta GA USA Edward Via College of Osteopathic Medicine Blacksburg VA USA Lewis Katz School of Medicine Temple University Philadelphia PA USA College of Osteopathic Medicine California Health Sciences University Clovis CA USA

This comprehensive review explores the intricate dynamics between psychosocial factors and chronic wound healing processes, specifically focusing on prevalent conditions such as pressure ulcers, diabetic foot ulcers, and venous leg ulcers. By examining the roles of psychiatric conditions, including depression, anxiety, and post-traumatic stress disorder (PTSD), this paper illuminates how these factors intricately influence wound healing dynamics, including mechanisms of pain perception and inflammatory responses. Furthermore, we evaluate the effectiveness of integrated biopsychosocial interventions, which encompass a holistic approach to wound care, thereby enhancing healing outcomes for dermatology patients. Future studies should focus on investigating the specific psychosocial determinants that significantly influence wound healing, exploring novel therapeutic strategies, and implementing personalized interventions to meet the unique needs of each patient. Such endeavors hold promise in advancing the fields of psychodermatology and wound management, fostering a deeper understanding and application of psychosocial considerations in dermatological care.

关键词： Psychosocial Factors Chronic Wound Healing Biopsychosocial Interventions Psychiatric Conditions Dermatology Patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

滑板公园进化正当时

商业周刊（中文版） 2024年第13期 34-38页

作者： alexandra Lange 程玺(译) 不详

在奥运会的推动下,这项街头朋克运动已经蔚为风潮,“滑板公园”这一配套设施也悄然兴起.滑板族的舞台,包括楼梯、栏杆、长凳、坡道、涵洞,乃至1970年代中期夏日旱季里那些干涸了的泳池。滑板公园往往隐匿于城市的角落:高架桥和立交桥下... 详细信息

在奥运会的推动下,这项街头朋克运动已经蔚为风潮,“滑板公园”这一配套设施也悄然兴起.滑板族的舞台,包括楼梯、栏杆、长凳、坡道、涵洞,乃至1970年代中期夏日旱季里那些干涸了的泳池。滑板公园往往隐匿于城市的角落:高架桥和立交桥下,通风管道和港口码头旁,抑或城市边陲的公园里。

关键词：港口码头通风管道高架桥和立交桥配套设施奥运会涵洞滑板