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Successful lifestyle modifications may underlie umbilical cordmesenchymal stromal cell effects in type 2 diabetes mellitus

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World Journal of Diabetes 2023年第3期14卷 347-351页

作者： alexandra Papadopoulou Konstantinos I Papadopoulos Occupational and Environmental Health Services Feelgood LundLund 22363SkåneSweden Department of Research and Development THAI StemLife Co.Ltd.Bangkok 10310BangkokThailand

Type 2 diabetes mellitus(T2DM)is a lifelong condition and a grave threat to human *** efforts to relieve its detrimental effects are acutely *** sine qua non in T2DM management is consistent adherence to a prudent lifestyle and nutrition,combined with aerobic and resistance exercise regimens,together repeatedly shown to lead to complete reversal and even longterm ***-adherence to the above lifestyle adjustments condemns any treatment effort and ultimately the patient to a grim *** is thus imperative that every study evaluating the effects of innovative interventions in T2DM objectively compares the novel treatment modality to lifestyle modifications,preferably through double-blind controlled randomization,before claiming efficacy.

关键词： Type 1 diabetes mellitus Type 2 diabetes mellitus Human umbilical cord mesenchymal stem cells Diabetes remission Diabetes reversal Lifestyle modifications

Effects of spatial variation in cohesion over the concrete-rock interface on dam sliding stability

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Journal of Rock Mechanics and Geotechnical Engineering 2015年第6期7卷 659-667页

作者： alexandra Krounis Fredrik Johansson Stefan Larsson Division of Soil and Rock Mechanics KTH Royal Institute of Technology

The limit equilibrium method （LEM） is widely used for sliding stability evaluation of concrete gravitydams. Failure is then commonly assumed to occur along the entire sliding surface ***, the brittle behaviour of bonded concrete-rock contacts, in combination with the varying stressover the interface, implies that the failure of bonded dam-foundation interfaces occurs progressively. Inaddition, the spatial variation in cohesion may introduce weak spots where failure can be ***, the combined effect of brittle failure and spatial variation in cohesion on the overall shearstrength of the interface has not been studied previously. In this paper, numerical analyses are used toinvestigate the effect of brittle failure in combination with spatial variation in cohesion that is taken intoaccount by random fields with different correlation lengths. The study concludes that a possible existenceof weak spots along the interface has to be considered since it significantly reduces the overallshear strength of the interface, and implications for doing so are discussed.

关键词： Concrete gravity dam Sliding stability Cohesion Brittle failure Spatial variation

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JIC总部设计

现代装饰 2024年第3期 78-85页

作者： Tomas Kozelsky(设计) Viktor Odstrcilik(设计) alexandra Georgescu(设计) Katerina Batkova(设计) Tana Kantor(设计) Marketa Fiserova(设计) Josef Rehak(设计) Natalie Hradilikova(设计) BoysPlayNice(摄影) 舒禹(编译) 不详

捷克建筑工作室KOGAA与南摩拉维亚创新中心(JIC)共同完成了其位于布尔诺的第二个改造项目,JIC作为支持该地区企业的重要开放创新生态系统,为学生、初创企业、规模化企业和老牌企业提供空间和支持服务。疫情期间和之后,工作模式发生变化... 详细信息

捷克建筑工作室KOGAA与南摩拉维亚创新中心(JIC)共同完成了其位于布尔诺的第二个改造项目,JIC作为支持该地区企业的重要开放创新生态系统,为学生、初创企业、规模化企业和老牌企业提供空间和支持服务。疫情期间和之后,工作模式发生变化,更趋向开放和协作。因此,原先的固定结构布局已过时,作为另类改造工作空间的专家,KOGAA被要求为办公室提出一个新的愿景,以促进协作,激活创造力,为新的公司结构寻找可持续的解决方案。

关键词：创新生态系统初创企业改造项目摩拉维亚布尔诺建筑工作室结构布局可持续的

Cytoskeletal changes in diseases of the nervous system

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Frontiers in Biology 2014年第1期9卷 5-17页

作者： alexandra K. SUCHOWERSKA Thomas FATH Neurodegeneration and Repair Unit School of Medical Sciences University of New South Wales Randwick New South Wales 2052Australia

The neuronal cytoskeleton not only provides the structural backbone of neurons, but also plays a fundamental role in maintaining neuronal functions. Dysregulation of neuronal architecture is evident in both injury and diseases of the central nervous system. These changes often result in the disruption of protein trafficking, loss of synapses and the death of neurons, ultimately impacting on signal transmission and manifesting in the disease phenotype. Furthermore, mutations in cytoskeletal proteins have been implicated in numerous diseases and, in some cases, identified as the cause of the disease, highlighting the critical role of the cytoskeleton in disease pathology. This review focuses on the role of cytoskeletal proteins in the pathology of mental disorders, neurodegenerative diseases and motor function deficits. In particular, we illustrate how cytoskeletal proteins can be directly linked to disease pathology and progression.

