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Medicinal properties of Angelica archangelica root extract: cytotoxicity in breast cancer cells and its protective effects against in vivo tumor development

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Journal of Integrative Medicine 2019年第2期17卷 132-140页

作者： carlos R.Oliveira Daniel G.Spindola Daniel M.Garcia Adolfo Erustes Alexandre Bechara caroline Palmeira-dos-Santos Soraya S.Smaili Gustavo J.S.Pereira André hinsberger Ezequiel P.Viriato Maria cristina Marcucci alexandra c.h.f.sawaya Samantha L.Tomaz Elaine G.Rodrigues claudia Bincoletto Departamento de farmacologia Escola Paulista de Medicina (EPM) Universidade Federal de Sao Paulo (UNIFESP) Grupo de fitocomplexos e Sinalizacao celular Escola de Ciências da Saúde Universidade Anhembi Morumbi faculdade de ciências farmacêuticas e Bioquímicas Oswaldo cruz Laboratório de Produtos Naturais e Quimiometria Programa de pós-graduacao em Farmácia e Biotecnologia Universidade Anhanguera de Sao Paulo faculdade de ciências farmacêuticas Universidade Estadual de Campinas (UNICAMP) Unidade de Oncologia Experimental EPM Universidade Federal de Sao Paulo (UNIFESP)

Objective: Although Angelica archangelica is a medicinal and aromatic plant with a long history of use for both medicinal and food purposes, there are no studies regarding the antineoplastic activity of its root.This study aimed to evaluate the cytotoxicity and antitumor effects of the crude extract of A. archangelica root(cEAA) on breast cancer.Methods: The cytotoxicity of cEAA against breast adenocarcinoma cells(4T1 and Mcf-7) was evaluated by a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-h-tetrazolium bromide(MTT) assay. Morphological and biochemical changes were detected by hoechst 33342/propidium iodide(PI) and annexin V/PI staining. cytosolic calcium mobilization was evaluated in cells staining with fURA-4 NW. Immunoblotting was used to determine the effect of cEAA on anti-and pro-apoptotic proteins(Bcl-2 and Bax, respectively).The 4 T1 cell-challenged mice were used for in vivo assay.Results: Using ultra-high-performance liquid chromatography–mass spectrometry analysis, angelicin, a constituent of the roots and leaves of A. archangelica, was found to be the major constituent of the cEAA evaluated in this study(73 mg/mL). The cEAA was cytotoxic for both breast cancer cell lines studied but not for human fibroblasts. Treatment of 4 T1 cells with the cEAA increased Bax protein levels accompanied by decreased Bcl-2 expression, in the presence of cleaved caspase-3 and cytosolic calcium mobilization, suggesting mitochondrial involvement in breast cancer cell death induced by the cEAA in this cell line. No changes on the Bcl-2/Bax ratio were observed in cEAA-treated Mcf7 cells. Gavage administration of the cEAA(500 mg/kg) to 4T1 cell-challenged mice significantly decreased tumor growth when compared with untreated animals.conclusion: Altogether, our data show the antitumor potential of the cEAA against breast cancer cells in vitro and in vivo. further research is necessary to better elucidate the pharmacological application of the cEAA in breast cancer therapy.

关键词： Angelica archangelica Umbelliferae Apoptosis cell death Breast cancer Angelicin

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Only Attract Ants?The Versatility of Petiolar Extrafloral Nectaries in Passiflora

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American Journal of Plant Sciences 2013年第2期4卷 460-469页

作者： Poliana cardoso-Gustavson Nathalia L.Andreazza alexandra c.h.f.sawaya Marilia de Moraes castro Pós-Graduacao em Biologia Vegetal Instituto de BiologiaUniversidade Estadual de CampinasCampinasBrazil Núcleo de Pesquisa em Anatomia Vegetal Instituto de BotanicaSao PauloBrazil Departamento de Biologia Vegetal Instituto de BiologiaUniversidade Estadual de CampinasCampinasBrazil

