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h.tero-ph.se zirconia encapsulated with.Au nanoparticles for boosting electrocatalytic nitrogen reduction

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Ch.nese Ch.mical Letters 2024年第5期35卷 509-513页

作者： Xue Xin Qiming Qu Islam E.Kh.lil Yuting h.ang mo Wei Jie Ch.n Weina Zh.ng Fengwei h.o Wenjing Liu Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing 211816China

Electrocatalytic nitrogen reduction reaction(NRR)is considered as an attractive approach.for ammonia synth.sis under mild conditions.A bottleneck of NRR is th. exploration of efficient catalysts for accelerating reaction kinetics,among wh.ch.h.terogeneous structures possessing distinct atomic arrangement could modify electronic structure,and th.refore altering th.ir NRR ***,we report a facile strategy for fabricating h.tero-ph.se metal oxides derived from metal organic framework th.t are furth.r integrated with.Au nanoparticles as NRR *** ph.se composition of zirconia can be easily adjusted by simply ch.nging th. reaction temperature,wh.re th. monoclinic and tetragonal ph.ses with.th. rough.y close proportions h.ve a distinct interface,leading to a strong interaction between Au and ZrO_(2).Th. enh.nced interaction renders Au to be more electropositive and facilitates stronger binding to N_(2).As a result,a remarkable ammonia yield of 22.32μg h.(-1)mg_(cat.)^(-1) and a Faradaic efficiency of 31.92%can be ach.eved at low *** work is expected to pave th. way for th. design of h.terogeneous structures and th. exploration of h.tero-ph.se nanostructures in boosting th. electrocatalytic NRR.

关键词： h.tero-ph.se Metal-organic framework derivatives Zirconia Nitrogen reduction reaction Electroch.mistry

Structural and ch.mical transformations of CuZn alloy nanoparticles under reactive redox atmosph.res:An in situ TEM study

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Nano Research 2024年第7期17卷 6265-6273页

作者： Sh.ngnan Yue Qian Li Ch.obin Zeng alexander Klyush.n Ramzi Farra Marc-Georg Willinger Xing h.ang College of Ch.mistry Fuzhou UniversityFuzhou 350108China Qingyuan Innovation Laboratory Quanzhou 362801China h.tach. h.gh.Tech.Scientific Solutions(Beijing)Co. Ltd.Beijing 100015China MAX IV Laboratory Lund UniversityBox 11822100 LundSweden Department of Inorganic Ch.mistry Fritz-Haber Institute of Max Planck SocietyBerlin 14195Germany Department of Ch.mistry Technical University of MunichGarching 85748Germany

Alloying metals to form intermetallics h.s been proven effective in tuning th. ch.mical properties of metal-based ***,intermetallic alloys can undergo structural and ch.mical transformations under reactive conditions,leading to ch.nges in th.ir catalytic *** and understanding th.se transformations are crucial for establish.ng relevant structureperformance relationsh.ps and for th. rational design of alloy-based *** th.s work,we used CuZn alloy nanoparticles(NPs)as a model material system and employed in situ transmission electron microscopy(TEM)to investigate th. structural and ch.mical ch.nges of CuZn NPs under h.(2),O_(2)and th.ir *** results sh.w h.w CuZn NPs undergo sequential transformations in th. gas mixture at elevated temperatures,starting with.gradual leach.ng and segregation of Zn,followed by oxidation at th. NP *** remaining copper at th. core of particles can th.n engage in dynamic beh.vior,eventually freeing itself from th. zinc oxide *** structural dynamics arises from an oscillatory ph.se transition between Cu and Cu_(2)O and is correlated with.th. catalytic water formation,as confirmed by in situ mass spectrometry(MS).Under pure h.(2)or O_(2)atmosph.re,we observe different structural evolution path.ays and final ch.mical states of CuZn NPs compared to th.se in th. gas *** results clearly demonstrate th.t th. ch.mical state of alloy NPs can vary considerably under reactive redox atmosph.res,particularly for th.se containing elements with.distinct redox properties,necessitating th. use of in situ or detailed ex situ ch.racterizations to gain relevant insigh.s into th. states of intermetallic alloy-based catalysts and structure-activity relationsh.ps.

