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Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma

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World Journal of Gastroenterology 2008年第7期14卷 1097-1101页

作者： Andreas Weber Claus von Weyhern Falko Fend Jochen Schneider Bruno Neu alexander meining Hans Weidenbach Roland M Schmid Christian Prinz Department of Internal Medicine Ⅱ Technical University of Munich Munich 81675 Germany Department of Pathology Technical University of Munich Munich 81675 Germany

AIM: To evaluate the sensitivity of brush cytology and forceps biopsy in a homogeneous patient group with hilar ***: Brush cytology and forceps biopsy were routinely performed in patients with suspected malignant biliary strictures. Fifty-eight consecutive patients undergoing endoscopic retrograde cholangio-pancreatography (ERCP) including forceps biopsy and brush cytology in patients with hilar cholangiocarcinoma between ***: Positive results for malignancy were obtained in 24/58 patients (41.4%) by brush cytology and in 31/58 patients (53.4%) by forceps biopsy. The combination of both techniques brush cytology and forceps biopsy resulted only in a minor increase in diagnostic sensitivity to 60.3% (35/58 patients). In 20/58 patients (34.5%), diagnosis were obtained by both positive cytology and positive histology, in 11/58 (19%) by positive histology (negative cytology) and only 4/58 patients (6.9%) were confirmed by positive cytology (negative histology).CONCLUSION: Brush cytology and forceps biopsy have only limited sensitivity for the diagnosis of malignant hilar tumors. In our eyes, additional diagnostic techniques should be evaluated and should become routine in patients with negative cytological and histological findings.

关键词： Brush cytology Forceps biopsy Cholangiocarcinoma Klatskin tumor Endoscopy Diagnostic approaches

Positive predictors for gastroesophageal reflux disease and the therapeutic response to proton-pump inhibitors

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World Journal of Gastroenterology 2014年第14期20卷 4017-4024页

作者： Valentin Becker Stefan Grotz Christoph Schlag Simon Nennstiel Analena Beitz Bernhard Haller Roland M Schmid alexander meining Monther Bajbouj Ⅱ. Medizinische Klinik und Poliklinik Technische Universit?t München Institut für Medizinische Statistik und Epidemiologie Technische Universit?t München

AIM: To identify objective and subjective predictors for the reliable diagnosis of gastroesophageal reflux disease (GERD) and the response to proton pump inhibitor (PPI) therapy.

关键词： Gastroesophageal reflux Gastroesophageal reflux disease Non-erosive reflux disease Impedance pH measurement Follow-up Therapy Proton pump inhibitor

Over-the-scope-grasper: A new tool for pancreatic necrosectomy and beyond-first multicenter experience

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World Journal of Gastrointestinal Surgery 2022年第8期14卷 799-808页

作者： Markus Brand Jeannine Bachmann Christoph Schlag Ulrich Huegle Imdadur Rahman Edris Wedi Benjamin Walter Oliver Moschler Lukas Sturm alexander meining Department of Internal Medicine II University of WürzburgWürzburg 97080Germany Department of Surgery Klinikum rechts der IsarUniversity of MünchenMünchen 81675Germany Department of Gastroenterology and Hepatology University of ZürichZürich 8091Switzerland Department of Gastroenterology and Hepatology Klinikum Koln-HolweideKoln 50968Germany Department of Gastroenterology University Hospital SouthamptonSouthampton SO166YDUnited Kingdom Department of Gastroenterology Gastrointestinal Oncology and Interventionell EndoscopySana Klinikum OffenbachOffenbach 63069Germany Department of Internal Medicine I University of UlmUlm 89070Germany Department of Gastroenterology Marienhospital OsnabrückOsnabrück 49074Germany Department of Internal Medicine II University of FreiburgFreiburg 79106Germany

