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flap reconstruction of the abdominal wall

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Plastic and Aesthetic Research 2020年第4期7卷 20-26页

作者： Sneha Patel alexander f.mericli Sahil K.Kapur Margaret S.Roubaud Charles E.Butler Department of Plastic Surgery The University of Texas M.D. Anderson Cancer CenterHoustonTX 77030USA

Large abdominal cutaneous defects may occur in association with complex ventral hernias, trauma, tumor resection, necrotizing infections or septic evisceration. Soft tissue reconstruction of the abdominal wall is performed when there is insufficient adipocutaneous tissue to permit standard, primary closure. A number of reconstructive techniques are available, the choice of which is based on a number of factors, including the size and location of the defect, etiology, and timing of closure. In general, local fasciocutaneous advancement flaps and adjacent tissue rearrangement are the workhorse techniques, followed by regional myocutaneous flaps and free tissue transfers for the most complex and extensive of defects. Herein, we describe our approach to abdominal soft tissue reconstruction, indications, technical nuances, and management of complications.

关键词： Abdominal wall reconstruction surgical flaps pedicled flap free flap bioprosthetic mesh hernia reconstructive surgical procedures

Optical probing of ultrafast laser-induced solid-to-overdense-plasma transitions

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Light(Science & Applications) 2024年第5期13卷 973-984页

作者： Yasmina Azamoum Georg alexander Becker Sebastian Keppler Guillaume Duchateau Stefan Skupin Mickael Grech fabrice Catoire Sebastian Hell Issa Tamer Marco Hornung Marco Hellwing alexander Kessler franck Schorcht Malte Christoph Kaluza GSI Helmholtzzentrum für Schwerionenforschung Planckstr.164291 DarmstadtGermany. Helmholtz Institute Jena Fröbelstieg 307743 JenaGermany. Institute of Optics and Quantum Electronics Friedrich-SchillerUniversität JenaMax-Wien-Platz 107743 JenaGermany. CEA-CESTA 15 Avenue des SablièresCS6000133116 Le BarpCedexFrance Institut Lumière Matière UMR 5306-CNRSUniversitéde Lyon 169622 VilleurbanneFrance. LULI CNRSCEASorbonne UniversitéInstitut Polytechnique de ParisPalaiseauFrance. Universitéde Bordeaux-CNRS-CEA CELIAUMR 5107 TalenceFrance

Understanding the solid target dynamics resulting from the interaction with an ultrashort laser pulse is a challenging fundamental multi-physics problem involving atomic and solid-state physics,plasma physics,and laser *** of the initial interplay of the underlying processes is essential to many applications ranging from lowpower laser regimes like laser-induced ablation to high-power laser regimes like laser-driven ion *** the properties of the so-called pre-plasma formed as the laser pulse’s rising edge ionizes the target is complicated from the theoretical and experimental point of view,and many aspects of this laser-induced transition from solid to overdense plasma over picosecond timescales are still open *** the one hand,laser-driven ion acceleration requires precise control of the pre-plasma because the efficiency of the acceleration process crucially depends on the target properties at the arrival of the relativistic intensity peak of the *** the other hand,efficient laser ablation requires,for example,preventing the so-called“plasma shielding”.By capturing the dynamics of the initial stage of the interaction,we report on a detailed visualization of the pre-plasma formation and ***-thin diamond-like carbon foils are shown to transition from solid to plasma during the laser rising edge with intensitiesfrared probe transmission measurements evidence sub-picosecond dynamics of an expanding plasma with densities above 10^(23)cm^(−3)(about 100 times the critical plasma density).The complementarity of a solid-state interaction model and kinetic plasma description provides deep insight into the interplay of initial ionization,collisions,and expansion.

