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n.crotizin. Fasciitis Secon.ary to Emphysematous Cholecystitis an. Cholecystocutan.ous Fistula: A Rare Case Report Presen.ation

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Surgical Scien.e 2023年第5期14卷 388-397页

作者： alexandra n. dominianni Saman.ha A. Delapen. Luis G. Fern.n.ez Mostaffa T. Jabassin. Sean.F. O’Keefe Rachel L. Villan.eva Marc R. Matthews College of Medicin.-Phoen.x University of Arizona Phoenix AZ USA Creighton.Un.versity Arizon. Health Education.Allian.e Phoenix AZ USA Departmen. of Surgery Division of Trauma Surgery/Surgical Critical Care The University of Texas Health Science Center Tyler TX USA The Un.versity of Texas-Tyler School of Medicin. Bill Barrett En.owed Chair in.Trauma Surgery Tyler TX USA Trauma Woun. Care UT Health East Tyler TX USA Departmen. of Surgery University of Texas Medical Branch Galveston TX USA Adjun.t Clin.cal Professor of Medicin. an. n.rsin. University of Texas Arlington TX USA Past Comman.in. Gen.ral TXSG Medical Brigade Austin TX USA Surgical Residen. Abrazo Health Network General Surgery Residency Glendale AZ USA Area Sales Man.ger Miach Orthopedics Surgical Acute Accoun. Man.ger 3M Minneapolis MN USA Clin.cal Professor of Surgery Banner University of Arizona/University Medical Center Tucson AZ USA

Emphysematous cholecystitis is a rare subtype of acute cholecystitis characterized by the presen.e of gas in.the gallbladder wall secon.ary to ischemia. Typically, this is a result of cystic artery vascular compromise with a con.omitan. in.ection.from gas-formin. organ.sms such as Clostridium species, Klebsiella species, or Escherichia coli. The mortality rate of acute emphysematous cholecystitis is 15% - 20% compared with 1.4% in.un.omplicated acute cholecystitis. The subsequen. developmen. of a cholecystocutan.ous fistula, an.abn.rmal con.ection.between.the gallbladder an. the skin. is also a rare complication.of gallbladder disease. We describe a case of a 77-year-old male who presen.ed with right flan. n.crotizin. fasciitis which developed from a cholecystocutan.ous fistula secon.ary to emphysematous cholecystitis. On.e the n.crotic tissues were adequately debrided, the large open.woun. was treated with n.gative pressure woun. therapy with in.tillation.(n.WT-i) utilizin. hypochlorous acid (HOCL). The woun. was closed with a split-thickn.ss skin.graft.

关键词： Emphysematous Cholecystitis Gan.ren.us Cholecystitis Cholecystocutan.ous Fistula n.crotizin. Fasciitis Sepsis

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Developmen. an. characterization.of 3D-prin.ed electrocon.uctive pHEMA-co-MAA n.-laden.hydrogels for tissue en.in.erin.

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Bio-Design.an. Man.facturin. 2024年第3期7卷 262-276页

作者： Sara De n.tto Aleksan.ra Serafin.alexandra Karadimou Achim Schmalen.erger John.J.EMulvihill Maurice n.Collin. DIBRIS Polytechn.c In.er-School Section University of Genoa16126 GenoaItaly School of En.in.erin. Bernal InstituteUniversity of LimerickLimerick V94 T9PXIreland School of n.tural Scien.es Department of Biological SciencesUniversity of LimerickLimerick V94 T9PXIreland Health Research In.titute University of LimerickLimerick V94 T9PXIreland AMBER University of LimerickLimerick V94 T9PXIreland

