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The influence of resistance exercise training prescription variables on skeletal muscle mass,strength,and physical function in healthy adults:An umbrella review

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Journal of Sport and Health Science 2024年第1期13卷 47-60页

作者： Jonathan C.Mcleod Brad S.Currier Caroline v.Lowisz Stuart M.Phillips Department of Kinesiology Faculty of ScienceMcMaster UniversityHamilton L8S4L8Canada

Purpose:The aim of this umbrella review was to determine the impact of resistance training(RT)and individual RT prescription variables on muscle mass,strength,and physical function in healthy ***:Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,we systematically searched and screened eligible systematic reviews reporting the effects of differing RT prescription variables on muscle mass(or its proxies),strength,and/or physical function in healthy adults aged>18 ***:We identified 44 systematic reviews that met our inclusion *** methodological quality of these reviews was assessed using A Measurement Tool to Assess Systematic Reviews;standardized effectiveness statements were *** found that RT was consistently a potent stimulus for increasing skeletal muscle mass(4/4 reviews provide some or sufficient evidence),strength(4/6 reviews provided some or sufficient evidence),and physical function(1/1 review provided some evidence).RT load(6/8 reviews provided some or sufficient evidence),weekly frequency(2/4 reviews provided some or sufficient evidence),volume(3/7 reviews provided some or sufficient evidence),and exercise order(1/1 review provided some evidence)impacted RT-induced increases in muscular *** discovered that 2/3 reviews provided some or sufficient evidence that RT volume and contraction velocity influenced skeletal muscle mass,while 4/7 reviews provided insufficient evidence in favor of RT load impacting skeletal muscle *** was insufficient evidence to conclude that time of day,periodization,inter-set rest,set configuration,set end point,contraction velocity/time under tension,or exercise order(only pertaining to hypertrophy)influenced skeletal muscle adaptations.A paucity of data limited insights into the impact of RT prescription variables on physical ***:Overall,RT increased muscle mass,strength,and physical function compared to no ***

关键词： Hypertrophy Resistance training Resistance training prescription variables Strength Umbrella review

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Regulation of TRP-like muscarinic cation current in gastrointestinal smooth muscle with special reference to PLC/InsP3/Ca2+ system

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Acta Pharmacologica Sinica 2006年第7期27卷 833-842页

作者： alexander v ZHOLOS Department of Physiology Queen’s University Belfast UK

Acetylcholine,the main enteric excitatory neuromuscular transmitter,evokes mem-brane depolarization and contraction of gastrointestinal smooth muscle cells byactivating G protein-coupled muscarinic *** the cholinergic exci-tation is generally underlined by the multiplicity of ion channel effects,the pri-mary event appears to be the opening of cation-selective channels;among themthe 60 pS channel has been recently identified as the main target for the acetylcho-line action in gastrointestinal *** evoked cation current,termed mICAT,causes either an oscillatory or a more sustained membrane depolarization response,which in turn leads to increases of the open probability of voltage-gated Ca2+channels,thus providing Ca2+entry in parallel with Ca2+release for intracellularCa2+concentration rise and *** recent years there have been severalsignificant developments in our understanding of the signaling processes under-lying *** have revealed important synergistic interactionsbetween M2and M3receptor subtypes,single channel mechanisms,and the in-volvement of TRPC-encoded proteins as essential components of native musca-rinic cation *** review summarizes these recent findings and in par-ticular discusses the roles of the phospholipase C/InsP3/intracellular Ca2+releasesystem in the mICATphysiological regulation.

关键词： smooth muscle muscarinic receptor G protein phospholipase C InsP3 calcium TRP cation channel

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Structural correlation and chemistry of molten NaF-ScF_(3) with dissolved metal aluminium:TG/DTA,XRD,NMR and molecular dynamics simulations

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Rare Metals 2024年第7期43卷 3356-3369页