关键词： laser acceleration solid

A new look at the first dinosaur discovered in Antarctica:reappraisal of Antarctopelta oliveroi(Ankylosauria:Parankylosauria)

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Advances in Polar Science 2024年第1期35卷 78-107页

作者： Sergio SOTO ACUÑA alexander OVARGAS Jonatan KALUZA Red Paleontológica U-Chile Departamento de BiologíaFacultad de CienciasUniversidad de ChileÑuñoa 7800003Chile Escuela de Geología Facultad de CienciasIngeniería y TecnologíaUniversidad MayorProvidenciaSantiago 7500994Chile fundación de Historia Natural félix de Azara Universidad MaimónidesBuenos Aires C1405Argentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Buenos Aires C1425FQBArgentina

The first dinosaur discovered in the Antarctic continent was the ankylosaur Antarctopelta oliveroi in the ***,since then several hypotheses of phylogenetical relationships have been proposed because these have been depended on how the skeletal remains have been *** main obstacle for clarifying its phylogenetic position is that many portions of the skeleton remain unknown,in addition to the presence of unknown characters in typical *** an ankylosaurid,nodosaurid,or even a chimaera,a recent proposal based on mostly complete material of a new ankylosaur from Chilean Patagonia provided support for a novel phylogenetic hypothesis:Antarctopelta and other southern ankylosaurs are an early branching clade,the Parankylosauria,whose origin probably dates to the Late *** the light of this new view,a redescription of the available skeletal remains is provided together with a new reconstruction of the first Antarctic dinosaur known to the science community.

关键词： Antarctic Peninsula Biogeographic Weddellian Province Parankylosauria Antarctopelta

A novel diagnostic gene region for distinguishing between two pest fruit flies:Bactrocera tryoni(froggatt)and Bactrocera neohumeralis(Hardy)(Diptera:Tephritidae)

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Insect Science 2024年第4期31卷 1285-1295页

作者： Melissa L.Starkie Elizabeth V.fowler alexander M.Piper Xiaocheng Zhu Pauline Wyatt David Gopurenko Matt N.Krosch francesca Strutt Karen f.Armstrong Hamish Patrick Mark K.Schutze Mark J.Blacket Department of Agriculture and fisheries BiosecurityBrisbaneQueenslandAustralia Agriculture Victoria AgriBioBundooraVictoriaAustralia Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia forensic Services Group Queensland Police ServiceBrisbaneQueenslandAustralia Department of Pest-management and Conservation Lincoln UniversityLincolnNew Zealand Better Border Biosecurity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohumeralis are morphologically similar sibling pest fruit fly species that possess different biological attributes,geographic distributions,and host *** need to differentiate between the two species is critical for accurate pest status assessment,management,biosecurity,and maintenance of reference *** morphologically similar,adults may be separated based on subtle characters;however,some characters exhibit intraspecific variability,creating overlap between the two ***,there is currently no single molecular marker or rapid diagnostic assay that can reliably distinguish between *** and ***;therefore,ambiguous samples remain *** we report the first molecular marker that can consistently distinguish between *** and *** diagnostic region consists of two adjacent single nucleotide polymorphisms(SNPs)within the pangolin(pan)gene *** confirmed the genotypes of each species are consistent across their distributional range,then developed a tetra-primer amplification refractory mutation system(ARMS)PCR assay for rapid diagnosis of the *** assay utilizes four primers in multiplex,with two outer universal primers,and two internal primers:one designed to target two adjacent SNPs(AA)present in *** and the other targeting adjacent SNPs present in ***(GG).The assay accurately discriminates between the two species,but their SNP genotypes are shared with other nontarget tephritid fruit fly ***,this assay is most suited to adult diagnostics where species confirmation is necessary in determining ambiguous surveillance trap catches;maintaining pure colony lines;and in Sterile Insect Technique management responses.