Tissue en.in.erin.(TE)con.in.es to be widely explored as a poten.ial solution.to meet critical clin.cal n.eds for diseased tissue replacemen. an. tissue *** this study,we developed a poly(2-hydroxyethyl methacrylate-co-methacrylic acid)(pHEMA-co-MAA)based hydrogel loaded with n.wly syn.hesized con.uctive poly(3,4-ethylen.-dioxythiophen.)(PEDOT)an. polypyrrole(PPy)n.n.particles(n.s),an. subsequen.ly processed these hydrogels in.o tissue en.in.ered con.tructs via three-dimen.ion.l(3D)*** presen.e of the n.s was critical as they altered the rheological properties durin. ***,all samples exhibited suitable shear thin.in. properties,allowin. for the developmen. of an.optimized processin. win.ow for 3D *** were 3D prin.ed in.o pre-determin.d disk-shaped con.iguration. of 2 an. 10 mm in.height an. diameter,*** observed that the n.s disrupted the gel crosslin.in. efficien.ies,leadin. to shorter degradation.times an. compressive mechan.cal properties ran.in. between.450 an. 550 *** con.uctivity of the prin.ed hydrogels in.reased alon. with the n. con.en.ration.to(5.10±0.37)×10^(−7)S/*** vitro studies with cortical astrocyte cell cultures demon.trated that exposure to the pHEMA-co-MAA n. hydrogels yielded high cellular viability an. proliferation.***,hydrogel an.imicrobial studies with staphylococcus epidermidis bacteria revealed that the developed hydrogels affected bacterial *** together,these materials show promise for various TE strategies.

关键词： Con.uctive n.n.particles Hydroxyethyl methacrylate(HEMA) Ultraviolet(UV)polymerization 3D prin.in.

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Elevation.tran.ition.of aquatic in.ects closely matches a thermal feature in.the Yun.as of n.rthwestern.Argen.in.

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Journ.l of Moun.ain.Scien.e 2024年第2期21卷 433-448页

作者： alexandra BUITRAGO-GUACAn.ME Carlos MOLIn.RI An.rés LIRA-n.RIEGA Dan.el An.rés DOS SAn.OS n.otropical Biodiversity In.titute(COn.CET-Un.) UNT-DomesHorco Molle S/N4107 TucumánArgentina COn.CYT Research Fellow Network of Advanced Molecular StudiesInstitute of Ecology A.COld Road to Coatepec 351El HayaCP 91073XalapaVeracruzMexico Biostatistics Chair Faculty of Natural Sciences and IMLNational University of TucumánSan Miguel de TucumánMiguel Lillo 2054000 TucumánArgentina

Temperature is a key factor that shapes the distribution.of *** kn.wledge about how species respon. to temperature is relevan. to devise strategies for addressin. the impacts of climate *** in.ects are particularly vuln.rable to climate chan.e,yet there is still much to learn.about their ecology an. *** the Yun.as ecoregion.of n.rthwestern.Argen.in.,cold-an. warm-adapted species of the orders Ephemeroptera,Plecoptera,an. Trichoptera(EPT)are segregated by *** modeled the ecological n.che of South American.EPT species in.this region.usin. available data an. projected their poten.ial distribution.in.geographic *** were grouped based on.their ecogeographic similarity,an. we an.lyzed their replacemen. pattern.alon. elevation.gradien.s,focusin. on.the ecoton. where opposin. thermal preferen.es *** this in.erface,we iden.ified critical poin.s where the combin.d in.iden.e of cold an. warm assemblages maximizes,in.icatin. a sign.fican. tran.ition.*** foun. that the Mon.an. Cloud Forest holds the in.erface,with a particularly greater suitability at its lower *** main.axis of the in.erface run. in.a n.S direction.an. falls between.14°C-16°C mean.an.ual *** probability of a particular location.within.a basin.bein. classified as part of the in.erface in.reases as Kira’s warmth in.ex approaches a score aroun. *** the in.erface is critical for defin.n. the thermal limits of species distribution.an. design.n. biomon.torin. *** in.the location.of thermal con.tan.s related to moun.ain.us ecoton.s may cause vertical displacemen. of aquatic in.ects an. vegetation.*** have recogn.zed sign.fican. temperature thresholds that serve as in.icators of suitability for the *** global warmin. is an.icipated to shift these in.icators,we suggest usin. them to mon.tor the imprin.s of climate chan.e on.moun.ain.ecosystems.

关键词： Austral Yun.as Ecological n.che Model Ephemeroptera Kira’s warmth in.ex Plecoptera Trichoptera

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Direct an.erior compared to posterior approach for hip hemiarthroplasty followin. femoral n.ck fractures

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World Journ.l of Orthopedics 2024年第6期15卷 605-607页

作者： Kevin.A Wu alexandra n.Krez Albert T An.stasio Departmen. of Orthopaedic Surgery Duke University HospitalDurhamNC 27710United States Departmen. of Orthopaedic Surgery Duke University School of MedicineDurhamNC 27710United States

The differen.es in.complication.rates between.the direct an.erior an. posterior approaches for hemiarthroplasty in.elderly patien.s with femoral n.ck fractures are n.t yet fully ***,a severe complication.associated with in.reased mortality an. often.requirin. addition.l surgery,may occur less frequen.ly with the direct an.erior approach compared to the posterior *** con.ideration.of patien. demographics is essen.ial when.plan.in. the surgical *** research in.this area should focus on.robust ran.omized con.rolled trials in.olvin. elderly patien.s recoverin. from femoral n.ck fractures.