BACKGROUND Endoscopic treatment of pancreatic necrosis can be challenging and timeconsuming because sticky necrotic debris is sometimes difficult to remove. The over-the-scope-grasper, a new tool that has recently become available for this purpose, might also be useful for other indications. However, clinical data on the efficacy and safety of this new device are *** To evaluate the technical success and safety of the device in a multicenter *** The over-the-scope-grasper was used in nine selected endoscopic centers between November 2020and October 2021 for appropriate indications. Overall, 56 procedures were included in the *** retrospectively evaluated procedural parameters of all endoscopic interventions using a predefined questionnaire, with special respect to technical success, indications, duration of intervention, type of sedation, and complications. In the case of pancreatic necrosectomy, the access route, stent type, number of necrosis pieces removed, and clinical handling were also *** A total of 56 procedures were performed, with an overall technical success rate of 98%. Most of the procedures were endoscopic pancreatic necrosectomies(33 transgastric, 4 transduodenal). In 70%of the procedures, access to the necrotic cavity was established with a lumen apposing metal *** technical success of pancreatic necrosectomy was 97%, with a mean of 8 pieces(range, 2-25pieces) of necrosis removed in a mean procedure time of 59 min(range, 15-120 min). In addition,the device has been used to remove blood clots(n = 6), to clear insufficiency cavities before endoluminal vacuum therapy(n = 5), and to remove foreign bodies from the upper gastrointestinal tract(n = 8). In these cases, the technical success rate was 100%. No moderate or severe/fatal complications were reported in any of the 56 *** These first multicenter data demonstrate that the over-the-scope-grasper is a promising device for endoscopic pancreat

关键词： Over-the-scope-grasper Endoscopic pancreatic necrosectomy Grasper Direct endoscopic necrosectomy Pancreatic necrosis Endoscopic tool

Endoscopic stent therapy in patients with chronic pancreatitis:A 5-year follow-up study

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World Journal of Gastroenterology 2013年第5期19卷 715-720页

作者： Andreas Weber Jochen Schneider Bruno Neu alexander meining Peter Born Stefan von Delius Monther Bajbouj Roland M Schmid Hana Algül Christian Prinz II Medizinische Klinik und Poliklinik Klinikum Rechts der IsarTechnische Universitt München81675 MünchenGermany II Medizinische Klinik Gastroenterologie und HepatologieHelios Klinikum WuppertalUniversitt Witten/Herdecke42283 WuppertalGermany

AIM:This study analyzed clinical long-term outcomes after endoscopic therapy,including the incidence and treatment of relapse. METHODS:This study included 19 consecutive patients(12 male,7 female,median age 54 years)with obstructive chronic pancreatitis who were admitted to the 2nd Medical Department of the Technical University of *** patients presented severe chronic pancreatitis(stageⅢ°)according to the Cambridge *** majority of the patients suffered intermittent pain attacks.6 of 19 patients had strictures of the pancreatic duct;13 of 19 patients had strictures and *** first endoscopic retrograde pancreatography(ERP)included an endoscopic sphincterotomy, dilatation of the pancreatic duct,and stent *** first control ERP was performed 4 wk after the initial intervention,and the subsequent control ERP was performed after 3 mo to re-evaluate the clinical and morphological *** follow-up was performed annually to document the course of pain and the management of *** course of pain was assessed by a pain scale from 0 to *** date and choice of the therapeutic procedure were documented in case of relapse. RESULTS:Initial endoscopic intervention was successfully completed in 17 of 19 *** 17 patients reported partial or complete pain relief after endoscopic *** therapy failed in 2 patients. Both patients were excluded from further *** failed patient underwent surgery,and the other patient was treated conservatively with pain *** of 19 patients were followed after the successful completion of endoscopic stent *** of 17 patients were lost to *** patient was not avail-able for interviews after the 1st year of *** patients died during the 3rd year of *** both patients chronic pancreatitis was excluded as the cause of *** patient died of myocardial infarction, and one patient succumbed to *** three patient

关键词： Chronic pancreatitis Pain Stent therapy Endoscopic retrograde cholangiopancreatography Pancreaticolithiasis

Testing and modelling of transient adhesion phenomena in rolling-sliding contacts

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Friction 2024年第5期12卷 1016-1027页

作者： Daniel KVARDA alexander MEIERHOFER Klaus SIX Faculty of Mechanical Engineering Brno University of TechnologyBrno61669Czech Republic Virtual Vehicle Research GmbH Graz8010Austria

Transient adhesion effects in rolling–sliding contacts influence all aspects of train–track *** is of high importance specifically when these effects result in critically low adhesion,which poses a risk to traction and braking of railway *** study presents a model that can replicate the transient changes of the coefficient of adhesion with tested water and solid particle *** experimental data for the model are measured using a commercial ball-on-disc *** experimental results showed a liquid reservoir in front of the contact area that slowly reduces in *** observation was used in the modelling approach to divide the calculation into two stages where the reservoir is present and when it *** model was able to reproduce the occurrence of low adhesion region seen in experimental results with different particle concentrations.

