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Fluctuating temperature modifies heat-mortality association around the globe

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The Innovation 2022年第2期3卷 65-72页

作者： Yao Wu Bo Wen Shanshan Li Antonio Gasparrini Shilu Tong Ala Overcenco Ales Urban Alexandra Schneider Alireza Entezari Ana maria Vicedo-Cabrera Antonella Zanobetti Antonis Analitis Ariana Zeka Aurelio Tobias Barrak Alahmad Ben Armstrong Bertil Forsberg CarmenÍñiguez Caroline Ameling César De la Cruz Valencia ChristoferÅström Danny Houthuijs Do Van Dung Dominic Royé Ene Indermitte Eric Lavigne Fatemeh mayvaneh Fiorella Acquaotta Francesca de’Donato Francesco Sera Gabriel Carrasco-Escobar Haidong Kan Hans Orru Ho Kim Iulian-Horia Holobaca Jan Kyselý Joana madureira Joel Schwartz Klea Katsouyanni magali Hurtado-Diaz martina SRagettli masahiro Hashizume mathilde Pascal micheline de Sousa Zanotti Stagliorio Coélho Noah Scovronick Paola michelozzi Patrick Goodman Paulo Hilario Nascimento Saldiva Rosana Abrutzky Samuel Osorio Tran Ngoc Dang Valentina Colistro Veronika Huber Whanhee Lee Xerxes Seposo Yasushi Honda michelle L.Bell Yuming Guo Department of Epidemiology and Preventive medicine School of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Department of Public Health Environments and SocietyLondon School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre for Statistical methodology London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre on Climate Change&Planetary Health London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Shanghai Children’s medical Centre Shanghai Jiao Tong UniversityShanghai 200025China School of Public Health Institute of Environment and Human HealthAnhui Medical UniversityHefei 230032China Center for Global Health Nanjing Medical UniversityNanjing 211166China School of Public Health and Social Work Queensland University of TechnologyBrisbane 4000Australia National Agency for Public Health of the ministry of Health Labour and Social Protection of the Republic of MoldovaChisinau MD-2009Republic of Moldova Institute of Atmospheric Physics Czech Academy of SciencesPrague 14100Czech Republic Faculty of Environmental Sciences Czech University of Life SciencesPrague 16500Czech Republic Institute of Epidemiology Helmholtz Zentrum M€unchen-German Research Center for Environmental HealthNeuherberg 85747Germany Faculty of Geography and Environmental Sciences Hakim Sabzevari UniversitySabzevar ***Iran Institute of Social and Preventive medicine University of BernBern 3012Switzerland Oeschger Center for Climate Change Research University of BernBern 3012Switzerland Department of Environmental Health Harvard T.H.Chan School of Public HealthHarvard UniversityBostonMA 02115USA Department of Hygiene Epidemiology and Medical StatisticsNational and Kapodistrian University of AthensAthens 11527Greece Institute for Environment Healthand SocietiesBrunel University LondonLondon UB83PNUK Institute of Environmental Assessment and

Studies have investigated the effects of heat and temperature variability(TV)on ***,few assessed whether TV modifies the heat-mortality *** on daily temperature and mortality in the warm season were collected from 717 locations across 36 *** was calculated as the standard deviation of the average of the same and previous days’minimum and maximum temperatures.

关键词： deviation modif heat

伴有GFAP突变和线粒体畸形的幼稚型alexander病

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 57-57页

作者： N.obuhara Y. Nakahara K. HiguchiI. m. Nakagawa 高方 Res. Inst. Neurologic Dis. Geriat. Dept. of Neurology and Ge rontology Kyoto Pref. University of Medicine Kawaramachi Hirokoji 465 Kamigyo ku Kyoto 602 0841 Japan Dr.

The authors report a 29 year old woman with marked atrophy of the cerebellum , medulla oblongata, and spinal cord, dementia, diffuse white matter abnormality on mRI, ragged red fibers, and R88C mutation in the human glial fibrillary aci dic protein (GFAP). mitochondria DNA (mtDNA) analysis showed a rare polymorphism at A8291G. This mtDNA polymorphism, which has been associated with limb girdle type mitochondrial myopathy, may modify the clinical symptoms of this juvenile form of alexander disease with GFAP mutation.

