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髋关节保护器降低长期接受护理人群跌倒所致髋部骨折风险的效果(摘译)

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伤害医学（电子版） 2020年第2期9卷 60-63页

作者：陈晓东(译) 杨怿健(审校) 李丽萍(审校) alexandra mb korall Fabio Feldman Yijian Yang Ian D Cameron Pet-Ming Leung Joanie Sims-Gould Stephen N Robinovitch 汕头大学医学院伤害预防研究中心汕头515041 香港中文大学体育运动科学系中国香港999077

跌倒是导致老年人髋部骨折的主要原因,而髋部骨折会增加死亡率及医疗负担。长期接受护理(long-term care,LTC)的老年人发生跌倒及髋部骨折是社区老年人的两倍,因此预防跌倒对接受长期接受护理的老年人来说是一个重大挑战。髋关节保护器... 详细信息

跌倒是导致老年人髋部骨折的主要原因,而髋部骨折会增加死亡率及医疗负担。长期接受护理(long-term care,LTC)的老年人发生跌倒及髋部骨折是社区老年人的两倍,因此预防跌倒对接受长期接受护理的老年人来说是一个重大挑战。髋关节保护器由固定在髋部股骨大转子附近的带软垫或硬穹顶的特殊服饰组成.

关键词：髋部骨折股骨大转子医疗负担预防跌倒社区老年人髋关节保护器护理人群

Epidural oscillating field stimulation increases axonal regenerative capacity and myelination after spinal cord trauma

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Neural Regeneration Research 2022年第12期17卷 2730-2736页

作者： Maria Bacova Katarina Bimbova alexandra Kisucka Nadezda Lukacova Jan Galik Institute of Neurobiology of Biomedical Research Center Slovak Academy of SciencesSoltesovejKosiceSlovak Republic

Oscillating field stimulation(OFS)with regular alterations in the polarity of electric current is a unique,experimental approach to stimulate,support,and potentially guide the outgrowth of both sensory and motor nerve fibers after spinal cord injury(SCI).In previous experiments,we demonstrated the beneficial effects of OFS in a 4-week survival period after *** this study,we observed the major behavioral,morphological,and protein changes in rats after 15 minutes of T9 spinal compression with a 40 g force,followed by long-lasting OFS(50μA),over a 8-week survival *** groups of rats were analyzed:rats after T9 spinal compression(SCI group);SCI rats subjected to implantation of active oscillating field stimulator(OFS+SCI group);and SCI rats subjected to nonfunctional OFS(nOFS+SCI group).Histopathological analysis of spinal tissue indicated a strong impact of epidural OFS on the reduction of tissue and myelin loss after SCI in the segments adjacent to the lesion *** fluorescent analysis of the most affected areas of spinal cord tissue revealed a higher number of spared axons and oligodendrocytes of rats in the OFS+SCI group,compared with rats in the SCI and nOFS+SCI *** protein levels of neurofilaments(NF-l),growth-associated protein-43(marker for newly sprouted axons),and myelin basic protein in rats were signifiantly increased in the OFS+SCI group than in the nOFS+SCI and SCI *** suggests a supporting role of the OFS in axonal and myelin regeneration after ***,rats in the OFS+SCI group showed great improvements in sensory and motor functions than did rats in the nOFS+SCI and SCI *** these findings suggest that long-lasting OFS applied immediately after SCI can provide a good microenviroment for recovery of damaged spinal tissue by triggering regenreative processes in the acute phase of injury.

关键词： axonal regenerative capacity behavioral assessment epidural stimulation motor recovery myelin regeneration oscillating field stimulation spinal cord injury

Targeting hormone-resistant breast cancer cells with docetaxel:a look inside the resistance

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Cancer Drug Resistance 2023年第1期6卷 103-115页

作者： Alexander M.Scherbakov Anna A.Basharina Danila V.Sorokin Ekaterina I.Mikhaevich Iman E.Mizaeva alexandra L.Mikhaylova Tatiana A.Bogush Mikhail A.Krasil’nikov Department of Experimental Tumor Biology Blokhin N.N.National Medical Research Center of OncologyMoscow 115522Russian Federation Group of Molecular Tumor Markers Blokhin N.N.National Medical Research Center of OncologyMoscow 115522Russian Federation