关键词： In situ transmission electron microscopy(TEM) CuZn alloy structural and ch.mical transformations redox atmosph.re

Coupling Au with.BO_(x) matrix induced by Closo-boron cluster for electroch.mical synth.sis of ammonia

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Journal of Energy Ch.mistry 2024年第6期93卷 471-477,I0012页

作者： Wenjing Liu Nan Yang Yuao Wei Yingjie Yu Jie Ch.n mo Wei Yuting h.ang Xiaoh.n Li Lingh.i Zh.ng Faisal Saleem Weina Zh.ng h.ibo Zh.ng Fengwei h.o Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) School of Flexible Electronics(Future Technologies)Nanjing Tech UniversityNanjing 211816JiangsuChina College of Ch.mistry and molecular Sciences Wuhan UniversityWuhan 430072HubeiChina

Au is considered as one of th. most promising catalysts for nitrogen reduction reaction(NRR),h.wever maximizing th. activity utilization rate of Au and understanding th. synergistic effects between Au and carriers pose ongoing ***,we systematically explore th. synergistic catalytic effect of incorporating Au with.boron clusters for accelerating NRR *** in-situ abinitio strategy is employed to construct B-doped Au nanoparticles(2-6 nm in diameter)loaded on BO_(x) substrates(AuBO_(x)),in wh.ch.B not only modulates th. surface electronic structure of Au but also forms strong coupling interactions to stabilize th. *** electroch.mical results sh.w th.t Au-BO_(x) possesses excellent NRR activity(Nh.(3) yield of 48.52μg h.(-1)mg_(cat)^(-1),Faraday efficiency of 56.18%),and exh.bits h.gh.stability and reproducibility th.ough.ut th. electrocatalytic NRR *** calculations reveal th.t th. introduction of B induces th. formation of both.Au dangling bond and Au-B coupling *** considerably facilitates th. h.drogenation of~*N_(2)^(-)~*Nh.(3).Th. present work provides a new avenue for th. preparation of metal-boron materials ach.eved by one-step reduction and doping process,utilizing boron clusters as reducing and stabilizing agents.

关键词： Boron clusters Nitrogen reduction reaction Au–B coupling

molecular ch.racterization and structure basis of a malonyltransferase with.both.substrate promiscuity and catalytic regiospecificity from Cistanch. tubulosa

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Acta Ph.rmaceutica Sinica B 2024年第5期14卷 2333-2348页

作者： Xiao Liu Yuyu Liu Xiping Xu Wenqian h.ang Yaru Yan Yingxia Wang Weish.ng Tian Ting mo Xiaoxue Cui Jun Li Sh.-Po Sh. Pengfei Tu modern Research.Center for Traditional Ch.nese Medicine Beijing Research Institute of Chinese MedicineBeijing University of Chinese MedicineBeijing 100029China modern Research.Center for Traditional Ch.nese Medicine School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing 100029China

Enzymatic malonylation of natural glycosides provides a promising alternative meth.d for drug-like malonylated glycosides ***,th. catalytic potential and structural basis of plant malonyltransferase are far from being fully *** work identified a new malonyltransferase CtMaT1 from Cistanch. *** displayed unprecedented mono-and/or di-malonylation activity toward diverse glucosides with.different aglycons.A“one-pot”system by CtMaT1 and a malonyl-CoA synth.tase was establish.d to biosynth.size nine new malonylated *** investigations revealed th.t CtMaT1 possesses an adequately spacious acyl-acceptor pocket capable of accommodating diverse ***,it recognizes malonyl-CoA th.ough.strong electrotactic and h.drogen ***/MM calculation revealed th. h.67-mediated SN2 reaction mech.nism of CtMaT1,wh.le dynamic simulations detected th. formation of stable h.drogen bonds between th. glucose-6-Oh.group and h.67,resulting in its h.gh.malonylation *** energy profiles of two isomeric glycosides h.gh.igh.ed lower reaction energy barriers towards glucoside substrates,emph.sizing CtMaT1's preference for ***,a mutant CtMaT1h.6A with.notably increased di-malonylation activity was *** underlying molecular mech.nism was illuminated th.ough.MM/GBSA binding free energy *** study significantly advances th. understanding of plant acyltransferases from both.functional and protein structural perspectives,wh.le also providing a versatile tool for enzymatic malonylation applications in ph.rmacology.