关键词：幼稚型 alexander病线粒体肌病破碎红纤维带型多态性 DNA 临床症状

一个基于深度学习的眼病和肺炎两大类疾病的AI诊断系统

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科学新闻 2019年第2期 33-33页

作者： Daniel S.Kermany michael Goldbaum Wenjia Cai Carolina C.S.Valentim Huiying Liang Sally L.Baxter Alex mcKeown Ge Yang Xiaokang Wu Fangbing Yan Justin Dong made K.Prasadha Jacqueline Pei magdalene Y.L.Ting Jie Zhu Christina Li Sierra Hewett Jason Dong Ian Ziyar alexander Shi Runze Zhang Rui Hou William Shi Xin Fu Yaou Duan Viet A.N. Huu Cindy Wen Edward D. Zhang Charlotte L. Zhang Oulan Li Xiaobo Wang michael A. Singer Xiaodong Sun Jie Xu Ali Tafreshi m. Anthony Lewis Huimin Xia 张康美国加州大学圣地亚哥分校人类基因组医学研究所

文章简介本研究开发了一个基于深度学习框架能诊断致盲性视网膜疾病的人工智能(AI)诊断工具。而且,该AI诊断工具还可用于诊断小儿肺炎。这是一项将AI应用于医疗领域的重磅研究成果,有望高精确诊断多种可治疗性疾病。在眼科治疗中,视网膜... 详细信息

文章简介本研究开发了一个基于深度学习框架能诊断致盲性视网膜疾病的人工智能(AI)诊断工具。而且,该AI诊断工具还可用于诊断小儿肺炎。这是一项将AI应用于医疗领域的重磅研究成果,有望高精确诊断多种可治疗性疾病。在眼科治疗中,视网膜OCT(光学相干断层扫描)

关键词： AI 深度学习

Nat Genet:科学家设计新方法找到抑制癌症发育的新基因

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现代生物医学进展 2017年第15期17卷 I0004-I0004页

作者： Jorge de la Rosa, mathias Josef Friedrich, Yilong Li, Lena Rad, Hannes Ponstingl, Qi Liang, Sandra Bernaldo de Quirós, Imran Noorani, Emmanouil metzakopian, alexander Strong, meng Amy Li, Gary J Hoffman, Rocío Fuente, George S Vassiliou, Roland Rad, Allan Bradley Juan Cadiñanos Jorge de la Rosa Juan Cadiñanos Jorge de la Rosa Carlos López-Otín Julia Weber Roland Rad Julia Weber Roland Rad Aurora Astudillo maría Teresa Fernández-García maría Soledad Fernández-García Gary J Hoffman Carlos López-Otín The Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton UK Instituto de medicina Oncológica y molecular de Asturias (ImOmA) Oviedo Spain Departamento de Bioquímica y Biología molecular Facultad de Medicina Instituto Universitario de Oncología (IUOPA) Universidad de Oviedo Oviedo Spain Department of Internal medicine II Klinikum rechts der Isar Technische Universität München München Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Servicio de Anatomía Patológica Hospital Universitario Central de Asturias Oviedo Spain Unidad de Histopatología molecular Facultad de Medicina IUOPA Universidad de Oviedo Oviedo Spain School of medicine University of Western Australia Crawley Western Australia Australia Centro de Investigación Biomédica en Red de Cáncer Spain.