关键词： cytoskeleton actin microtubules intermediate filaments nervous system disease

Validation of Pore-Scale Simulations of Hydrodynamic Dispersion in Random Sphere Packings

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Communications in Computational Physics 2013年第3期13卷 801-822页

作者： Siarhei Khirevich alexandra Holtzel Ulrich Tallarek Department of Chemistry Philipps-Universitat MarburgHans-Meerwein-Strasse35032 MarburgGermany

We employ the lattice Boltzmann method and random walk particle tracking to simulate the time evolution of hydrodynamic dispersion in bulk,random,monodisperse,hard-sphere packings with bed porosities(interparticle void volume fractions)between the random-close and the random-loose packing *** JodreyTory and Monte Carlo-based algorithms and a systematic variation of the packing protocols we generate a portfolio of packings,whose microstructures differ in their degree of heterogeneity(DoH).Because the DoH quantifies the heterogeneity of the void space distribution in a packing,the asymptotic longitudinal dispersion coefficient calculated for the packings increases with the packings’*** investigate the influence of packing length(up to 150 d_(p),where d_(p) is the sphere diameter)and grid resolution(up to 90 nodes per d_(p))on the simulated hydrodynamic dispersion coefficient,and demonstrate that the chosen packing dimensions of 10 d_(p)×10 d_(p)×70 d_(p) and the employed grid resolution of 60 nodes per d_(p) are sufficient to observe asymptotic behavior of the dispersion coefficient and to minimize finite size *** values of the dispersion coefficients calculated for the generated packings are compared with simulated as well as experimental data from the literature and yield good to excellent agreement.

关键词： Packing microstructure degree of heterogeneity packing algorithm hydrodynamic dispersion random sphere packings

Limited tree richness effects on herb layer composition,richness and productivity in experimental forest stands

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Journal of Plant Ecology 2017年第1期10卷 190-200页

作者： Markus S.Germany Helge Bruelheide alexandra Erfmeier Institute for Ecosystem Research GeobotanyKiel UniversityOlshausenstr.7524118 KielGermany Institute of Biology/Geobotany and Botanical Garden Martin Luther University Halle-WittenbergAm Kirchtor 106120 HalleGermany German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-Leipzig Deutscher Platz 5e04103 LeipzigGermany

Aims In forests,the herbaceous understory vegetation plays an important role for ecosystem functioning as it represents a significant component of total aboveground *** addition,the herb layer contributes to overall forest species richness and controls tree species *** versa,trees in the overstory control understory herb and shrub growth through competition for *** an experimental forest plantation with manipulated tree richness,we asked to which degree tree species richness and identity affect herb layer composition,richness and productivity and how these relationships across strata change with abiotic environmental conditions and competition *** In the context of the Biodiversity-Ecosystem Functioning project in subtropical China(BEF-China),we made use of the integrated BEFmod experiment arranged along a tree species richness gradient at two sites,with additional subplot treatments of phosphorus addition,herb layer weeding and no *** recorded the understory vegetation and determined herb layer biomass production on a total of 201 *** Findings We found only minor effects of tree layer richness on herb layer species composition and no significant effect on herb layer richness or productivity ***,there were strong tree layer identity effects on all response variables,which were partly explained by differences in leaf area index and by a high share of woody species both in total herb layer species richness and *** were strong treatment effects,which were largest in the‘no weeding’treatment but we did not find any treatment×tree layer richness interaction in herb layer ***,these effects are mainly explained by increased competition intensity within the herb layer in the absence of *** the young age of the experiment,the interactions between tree species identity,tree richness and the herb layer did already emerge and can be expected to become stronger with

关键词： experimental research platform of BEF-China functional biodiversity research forest understory biomass Jiangxi Province

Modeling Size-number Distributions of Seeds for Use in Soil Bank Studies

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Journal of Integrative Plant Biology 2008年第5期50卷 531-535页

作者： Hugo Casco alexandra Soveral Dias Luís Silva Dias Chemical Ecology Unit Centre of Ecology and EnvironmentUniversidade de vora7002-554 vora Portugal