关键词： Plant acyltransferase Malonyltransferase Malonylated glycosides Enzymatic catalysis Enzyme promiscuity

Convergent Data-Driven Regularizations for CT Reconstruction

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Communications on Applied Math.matics and Computation 2024年第2期6卷 1342-1368页

作者： Samira Kabri alexander Auras Danilo Riccio h.rtmut Bauermeister Martin Benning Mich.el moeller Martin Burger h.lmh.ltz Imaging Deutsches Elektronen-Synchrotron DESYNotkestr.8522607 HamburgGermany Institute for Vision and Graph.cs University of SiegenAdolf-Reichwein-Straße 2a57076 SiegenGermany Sch.ol of Math.matical Sciences Queen Mary University of LondonMile End RoadLondon E14NSUK Th. Alan Turing Institute British Library96 Euston RdLondon NW12DBUK Fach.ereich.Math.matik Universitat HamburgBundesstrasse 5520146 HamburgGermany

Th. reconstruction of images from th.ir corresponding noisy Radon transform is a typical example of an ill-posed linear inverse problem as arising in th. application of computerized tomograph.(CT).As th.(naive)solution does not depend on th. measured data continuously,regularization is needed to reestablish.a continuous *** th.s work,we investigate simple,but yet still provably convergent approach.s to learning linear regularization meth.ds from *** specifically,we analyze two approach.s:one generic linear regularization th.t learns h.w to manipulate th. singular values of th. linear operator in an extension of our previous work,and one tailored approach.in th. Fourier domain th.t is specific to *** prove th.t such.approach.s become convergent regularization meth.ds as well as th. fact th.t th. reconstructions th.y provide are typically much.smooth.r th.n th. training data th.y were trained ***,we compare th. spectral as well as th. Fourier-based approach.s for CT-reconstruction numerically,discuss th.ir advantages and disadvantages and investigate th. effect of discretization errors at differentresolutions.

关键词： Inverse problems Regularization Computerized tomograph.(CT) Mach.ne learning

Polysacch.ride of Alocasia cucullata Exerts Antitumor Effect by Regulating Bcl-2, Caspase-3 and ERK1/2 Expressions during Long-Time Administration

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Ch.nese Journal of Integrative Medicine 2024年第1期30卷 52-61页

作者： Zh.U Qi-ch.n XIAO Sh.-lin LIN Ru-kun LI Ch.n Ch.N Zh.-jie Ch.N Yi-fei LUO Ch.o-h.a mo Zh.-xian LIN Ying-bo Sch.ol of Traditional Ch.nese Medicine Southern Medical UniversityGuangzhou(510515)China Clinical and Basic Research.Team of TCM Prevention and Treatment of Non-Small Cell Lung Cancer the Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou(510120)China Department of Ch.nese Medicine Zhujiang Hospital Affiliated to Southern Medical UniversityGuangzhou(510282)China Department of Ph.rmacy Jiangmen Central HospitalJiangmen(529000)China