英国桑格研究院的研究人员和他们的合作者们最近发现了帮助阻止前列腺癌、皮肤癌和乳腺癌发育的新基因。这些基因能够与众所周知的肿瘤抑制基因PTEN配合发挥作用，该研究还发现这些基因与人类前列腺肿瘤存在相关性。相关研究结果发表在... 详细信息

英国桑格研究院的研究人员和他们的合作者们最近发现了帮助阻止前列腺癌、皮肤癌和乳腺癌发育的新基因。这些基因能够与众所周知的肿瘤抑制基因PTEN配合发挥作用，该研究还发现这些基因与人类前列腺肿瘤存在相关性。相关研究结果发表在国际学术期刊Nature Genetics上。该研究揭示了一些参与癌症发育的新途径，这些基因有望成为治疗PTEN突变癌症的新药物靶点。这项研究开发的一些方法也可以用于发现其他协同抑制癌症生长的基因。

关键词：新基因癌症发育 Nat 科学家设计肿瘤抑制基因国际学术期刊

身材矮小的父母所生的小于胎龄儿或足月儿婴儿期的发育减慢

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世界核心医学期刊文摘（儿科学分册） 2006年第11期2卷 23-23页

作者： Vlkl T.m.K. Haas B Beier C. H.G. Drr 朱新菊 Division of Pediatric Endocrinology Hospital for Children and Adolescents Friedrich-Alexander-University of ErlangenNuremberg Germany Dr.

Objective: We analyzed postnatal growth in children with familial short stature (FSS)with regard to small (SGA) or appropriate(AGA) for gestational age status at birth. Study design: We studied 96 otherwise healthy short-statured children (58 males;SGA: n = 41, AGA: n = 55). At least one of the parents was short-statured. Cross-sectional data for length/height and weight for the first 4 years of age were collected ***: AGA children had a mean length of 0.09 ±1.02 standard deviation score (SDS) at birth, -1.57 ±1.16 SDS after 1year of age, and -2.36 ±0.72 SDS after 4 years. SGA children had a mean length of -2.04 ±1.06 SDS at birth, -2.70 ±1.12 SDS at 1 year of age, and -3.05±0.86 SDS at 4 years. The loss of length SDS within the first 2 years of life was greater in AGA than in SGA children. SGA children were significantly shorter than AGA children at all of the study points (p milial range during the first 2 years of life. SGA children did not catch up to their AGA peers at any time.

关键词：小于胎龄儿身材矮小婴儿期出生后家庭史生时族性研究设计

Nature：研究鉴定出侵袭性胰腺癌细胞及其弱点

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现代生物医学进展 2017年第14期17卷 I0002-I0003页

作者： Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, maria Nezi, Luigi Corti, Denise minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar Dal molin, marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia muller, Florian Dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, michael G. Wood, Laura D. Sgambato, Alessandro Agaimy, Abbas maitra, Anirban Roberts, Charles W. m. Wang, Huamin Viale, Andrea DePinho, Ronald A. Draetta, Giulio F. Chin, Lynda Univ Texas mD Anderson Canc Ctr Dept Genom Med Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Inst Appl Canc Sci Houston TX 77030 USA European Inst Oncol I-20141 Milan Italy Sun Yat Sen Univ Ctr Canc State Key Lab Oncol South China Guangzhou 510060 Guangdong Peoples R China Univ Cattolica Sacro Cuore Ist Patol Gen I-00168 Rome Italy Baylor Coll med Grad Program Struct & Computat Biol & Mol Biophys Houston TX 77030 USA Johns Hopkins Univ Sol Goldman Pancreat Canc Res Ctr Dept Pathol Baltimore MD 21287 USA Univ Texas mD Anderson Canc Ctr Dept Mol & Cellular Oncol Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Dept Translat Mol Pathol Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Dept Leukemia Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Off Technol Commercializat Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Dept Canc Syst Imaging Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Dept Canc Biol Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Dept Expt Therapeut Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr ORBIT Platform Houston TX 77030 USA Univ Texas mD Anderson Canc Ctr Dept Surg Oncol Houston TX 77030 USA Friedrich alexander Univ Erlangen Nuremberg Univ Hosp Dept Pathol D-91054 Erlangen Germany Friedrich alexander Univ Erlangen Nuremberg Dept Pathol D-91054 Erlangen Germany Friedrich alexander Univ Erlangen Nuremberg Sheikh Ahmed Bin Zayed Nahyan Ctr Pancreat Canc R D-91054 Erlangen Germany St Jude Childrens Res Hosp Ctr Comprehens Canc Memphis TN 77027 USA St Jude Childrens Res Hosp Dept Oncol Memphis TN 77027 USA C4 Therapeut Cambridge MA 02142 USA Univ Texas Syst Inst Hlth Transformat Austin TX 78701 USA