作者： Aydar Rakhmatullin Frantisek Simko Didier Zanghi Zuzana Netriová Ilya BPolovov Ayrat Dimiev Konstantin v.Maksimtsev Catherine Bessada Michal Korenko Conditions Extrêmes et Materiaux:Haute Température et Irradiation CEMHTIUPR 3079-CNRS Univ Orleans45071 OrleansFrance Department of Molten Systems Institute of Inorganic ChemistrySlovak Academy of Sciences84536 BratislavaSlovakia Centre of Excellence for Advanced Materials Application-CEMEA Slovak Academy of Sciences84511Bratislava.Slovakia Department of Rare Metals and Nanomaterials Institute of Physics and TechnologyUral Federal UniversityUral Federal University620002 EkaterinburgRussia alexander Butlerov Institute of Chemistry Kazan Federal University420008KazanRussia

For the first time,the mechanism of metal aluminum dissolution in NaF-ScF_(3) eutectic melts and the chemical interaction between the constituents of this mixture have been thoroughly studied by a combination of differential thermal analysis(DTA),high temperature and solid-state nuclear magnetic resonance(NMR),and X-ray diffraction(XRD) coupled with the molecular dynamic *** formation of an insoluble Al_(3)Sc alloy in molten(NaF-ScF_(3))_(eut)system was proven,and the chemical mechanism of this aluminothermic Al_(3)Sc alloy production was *** ex situ examinations bring to light the formation of NaScF_4 and solid solution of Na_(3)(Al,Sc)F_(6) in cooled *** molecular dynamics calculations of the bath allow us to construct the structural model and to predict viscosity,density and electrical conductivity of the reagent melt to help to optimize the conditions of the alloy synthesis.

关键词： Scandium Alloy Molten salts NMR Molecular dynamics

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Stem Cell Therapy of Ischemic Heart Disease

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Journal of Biomedical Science and Engineering 2016年第4期9卷 191-215页

作者： Mikhail Konoplyannikov vladimir Kalsin alexander averyanov alexander Troitsky Federal Research Clinical Center of the FMBA of Russia Moscow Russia

Ischemic heart disease (IHD) accelerates death of cardiomyocytes and leads to the onset of cardiac failure. Due to the application of stem cells, there exists a potential for the regeneration of a damaged myocardium. Here we present a brief review of the modern data on the application of various types of stem cells for the IHD therapy. We consider different types of stem cells, which are most preferable for the clinical application, including mesenchymal stem cells, cardiac stem cells, embryonic stem cells, iPS cells and others. In particular, we discuss their advantages and strategies which can be applied in order to boost their regenerative potential, as well as optimization of their delivery. Besides, our review refers to the contemporary achievements in the field of tissue engineering of heart, using both polymer scaffolds and scaffold-free constructs. We also discuss the most prominent known clinical trials on stem cell therapy of ischemic heart disease.

关键词： IHD Remodeling Regeneration Stem Cells MSC Pre-Conditioning Paracrine Factors

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Characteristics of the SOL ion-to-electron temperature ratio on the J-TEXT tokamak with different plasma configurations

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Plasma Science and Technology 2024年第2期26卷 13-21页

作者：李存凯梁云峰江中和周松华建坤阳杰杨庆虎 alexander KNIEPS Philipp DREWS 徐鑫毛飞越谢伟杨雨桐郭金龙李杨波任正康陈志鹏王能超 the J-TEXT Team International Joint Research Laboratory of Magnetic Confinement Fusion and Plasma Physics State Key Laboratory of Advanced Electromagnetic Engineering and TechnologySchool of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People's Republic of China Forschungszentrum Jülich GmbH Institut für Energie-und Klimaforschung—PlasmaphysikPartner of the Trilateral Euregio Cluster(TEC)Julich 52425Germany 不详

Accurate measurement of the average plasma parameters in the edge region,including the temperature and density of electrons and ions,is critical for understanding the characteristics of the scrape-off layer(SOL) and divertor plasma transport in magnetically confined fusion *** the J-TEXT tokamak,a multi-channel retarding field analyzer(RFA) probe has been developed to study average plasma parameters in the edge region under various poloidal divertor and island divertor *** edge radial profile of the ion-to-electron temperature ratio,τ_(i/e),has been determined,which gradually decreases as the SOL ion self-collisionality,v_(SOL)*,*** is broadly consistent with what has been observed previously from various tokamak ***,the comparison of experimental results under different configurations shows that in the poloidal divertor configuration,even under the same v_(SOL)*,τ_(i/e) in the SOL region becomes smaller as the distance from the X-point to the target plate *** the island divertor configuration,τ_(i/e) near the O-point is higher than that near the X-point at the same v_(SOL)*,and both are higher than those in the limiter *** results suggest that the magnetic configuration plays a critical role in the energy distributions between electrons and ions at the plasma boundary.

