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The Journal of Biomedical Research 2023年第4期37卷 255-267页

作者： Leonid N.Maslov Natalia v.Naryzhnaya Maria Sirotina alexandr v.mukhomedzyanov Boris K.Kurbatov Alla A.Boshchenko Huijie Ma Yi Zhang Feng Fu Jianming Pei viacheslav N.Azev vladimir A.Pereverzev Cardiology Research Institute Tomsk National Research Medical Centerthe Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Physiology Hebei Medical UniversityShijiazhuangHebei 050017China Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China The Branch of the Institute of Bioorganic Chemistry Russian Academy of SciencesPushchinoMoscow Oblast 142290Russia Department of Normal Physiology Belarusian State Medical UniversityMinsk 220083Belarus

The role of reactive oxygen species(ROS)in ischemic and reperfusion(I/R)injury of the heart has been discussed for more than 40 *** has been demonstrated that reperfusion triggers a multiple increase in free radical generation in the isolated *** were found to have the ability to mitigate I/R injury of the ***,it is unclear whether their cardioprotective effect truly depends on the decrease of ROS levels in myocardial *** high doses and high concentrations of antioxidants were experimentally used,it is highly likely that the cardioprotective effect of antioxidants depends on their interaction not only with free radicals but also with other *** has been demonstrated that the antioxidant N-2-mercaptopropionyl glycine or NDPH oxidase knockout abolished the cardioprotective effect of ischemic ***,there is evidence that ROS protect the heart against the I/R injury.

关键词： reactive oxygen species free radicals antioxidants heart reperfusion patients

A historical literature review of coronary microvascular obstruction and intra-myocardial hemorrhage as functional/structural phenomena

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The Journal of Biomedical Research 2023年第4期37卷 268-289页

作者： Leonid N.Maslov Natalia v.Naryzhnaya Sergey v.Popov alexandr v.mukhomedzyanov Ivan A.Derkachev Boris K.Kurbatov Andrey v.Krylatov Feng Fu Jianming Pei vyacheslav v.Ryabov Evgenii v.vyshlov Svetlana v.Gusakova Alla A.Boshchenko Akpay Sarybaev Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China Siberian State Medical University TomskTomsk Region 634050Russia National Center of Cardiology and Internal Medicine Bishkek 720040Kyrgyzstan.

The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon,also known as microvascular obstruction(MvO).However,studies performed in the isolated perfused hearts subjected to ischemia/reperfusion(I/R)do not suggest the involvement of microembolization and microthrombi in this *** intracoronary administration of alteplase has been found to have no effect on the occurrence of MvO in patients with acute myocardial ***,the major events preceding the appearance of MvO in coronary arteries are independent of microthrombi,platelets,and *** cells appear to be the target where ischemia can disrupt the endothelium-dependent vasodilation of coronary ***,reperfusion triggers more pronounced damage,possibly mediated by *** and intra-myocardial hemorrhage contribute to the adverse post-infarction myocardial ***,pharmacological agents used to treat MvO should prevent endothelial injury and induce relaxation of smooth *** conditioning protocols have been shown to prevent MvO,with L-type Ca2+channel blockers appearing the most effective in treating MvO.

关键词： heart ischemia reperfusion microvascular obstruction intra-myocardial hemorrhage

Cladophora mats in a Crimean hypersaline lake:structure,dynamics,and inhabiting animals

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Journal of Oceanology and Limnology 2018年第6期36卷 1930-1940页

作者： alexandr v.PRAZUKIN Elena v.ANUFRIIEvA Nickolai v.SHADRIN The A.O.Kovalevsky Institute of Marine Biological Research of RAS 2 Nakhimov Av.Sevastopol 299011Russia

