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Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma

Cancer Biology & Medicine 2021年第3期18卷 910-930页

作者： Evgeniya v.Dolgova Oleg M.Andrushkevich Polina E.Kisaretova Anastasia S.Proskurina Genrikh S.Ritter Tatyana D.Dubatolova Margarita v.Romanenko Oleg S.Taranov Yaroslav R.Efremov Evgeniy L.Zavyalov alexandr v.romaschenko Sergey v.Mishinov Svetlana S.Kirikovich Evgeniy v.Levites Ekaterina A.Potter alexandr A.Ostanin Elena R.Chernykh Stanislav Yu.Roshchin Anatoliy v.Bervitskiy Galina I.Moysak Jamil A.Rzaev Sergey S.Bogachev Institute of Cytology and Genetics SB RAS Novosibirsk 630090Russia A.I.Evdokimov Moscow State University of Medicine and Dentistry Moscow 127473Russia Institute of Molecular and Cellular Biology Novosibirsk 630090Russia Novosibirsk State University Novosibirsk 630090Russia The State Research Center of virology and Biotechnology"vector" KoltsovoNovosibirsk 630559Russia First Department of Neurosurgery Ya.L.Tsivian Novosibirsk Research Institute of Traumatology and OrthopaedicsNovosibirsk 630091Russia Institute of Fundamental and Clinical immunology Novosibirsk 630099Russia Sklifosovsky Research Institute of Emergency Medicine Moscow 129010Russia Federal Center of Neurosurgery Novosibirsk 630048Russia

Objective:Glioma is a highly invasive tumor,frequently disposed in essential areas of the brain,which makes its surgical excision extremely difficult;meanwhile adjuvant therapy remains quite ***:In the current report,a new therapeutic approach in curing malignant neoplasms has been performed on the U87 human glioblastoma *** approach,termed"Karanahan",is aimed at the eradication of cancer stem cells(CSCs),which were recently shown to be capable of internalizing fragments of extracellular double-stranded *** being internalized,these fragments interfere in the process of repairing interstrand cross-links caused by exposure to appropriate cytostatics,and such an interference results either in elimination of CSCs or in the loss of their tumorigenic *** of the approach requires a scheduled administration of cytostatic and complex composite double-stranded DNA ***:U87 cells treated in vitro in accordance with the Karanahan approach completely lost their tumorigenicity and produced no grafts upon intracerebral transplantation into immunodeficient *** SCID mice with developed subcutaneous grafts,the treatment resulted in reliable slowing down of tumor growth rate(Pveloped graft and subsequent therapeutic treatment,the Karanahan approach was shown to reliably slow down the tumor growth rate and increase the median survival of the mice twofold relative to the ***:The effectiveness of the Karanahan approach has been demonstrated both in vitro and in vivo in treating developed subcutaneous grafts as well as orthotopic grafts after surgical excision of the tumor.

关键词： Glioblastoma U87 cell line mytomycin C cancer stem cells TAMRA

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A system-integrated approach for the design of tourist areas at the local level under changing conditions:A case study in the Altay Mountains

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Regional Sustainability 2024年第2期5卷 89-102页

作者： alexandr Nikolaevich DUNETS Evgeniya Mikhailovna TABAKAEvA HAN Fang Department of Scientific and Innovative Development Altai State UniversityBarnaul656049Russia Department of Recreational Geography ServiceTourism and HospitalityInstitute of GeographyAltai State UniversityBarnaul656049Russia State Key Laboratory of Desert and Oasis Ecology Key Laboratory of Ecological Safety and Sustainable Development in Arid LandsXinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi830011China

