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作者： L.G.alexander R.h.Kingsbury

Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry

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Protein & Cell 2010年第7期1卷 664-674页

作者： Kristelle S.Brown Michael J.Keogh Ania M.Owsianka Richard Adair Arvind h.Patel James N.Arnold Jonathan K.Ball Robert B.Sim alexander W.Tarr Timothy P.hickling Institute of Infection Immunity and InflammationSchool of Molecular Medical SciencesThe University of NottinghamQueen’s Medical CentreNottinghamNG72UHUK The Medical Research Council-University of Glasgow Centre for Virus Research University of GlasgowChurch StreetGlasgowG115JRUK MRC Immunochemistry Unit Department of BiochemistryUniversity of OxfordOX13QUUK Present address:Vitrology Biotech 5 South AvenueClydebank Business ParkGlasgowG812LGUK Present address:Pfizer Technologies Ltd. Ramsgate RoadSandwichKentCT139NJUK

Mannan-binding lectin(MBL)is a soluble innate immune protein that binds to glycosylated *** acts as an opsonin and activates complement,contributing to the destruction and clearance of infecting *** C virus(hCV)encodes two envelope glycoproteins E1 and E2,expressed as non-covalent E1/E2 heterodimers in the viral envelope.E1 and E2 are potential ligands for *** we describe an analysis of the interaction between hCV and MBL using recombinant soluble E2 ectodomain fragment,the full-length E1/E2 heterodimer,expressed in vitro,and assess the effect of this interaction on virus entry.A binding assay using antibody capture of full length E1/E2 heterodimers was used to demonstrate calcium dependent,saturating binding of MBL to hCV *** with various saccharides further confirmed that the interaction was via the lectin domain of *** binds to E1/E2 representing a broad range of virus *** was shown to neutralize the entry into huh-7 cells of hCV pseudoparticles(hCVpp)bearing E1/E2 from a wide range of *** were neutralized to varying *** was also shown to neutralize an authentic cell culture infectious virus,strain JFh-1(hCVcc).Furthermore,binding of MBL to E1/E2 was able to activate the complement system via MBL-associated serine protease *** conclusion,MBL interacts directly with hCV glycoproteins,which are present on the surface of the virion,resulting in neutralization of hCV particles.

关键词： hepatitis C virus neutralization mannose binding lectin chronic viral infection

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作者： L.G.alexander R.h.Kingsbury

The effect of downstream resistance on flow diverter treatment of a cerebral aneurysm at a bifurcation: A joint computational-experimental study

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Journal of hydrodynamics 2018年第5期30卷 803-814页

作者： ANDerson C.O.Tsang Billy Y.S.Yiu Abraham Y.S.Tang W.C.Chung Gilberto K.K.Leung alexander K.K.Poon Alfred C.h.Yu Simon S.M.Lai K.W.Chow Department of Surgery Li Ka Shing Faculty of Medicine University of Hong Kong Department of Electrical and Computer Engineering University of Waterloo Department of Mechanical Engineering University of Hong Kong Department of Electrical and Electronic Engineering University of Hong Kong

Intracranial aneurysm can lead to hemorrhagic stroke upon rupture. Deployment of flow diverters can restrict the blood flow into aneurysm and mitigate the rupture risk. Computational fluid dynamics（CFD） and ultrasonography with pulse-wave and color Doppler ultrasound measurements were employed jointly to investigate the complex flow pattern in cerebral aneurysms, both before and after the deployment of flow diverters. Patient-specific configurations of both bifurcation and side-wall aneurysms were selected. The effect of downstream flow resistance was investigated by adjusting the volume flow rate and pressure at the outlet vessels computationally and experimentally. Velocity profiles in the aneurysm measured from ultrasonography showed good agreement with those from computer simulations. The discrepancy in velocity between the computational and experimental sets of data is less than 10%. The downstream resistance can alter the volume flux into a bifurcation aneurysm with a flow diverter deployed by 236%, while the corresponding value of a side-wall aneurysm is negligible. The vorticity of the aneurysmal flow was reduced by more than 80% in both cases after stenting. This study demonstrated that careful investigation of downstream flow resistance of a bifurcation aneurysm is essential to provide an accurate assessment of the aneurysmal flow dynamics after flow diverter deployment.