Aim:The study aims to analyze the effect of long-term incubation of ERα-positive MCF7 breast cancer cells with 4-hydroxytamoxifen(HT)on their sensitivity to tubulin polymerization inhibitor ***:The analysis of cell viability was performed by the MTT *** expression of signaling proteins was analyzed by immunoblotting and flow ***αactivity was evaluated by gene reporter *** establish hormone-resistant subline MCF7,breast cancer cells were treated with 4-hydroxytamoxifen for 12 ***:The developed MCF7/HT subline has lost sensitivity to 4-hydroxytamoxifen,and the resistance index was *** Akt activity(2.2-fold)and decreased ERαexpression(1.5-fold)were revealed in MCF7/HT *** activity of the estrogen receptorαwas reduced(1.5-fold)in MCF7/*** of class Ⅲβ-tubulin expression(TUBB3),a marker associated with metastasis,revealed the following trends:higher expression of TUBB3 was detected in triple-negative breast cancer MDA-mb-231 cells compared to hormone-responsive MCF7 cells(Pmb-231,approximately 1:2:4).High TUBB3 expression strongly correlated with docetaxel resistance:IC_(50)value of docetaxel for MDA-mb-231 cells was greater than that for MCF7 cells,whereas resistant MCF7/HT cells were the most sensitive to the *** accumulation of cleaved PARP(a 1.6-fold increase)and Bcl-2 downregulation(1.8-fold)were more pronounced in docetaxel-treated resistant cells(P<0.05).The expression of cyclin D1 decreased(2.8-fold)only in resistant cells after 4 nM docetaxel treatment,while this marker was unchanged in parental MCF7 breast cancer ***:Further development of taxane-based chemotherapy for hormone-resistant cancer looks highly promising,especially for cancers with low TUBB3 expression.

关键词： Cancer docetaxel 4-hydroxytamoxifen classⅢβ-tubulin resistance breast cancer estrogen receptors alpha

A prospective cancer chemo-immunotherapy approach mediated by synergistic CD326 targeted porous silicon nanovectors

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Nano Research 2015年第5期8卷 1505-1521页

作者： Mohammad-Ali Shahbazi Neha Shrestha Ermei Makila Francisca Araujo alexandra Correia Tomas Ramos Bruno Sarmento Jarno Salonen Jouni Hirvonen Helder A. Santos Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University ofHelsinki FI-00014 Helsinki Finland Laboratory of Industrial Physics Departmen t of Physics and Astronomy University of Turku FI-20014 Turku Finland INEB - Instituto de Engenharia Biomedica NewTherapies Group Universidade do Porto Rua do Campo Alegre 823 4150-180 Porto Portuga ICBAS - Instituto Ciencias Biomedicas Abel Salazar University of Porto Rua de Jorge Viterbo Ferreira 4050-313 Porto Portugal Faculty of Pharmacy University of Coimbra 3000-548 Coimbra Portugal IINFACTS - Instituto de Investigacao e Formacao Avancada em Ciencias e Tecnologias da Saude Instituto Superior de Ciencias da Saude-Norte Department of Pharmaceutical Sciences CESPU Rua Central de Gandra 4585-116 Gandra Portugal

经由 nanoparticulate 系统的联合治疗已经为癌症治疗作为一条 synergistic 途径被建议了。此处， undecylenic 酸热地修改了多孔的硅 nanoparticles (UnTHCPSi NP ) 与 sorafenib 装载了的 hydrocarbonized，有 anti-CD326 抗体(Ab ) ... 详细信息

经由 nanoparticulate 系统的联合治疗已经为癌症治疗作为一条 synergistic 途径被建议了。此处， undecylenic 酸热地修改了多孔的硅 nanoparticles (UnTHCPSi NP ) 与 sorafenib 装载了的 hydrocarbonized，有 anti-CD326 抗体(Ab ) 的 surface-biofunctionalized 在 MCF-7 和 MDA-mb-231 乳癌房间为癌症 chemo 免疫疗法被开发。cytocompatibility 学习没在比 200 g 低的集中为赤裸、结合抗体的 UnTHCPSi (Un-Ab ) NP 显示出重要毒性 ? 浩汰楹杮愠搠 ' 糖锚?湩琠敨漠潸桰汩捩瑩 ? 景琠敨猠牵慦散倠 ? 瑡浯吗？

