检索结果-南通市图书馆

Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor

引用

Cellular & Molecular Immunology 2016年第5期13卷 651-657页

作者： j.ssy j. alexander Lee D. Chaves Anthony Chang Shruti Dighe alexander j.cob Richard j. Quigg Division of Nephrology Department of Medicine University at Buffalo School of Medicine and Health Sciences Buffalo NY USA Department of Pathology The University of Chicago Chicago IL USA Correspondence: Dr Jessy J. Alexander Division of Nephrology State University of New York at Buffalo Clinical and Translational Research Center 875 Ellicott Street 8-022 Buffalo NY 14203 USA

Activation of complement generates C5a which leads to signaling through C5aR 1. This is tightly controlled, including by the plasma proteins factor H （FH） and carboxypeptidase N. Here we studied a chronic serum sickness （CSS） model of glomerulonephritis （GN） in which there is an active humoral immune response, formation of glomerular immune complexes （ICs）, and resulting glomerular inflammation. The antibody response, glomerular IC deposition, the degree of GN, and consequent renal functional insufficiency in CSS were all worse in FH-/- mice compared to wild-type FH＋/＋ animals. This was ameliorated in the former by giving a C5aR1 antagonist for the final 3 weeks of the 5-week protocol. In contrast, blocking CP-mediated inactivation of C5a increased these disease measures. Thus, complement regulation by both plasma FH and CP to limit the quantity of active C5a is important in conditions where the humoral immune response is directed to a continuously present foreign antigen. Signaling through C5aR1 enhances the humoral immune response as well as the inflammatory response to ICs that have formed in glomeruli. Both effects are relevant even after disease has begun. Thus, pharmacological targeting of C5a in IC-mediated GN has potential clinical relevance.

关键词： C5a carboxypeptidase N factor H glomerulonephritis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Derivation of Hydrodynamics for Multi-Relaxation Time Lattice Boltzmann using the Moment Approach

引用

Communications in Computational Physics 2013年第3期13卷 614-628页

作者： Goetz Kaehler alexander j.Wagner Department of Physics North Dakota State UniversityFargoND 58105USA

A general analysis of the hydrodynamic limit of multi-relaxation time lattice Boltzmann models is *** examine multi-relaxation time BGK collision operators that are constructed similarly to those for the MRT case,however,without explicitly moving into a moment space *** corresponding’moments’are derived as left eigenvectors of said collision operator in velocity *** we can,in a representation independent of the chosen base velocity set,generate the conservation *** find a significant degree of freedom in the choice of the collision matrix and the associated basis which leaves the collision operator *** explain why MRT implementations in the literature reproduce identical hydrodynamics despite being based on different orthogonalization *** importantly,however,we outline a minimal set of requirements on the moment base necessary to maintain the validity of the hydrodynamic *** is particularly useful in the context of position and time-dependent moments such as those used in the context of peculiar velocities and some implementations of fluctuations in a lattice-Boltzmann simulation.

关键词： Lattice Boltzmann kinetic theory Navier-Stokes hydrodynamics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of lattice relaxations on phase transitions in a high-entropy alloy studied by machine-learning potentials

引用

npj.Computational Materials 2019年第1期5卷 670-676页

作者： Tatiana Kostiuchenko Fritz Körmann j.rg Neugebauer alexander Shapeev Skolkovo Institute of Science and Technology Skolkovo Innovation CenterNobel St.3Moscow 143026Russia Computational Materials Design Max-Planck-Institut für Eisenforschung GmbH40237 DüsseldorfGermany Materials Science and Engineering Delft University of Technology2628 CD DelftThe Netherlands

Recently,high-entropy alloys(HEAs)have attracted wide attention due to their extraordinary materials properties.A main challenge in identifying new HEAs is the lack of efficient approaches for exploring their huge compositional *** initio calculations have emerged as a powerful approach that complements ***,for multicomponent alloys existing approaches suffer from the chemical complexity *** this work we propose a method for studying HEAs *** approach is based on the application of machine-learning potentials based on ab initio data in combination with Monte Carlo *** high efficiency and performance of the approach are demonstrated on the prototype bcc NbMoTaW *** approach is employed to study phase stability,phase transitions,and chemical short-range *** importance of including local relaxation effects is revealed:they significantly stabilize single-phase formation of bcc NbMoTaW down to room ***,a so-far unknown mechanism that drives chemical order due to atomic relaxation at ambient temperatures is discovered.