关键词： coefficient of adhesion tribology transient effects wheel-rail contact

Prediction of ball-on-plate friction and wear by ANN with data-driven optimization

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Friction 2024年第6期12卷 1235-1249页

作者： alexander KOVALEV Yu TIAN Yonggang MENG State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China

For training artificial neural network(ANN),big data either generated by machine or measured from experiments are used as input to"learn"the unspecified functions defining the *** experimental data are fed directly into the optimizer allowing training to be performed according to a predefined loss *** predict sliding friction and wear at mixed lubrication conditions,in this study a specific ANN structure was so designed that deep learning algorithms and data-driven optimization models can be *** ball-on-plate friction and wear data were analyzed using the specific training procedure to optimize the weights and biases incorporated into the neural layers of the ANN,and only two independent experimental data sets were used during the ANN optimization *** the training procedure,the ANN is capable to predict the contact and hydrodynamic pressure by adapting the output data according to the tribological condition implemented in the optimization algorithm.

关键词： machine learning deep learning artificial neural network mixed lubrication

Competitive Resource Allocation Among Urban Congestion Areas in a Modern Big City

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Journal of the Operations Research Society of China 2024年第1期12卷 133-153页

作者： alexander Krylatov Anastasiya Raevskaya Institute of Applied Mathematical Research of the Karelian Research Centre of the Russian Academy of Sciences Petrozavodsk185910Russia Saint Petersburg State University Saint Petersburg199034Russia

The continuing growth of modern big cities leads to their spatial expansion and the emergence of new road connections and urban *** where large transportation flows of pedestrians,passengers,and drivers come together create demand points,which attract business companies that strive to allocate their resources in the most sought-after ***,the law of supply and demand restrains companies from allocating all their resources solely in the most popular congestion areas since the more valuable an urban area,the higher the cost to be paid for a resource unit allocation *** a result,companies act in a non-cooperative manner and try to minimize their own overall costs when allocating resources across available commercial areas in a big ***-cooperative behavior of companies leads to the problem of Nash equilibrium search in the game of competing *** this paper,we study the corresponding resource allocation game under affine cost functions and obtain Nash equilibrium strategies in explicit *** findings allow us to develop a simple procedure for computing Nash equilibria in the game of companies allocating their resources among urban congestion *** computational study demonstrates the dependence of the average price for resource allocation on the number of players and their resource *** outcome of the paper contributes to flow theory and seems to be fresh and useful for managers.

关键词： Resource allocation Nash equilibrium Affine costs

A Converse Theorem for Split SO_(2l) over Finite Fields

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Acta Mathematica Sinica,English Series 2024年第3期40卷 731-771页

作者： alexander HAZELTINE Bai Ying LIU Department of Mathematics Purdue University150 N.University St.West LafayetteIN 47907USA E-mail:ahazelti@purdue.edu liu2053@purdue.edu

We prove a converse theorem for split even special orthogonal groups over finite *** is the only case left on converse theorems of classical groups and the difficulty is the existence of the outer automorphism. In thi... 详细信息

关键词： Converse theorems generic cuspidal representations even special orthogonal groups

Architecture of Graphics System with 3D Acceleration Support for Embedded Operating Systems

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Tsinghua Science and Technology 2024年第3期29卷 863-873页

作者： alexander Giatsintov Kirill Mamrosenko Pavel Bazhenov Center of Visualization and Sattelite Information Technologies Scientific Research Institute for System Analysis of the Russian Academy of Sciences(SRISA RAS)Moscow 117218Russia

An increasing number of tasks now require the use of hardware accelerators to reduce the time required for computation and display the computational *** paper presents a new graphics system architecture for operating systems(OSs)with microkernel architecture,including real-time *** proposed system architecture provides capabilities for displaying graphical images on various information display devices and for accelerating graphical operations on *** architecture of the graphics system uses a concept of allocators to manage system and video memory,provides an abstraction of memory operations with a single interface for video memory management,and simplifies memory handling where incorrect operation is the cause of many failures.A comparison between the performance of a real-time OS and Linux OS implementing the graphics system using the example of a glmark2 benchmark is presented,thereby the superiority of the proposed architecture in several scenarios is demonstrated.

关键词： real-time operating system(RTOS) graphics system rendering system architecture operatingsystem visualization system programming