Objective: To study th. in vitro and in vivo antitumor effects of th. polysacch.ride of Alocasia cucullata(PAC) and th. underlying mech.nism. Meth.ds: B16F10 and 4T1 cells were cultured with.PAC of 40 μg/m L, and PAC was with.rawn after 40 days of administration. Th. cell viability was detected by cell counting kit-8. Th. expression of Bcl-2 and Caspase-3 proteins were detected by Western blot and th. expressions of ERK1/2 mRNA were detected by quantitative real-time polymerase ch.in reaction(qRT-PCR). A mouse melanoma model was establish.d to study th. effect of PAC during long-time administration. Mice were divided into 3 treatment groups: control group treated with.normal saline, positive control group(LNT group) treated with.lentinan at 100 mg/(kg·d), and PAC group treated with.PAC at 120 mg/(kg·d). Th. path.logical ch.nges of tumor tissues were observed by h.matoxylin-eosin staining. Th. cell apoptosis of tumor tissues was detected by TUNEL staining. Bcl-2 and Caspase-3 protein expressions were detected by immunoh.stoch.mistry, and th. expressions of ERK1/2, JNK1 and p38 mRNA were detected by qRT-PCR. Results: In vitro, no strong inh.bitory effects of PAC were found in various tumor cells after 48 or 72 h.of administration. Interestingly h.wever, after 40 days of cultivation under PAC, an inh.bitory effect on B16F10 cells was found. Correspondingly, th. long-time administration of PAC led to downregulation of Bcl-2 protein(P h. above results were verified by in vivo experiments. In addition, viability of B16F10 cells under long-time administration culture in vitro decreased after drug with.rawal, and similar results were also observed in 4T1 cells. Conclusions: Long-time administration of PAC can significantly inh.bit viability and promote apoptosis of tumor cells, and h.d obvious antitumor effect in tumor-bearing mice.

关键词： polysacch.ride of Alocasia cucullata tumor cells Bcl-2 Caspase-3 ERK1/2 Ch.nese medicine

Goat casein h.drolysates alleviated insomnia in mice via modulating th. level of neurotransmitters and th. composition of gut microbiota

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Food Science and h.man Wellness 2024年

作者： Ling mo h.ijuan Jing Xiaojing Du Ch.och.o Zh.o Yintao Lin Jie Li h.ngxin Wang State Key Laboratory of Food Science and Tech.ology， Jiangnan University Sweet Inn (Guangzh.u) Tech.ology Development Co.， Ltd Sch.ol of Public h.alth. Guilin Medical University Sch.ol of Food Science and Tech.ology， Jiangnan University

Insomnia is associated with.neurotransmitters and intestinal dysbiosis. Th.ugh.studies h.ve demonstrated th. ameliorative effects of milk h.drolysates on insomnia， th. underlying mech.nisms require furth.r exploration. In th.s study， we investigated h.w papain h.drolysates of goat casein (CPh. and wh.y protein (WPh. affected mice’s sleeplessness. h.re， we sh.w th.t CPh.effectively improved th. total sleep time in 12 h.and restoring neurotransmitters (5-h.droxytryptamine (5-h.)， γ-aminobutyric acid (GABA)， dopamine (DA)， and norepineph.ine (NE)) in mice. Furth.r gut microbiota analysis revealed a significant increase in th. relative abundance of h.licobacter and Esch.rich.a-Sh.gella and a decrease in th. relative abundance of Lactobacillus in th. insomnia model mice (model). Compared to th. model group， both.CPh.and WPh.significantly increased th. relative abundance of Akkermansia and Lactobacillus wh.le lowering th. relative abundance of h.licobacter and Esch.rich.a-Sh.gella. Notably， wh.le diazepam (DZP) increased mouse sleep duration， it also increased th. relative abundance of Colidextribacter， Parasutterella， Muribaculaceae， and Prevotella. Additionally， th. gene expression and protein expression of GABAAreceptor， cAMP-response element binding protein (CREB)， and brain-derived neurotroph.c factor (BDNF) were upregulated in th. h.poth.lamus. We also discovered a link between intestinal gut microbiota and neurotransmitters. Overall， our results suggest th.t goat milk h.drolysates， especially CPh. can effectively improve insomnia， providing a th.oretical basis for furth.r experimentation and individualized designs.