The existing approaches for the design of tourist areas often lead to limited flexibility in project *** realize a more flexible approach,in this study,we formulated a model for planning and designing tourist areas at the local ***,specific tools for analyzing tourist areas and ensuring sustainable development under changing conditions were *** study was conducted in two tourist regions,Biryuzovaya Katun tourist complex and Belokurikha destination(including Belokurikha City with Belokurikha 2 Gornaya tourist complex and surrounding areas),in the Altay *** employed the recreation opportunity spectrum and proposed a system-integrated programming approach for the design of tourist areas at the destination and site *** key of this approach was the collection and analysis of current spatial data,including the spatial distribution of attractions and visitor *** constructed heat maps using video recording and unmanned aerial vehicle(UAv)observation ***,we analyzed the video stream using an image-analyzing framework You Only Look Once(YOLO)v5 *** heat map of visitor flows based on video recording data in the Andreevskaya Sloboda museum of Belokurikha 2 Gornaya tourist complex allowed us to highlight the most attractive sites in this area and classify them into one of three types:points of functional concentration,points of transitional concentration,and points of *** heat maps in Biryuzovaya Katun tourist complex,created using UAv observation data,allowed us to determine the spatiotemporal patterns of visitor flows and tourists’preferences throughout the day within four time intervals:09:00-12:00,13:00-14:00,14:00-15:00,and 16:00-18:00(LST).The maximum visitor flow density occurred from 16:00 to 18:00 in the beach area of the artificial lake.A comparison between the visitor-concentrated sites and the current facilities provided insights into the demand for attractions and facilities and

关键词： Tourism planning Tourist areas Unmanned aerial vehicle(UAv) visitor flows Heat map Altay Mountains

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Cladophora mats in a Crimean hypersaline lake:structure,dynamics,and inhabiting animals

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Journal of Oceanology and Limnology 2018年第6期36卷 1930-1940页

作者： alexandr v.PRAZUKIN Elena v.ANUFRIIEvA Nickolai v.SHADRIN The A.O.Kovalevsky Institute of Marine Biological Research of RAS 2 Nakhimov Av.Sevastopol 299011Russia

Filamentous green algae play an important functional role in element cycling and productivity in the diff erent water bodies. In hypersaline lakes and lagoons of the Crimea, filamentous green algae are present and form bottom and floating mats that occupy large areas with high biomass, up to 4–5 kg(wet biomass)/m2. Cladophora spp. dominated in those mats. Five species of filamentous green algae(Chlorophyta) in Lake Chersonesskoye: C ladophora vadorum(Aresch.) Kütz., C. siwaschensis C. Meyer, C. echinus(Biasol.) Kütz., Ulothrix implexa(Kütz.) Kütz., Rhizoclonium tortuosum(Dillw.) Kütz., and seagrass(Angiospermae) R uppia cirrhosa(Petagna) Grande were found. Cladophora spp. and R. cirrhosa were found in the lake throughout the year, other types of algae were encountered episodically. In most cases the biomass of bottom mat exceeded that of the floating mat. In general, the total biomass of the bottom and floating mats in the lake areas at depths up to 30 cm was in a stable range of values from 100 to 290 mg(dry weight)/cm2. Animal and infusorian average abundance in mats reach high values: infusorians—up to 15 000 000 ind./m2, Cletocamptus retrogressus(Copepoda, Harpacticoida)—up to 730 000 ind./m2, Eucypris mareotica(Ostracoda)—up to 91 000 ind./m2 and Chironomidae larvae(Insecta, Diptera)—up to 140 ind./m2. Those values were much higher than in the plankton.

关键词： green algae mats hypersaline lake photosynthesis invertebrates

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Autoimmunity in acute ischemic stroke and the role of bloodbrain barrier: the dark side or the light one?

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Frontiers of Medicine 2019年第4期13卷 420-426页

作者： Nikolay v. Tsygan alexandr P. Trashkov Igor v. Litvinenko viktoriya A. Yakovleva alexandr v. Ryabtsev Andrey G. vasiliev Leonid P. Churilov Department of Molecular and Radiation Biophysics B.P. Konstantinov Petersburg Nuclear Physics Institute Gatchina Leningrad Region 188300 Russian Federation Department of Nervous Diseases S.M. Kirov Military Medical Academy Saint Petersburg 194044 Russian Federation Department of Experimental Pharmacology I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry Saint Petersburg 194223 Russian Federation Department of Pathological Physiology with the Course of Immunopathology Saint Petersburg State Pediatric Medical University Saint Petersburg Russian Federation Department of Pathology Laboratory of the Mosaic of Autoimmunity Saint Petersburg State University Saint Petersburg 199034 Russian Federation