Passiflora species presents a coevolutive relationship with heliconiini butterflies, their primary herbivores. The heliconiini caterpillars are able to detoxify toxic compounds produced by Passiflora, thus morphological defense strategies stand out over chemical innovations. In this framework, we highlight the presence of mimetic structures and extrafloral nectaries (EfN) as morphological strategies. heliconian butterflies oviposit only on leaves that do not possess previous eggs, so the presence of egg mimics could prevent the oviposition. EfN are glands that offer nectar to territorial and aggressive ants, establishing mutualistic relationships. here, we present a structural and chemical analysis of petiolar EfN and nectar from Passiflora alata and P. edulis in order to have insights about the implications of these features in deterring heliconian caterpillars. P. alata have one to four stipitate-crateriform EfN while P. edulis possess a pair of convex glands. Butterflies lay their eggs isolatedly or in up to three on leaves of both species. Our morphological results suggest that EfN from P. alata may act as egg mimics. Ontogenetic data suggest that the variation in the number of glands observed in this species is a serial homology, wherein the selection pressure for this variation is possibly the oviposition pattern. P. alata retain alkaloids, flavonoids and terpenoids inside nectariferous cells;sugars and flavonoids are found in the nectar of both species, while alkaloids are also detected in P. edulis. There is a selective retention/release of secondary metabolites from the EfN tissues to nectar. Knowing that these compounds can be dissuasive to some herbivores and inoffensive to others, we plotted this relationship in a consumer growth versus secondary metabolite concentration diagram. Our results suggest a more active role in the modulation of the gland defense from plants besides the establishment of a mutualistic relationship with ants, an important response in a coevolutive scenario.

关键词： Passiflora alata curtis Passiflora edulis Sims Egg Mimics Anatomy Secondary Metabolites

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Macroalgal deep genomics illuminate multiple paths to aquatic,photosynthetic multicellularity

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Molecular Plant 2024年第5期17卷 747-771页

作者： David R.Nelson alexandra Mystikou Ashish Jaiswal cecilia Rad-Menendez Michael J.Preston frederik De Boever Diana c.El Assal Sarah Daakour Michael W.Lomas Jean-claude Twizere David h.Green William c.Ratcliff Kourosh Salehi-Ashtiani Division of Science and Math New York University Abu DhabiAbu DhabiUAE center for Genomics and Systems Biology(cGSB) New York University Abu DhabiAbu DhabiUAE Biotechnology Research center Technology Innovation InstitutePO Box 9639Masdar CityAbu DhabiUAE culture collection of Algae and Protozoa Scottish Association for Marine ScienceObanScotlandUK National center for Marine Algae and Microbiota Bigelow Laboratory for Ocean SciencesEast BoothbayMEUSA Laboratory of Viral Interactomes GIGA InstituteUniversity of LiegeLiegeBelgium School of Biological Sciences Georgia Institute of TechnologyAtlantaGAUSA

Macroalgae are multicellular,aquatic autotrophs that play vital roles in global climate maintenance and have diverse applications in biotechnology and eco-engineering,which are directly linked to their multicellularity phenotypes.however,their genomic diversity and the evolutionary mechanisms underlying multicellularity in these organisms remain uncharacterized.In this study,we sequenced 110 macroalgal genomes from diverse climates and phyla,and identified key genomic features that distinguish them from their microalgal relatives.Genes for cell adhesion,extracellular matrix formation,cell polarity,transport,and cell differentiation distinguish macroalgae from microalgae across all three major phyla,constituting conserved and unique gene sets supporting multicellular processes.Adhesome genes show phylum-and climate-specific expansions that may facilitate niche adaptation.collectively,our study reveals genetic determinants of convergent and divergent evolutionary trajectories that have shaped morphological diversity in macroalgae and provides genome-wide frameworks to understand photosynthetic multicellular evolution in aquatic environments.

关键词： macroalgae multicellularity comparative genomics evolution adhesome endogenous viral elements

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Elevation transition of aquatic insects closely matches a thermal feature in the Yungas of Northwestern Argentina

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Journal of Mountain Science 2024年第2期21卷 433-448页

作者： alexandra BUITRAGO-GUAcANAME carlos MOLINERI Andrés LIRA-NORIEGA Daniel Andrés DOS SANTOS Neotropical Biodiversity Institute(cONIcET-UNT) UNT-DomesHorco Molle S/N4107 TucumánArgentina cONAcYT Research fellow Network of Advanced Molecular StudiesInstitute of Ecology A.COld Road to Coatepec 351El HayaCP 91073XalapaVeracruzMexico Biostatistics chair Faculty of Natural Sciences and IMLNational University of TucumánSan Miguel de TucumánMiguel Lillo 2054000 TucumánArgentina

Temperature is a key factor that shapes the distribution of organisms.having knowledge about how species respond to temperature is relevant to devise strategies for addressing the impacts of climate change.Aquatic insects are particularly vulnerable to climate change,yet there is still much to learn about their ecology and distribution.In the Yungas ecoregion of Northwestern Argentina,cold-and warm-adapted species of the orders Ephemeroptera,Plecoptera,and Trichoptera(EPT)are segregated by elevation.We modeled the ecological niche of South American EPT species in this region using available data and projected their potential distribution in geographic space.Species were grouped based on their ecogeographic similarity,and we analyzed their replacement pattern along elevation gradients,focusing on the ecotone where opposing thermal preferences converge.Along this interface,we identified critical points where the combined incidence of cold and warm assemblages maximizes,indicating a significant transition zone.We found that the Montane cloud forest holds the interface,with a particularly greater suitability at its lower boundary.The main axis of the interface runs in a N-S direction and falls between 14°c-16°c mean annual isotherms.The probability of a particular location within a basin being classified as part of the interface increases as Kira’s warmth index approaches a score around 150.Understanding the interface is critical for defining the thermal limits of species distribution and designing biomonitoring programs.changes in the location of thermal constants related to mountainous ecotones may cause vertical displacement of aquatic insects and vegetation communities.We have recognized significant temperature thresholds that serve as indicators of suitability for the interface.As global warming is anticipated to shift these indicators,we suggest using them to monitor the imprints of climate change on mountain ecosystems.