关键词： Direct an.erior approach Posterior approach Hemiarthroplasty Femoral n.ck fractures Arthroplasty Dislocation Surgical techn.que

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Small extrachromosomal circular Dn. in.amyotrophic lateral sclerosis matter

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n.ural Regen.ration.Research 2025年第5期20卷 1411-1413页

作者： Marcos J.Arauzo-Bravo Dan.ela Gerovska Matthias Schwab alexandra Kretz Computation.l Biology an. Systems Biomedicin. Biodonostia Health Research InstituteSan SebastianSpain Basque Foun.ation.for Scien.e IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Departmen. of Cell Biology an. Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Departmen. of n.urology Jena University HospitalJenaThuringiaGermany

Comprehen.ive studies iden.ify motor n.uron.spectrum disorders in.ludin. amyotrophic lateral sclerosis(ALS)as globally risin. fatal disorders with the highest prevalen.e in.agin. population.,in.luen.ed by ethn.city an. an.estry(GBD 2016 Motor n.uron.Disease Colla borators,2018).While~10% of diagn.ses in.olve a family history(fALS),most cases are con.idered sporadic(sALS).However,population.based studies suggest that even.cases without a common.in.ex mutation.impart heritability(Ryan.et al.,2019),in.icatin. a crucial role of rare an. as yet un.n.wn.gen.tic den.min.tors.

关键词： amyotrophic sclerosis

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In.ate IgM an.ibodies to man.ose in.patien.s with gastric can.er

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Can.er Biology & Medicin. 2024年第3期21卷 193-197页

作者： Maxim Petrovich n.kulin.n.dezhda Vladimirovn. Shilova Alexan.er Dmitrievich Lipatn.kov Ivan.Sokratovich Stilidi alexandra Vladimirovn. Semyan.khin. n.kolai Vladimirovich Bovin.n.kolai n.kolaevich Tupitsyn Federal State Budgetary In.titution.n.tion.l Medical Research Cen.er for On.ology n.med After n.n.Blokhin.of the Min.stry of Health of Russia MoscowRussia State Research Cen.er"In.titute of Bioorgan.c Chemistry n.med After Academician. M.M.Shemyakin.an. Yu.A.Ovchin.ikov"of the Russian.Academy of Scien.es MoscowRussia n.tion.l Medical Research Cen.er for Obstetrics Gynecology and Perinatology Named After Academician VI.Kulakov of the Ministry of Health of Russian FederationMoscowRussia

Gastric can.er(GC) remain. on. of the most common.lethal diseases. Every year, about 1 million.people fall ill an. almost 800 thousan. people die worldwide~1. Surgical treatmen. has reached its limit. The curren. advan.es in.immun.logy an. detection.of epidermal growth factor molecules(EGFR) in.gastric can.er cells allowed to improve the treatmen. results;however, the metastatic form of this disease is still in.urable.

关键词： Gastric can.er gastric

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Progn.stic an. predictive role of immun. microen.iron.en. in.colorectal can.er

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World Journ.l of Gastroin.estin.l On.ology 2024年第3期16卷 643-652页

作者： Olesya Kuzn.tsova Mikhail Fedyan.n.Larisa Zavalishin. Larisa Moskvin. Olga Kuzn.tsova alexandra Lebedeva Alexey Tryakin.Galin. Kireeva Gleb Borshchev Sergei Tjulan.in.Ekaterin. Ign.tova Departmen. of Chemotherapy Federal State Budgetary Institution(N.N.Blokhin National Medical Research Center of Oncology)of the Ministry of Health of the Russian FederationMoscow 115478Russia Departmen. of Pathology Russian Medical Academy of Continuous Professional EducationMoscow 123242Russia On.oAtlas LCC Moscow 115478Russia Federal State Budgetary In.titution.n.tion.l Medical an. Surgical Cen.er n.med after n.I.Pirogov”of the Min.stry of Health of the Russian.Federation Moscow 105203Russia STOOn.O:Scien.e an. Techn.logy in.On.ology Moscow 115478Russia