This article presents a synopsis of the current data on the mechanisms of blood-brain barrier (BBB) alteration and autoimmune response in acute ischemic stroke. Most researchers confirm the relationship between the severity of immunobiochemical changes and clinical outcome of acute ischemic stroke. Ischemic stroke is accompanied by aseptic inflammation, which alters the brain tissue and exposes the co-stimulatory molecules of the immune system and the neuronal antigens. To date, BBB is not considered the border between the immune system and central nervous system, and the local immune subsystems are found within and behind the BBB. BBB disruption contributes to the leakage of brain autoantigens and induction of secondary autoimmune response to neuronal antigens and long-term inflammation. Glymphatic system function is altered and jeopardized both in hemorrhagic and ischemic stroke types. The receptors of innate immunity (toll-like receptor-2 and toll-like receptor-4) are also involved in acute ischemia-reperfusion injury. Immune response is related to the key processes of blood clotting and fibrinolysis. At the same time, the stroke-induced immune activation may promote reparation phenomena in the brain. Subsequent research on the reduction of the acute ischemic brain injury through the target regulation of the immune response is promising.

关键词： stroke blood-brain barrier autoimmunity innate immunity inflammation cell death

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Practical obstacles and their mitigation strategies in compressional optical coherence elastography of biological tissues

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 51-63页

作者： vladimir Y.Zaitsev alexandr L.Matveyev Lev A.Matveev Ekaterina v.Gubarkova alexandr A.Sovetsky Marina A.Sirotkina Grigory v.Gelikonov Elena v.Zagaynova Natalia D.Gladkova Alex vitkin Institute of Applied Physics Russian Academy of Sciences Ulyanova Street 46 Nizhny Novgorod 603950 Russia Nizhny Novgorod State Medical Academy 10/1 Minina Square Nizhny Novgorod 603005 Russia University of Toronto and University Health Network 610 University Avenue Toronto ON M5G 2M9Canada

In this paper,we point out some practical obstacles arising in realization of compressional optical coherence elastography(OCE)that have not attracted sufficient attention ***-cally,we discuss(i)complications in quantification of the Young modulus of tissues related to partial adhesion between the OCE probe and soft intervening reference layer sensor,(i)distorting influence of tisue suface curvature/corrugation on the subsurface strain distri-bution mapping,(ii)ways of signal-to-noise mtio(SNR)enhancement in OCE strain mapping when periodic averaging is not realized,and(iv)potentially significant infuence of tissue elastic nonlinearity on quantification of its *** pnactical approaches to mitigate the effects of these complications are also described.

关键词： Optical coherence elastography optical coherence tomography phase-resolved methods strain mapping stiffness characterization

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Composition of the Diamond Indicator Minerals on the Mitchell Chart――Criteria of CLIPPIR Diamonds in Kimberlites and Conditions of their Mantle Crystallization

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Acta Geologica Sinica(English Edition) 2021年第S1期95卷 121-124页

作者： vladimir N.ZINCHENKO alexandr S.IvANOv Igor v.ASHCHEPKOv CATOCA Mining Society СatocaAngola ALROSA Ltd. MirnyRussia v.S.Sobolev Institute of Geology and Mineralogy SB RAS NovosibirskRussia

In the last decade,researchers have been particularly interested in IIa CLIPPIR type diamonds,which differ in composition and physical characteristics from diamonds of peridotite related"P"and eclogite related"E"***(Moore,2009)sought them as mantle kimberlite related megacrysts,but light C isotopy and chemical features needs special explanation.

关键词： CLIPPIR diamonds kimberlite mantle pyrope clinopiroxene chromite ilmenite

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Mantle Transects in Africa According to Data of Mantle Xenocrysts and Diamond Inclusions

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Acta Geologica Sinica(English Edition) 2021年第S1期95卷 15-17页

作者： Igor v.ASHCHEPKOv vladimir N.ZINCHENKO alexandr S.IvANOv v.S.Sobolev Institute of Geology and Mineralogy SB RAS Novosibirsk 630090Russia CATOCA Mining Society СatocaMoscow 127473Russia ALROSA Ltd. Mirny 678174Russia

We designed the mantle transects using the PTXFO2 diagrams(Ashchepkov et al.,2010,2013,2017)constructed(Figs.1 a–c)for mantle columns beneath kimberlite and sections of the lithospheric mantle(SCLM)under the Kaapvaal... 详细信息