Knowledge of soil seed banks is essential to understand the dynamics of plant populations and communities and would greatly benefit from the integration of existing knowledge on ecological correlations of seed size and shape. The present study aims to establish a feasible and meaningful method to describe size-number distributions of seeds in multi-species situations. For that purpose, size-number distributions of seeds with known length, width and thickness were determined by sequential sieving. The most appropriate combination of sieves and seeds dimensions was established, and the adequacy of the power function and the Weibull model to describe size-number distributions of spherical, non-spherical, and all seeds was investigated. We found that the geometric mean of seed length, width and thickness was the most adequate size estimator, providing shape-independent measures of seeds volume directly related to sieves mesh side, and that both the power function and the Weibull model provide high quality descriptions of size-number distributions of spherical, non-spherical, and all seeds. We also found that, in spite of its slightly lower accuracy, the power function is, at this stage, a more trustworthy model to characterize size-number distributions of seeds in soil banks because in some Weibull equations the estimates of the scale parameter were not acceptable.

关键词： accuracy power function seeds shape seeds size size-number distributions Weibull model.

Mental health of the Slovak population during COVID-19 pandemic:A cross-sectional survey

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World Journal of Clinical Cases 2022年第25期10卷 8880-8892页

作者： Maria Kralova alexandra Brazinova Veronika Sivcova Lubomira Izakova Department of Psychiatry Faculty of Medicine Comenius University and University Hospital BratislavaBratislava 81369Slovakia Institute of Epidemiology Faculty of Medicine Comenius University BratislavaBratislava 81372Slovakia

BACKGROUND Population’s mental health surveillance is essential for knowing the distribution of mental well-being and mental disorders in the *** allows for the establishment,evaluation,and revision of preventive measures and curative *** results of such monitoring should serve as a database for evidencebased mental health *** disorders are among the top ten causes of burden globally and crisis situations such as the pandemic increase the risk of mental health problems,as they cause constant fear of contagion and the implementation of restrictive *** impact of the coronavirus disease 2019(COVID-19)pandemic on the general population of the Slovak Republic has not yet been *** hypothesis was that more than one fifth of the population(women to a greater extent)will have symptoms of anxiety and *** To assess the mental health of the general Slovak population aged 15 years and older in the summer of 2021 by determining the prevalence of depressive and anxiety *** An anonymous cross-sectional survey was implemented in a sample of 1501 respondents in the summer of 2021 during the COVID-19 *** inclusion criteria were age of 15 years and older and ability to complete the survey questionnaire online or in a face-to-face *** survey assessed anxiety symptoms by the seven-item general anxiety disorder and depressive symptoms by the nine-item patient health questionnaire *** cut-off scores of 10 or greater were used for *** Anxiety symptoms were present in 19.32%and depression in 24.65%of the *** of both disorders were more common in females:15.00%of males and 24.00%of females experienced anxiety symptoms,and 19.00%of males and 30.00%of females experienced symptoms of *** of both disorders were the most common in the youngest age group(15-25 years old):One fifth of males(20.29%)and one third of females(35.32%)had symptoms of anxiety,and 2

关键词： Mental health COVID-19 pandemic Anxiety Depression Slovak Republic

Moving of a submarine under an ice cover in fluid of finite depth

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Journal of Hydrodynamics 2019年第3期31卷 562-569页

作者： alexandra V. Pogorelova Vitali L. Zemlyak Victor M. Kozin Sholom-A leichem Priamursky State University Birobidzhan Russia Institute of Machining and Metallurgy FEB RAS Komsomolsk-na-Amure Russia

The influence of a basin depth on ice cover deflections, when a submarine moves under it in fluid, is experimentally and theoretically analyzed. For a theoretical research the ice cover is modelled by an elastic floating plate, and the submarine is modelled by a source-sink system in a fluid flow. The problem is solved by means of asymptotic analysis and integral transformations. The experimental study is conducted with submarine models in the pool with the sizes L*B*H= 10m*3m*lm . The ice cover for experiments is modelled in two ways. The first way is the thin ice plate received by freezing of the surface layer of water at low temperatures. In the second case the rubber sheet floating on a reservoir surface is used. The special velocity (the velocity at which maximum values of the wave height are reached) is analyzed. It is obtained that the decrease of the basin depth leads to decrease of the special speed. For small speeds (less than the special speed) there is the fact that the basin depth decrease leads to the increase of the height of the flexural-gravity wave.

关键词： Ice cover submarine flexural gravity wave source-sink system