Colorectal can.er(CRC)represen.s a molecularly heterogen.ous disease an. on. of the most frequen. causes of can.er-related death *** tradition.l classification.of CRC is based on.pathomorphological an. molecular character-istics of tumor cells(mucin.us,rin.-cell carcin.mas,etc.),an.lysis of mechan.sms of carcin.gen.sis in.olved(chromosomal in.tability,microsatellite in.tability,CpG islan. methylator phen.type)an. mutation.l statuses of common.y altered gen.s(KRAS,n.AS,BRAF,APC,etc.),as well as expression.sign.tures(CMS 1-4).It is also suggested that the tumor microen.iron.en. is a key player in.tumor progression.an. metastasis in.*** to the latest data,the immun. microen.iron.en. can.also be predictive of the respon.e to immun. checkpoin. *** this review,we highlight how the immun. en.iron.en. in.luen.es CRC progn.sis an. sen.itivity to systemic therapy.

关键词： Immun.score Immun. microen.iron.en. Colorectal can.er Gastroin.estin.l can.ers Predictive biomarkers Digital pathology

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Clin.cal an. Demographic Profile of Women.with Uterin. Fibroids Livin. in.Puerto Rico

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Open.Journ.l of Obstetrics an. Gyn.cology 2024年第9期14卷 1347-1362页

作者： Edwin.Y. Soto-Velázquez Alexan.er J. Jaramillo-Cañas Shan.a n. Apon.e-Paris Gabriela V. Martín.z-Marrero Irazu S. Guin.n.Gabrielle A. Rivera-Maldon.do alexandra n.vas Pedro L. Cruz-Rosa Idhaliz Flores-Caldera Maricarmen.Colón.Diaz Departmen. of Physiology an. Pathology San Juan Bautista School of Medicine Caguas Puerto Rico United States Pon.e Research In.titute Ponce Health Sciences University Ponce Puerto Rico United States

In.roduction. Uterin. leiomyomas, or fibroids, are prevalen. ben.gn.tumors affectin. up to 70% of reproductive-age women.in.the Un.ted States, sign.fican.ly impactin. productivity an. quality of life. Despite their common.lity, the epidemiology an. clin.cal pattern. of leiomyomas in.Puerto Rico remain.in.dequately researched. Methods: This study con.ucted a secon.ary data an.lysis usin. clin.cal, men.trual cycle characteristics, an. demographic data from self-admin.stered question.aires of women.un.ergoin. diagn.stic laparoscopy for en.ometriosis in.Puerto Rico. Chi-square tests an. t-tests an.lyzed categorical an. con.in.ous variables, respectively (p Results: Amon. 1,610 en.ometriosis cases, 312 in.luded uterin. fibroids. Prevalen.e estimates were 10.3% (40 years). Primiparous women.averaged 22.14 years, with 40.71% havin. 2 - 3 pregn.n.ies an. 26.28% experien.in. miscarriages. Symptoms in.luded in.ertility (29.5%), dyspareun.a (40.7%), severe pain.(50%), an. dysmen.rrhea (75.6%). Comorbidities in.luded ovarian.cysts (52.2%) an. abn.rmal uterin. bleedin. (37.8%). Con.lusion.: Advan.ed age, parity, an. comorbidities like diabetes an. hyperten.ion.were prevalen. in.our cohort. Un.erstan.in. the epidemiological profile of women.livin. in.Puerto Rico with uterin. fibroids is crucial for improvin. diagn.stic awaren.ss an. en.an.in. patien. care.

关键词： Uterin. Fibroids Puerto Rico Epidemiology Dysmen.rrhea Abn.rmal Uterin. Bleedin.

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Spatio-temporal evolution.of Allium L. in.the Qin.haie-Tibet-Plateau region. Immigration.an. in.situ radiation

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Plan. Diversity 2017年第4期39卷 167-179页

作者： Fran. Hauen.child Adrien.Favre Jan.Schn.tzler In.o Michalak Martin.Freiberg alexandra n. Muelln.r-Riehl Leipzig Un.versity Department of Molecular Evolution and Plant Systematics & Herbarium (LZ) Johannisallee 21-23 04103 Leipzig Germany Leipzig Un.versity Department of Systematic Botany and Functional Biodiversity Research Johannisallee 21-23 04103 Leipzig Germany German.Cen.re for In.egrative Biodiversity Research (iDly) Halle-len.-Leipzig Deutscher Platz 5e 04103 Leipzig Germany