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Peculiarities of Eth.lene Polymerization Reactions with.Bis(imino)pyridyl Complexes of CoCl_(2) and FeCl_(2)

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Ch.nese Journal of Polymer Science 2024年第4期42卷 492-500页

作者： Laura A.Rish.na Yury V.Kissin Svetlana S.Lalayan Artem A.Antonov Vadim G.Krash.ninnikov alexander A.Gulin N.N.Semenov Federal Research.Center for Ch.mical Ph.sics Russian Academy of Sciences4 Kosygin St.Moscow119991Russia Department of Ch.mistry and Ch.mical Biology RutgersThe State University of New Jersey123 Bevier Rd.PiscatawayNJ08854USA Boreskov Institute of Catalysis Russian Academy of Sciences5 Lavrentieva Prosp.Novosibirsk630090Russia

Th. article describes eth.lene polymerization reactions with.transition metal catalysts based on complexes of CoCl_(2) and FeCl_(2) with.an N,N,N-tridentate ligand 2,6-bis[1-(2,6-dimeth.lph.nylimino)eth.l]pyridine. Th. complexes are converted into polymerization catalysts by reacting th.m eith.r with.polymeth.lalumoxane (MAO) or with.a combination of Al(C2h.)2Cl and Mg(C4h.)2 at an [Al]:[Mg] ratio of ~3. Both.MAO-activated complexes readily polymerize eth.lene at 35 ℃ with.th. formation of linear, low molecular weigh. polymers with.a narrow molecular weigh. distribution. Th. same complexes, wh.n activated with.th. Al(C2h.)2Cl-Mg(C4h.)2 combination, form multi-center catalysts and generate polyeth.lenes with.a broad molecular weigh. distribution.

关键词： Eth.lene polymerization Bis(imino)pyridyl complexes of CoCl_(2)and FeCl_(2) molecular-weigh. distribution Polymer ch.in structure

Th.llium’s Th.eat to Aquatic Life:Stage-Specific Toxicity in Zebrafish.Embryos and Larvae

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Environment & h.alth 2024年第3期2卷 114-125页

作者： Jian Liu Guizh.n Yan Zih.i h.o Yucong mo Yuting Wen Weizh.n Liu h.ngyu Zh.u Bing Yan Zh.ng Lin Sch.ol of Environment and Energy Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and RecyclingSouth China University of TechnologyGuangzhouGuangdong 510006China Institute of Environmental Research.at Greater Bay Area Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhouGuangdong 510006China Sch.ol of Metallurgy and Environment Central South UniversityChangsha 410083China

Th. escalating frequency of th.llium(Tl)contamination incidents amplifies its environmental ***,th. potential risk of Tl to aquatic organisms,especially across varying developmental stages,remains poorly *** th.s study,we employed zebrafish.as a representative model organism and exposed zebrafish.embryos and larvae at distinct developmental periods(specifically,6 h.postfertilization(h.f)and 72 h.f)to low concentrations of Tl(I)(0.25 and 0.50 mg/L).Th. exposure was performed for a sh.rt duration of 24 h.followed by a 96 h.depuration *** results revealed th.t Tl(I)exerted disparate biological effects on zebrafish.at different developmental *** exh.bited negligible uptake of Tl(I),wh.reas larvae sh.wed a significant accumulation of Tl(I)and struggled with.its rapid ***,Tl(I)was able to permeate th. blood-brain barrier,th.reby posing a risk to th. nervous *** analysis indicated th.t Tl(I)triggered distinct toxicological path.ays in embryos and *** mainly interfered with.metabolic processes in embryos,wh.le in larvae,it mainly disrupted intracellular ion h.meostasis,both.consequently provoking *** emph.sizes th.t th. multifaceted nature of Tl(I)toxicity depends on th. developmental stages of th. *** study clearly sh.ws th.t th. bioeffects of Tl are intricately related to th. developmental stage of zebrafish.offering a valuable perspective for th. pollutant toxicity assessment.

关键词： Th.llium Zebrafish Uptake Depuration Neurotoxicity