关键词： ion temperature island divertor poloidal divertor retarding field analyzer(RFA)probe

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Competing magnetic states in silicene and germanene 2D ferromagnets

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Nano Research 2020年第12期13卷 3396-3402页

作者： Dmitry v.averyanov Ivan S.Sokolov Mikhail S.Platunov Fabrice Wilhelm Andrei Rogalev Pierluigi Gargiani Manuel valvidares Nicolas Jaouen Oleg E.Parfenov alexander N.Taldenkov Igor A.Karateev Andrey M.Tokmachev vyacheslav G.Storchak National Research Center“Kurchatov Institute” Kurchatov Sq.1Moscow123182Russia ESRF-The European Synchrotron CS 4022038043Grenoble Cedex 9France ALBA Synchrotron Light Source Cerdanyola del Vallès08290BarcelonaSpain L’Orme des Merisiers Synchrotron SOLEILGyf-sur-Yvette91192France

Two-dimension(2D)magnets have recently developed into a class of stoichiometric materials with prospective applications in ultra-compact spintronics and quantum *** functionality is particularly rich when different magnetic orders are competing in the same *** REX2(RE=Eu,Gd;X=Si,Ge),silicene or germanene—heavy counterparts of graphene—coupled with a layer of rare-earth metals,evolve from three-dimension(3D)antiferromagnets in multilayer structures to 2D ferromagnets in a few *** evolution,however,does not lead to fully saturated 2D ferromagnetism,pointing at a possibility of coexisting/competing magnetic ***,REX2 magnetism is explored with element-selective X-ray magnetic circular dichroism(XMCD).The measurements are carried out for GdSi2,EuSi2,GdGe2,and EuGe2 of different thicknesses down to 1 monolayer employing K absorption edges of Si and Ge as well as M and L edges of the *** access the magnetic state in REX2 and determine the seat of magnetism,orbital,and spin contributions to the magnetic ***-field measurements probe remnants of the bulk antiferromagnetism in 2D *** results provide a new platform for studies of complex magnetic structures in 2D materials.

关键词： silicene germanene 2D ferromagnetism X-ray magnetic circular dichroism(XMCD) monolayer

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Leveraging Robust Artificial Intelligence for Mechatronic Product Development—A Literature Review

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International Journal of Intelligence Science 2024年第1期14卷 1-21页

作者： alexander Nüßgen René Degen Marcus Irmer Fabian Richter Cecilia Boström Margot Ruschitzka CAD CAM Center Cologne Institute of Automotive Engineering Cologne (IFK) Faculty of Automotive Systems and Production Cologne University of Applied Science Cologne Germany Division of Electricity Department of Electrical Engineering Uppsala University Uppsala Sweden

Mechatronic product development is a complex and multidisciplinary field that encompasses various domains, including, among others, mechanical engineering, electrical engineering, control theory and software engineering. The integration of artificial intelligence technologies is revolutionizing this domain, offering opportunities to enhance design processes, optimize performance, and leverage vast amounts of knowledge. However, human expertise remains essential in contextualizing information, considering trade-offs, and ensuring ethical and societal implications are taken into account. This paper therefore explores the existing literature regarding the application of artificial intelligence as a comprehensive database, decision support system, and modeling tool in mechatronic product development. It analyzes the benefits of artificial intelligence in enabling domain linking, replacing human expert knowledge, improving prediction quality, and enhancing intelligent control systems. For this purpose, a consideration of the v-cycle takes place, a standard in mechatronic product development. Along this, an initial assessment of the AI potential is shown and important categories of AI support are formed. This is followed by an examination of the literature with regard to these aspects. As a result, the integration of artificial intelligence in mechatronic product development opens new possibilities and transforms the way innovative mechatronic systems are conceived, designed, and deployed. However, the approaches are only taking place selectively, and a holistic view of the development processes and the potential for robust and context-sensitive artificial intelligence along them is still needed.