关键词： alloy relaxation entropy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于分布格模型的英语词类习得研究

引用

外语教学与研究 2017年第1期49卷 111-123页

作者：朱海婷 alexander clark 北京航空航天大学伦敦国王学院

本文采用新型的词类学习模型—分布格学习模型,考察分布特征对词类习得的影响。分布格是以词的分布特征相似性为基础的一种分析模型。本文选取英语儿童语料库Brent中100个高频词和500个高频语境作为学习对象,通过该模型计算100个高频词... 详细信息

本文采用新型的词类学习模型—分布格学习模型,考察分布特征对词类习得的影响。分布格是以词的分布特征相似性为基础的一种分析模型。本文选取英语儿童语料库Brent中100个高频词和500个高频语境作为学习对象,通过该模型计算100个高频词的分布特征相似性并进行分类,生成一系列词类。研究发现,分布格学习模型可以准确地生成名词、动词、形容词、代词、副词等一系列常见的词类,总体准确率为90%,其中动词的准确率高达94%,进一步验证分布特征在词类形成中发挥着重要作用。

关键词：语言习得词类学习分布特征分布格模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A plant-based diet and hypertension

引用

j.urnal of Geriatric Cardiology 2017年第5期14卷 327-330页

作者： Sarah alexander Robert j.Ostfeld Kathleen Allen Kim A Williams Rush University Medical Center Division of Cardiology Chicago IL USA Montefiore Medical Center Division of Cardiology Bronx NY USA New York University Department of Nutrition & Food Studies NY USA

Hypertension is an insidious, common, and deadly dis-ease, often detected incidentally at a routine doctor＇s visit orworkplace health screening. Worldwide, it is estimated thatone billion people have hypertension and... 详细信息

关键词： Hypertension Vegan Vegetarian Plant-based diet

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phonon imaging in 3D with a fibre probe

引用

Light(Science & Applications) 2021年第6期10卷 1007-1019页

作者： Salvatore La Cavera III Fernando Perez-Cota Richard j.mith Matt clark Optics and Photonics Group Faculty of EngineeringUniversity of NottinghamUniversity ParkNottingham NG72RDUK

We show for the first time that a single ultrasonic imaging fibre is capable of simultaneously accessing 3D spatial information and mechanical properties from microscopic *** novel measurement system consists of two ultrafast lasers that excite and detect high-frequency ultrasound from a nano-transducer that was fabricated onto the tip of a single-mode optical fibre.A signal processing technique was also developed to extract nanometric in-depth spatial measurements from GHz frequency acoustic waves,while still allowing Brillouin spectroscopy in the frequency ***-free and non-contact imaging performance was demonstrated on various polymer *** singular device is equipped with optical lateral resolution,2.5μm,and a depth-profiling precision of 45 nm provided by *** endoscopic potential for this device is exhibited by extrapolating the single fibre to tens of thousands of fibres in an imaging *** a device catalyses future phonon endomicroscopy technology that brings the prospect of label-free in vivo histology within reach.

关键词： fibre equipped acoustics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Weak mismatch epitaxy and structural feedback in graphene growth on copper foil

引用

Nano Research 2013年第2期6卷 99-112页

作者： Neil R. Wilson alexander j. Marsden Mohammed Saghir Catherine j. Bromley Renald Schaub Giovanni Costantini Thomas W. White Cerianne Partridge Alexei Barinov Pavel Dudin Ana M. Sanchez j.mes j. Mudd Marc Walker Gavin R. Bell Department of Physics University of Warwick Coventry CV4 7AL UK EaStCHEM School of Chemistry University of St Andrews St Andrews KY16 9ST UK Department of Chemistry University of Warwick Coventry CV4 7AL UK Sincrotrone Trieste S.Cp.A. Area Science Park 1-34012 Basovizza Trieste Italy

Graphene growth by low-pressure chemical vapor deposition on low cost copper foils shows great promise for large scale applications. It is known that the local crystallography of the foil influences the graphene growth rate. Here we find an epitaxial relationship between graphene and copper foil. Interfacial restructuring between graphene and copper drives the formation of （nl0） facets on what is otherwise a mostly Cu（100） surface, and the facets in turn influence the graphene orientations from the onset of growth. Angle resolved photoemission shows that the electronic structure of the graphene is decoupled from the copper indicating a weak interaction between them. Despite this, two preferred orientations of graphene are found, ±8° from the Cu[010] direction, creating a non-uniform distribution of graphene grain boundary misorientation angles. Comparison with the model system of graphene growth on single crystal Cu（110） indicates that this orientational alignment is due to mismatch epitaxy. Despite the differences in symmetry the orientation of the graphene is defined by that of the copper. We expect these observations to not only have importance for controlling and understanding the growth process for graphene on copper, but also to have wider implications for the growth of two-dimensional materials on low cost metal substrates.