关键词：免疫治疗剂癌症治疗协同方法多孔硅介导化疗乳腺癌细胞纳米粒子

Which treatment protocol, among classical methods and/or various laser applications is the most effective in root canal disinfection, <i>in vitro</i>? A systematic review

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Open Journal of Stomatology 2011年第4期1卷 126-139页

作者： Joanna Theodosopoulou Konstantinos Chochlidakis alexandra Tsigarida 不详

Purpose: The aim of this systematic review was to answer the question “Which treatment protocol, am- ong classical methods and/or various laser applica- tions is the most effective in root canal disinfection, in vitro”. Materials and Methods: A MEDLINE, a Co- chrane and an Embase search (three specified search- es) were conducted to identify randomized controlled trials (RCT) until June 2010, conducted on human teeth and published in English, German or French language, examining the root canal disinfection after the use of lasers with or without mechanical instru-mentation. Additionally, hand search was conducted and contact with authors, when needed. Results: The MEDLINE, the Cochrane and the EmbASE search identified 240, 28, and 35 published articles, respec-tively. Ten articles from the MEDLINE and 5 articles from the Cochrane search (that were also identified in the MEDLINE search) met the inclusion and va-lidity assessment criteria. In E. faecalis elimination, instrumentation of the root canal and diode laser/665 nanometer/1 Watt (diode laser/665 nm/1 W) irradia-tion with the combined effect of Methylene Blue (mb) as photosensitizing agent (logCFU/ml = 1636) seemed to be the best method. In P. aeruginosa and in *** elimination, instrumentation of the root canal followed by irrigation with 5, 25% NaOCl (log-CFU/ml = 0) seemed to be the best method. In gen-eral, instrumentation of the root canal followed by irrigation with 5, 25% NaOCl (logCFU/ml = 0) and instrumentation of the root canal and Er: YAG laser/ 2940 nm/0.8 W irradiation (logCFU/ml = 1924) seemed to be the best (polymicrobial studies). Conclusions: There are treatment protocols with the assistance or not of laser irradiation that can eliminate E. faecalis, E. coli and S. aureus inside the root canal. However, there is a serious number of S. anginosus, F. nuclea-tum, A. naeslundii and P. aeruginosa that remain in-side the root canal even after laser irradiation. New research is needed in order

关键词： Lasers Classical Methods Endodontic Root Canal Therapy Dentin Bacteria Disinfection

Alternative Methods for Preparation of Gluconate Salts Using Heterogeneous Non-Metal Catalysts

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材料科学与工程（中英文B版） 2013年第6期3卷 386-392页

作者： alexandra Costa Catarina Lourenqo Isabel Marrucho Luis C. Branco Departamento de Quimica REQUIMTE Faculdade de Ci~ncias e Tecnologia da Universidade Nova de Lisboa Caparica2829-516 Portugal. Instituto de Tecnologia Quimica e Biol6gica ITQB Universidade Nova de Lisboa Av. da Republica Estacao Agron6micaNacional Oeiras 2780-157 Portugal

Gluconate salts can be prepared using alternative non-metal catalysts based on methylene blue dye salt derivatives. Novel Methylene blue (mb) salts based on trifluoromethanesulfonate (TfO) and docusate (AOT) anions have been prepared and characterized by spectroscopic techniques, nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR) and UV-Visible spectra) in order to proof their chemical structure stability as well as final purity. [mb][TfO] showed a similar behavior of commercial available [mb]Cl as homogenous catalyst for preparation of sodium gluconate. Contrarily, [mb][AOT] as non-toxic, lower melting point and water-immiscible dye salt has been used as efficient and recycled heterogeneous catalyst for preparation of sodium gluconate in shorter reaction time, higher yields and purity grade. This alternative method can be extended to other relevant gluconate salts such as calcium, barium, magnesium, potassium, lithium and several transition metals.

关键词：葡萄糖酸盐催化剂制备非贵金属催化剂葡糖酸非均相催化剂葡萄糖酸钠异构非金属催化剂