关键词： mantle lithosphere craton transect monomineral thermobarometry oxygen fugacity peridotite eclogite garnet clinopyroxene

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Torque teno virus in liver diseases: On the way towards unity of view

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World Journal of Gastroenterology 2020年第15期26卷 1691-1707页

作者： vasiliy I Reshetnyak Igor v Maev alexandr I Burmistrov Igor A Chekmazov Tatiana I Karlovich Department of Propaedeutic of Internal Diseases and Gastroenterology A.I.Yevdokimov Moscow State University of Medicine and DentistryMoscow 127473Russia Central Clinical Hospital with Polyclinic Presidential Administration of the Russian FederationMoscow 121359Russia

The review presents the data accumulated for more than 20 years of research of torque teno virus(TTv).Its molecular genetic structure,immunobiology,epidemiology,diagnostic methods,possible replication sites,and pathogenicity factors are *** is a virus that is frequently detectable in patients with different viral hepatitides,in cases of hepatitis without an obvious viral agent,as well as in a healthy *** is evidence suggesting that biochemical and histological changes occur in liver tissue and bile duct epithelium in TTv *** are sufficient histological signs of liver damage,which confirm that the virus can undergo a replicative cycle in *** with this,cytological hybridization in TTv-infected cells has shown no substantial cytopathic(cell-damaging)effects that are characteristic of pathogenic hepatotropic *** TTv has led to the evolution of views on its role in the development of human *** first ideas about the hepatotropism of the virus were gradually reformed as new data became available on the prevalence of the virus and its co-infection with other viruses,including the viruses of the known types of *** high prevalence of TTv in the human population indicates its persistence in the body as a virome and a nonpathogenic *** has recently been proposed that the level of TTv DNA in the blood of patients undergoing organ transplantation should be used as an endogenous marker of the body’s immune *** available data show the polytropism of the virus and deny the fact that TTv can be assigned exclusively to hepatitis ***,the rare detection of the damaging effect of TTv on hepatic and bile duct epithelial cells may be indirect evidence of its conditionally pathogenic *** ubiquity of the virus and the variability of its existence in humans cannot put an end to its study.

关键词： Torque teno virus Prevalence of torque teno virus Torque teno virus in liver disease virome and torque teno virus Torque teno virus and human immune status

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Cherenkov radiation from electrons passing through human tissue

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Journal of Innovative Optical Health Sciences 2017年第1期10卷 94-98页

作者： Pavel Lukin Izmail Batkin alexandr N.Almaliev Tatyana A.Churakova Mikhail A.Dolgopolov Igor v.Kopytin Department of Physics Voronezh State University 1 Universitetskaya Sq.Voronezh 394000Russia School of Electrical Engineering and Computer Science University of Ottawa 800 King Edward A venue OttawaON CanadaK1N 6N5

A method for investigating the optical properties of human tissues is *** method is based on the measurement of Cherenkov radiation produced by relativistic electrons passing through the ***-Carlo simulation of visible photon emission and propagation is carried out taking into account multiple electron and photon scattering *** of the Cherenkov radiation to the optical characteristics of human tissues is demonstrated.

关键词： Coherent radiation human tissue optics multiple scattering.

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Investigating the light stability of solid-solution-based AgCl-AgBr and AgBr-T1I crystals

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Chinese Optics Letters 2016年第2期14卷 16-18页

作者： alexandr S.Korsakov alexandr E.Lvov Dmitry S.vrublevsky Liya v.Zhukova Department of Physical Chemistry and Chemistry of Colloids Ural Federal University Named After the First President of Russia B.N.Yeltsin

For the development of mid-infrared fiber-optical elements, one needs tight-stable, flexible materials that are transparent within this spectral band. Solid solutions of silver and monadic thallium halides prove to be the most suitable crystalline media for these needs. We study the light stability variation of high-purity AgCl1-xBrx （0 ≤ x ≤ 1） and Ag1-xTlxBr1-xIx （0 ≤ x ≤ 0.05） crystals by measuring the optical transmission change as func- tions of the composition and Uv exposure time. The former is executed in a broad spectral range from 6500 - 350 cm^-1, within which we choose three wavelengths to trace the transmission change. For thallimn- monoiodide-containing samples, an effect is observed that we assumed to be translucence.

关键词： AgBr AgCl

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