关键词： Austral Yungas Ecological Niche Model Ephemeroptera Kira’s warmth index Plecoptera Trichoptera

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Rational molecular design of efficient yellow-red dendrimer TADf for solution-processed OLEDs: a combined effect of substitution position and strength of the donors

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Science china chemistry 2024年第5期67卷 1613-1623页

作者： changfeng Si Dianming Sun Tomas Matulaitis David B.cordes alexandra M.Z.Slawin Eli Zysman-colman Organic Semiconductor centre EaStCHEM School of ChemistryUniversity of St AndrewsSt AndrewsKY169STUK

The development of high-performance solution-processed red organic light-emitting diodes(OLEDs) remains a challenge,particularly in terms of maintaining efficiency at high luminance. here, we designed and synthesized four novel orange-red thermally activated delayed fluorescence(TADf) dendrimers that are solution-processable: 2Gcz BP, 2DPAcz BP, 2fBP2Gcz and 2fBP2DPAcz. We systematically investigated the effect of substitution position and strength of donors on the optoelectronic properties. The reverse intersystem crossing rate constant(kRISc) of the emitters having donors substituted at positions 11and 12 of the dibenzo[a,c]phenazine(BP) is more than 10-times faster than that of compounds substituted having donors substituted at positions 3 and 6. compound 2DPAcz BP, containing stronger donors than 2Gcz BP, exhibits a red-shifted emission and smaller singlet-triplet energy splitting, ΔE_(ST), of 0.01 e V. The solution-processed OLED with 10 wt% 2DPAcz BP doped in m cP emitted at 640 nm and showed a maximum external quantum efficiency(EQE_(max)) of 7.8%, which was effectively maintained out to a luminance of 1,000 cd m-2. Such a device's performance at relevant display luminance is among the highest for solution-processed red TADf OLEDs. The efficiency of the devices was improved significantly by using 4cz IPN as an assistant dopant in a hyperfluorescence(hf) configuration, where the 2DPAcz BP hf device shows an EQEmaxof 20.0% at λEL of 605 nm and remains high at 11.8% at a luminance of 1,000 cd m-2, which makes this device one of the highest efficiency orange-to-red hf SP-OLEDs to date.

关键词： thermally activated delayed fluorescence solution-processing red OLEDs dibenzo[a,c]phenazine dendrimers

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c.elegans model of riboflavin transporter deficiency(RTD)disorder reveals deficits in synaptic transmission and movement

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Genes & Diseases 2024年第4期11卷 120-123页

作者： Ramesh K.Narayanan Gonzalo Perez-siles Kamila A.Marzec alexandra Boyling Brent Neumann Manoj P.Menezes Marina L.Kennerson Northcott Neuroscience Laboratory ANZAC Research Institute-Sydney Local Health DistrictSydneyNSW 2139Australia Sydney Medical School University of SydneySydneyNSw 2050Australia ANZAc Research Institute-Sydney Local health District SydneyNSW 2139Australia Neuroscience Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVictoria 3800Australia TY Nelson Department of Neurology and Neurosurgery and Kids Neuroscience Children's Hospital at WestmeadWestmeadSydneyNSW2145Australia Paediatrics and child health The University of SydneySydneySydneyNSW 2145Australia Molecular Medicine Laboratory Concord General Repatriation HospitalSydneyNSW 2139Australia

Riboflavin transporter deficiency(RTD),previously known as Brown-Vialetto-Van Laere syndrome,is a childhoodonset neurodegenerative disorder characterized by sensory and motor neuron degeneration causing ataxia,muscle weakness,optic atrophy,and respiratory failure.Mutations in SLc52A2 and SLc52A3,solute carrier family members that encode riboflavin(Rf)transporters RfVT2 and RfVT3,are known to cause RTD types 2 and 3,respectively.