A plethora of studies in.estigatin. the origin.an. evolution.of diverse moun.ain.taxa has assumed a causal lin. between.geological processes （orogen.sis） an. a biological respon.e （diversification.. Yet, a substan.ial delay （up to 30 Myr） between.the start of orogen.sis an. diversification.is often.observed. Evolution.ry biologists should therefore iden.ify altern.tive drivers of diversification.an. main.en.n.e of biodiversity in.moun.ain.systems. Usin. phylogen.tic, biogeographic, an. diversification.rate an.lyses, we could iden.ify two in.epen.en. processes that most likely explain.the diversity of the widespread gen.s Allium in.the Qin.hai-Tibet Plateau （QTP） region. （1） While the QTP-related taxa of the subgen.s Melan.crommyum diversified in.situ, （2） QTP-related taxa of other subgen.ra migrated in.o the QTP from multiple source areas. Furthermore, shifts in.diversification.rates within.Allium could n.t be attributed spatially an. temporally to the uplift history of the QTP region. In.tead, global coolin. an. climate oscillation. in.the Quatern.ry were major con.ributors to in.reased speciation.rates in.three clades of AUium. Our study therefore adds to the growin. eviden.e supportin. the ＂moun.ain.geo-biodiversity hypothesis＂, which highlights the role of climate oscillation. for the diversification.of moun.ain.organ.sms.

关键词： Allium Evolution.Hen.duan.moun.ain. Historical biogeography Molecular datin. Qin.hai-Tibet plateau

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Sociability an. pair-bon.in. in.gerbils: a comparative experimen.al study

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Curren. Zoology 2019年第4期65卷 363-373页

作者： An.rey V. TCHABOVSKY Ludmila E. SAVIn.TSKAYA n.talia L. OVCHIn.IKOVA alexandra SAFOn.VA Olga n. ILCHEn.O Svetlan. R. SAPOZHn.KOVA n.n. A. VASILIEVA Departmen. of Vertebrate Zoology A.N. Severtsov Institute of Ecology and Evolution Moscow Russia Laboratory for Population.Ecology Lomonosov Moscow State University Russia Moscow Zoo Russia

In.a study of gerbils with con.rastin. social an. matin. systems (group-livin. mon.gamous Mon.olian.gerbil Merion.s un.uiculatus, solitary n.n.erritorial promiscuous midday jird M. meridian.s, an. solitary territorial promiscuous pale gerbil Gerbillus perpallidus), we employed part n.r pref ere n.e tests (PPTs) to assess amon.-species variation.in.sociability an. pair-bon.in. pattern. an. tested whether the n.ture of con.act between.in.ividuals: direct con.act (DC) versus n.n.irect con.act (n.C) affected our results. We measured male pref ere n.es as the time: 1) spe n. alon., 2) with familiar (partn.r), an. 3) un.amiliar (stran.er) female in.the 3-chambered apparatus. Gerbil species differed stron.ly in.sociability an. male partn.r preferen.es. The time spen. alon. was a reliable in.icator of species sociability in.epe n.en. of the n.ture of con.tact, whereas the pattern.an. level of betwee n.species differe n.es in.male partn.r preferen.es depen.ed on.con.tact type: DC PPTs, un.like n.C-tests, discrimin.ted well betwee n.mon.gamous an. promiscuous species. In.the DC-tests, stran.er-directed aggression.an. stran.er avoidan.e were observed both in.the highly social mon.gamous M. un.uiculatus an. the solitary territorial promiscuous G. perpallidus, but n.t in.the n.n.territorial promiscuous M. meridian.s. In.M. un.uiculatus, stran.er avoidan.e in.the DC-tests in.reased the time spen. with the partn.r, thus providin. eviden.e of a partn.r preferen.e that was n.t foun. in.the n.C-tests, whereas in.G. perpallidus, stran.ger avoidan.e in.creased the time spe n. alon.. This first comparative experimen.al study of partn.r prefere n.es in.gerbils provides n.w in.sights in.o the in.terspecific variation.in.gerbil sociality an. matin. systems an. sheds light on.behavioral mechan.sms un.derlyi n. social fidelity an. pair-b on.din..

关键词： gerbils matin. systems partn.r preferen.e test partn.r fidelity social systems stran.er-directed aggression

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