关键词： graphene chemical vapordeposition mismatch epitaxy structural feedback low energy electrondiffraction angle resolvedphoto-emissionspectroscopy (ARPES)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surface-bound myeloperoxidase is a ligand for recognition of late apoptotic neutrophils by human lung surfactant proteins A and D

引用

Protein & Cell 2010年第6期1卷 563-572页

作者： Anne j.kel Howard clark Kenneth B.M.Reid Robert B.Sim Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK University of Southampton School of MedicineDivision of Infection Inflammation&ImmunitySouthampton General HospitalSouthampton SO166YDUK MRC Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUK

Surfactant proteins A(SP-A)and D(SP-D),both members of the collectin family,play a well established role in apoptotic cell recognition and *** in vitro data show that SP-A and SP-D interact with apoptotic neutrophils in a distinct ***-A and SP-D bind in a Ca^(2+)-dependent manner to viable and early apoptotic neutrophils whereas the much greater interaction with late apoptotic neutrophils is Ca^(2+)-*** surface molecules on the apoptotic target cells responsible for these interactions had not been identified and this study was done to find candidate target ***(MPO),a specific intracellular defense molecule of neutrophils that becomes exposed on the outside of the cell upon apoptosis,was identified by affinity purification,mass-spectrometry and western blotting as a novel binding molecule for SP-A and *** confirm its role in recognition,it was shown that purified immobilised MPO binds SP-A and SP-D,and that MPO is surface-exposed on late apoptotic ***-A and SP-D inhibit binding of an anti-MPO monoclonal Ab to late apoptotic *** microscopy confirmed that anti-MPO mAb and SP-A/SP-D colocalise on late apoptotic *** was identified as a further potential ligand for SP-A,and neutrophil defensin as a target for both proteins.

关键词： SP-A SP-D myeloperoxidase neutrophils flow cytometry mass spectrometry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of oxygen and nitrogen functionalization on the physical and electronic structure of graphene

引用

Nano Research 2015年第8期8卷 2620-2635页

作者： alexander j. Marsden Peter Brommer j.mes j. Mudd M. Adam Dyson Robert Cook Maria Asensio j.se Avila Ana Levy j.remy Sloan David Quigley Gavin R. Bell Neil R. Wilson Department of Physics University of Warwick Coventry UK Centre for Scientific Computing University of Warwick Coventry UK Synchrotron SOLEIL L'Orme des Merisiers Saint Aubin-BP 48 91192 Gifsur Yvette Cedex France

Covalent functionalization of graphene offers opportunities for tailoring its properties and is an unavoidable consequence of some graphene synthesis techniques. However, the changes induced by the functionalization are not well understood. By using atomic sources to control the extent of the oxygen and nitrogen functionalization, we studied the evolution in the structure and properties at the atomic scale. Atomic oxygen reversibly introduces epoxide groups whilst, under similar conditions, atomic nitrogen irreversibly creates diverse functionalities including substitutional, pyridinic, and pyrrolic nitrogen. Atomic oxygen leaves the Fermi energy at the Dirac point （i.e., undoped）, whilst atomic nitrogen results in a net n-doping; however, the experimental results are consistent with the dominant electronic effect for both being a transition from delocalized to localized states, and hence the loss of the signature electronic structure of graphene.

关键词： graphene functionalization chemical vapor deposition density functional theory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inherent robust stability of driver support systems

引用

Science China(Technological Sciences) 1999年第4期42卷 437-448页

作者：王龙 j. Ackermann Robust Control Group Institute of Robotics and System Dynamics German Aerospace Research CenterD-82230 Wessling Germany)

Presented are the fact that the transfer function from the front steering angle to yaw rate is strictly positive real, irrespective of the uncertain mass and uncertain velocity, how to determine the positivity margin for this transfer function (some stabilization results are obtained), and how to check the positivity of a controller family. Furthermore,by exploiting the intrinsic structure of system equations and uncertainties, a nonconservative PID stabilization criterion for driver support systems is established. Some interesting results on positivity and connections of PID controllers are shown. Finally, some extreme point results on PID α-stabilization are obtained. These results give certain explanations and j.stifications for the simulation results performed at German Aerospace Research Center.

关键词： driver support systems PID controllers positivity uncertain parameters stabilization car steering systems parameter space extreme point results.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：