关键词： ARMS-PCR colony molecular diagnostics pangolin tetra-primer

A new look at the first dinosaur discovered in Antarctica: reappraisal of Antarctopelta oliveroi(Ankylosauria: Parankylosauria)

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Advances in Polar Science 2024年

作者： Sergio SOTO ACU?A alexander O.VARGAS Jonatan KALUZA Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Red Paleontológica U-Chile Departamento de Biología facultad de Ciencias Universidad de Chile fundación de Historia Natural félix de Azara Universidad Maimónides Escuela de Geología facultad de Ciencias Ingeniería y Tecnología Universidad Mayor Providencia

The first dinosaur discovered in the Antarctic continent was the ankylosaur Antarctopelta oliveroi in the 1980s. Nevertheless， since then several hypotheses of phylogenetical relationships have been proposed because these have been depended on how the skeletal remains have been interpreted. The main obstacle for clarifying its phylogenetic position is that many portions of the skeleton remain unknown， in addition to the presence of unknown characters in typical ankylosaurs. Considered an ankylosaurid， nodosaurid， or even a chimaera， a recent proposal based on mostly complete material of a new ankylosaur from Chilean Patagonia provided support for a novel phylogenetic hypothesis: Antarctopelta and other southern ankylosaurs are an early branching clade， the Parankylosauria， whose origin probably dates to the Late Jurassic. In the light of this new view， a redescription of the available skeletal remains is provided together with a new reconstruction of the first Antarctic dinosaur known to the science community.

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Elucidating elusive quaternary selenide EuCeCuSe3:Synthesis,crystal structure,properties and theoretical studies

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Journal of Rare Earths 2024年第1期42卷 163-171,I0006页

作者： Maxim V.Grigoriev Anna V.Ruseikina Maxim S.Molokeev Vladimir A.Chernyshev Aleksandr S.Aleksandrovsky alexander S.Krylov Svetlana N.Krylova Nikolai P.Shestakov Dmitriy A.Velikanov alexander A.Garmonov Alexey V.Matigorov Evgeny A.Ostapchuk Thomas Schleid Damir A.Safin Laboratory of Theory and Optimization of Chemical and Technological Processes University of TyumenVolodarskogo Str.6625003TyumenRussian Federation Kirensky Institute of Physics Federal Research Center KSC SB RASAkademgorodok 50 Bld.38660036KrasnoyarskRussian Federation Department of Physics Far Eastern State Transport UniversitySerysheva Str.47680021KrasnoyarskRussian Federation Institute of Natural Sciences and Mathematics Ural Federal University Named After the First President of Russia B.N.YeltsinMira Str.19620002EkaterinburgRussian Federation Department of Photonics and Laser Technology Siberian Federal UniversitySvobodnii Ave.79660079KrasnoyarskRussian Federation Institute of Physics and Technology University of TyumenVolodarskogo Str.6625003 TyumenRussian Federation Institute for Inorganic Chemistry University of StuttgartPfaffenwaldring 55D-70569StuttgartGermany Scientific and Educational and Innovation Center for Chemical and Pharmaceutical Technologies Ural Federal University named after the First President of Russia B.N.YeltsinMira Str.19620002 EkaterinburgRussian Federation University of Tyumen Volodarskogo Str.6625003TyumenRussian Federation