Filamentous green algae play an important functional role in element cycling and productivity in the diff erent water bodies. In hypersaline lakes and lagoons of the Crimea, filamentous green algae are present and form bottom and floating mats that occupy large areas with high biomass, up to 4–5 kg(wet biomass)/m2. Cladophora spp. dominated in those mats. Five species of filamentous green algae(Chlorophyta) in Lake Chersonesskoye: C ladophora vadorum(Aresch.) Kütz., C. siwaschensis C. Meyer, C. echinus(Biasol.) Kütz., Ulothrix implexa(Kütz.) Kütz., Rhizoclonium tortuosum(Dillw.) Kütz., and seagrass(Angiospermae) R uppia cirrhosa(Petagna) Grande were found. Cladophora spp. and R. cirrhosa were found in the lake throughout the year, other types of algae were encountered episodically. In most cases the biomass of bottom mat exceeded that of the floating mat. In general, the total biomass of the bottom and floating mats in the lake areas at depths up to 30 cm was in a stable range of values from 100 to 290 mg(dry weight)/cm2. Animal and infusorian average abundance in mats reach high values: infusorians—up to 15 000 000 ind./m2, Cletocamptus retrogressus(Copepoda, Harpacticoida)—up to 730 000 ind./m2, Eucypris mareotica(Ostracoda)—up to 91 000 ind./m2 and Chironomidae larvae(Insecta, Diptera)—up to 140 ind./m2. Those values were much higher than in the plankton.

关键词： green algae mats hypersaline lake photosynthesis invertebrates

Autoimmunity in acute ischemic stroke and the role of bloodbrain barrier: the dark side or the light one?

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Frontiers of Medicine 2019年第4期13卷 420-426页

作者： Nikolay v. Tsygan alexandr P. Trashkov Igor v. Litvinenko viktoriya A. Yakovleva alexandr v. Ryabtsev Andrey G. vasiliev Leonid P. Churilov Department of Molecular and Radiation Biophysics B.P. Konstantinov Petersburg Nuclear Physics Institute Gatchina Leningrad Region 188300 Russian Federation Department of Nervous Diseases S.M. Kirov Military Medical Academy Saint Petersburg 194044 Russian Federation Department of Experimental Pharmacology I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry Saint Petersburg 194223 Russian Federation Department of Pathological Physiology with the Course of Immunopathology Saint Petersburg State Pediatric Medical University Saint Petersburg Russian Federation Department of Pathology Laboratory of the Mosaic of Autoimmunity Saint Petersburg State University Saint Petersburg 199034 Russian Federation

This article presents a synopsis of the current data on the mechanisms of blood-brain barrier (BBB) alteration and autoimmune response in acute ischemic stroke. Most researchers confirm the relationship between the severity of immunobiochemical changes and clinical outcome of acute ischemic stroke. Ischemic stroke is accompanied by aseptic inflammation, which alters the brain tissue and exposes the co-stimulatory molecules of the immune system and the neuronal antigens. To date, BBB is not considered the border between the immune system and central nervous system, and the local immune subsystems are found within and behind the BBB. BBB disruption contributes to the leakage of brain autoantigens and induction of secondary autoimmune response to neuronal antigens and long-term inflammation. Glymphatic system function is altered and jeopardized both in hemorrhagic and ischemic stroke types. The receptors of innate immunity (toll-like receptor-2 and toll-like receptor-4) are also involved in acute ischemia-reperfusion injury. Immune response is related to the key processes of blood clotting and fibrinolysis. At the same time, the stroke-induced immune activation may promote reparation phenomena in the brain. Subsequent research on the reduction of the acute ischemic brain injury through the target regulation of the immune response is promising.

关键词： stroke blood-brain barrier autoimmunity innate immunity inflammation cell death

Practical obstacles and their mitigation strategies in compressional optical coherence elastography of biological tissues

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 51-63页

作者： vladimir Y.Zaitsev alexandr L.Matveyev Lev A.Matveev Ekaterina v.Gubarkova alexandr A.Sovetsky Marina A.Sirotkina Grigory v.Gelikonov Elena v.Zagaynova Natalia D.Gladkova Alex vitkin Institute of Applied Physics Russian Academy of Sciences Ulyanova Street 46 Nizhny Novgorod 603950 Russia Nizhny Novgorod State Medical Academy 10/1 Minina Square Nizhny Novgorod 603005 Russia University of Toronto and University Health Network 610 University Avenue Toronto ON M5G 2M9Canada