关键词： Artificial Intelligence Mechatronic Product Development Knowledge Management Data Analysis Optimization Human Experts Decision-Making Processes v-Cycle

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On the Solution Accuracy Downstream of Shocks When Using Godunov-Type *** of Errors in One-Dimensional Problems

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Communications in Computational Physics 2023年第8期34卷 749-786页

作者： alexander v.Rodionov Keldysh Institute of Applied Mathematics Russian Academy of SciencesMoscow125047Russia RFNC–All-Russian Scientific Research Institute of Experimental Physics Sarov607188Russia

The article opens a series of publications devoted to a systematic study of numerical errors behind the shock wave when using high-order Godunov-type schemes,including in combination with the artificial viscosity *** proposed paper describes the numerical methods used in the study,and identifies the main factors affecting the accuracy of the solution for the case of one-dimensional gas dynamic *** physical interpretation of the identified factors is given and their influence on the grid convergence is analyzed.

关键词： Shock-capturing methods Riemann problem WENO reconstruction Runge-Kutta method Hancock-Rodionov method artificial viscosity approach Shu-Osher test problem

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Magnesium permeation through mechanosensitive channels:single-current measurements

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Cell Research 2006年第8期16卷 723-730页

作者： alexander v StanIschenko AnastasiyavSudarikova YuriANegulyaev ElenaAMorachevskaya Institute of Cytology Russian Academy of SciencesTikhoretskyAve.4St Petersburg 194064RussiaDepartment of PhysiologyUniversity of Texas Health Science Center at San Antonio7756-7703 Floyd Curl Drive San AntonioTX 78229.USA Institute of Cytology Russian Academv of SciencesTikhoretskyAve.4St Petersburg 194064Russia

Compelling evidence shows that intracellular flee magnesium [Mg2+]imay be a critical regulator of cell activity ***,membrane transport mechanisms mediating Mg2+influx in mammalian cells are poorly ***,we show that mechanosensitive(MS)cationic channels activated by stretch are permeable for Mg2+ions at differentextracellular concentrations including physiological ***-channel currents were recorded from cell-attached andinside-out patches on K562 leukaemia cells at various concentrations of MgCl2when Mg2+was the only available carrierof inward *** 2 mM Mg2+inward mechanogated currents representing Mg2+influx through MS channels cor-responded to the unitary conductance of about 5 *** higher Mg2+levels,only slight increase of single-channel currentsand conductance occurred,implying that Mg2+permeation through MS channels is characterized by strong *** 20 and 90 mM Mg2+mean conductance values for inward currents carried by Mg2+were rather similar,being equalto 6.8±0.5 and 6.4±0.5 pS,*** estimation of the channel-selective permeability according to constantfield equation is obviously limited due to saturation *** conclude that the detection of single currents is the mainevidence for Mg2+permeation through membrane channels activated by *** single-current measurements docu-ment Mg2+influx through MS channels in the plasma membrane of leukaemia cells.

关键词： magnesium single currents mechanosensitive channel human leukaemia cell

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Comparison of linear and nonlinear extreme wave statistics

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Acta Oceanologica Sinica 2016年第5期35卷 99-105页

作者： DMITRY Chalikov alexander v.Babanin Swinburne University of Technology Victoria 3122 Australia P.P. Shirshov Institute of Oceanology Saint-Petersburg 199053 Russia

An extremely large（＂freak＂） wave is a typical though rare phenomenon observed in the sea. Special theories（for example, the modulation instability theory） were developed to explain mechanics and appearance of freak waves as a result of nonlinear wave-wave interactions. In this paper, it is demonstrated that the freak wave appearance can be also explained by superposition of linear modes with the realistic spectrum. The integral probability of trough-to-crest waves is calculated by two methods： the first one is based on the results of the numerical simulation of a wave field evolution performed with one-dimensional and two-dimensional nonlinear *** second method is based on calculation of the same probability over the ensembles of wave fields constructed as a superposition of linear waves with random phases and the spectrum similar to that used in the nonlinear simulations. It is shown that the integral probabilities for nonlinear and linear cases are of the same order of values

关键词： freak waves numerical modeling probability of linear and nonlinear waves ensemble modeling

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