We report on the novel heterometallic quaternary selenide EuCeCuSe3,the fabrication of which has been a challenge until this *** structure of the reported selenide was elucidated from the powder X-ray diffraction data,which revealed the formation of EuCeCuSe3with excellent yield(96.7%)accompanied with a minor fraction of CeSe2(3.3%),and was best solved in orthorhombic space group Pnma with the BaLaCuS3structural ***,the crystal structure of the title compound completes the row of the heterometallic quaternary selenides EuRECuSe3(RE=La,Pr,Nd,Sm,Eu,Gd,Tb,Dy,Ho,Er,Tm,Yb,Lu,Y),of which the cerium-based derivative exclusively belongs to the BaLaCuS3structural *** distortion of the CuSe4polyhedron was compared for the whole series of EuRECuSe3compounds using theτ4-descriptor for four coordinated ions,which revealed the highest degree of distortion for the Ce3+-containing selenide,followed by the La3+-based ***,the crystallographic and geometrical parameters of the reported selenide were discussed in comparison to the Ce3+-based sulfides SrCeCuS3and *** initio calculations of the crystal structure,a phonon spectrum and elastic constants for the crystal of EuCeCuSe3were also *** types and wavenumbers of fundame ntal modes were determined and the involvement of ions participating in the phonon modes was *** experimental IR spectrum of the reported selenide was interpreted and found to be in agreement with the calculated *** experimental direct band gap of EuCeCuSe3was measured to be 1.36 eV that is consistent with the concept of its origin due to interband transitions between orbitals emerging mainly from 4f(valence band)and 5d(conduction band)levels of the Eu2+*** dependence of the Young’s modulus on the direction demonstrates the anisotropy of the elastic properties,while the Vickers hardness for EuCeCuSe3was calculated to be 5.2 ***,the title compound is paramagnetic above 4 K.

关键词： Quaternary selenide Synthesis Crystal structure Ab initio calculations Magnetic measurements Spectroscopy

Linking IL-10 signaling with lipid metabolic programs in macrophages:dysregulated ceramide homeostasis drives colitis

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2835-2836页

作者： Imke Atreya Markus f.Neurath Department of Medicine 1 University Hospital of ErlangenFriedrich-Alexander University Erlangen-NürnbergErlangenGermany Deutsches Zentrum Immuntherapie(DZI) ErlangenGermany

In a recent study published in Nature,York and coworkers identified the immunometabolic regulation of mono-unsaturated fatty acid(MUfA)pools and the subsequent increase in sphingolipid biosynthesis in TLR2-activated macrophages as an important link between impaired IL-10 signaling and the development of intestinal inflammation.1 Thus,targeted interference with the newly identified IL-10/MUfA/sphingolipid axis appears as a promising strategy to restore immunometabolic homeostasis in the intestine of patients with inflammatory bowel diseases(IBD).

关键词： homeostasis impaired intestine

Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

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Bone Research 2024年第1期12卷 180-198页

作者： Morten S.Hansen Kaja Madsen Maria Price Kent Søe Yasunori Omata Mario M.Zaiss Caroline M.Gorvin Morten frost alexander Rauch Molecular Endocrinology Laboratory(KMEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and Systems Research(IMSR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for Membrane Proteins and Receptors(COMPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(fLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(ffAR4/GPR120).Activating C5AR1 enhanced osteoclast formation,while activating SSTR2 decreased the resorptive activity of mature osteoclasts,and activating ffAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

Improved training framework in a neural network model for disruption prediction and its application on EXL-50

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Plasma Science and Technology 2024年第5期26卷 29-39页

作者：蔡剑青梁云峰 alexander KNIEPS 齐东凯王二辉向皓明廖亮黄杰阳杰黄佳刘建文 Philipp DREWS 徐帅顾翔高轶琛罗宇李直 the EXL-50 Team Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China forschungszentrum Jülich GmbH Institut für Energie-und Klimaforschung-PlasmaphysikPartner of the Trilateral Cluster(TEC)Jülich 52425Germany ENN Science and Technology Development Co. LtdLangfang 065001People’s Republic of China

A neural network model with a classical annotation method has been used on the EXL-50tokamak to predict impending ***,the results revealed issues of overfitting and overconfidence in predictions caused by inaccurate *** mitigate these issues,an improved training framework has been *** this approach,soft labels from previous training serve as teachers to supervise the further learning process;this has lead to a significant improvement in predictive model ***,this enhancement is primarily attributed to the coupling effect of the soft labels and correction *** improved training framework introduces an instance-specific label smoothing method,which reflects a more nuanced model assessment on the likelihood of a *** presents a possible solution to effectively address the challenges associated with accurate labeling across different machines.

关键词： neural network disruption soft label EXL-50 tokamak