In this paper,we point out some practical obstacles arising in realization of compressional optical coherence elastography(OCE)that have not attracted sufficient attention ***-cally,we discuss(i)complications in quantification of the Young modulus of tissues related to partial adhesion between the OCE probe and soft intervening reference layer sensor,(i)distorting influence of tisue suface curvature/corrugation on the subsurface strain distri-bution mapping,(ii)ways of signal-to-noise mtio(SNR)enhancement in OCE strain mapping when periodic averaging is not realized,and(iv)potentially significant infuence of tissue elastic nonlinearity on quantification of its *** pnactical approaches to mitigate the effects of these complications are also described.

关键词： Optical coherence elastography optical coherence tomography phase-resolved methods strain mapping stiffness characterization

Composition of the Diamond Indicator Minerals on the Mitchell Chart――Criteria of CLIPPIR Diamonds in Kimberlites and Conditions of their Mantle Crystallization

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Acta Geologica Sinica(English Edition) 2021年第S1期95卷 121-124页

作者： vladimir N.ZINCHENKO alexandr S.IvANOv Igor v.ASHCHEPKOv CATOCA Mining Society СatocaAngola ALROSA Ltd. MirnyRussia v.S.Sobolev Institute of Geology and Mineralogy SB RAS NovosibirskRussia

In the last decade,researchers have been particularly interested in IIa CLIPPIR type diamonds,which differ in composition and physical characteristics from diamonds of peridotite related"P"and eclogite related"E"***(Moore,2009)sought them as mantle kimberlite related megacrysts,but light C isotopy and chemical features needs special explanation.

关键词： CLIPPIR diamonds kimberlite mantle pyrope clinopiroxene chromite ilmenite

Mantle Transects in Africa According to Data of Mantle Xenocrysts and Diamond Inclusions

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Acta Geologica Sinica(English Edition) 2021年第S1期95卷 15-17页

作者： Igor v.ASHCHEPKOv vladimir N.ZINCHENKO alexandr S.IvANOv v.S.Sobolev Institute of Geology and Mineralogy SB RAS Novosibirsk 630090Russia CATOCA Mining Society СatocaMoscow 127473Russia ALROSA Ltd. Mirny 678174Russia

We designed the mantle transects using the PTXFO2 diagrams(Ashchepkov et al.,2010,2013,2017)constructed(Figs.1 a–c)for mantle columns beneath kimberlite and sections of the lithospheric mantle(SCLM)under the Kaapvaal... 详细信息

关键词： mantle lithosphere craton transect monomineral thermobarometry oxygen fugacity peridotite eclogite garnet clinopyroxene

Torque teno virus in liver diseases: On the way towards unity of view

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World Journal of Gastroenterology 2020年第15期26卷 1691-1707页

作者： vasiliy I Reshetnyak Igor v Maev alexandr I Burmistrov Igor A Chekmazov Tatiana I Karlovich Department of Propaedeutic of Internal Diseases and Gastroenterology A.I.Yevdokimov Moscow State University of Medicine and DentistryMoscow 127473Russia Central Clinical Hospital with Polyclinic Presidential Administration of the Russian FederationMoscow 121359Russia