在一项新的研究中，来自美国德州大学mD安德森癌症中心的研究人员利用患者源性肿瘤异种移植（patient—derived tumorxenograft,PDx）和模式小鼠开展一系列临床前实验，鉴定出一种门卫蛋白（gatekee Perprotein）阻止胰腺癌细胞转化为... 详细信息

在一项新的研究中，来自美国德州大学mD安德森癌症中心的研究人员利用患者源性肿瘤异种移植（patient—derived tumorxenograft,PDx）和模式小鼠开展一系列临床前实验，鉴定出一种门卫蛋白（gatekee Perprotein）阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型，并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。

关键词：胰腺癌癌细胞侵袭性鉴定异种移植研究人员细胞类型细胞转化

CEPC Technical Design Report

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Radiation Detection Technology and methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera alexander Belyaev michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert maarten Boonekamp marcello Borri Angelo Bosotti Vincent Boudry mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De maria Nicola De Filippis Christophe De La Taille Francesca De mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPm(AmU/IPhU&CNRS/INP) Marseille Dalian minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 mW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 mW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 marco Fargetta Dmitry Fedoseev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov marco Giammarchi Agnese Giaz Nunzio Giudice maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel marco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione di milano and Dipartimento di Fisica dell Universitàdi milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN milano Bicocca and University of milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN milano Bicocca and Politecnico of milano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector

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开放教育:一个有待进一步研究的领域

中国远程教育 2021年第2期 46-58,77页

作者： [德]奥拉夫·扎瓦克奇-里克特 [加]黛安·康拉德阿拉斯·博兹库尔特坚吉兹·哈坎·艾登斯韦尼亚·贝登利耶郑仁星约阿希姆·斯图特乔治·韦利特西亚诺斯丽莎·玛丽·布拉斯科梅丽莎·邦德安德里亚·布朗斯艾丽莎·布鲁恩卡莱娜·多尔西马可·卡尔兹迈克尔·克雷斯亚萨尔·孔达奇维多利亚·马林克斯汀·梅伯格沃尔夫冈·穆斯肯斯索姆·奈杜阿德南·卡尤姆詹妮弗·罗伯茨艾伯特·桑格拉弗兰克·森约·洛各洛帕特丽夏·J.斯莱格·范·特伦肖俊洪(译) 德国奥尔登堡大学开放教育研究中心COER团队德国奥尔登堡卡尔·冯·奥西茨基大学土耳其阿纳多卢大学德国埃尔朗根-纽伦堡弗里德里希·亚历山大大学日本国际基督教大学加拿大皇家大学欧洲远程E-Learning网络协会英国伦敦大学学院德国海德堡教育大学杜伊斯堡-埃森大学中东技术大学德国汉堡大学斐济南太平洋大学美国宾夕法尼亚州立大学南非大学西班牙加泰罗尼亚奥贝塔大学美国东卡罗来纳州立大学中国汕头开放大学不详

本文阐述高等教育背景下开放教育的内容。文章首先介绍开放教育的起源及其理论基础,随后根据远程开放学习研究的宏观、中观和微观层次框架讨论远程开放学习、开放教育实践、开放学术、开放教育资源、慕课、先前学习认定、学习者特征和... 详细信息

本文阐述高等教育背景下开放教育的内容。文章首先介绍开放教育的起源及其理论基础,随后根据远程开放学习研究的宏观、中观和微观层次框架讨论远程开放学习、开放教育实践、开放学术、开放教育资源、慕课、先前学习认定、学习者特征和开放教育国际化等主题的内容。最后从宏观、中观和微观层面提出今后的研究方向。

关键词：开放教育开放学习远程教育灵活学习在线学习开放教育资源国际化