关键词： Intracranial aneurysms computational fluid dynamics (CFD) doppler ultrasound

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作者： L.G.alexander R.h.Kingsbury

Ex vivo limb perfusion for traumatic amputation in military medicine

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Military Medical Research 2020年第4期7卷 489-496页

作者： alexander Kaltenborn Nicco Krezdorn Sebastian hoffmann AndréGutcke Kirsten haastert-Talini Peter M.Vogt Axel haverich Bettina Wiegmann Department of Trauma and Orthopedic Surgery PlasticHand and Reconstructive SurgeryArmed Forces Hospital WesterstedeWesterstedeGermany Department of Plastic AestheticHand and Reconstructive SurgeryHannover Medical SchoolHannoverGermany Institute of Neuroanatomy and Cell Biology Hannover Medical SchoolHannover and Center for Systems Neuroscience(ZSN)WesterstedeGermany Department of Cardiothoracic Transplantation and Vascular SurgeryHannover Medical SchoolHannoverGermany

Background:Limb loss has a drastic impact on a patient’s *** trauma to the extremities is common in current military *** other aspects,"life before limb"damage control surgery hinders immediate replantation within the short post-traumatic timeframe,which is limited in part by the ischemic time for successful *** vivo limb perfusion is currently being researched in animal models and shows promising results for its application in human limb replantation and *** of the hypothesis:The current lack of replantation possibilities in military operations with high rates of amputation can be addressed with the development of a portable ex vivo limb perfusion device,as there are several opportunities present with the introduction of this technique on the *** hypothesize that ex vivo limb perfusion will enable overcoming the critical ischemic time,provide surgical opportunities such as preparation of the stump and limb,allow for spare-part surgery,enable rigorous antibiotic treatment of the limb,reduce ischemiareperfusion injuries,enable a tissue function assessment before replantation,and enable the development of large limb transplant *** the hypothesis:Data from in vivo studies in porcine models are limited by the relatively short perfusion time of 24 *** the military setting,notably longer perfusion times need to be ***,future animal studies must focus especially on long-term perfusion,since this represents the military setting,considering the time for stabilization of the patient until evacuation to a tertiary treatment *** of the hypothesis:The development and clinical introduction of ex vivo limb perfusion in the military setting could lead to a drastic reduction in the number of limb amputations among service *** vivo limb perfusion enables replantation surgery in Role 4 facilities and changes the clinical setting from a highly urgent,lifethreatening s

关键词： Ex vivo limb perfusion traumatic amputation ischemia and reperfusion-related injuries hypothesis

Prostate magnetic resonance imaging at 3 Tesla:Is administration of hyoscine-N-butyl-bromide mandatory?

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World Journal of Radiology 2013年第7期5卷 259-263页

作者： Matthias C Roethke Timur h Kuru alexander Radbruch Boris hadaschik heinz-Peter Schlemmer Department of Radiology German Cancer Research Center Heidelberg (DKFZ) 69120 Heidelberg Germany Department of Urology Universityhospital Heidelberg 69120 Heidelberg Germany