The review presents the data accumulated for more than 20 years of research of torque teno virus(TTv).Its molecular genetic structure,immunobiology,epidemiology,diagnostic methods,possible replication sites,and pathogenicity factors are *** is a virus that is frequently detectable in patients with different viral hepatitides,in cases of hepatitis without an obvious viral agent,as well as in a healthy *** is evidence suggesting that biochemical and histological changes occur in liver tissue and bile duct epithelium in TTv *** are sufficient histological signs of liver damage,which confirm that the virus can undergo a replicative cycle in *** with this,cytological hybridization in TTv-infected cells has shown no substantial cytopathic(cell-damaging)effects that are characteristic of pathogenic hepatotropic *** TTv has led to the evolution of views on its role in the development of human *** first ideas about the hepatotropism of the virus were gradually reformed as new data became available on the prevalence of the virus and its co-infection with other viruses,including the viruses of the known types of *** high prevalence of TTv in the human population indicates its persistence in the body as a virome and a nonpathogenic *** has recently been proposed that the level of TTv DNA in the blood of patients undergoing organ transplantation should be used as an endogenous marker of the body’s immune *** available data show the polytropism of the virus and deny the fact that TTv can be assigned exclusively to hepatitis ***,the rare detection of the damaging effect of TTv on hepatic and bile duct epithelial cells may be indirect evidence of its conditionally pathogenic *** ubiquity of the virus and the variability of its existence in humans cannot put an end to its study.

关键词： Torque teno virus Prevalence of torque teno virus Torque teno virus in liver disease virome and torque teno virus Torque teno virus and human immune status

Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment

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World Journal of Diabetes 2018年第1期9卷 1-24页

作者： victoria A Serhiyenko alexandr A Serhiyenko Department of Endocrinology Lviv National Medical University Named by Danylo Halitsky

Cardiac autonomic neuropathy(CAN)is a serious complication of diabetes mellitus(DM)that is strongly associated with approximately five-fold increased risk of cardiovascular *** manifests in a spectrum of things,ranging from resting tachycardia and fixed heart rate(HR)to development of"silent"myocardial *** correlates or risk markers for CAN are age,DM duration,glycemic control,hypertension,and dyslipidemia(DLP),development of other microvascular *** risk factors for CAN are poor glycemic control in type 1 DM and a combination of hypertension,DLP,obesity,and unsatisfactory glycemic control in type *** manifestations of CAN include sinus tachycardia,exercise intolerance,orthostatic hypotension(OH),abnormal blood pressure(BP)regulation,dizziness,presyncope and syncope,intraoperative cardiovascular instability,asymptomatic myocardial ischemia and *** of CAN assessment in clinical practice include assessment of symptoms and signs,cardiovascular reflex tests based on HR and BP,short-term electrocardiography(ECG),QT interval prolongation,HR variability(24 h,classic24 h Holter ECG),ambulatory BP monitoring,HR turbulence,baroreflex sensitivity,muscle sympathetic nerve activity,catecholamine assessment and cardiovascular sympathetic tests,heart sympathetic *** it is common complication,the significance of CAN has not been fully appreciated and there are no unified treatment algorithms for *** is based on early diagnosis,life style changes,optimization of glycemic control and management of cardiovascular risk *** treatment of CAN includes:Balanced diet and physical activity;optimization of glycemic control;treatment of DLP;antioxidants,first of allα-lipoic acid(ALA),aldose reductase inhibitors,acetylL-carnitine;vitamins,first of all fat-soluble vitamin B1;correction of vascular endothelial dysfunction;prevention and treatment of thrombosis;in severe cases-treatm

关键词： Diabetes mellitus Risk factors Cardiac autonomic neuropathy Screening for cardiac autonomic neuropathy Cardiovascular reflex tests Orthostatic hypotension Heart rate variability Prophylaxis Treatment

Cherenkov radiation from electrons passing through human tissue

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Journal of Innovative Optical Health Sciences 2017年第1期10卷 94-98页

作者： Pavel Lukin Izmail Batkin alexandr N.Almaliev Tatyana A.Churakova Mikhail A.Dolgopolov Igor v.Kopytin Department of Physics Voronezh State University 1 Universitetskaya Sq.Voronezh 394000Russia School of Electrical Engineering and Computer Science University of Ottawa 800 King Edward A venue OttawaON CanadaK1N 6N5

A method for investigating the optical properties of human tissues is *** method is based on the measurement of Cherenkov radiation produced by relativistic electrons passing through the ***-Carlo simulation of visible photon emission and propagation is carried out taking into account multiple electron and photon scattering *** of the Cherenkov radiation to the optical characteristics of human tissues is demonstrated.

关键词： Coherent radiation human tissue optics multiple scattering.