关键词： RTD degeneration TD

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Effects of Grape Processing on Antioxidant capacity and ESI-MS fingerprints of Grape Products

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食品科学与工程：英文版（美国） 2013年第7期3卷 341-348页

作者： Solange M. cottica Damila R. de Morais1 Eliza M. Rotta Sheisa c. Sargi flamys L. N. Silva alexandra c.h. f. sawaya Marcos N. Eberlin Jesui V. Visentainer Department of chemistry State University of Maring6 Maring6 87020-900 Brazil ThoMSon Mass Spectrometry Laboratory Institute of Chemistry University of Campinas Campinas 13083-970 Brazil Plant Biology Department Institute of Biology University of Campinas Campinas 13083-970 Brazil

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Oxidative stress in retinal pigment epithelium degeneration:from pathogenesis to therapeutic targets in dry age-related macular degeneration

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Neural Regeneration Research 2023年第10期18卷 2173-2181页

作者： Meenakshi Maurya Kiran Bora alexandra K.Blomfield Madeline c.Pavlovich Shuo huang chi-hsiu Liu Jing chen Department of Ophthalmology Boston Children’s HospitalHarvard Medical SchoolBostonMAUSA

Age-related macular degeneration is a primary cause of blindness in the older adult population. Past decades of research in the pathophysiology of the disease have resulted in breakthroughs in the form of anti-vascular endothelial growth factor therapies against neovascular age-related macular degeneration;however, effective treatment is not yet available for geographical atrophy in dry agerelated macular degeneration or for preventing the progression from early or mid to the late stage of age-related macular degeneration. Both clinical and experimental investigations involving human agerelated macular degeneration retinas and animal models point towards the atrophic alterations in retinal pigment epithelium as a key feature in age-related macular degeneration progression. Retinal pigment epithelium cells are primarily responsible for cellular-structural maintenance and nutrition supply to keep photoreceptors healthy and functional. The retinal pigment epithelium constantly endures a highly oxidative environment that is balanced with a cascade of antioxidant enzyme systems regulated by nuclear factor erythroid-2-related factor 2 as a main redox sensing transcription factor. Aging and accumulated oxidative stress triggers retinal pigment epithelium dysfunction and eventually death. Exposure to both environmental and genetic factors aggravates oxidative stress damage in aging retinal pigment epithelium and accelerates retinal pigment epithelium degeneration in age-related macular degeneration pathophysiology. The present review summarizes the role of oxidative stress in retinal pigment epithelium degeneration, with potential impacts from both genetic and environmental factors in age-related macular degeneration development and progression. Potential strategies to counter retinal pigment epithelium damage and protect the retinal pigment epithelium through enhancing its antioxidant capacity are also discussed, focusing on existing antioxidant nutritional supplementation, and exploring nuclear factor erythroid-2-relat

关键词： age-related macular degeneration antioxidant nuclear factor erythroid-2-related factor 2 oxidative stress retinal pigment epithelium REV-ERBα

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calculating densities and viscosities of natural gas with a high content of c_(2+) to predict two-phase liquid-gas flow pattern

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Petroleum 2023年第4期9卷 579-591页

作者： Yekaterina Moisseyeva alexandra Saitova Sergey Strokin Peter the Great St.Petersburg Polytechnic University Russian Federation

The paper is devoted to the two-phase flow simulation.The gas-condensate mixture flow in a horizontal pipe under high pressure is considered.The influence of the equation of state(EOS)choice for mixture properties modelling on the flow regime calculation results is studied for gas with high content of methane homologues.An analytical overview of the methods to predict the flow pattern is provided.Based on this analysis,two techniques are selected.for these techniques,values of density and viscosity for each phase are required.Density calculation for the gas phase is performed with Van der Waals based EOS.The propriate EOS is selected based on studies of calculation errors for test mixtures.calculation of liquid phase density is done by means of Patela-Teja and Guo-Du equations,two different models are considered for viscosity estimation.The flow patterns of gas-condensate mixture in a range of temperatures and pressures are calculated and verified via probability map.The results of study allow to recommend the Brusilovsky EOS for calculation of densities for similar gas mixtures and make more rigorous flow regime evaluation.The probability map shows that for the chosen composition and parameters of media the flow pattern is mostly transitional between segregated and annular independent from EOS.

关键词： Two-phase flow flow pattern Natural gas Wet gas high content of c_(2+) high pressure

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Plasticity of callosal neurons in the contralesional cortex following traumatic brain injury

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Neural Regeneration Research 2023年第6期18卷 1257-1258页

作者： alexandra chovsepian Laura Empl florence M.Bareyre Institute of clinical Neuroimmunology Biomedical Building and Clinic of the Ludwig-Maximilians Universität MünchenMunichGermany

Traumatic brain injury(TBI) represents a significant cause of disability worldwide.It creates a vast array of damaging macro-and microscopic changes in the affected brain area(s),ranging from neuronal cell death,changes in structural spine integrity and dynamics to axonal injury and ove rall neuronal circuit disruption,ultimately leading to functional and cognitive deficits in both humans and animal models(N udo,2013).

关键词： injury traumatic cortex

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