AIM: To evaluate the value of administration of hyoscine-N-butyl-bromide (hBB) for image quality magnetic resonance imaging (MRI) of the prostate. METhODS: Seventy patients were retrospectively included in the study. Thirty-five patients were examined with administration of 40 milligrams of hBB (Buscopan ; Boehringer, Ingelheim, Germany); 35 patients were examined without hBB. A multiparametric MRI protocol was performed on a 3.0 Tesla scanner without using an endorectal coil. The following criteria were evaluated independently by two experienced radiologists on a five-point Likert scale: anatomical details (delineation between peripheral and transitional zone of the prostate, visualisation of the capsule, depiction of the neurovascular bundles); visualisation of lymph nodes; motion related artefacts; and overall image ***: Comparison of anatomical details between the two cohorts showed no statistically significant difference (3.9 ± 0.7 vs 4.0 ± 0.9, P = 0.54, and 3.8 ± 0.7 vs 4.2 ± 0.6, P = 0.07) for both readers. There was no significant advantage regarding depiction of local and iliac lymph nodes (3.9 ± 0.6 vs 4.2 ± 0.6, P = 0.07, and 3.8 ± 0.9 vs 4.1 ± 0.8, P = 0.19). Motion arte- facts were rated as 'none' to 'few' in both groups and showed no statistical difference (2.3 ± 1.0 vs 1.9 ± 0.9, P = 0.19, and 2.3 ± 1.1 vs 1.9 ± 0.7, P = 0.22). Overall image quality was rated 'good' in average for both cohorts without significant difference (4.0 ± 0.6 vs 4.0 ± 0.9, P = 0.78, and 3.8 ± 0.8 vs 4.2 ± 0.6, P = 0.09). CONCLUSION: The results demonstrated no significant effect of hBB administration on image quality. The study suggests that use of hBB is not mandatory for MRI of the prostate at 3.0 Tesla.

关键词： Butylscopolamine Buscopan Motion artefacts Magnetic resonance imaging Prostate cancer 3 Tesla

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Ein Liebesversuch

德语人文研究 2011年第3期 9-12+8页

作者： alexander Kluge

Als das billigste Mittel,in den Lagern Massensterilisationen durchzuführen,erschien 1943 R*** war.ob die so erzielte Unfruchtbarkeit nachhaltig *** führten einen mnnlichen und einen weiblichen Gefangenen zu eine... 详细信息

关键词： der Ein Liebesversuch

Ventilation after pancreaticoduodenectomy increases perioperative mortality: Identification of risk factors and their relevance in Germany that do not apply in England

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hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 379-388页

作者： Rieke-Sophie homeyer Keith JRoberts Robert P Sutcliffe alexander Kaltenborn Darius Mirza Zhi Qu Jurgen Klempnauer harald Schrem Core Facility Quality Management Transplantation Integrated Research and Treatment Center Transplantation(IFB-Tx)Hannover Medical SchoolCarl-Neuberg-Str.130625 HannoverGermany General Visceral and Transplant SurgeryHannover Medical SchoolCarl-Neuberg-Str.130625 HannoverGermany Department of hPB Surgery Queen Elizabeth Hospital BirminghamMindelsohn Way EdgbastonBirmingham B15 2GWUnited Kingdom Department of General Visceral and Transplant SurgeryMedical University GrazAuenbrugger Platz 58036 GrazAustria

Background:Pre-operative risk factors for post-operative ventilation and their influence on survival after pancreaticoduodenectomy for malignancy are ***:Totally 391 patients operated in hannover,Germany were investigated with multivariable logistic regression and Cox regression modeling to identify independent risk factors for post-operative ventilation≥6 h,patient survival and 90-day *** 84 patients operated in Birmingham,United Kingdom were analyzed to assess the external relevance of ***:Longer operations,history of thrombosis,intra-operative blood transfusion,lower estimated glomerular filtration rates(eGFR)and higher values of the age at operation divided by the horovitz Quotient independently increased the risk of post-operative ventilation≥6 h in German patients(n=108;27.6%)(Phe risk of early death in German patients significantly and independently of established prognostic factors.A history of thrombosis and lower eGFR levels were also independent significant risk factors for 90-day mortality in German patients but not in English *** of the English patients received post-operative *** more German patients were>75 years,had a history of thrombosis,received blood transfusions,and had significantly worse lung function ***4 tumors were detected in 18 German patients(4.6%),but not in the English ***:Identified risk factors for post-operative ventilation are clinically relevant in Germany but not in England and may be used to lower mortality *** German and the English cohorts displayed significant differences in the approach to patient selection and early post-operative extubation.

关键词： Pancreatic cancer Cholangiocellular carcinoma Periampullary carcinoma Comorbidity Outcome