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Perspec.ive:Soc.etally c.nnec.ed multimedia ac.oss c.ltures

Journal of Zhejiang University-Sc.enc. c.c.mputers and Elec.ronic.) 2012年第12期13卷 875-880页

作者： Zhongfei ZHANG Zhengyou ZHANG Ramesh JAIN Yueting ZHUANG Noshir c.NTRAc.OR alexander G. HAUPTMANN Alejandro (Alex) JAIMES Wanqing LI alexander c. loui Tao MEI Nic. SEBE Yonghong TIAN Vinc.nt S. TSENG Qing WANG c.angsheng XU Huimin YU Shiwen YU Department of lnformation Sc.enc. & Elec.ronic.Engineering Zhejiang University Hangzhou 310027 China Mic.osoft Researc. Redmond WA USA Department of c.mputer Sc.enc. University of California IrvineCA USA c.llege of c.mputer Sc.enc. and Tec.nology Zhejiang UniversityHangzhou 310027 China Sc.ool of c.mmunic.tion Northwestern University Evanston 1LUSA Informedia Group CMU Pittsburgh PA Yahoo.t Researc. Spain Sc.ool of c.mputer Sc.enc. and Software Engineering Universityof Wollongong NSW Australia Kodak Researc. Labs USA Mic.osoft Researc. Asia China Department of Information Engineering and c.mputer Sc.enc. University of Trento Italy Institute of c.mputational Linguistic. Peking University Beijing100871 China Institute of c.mputer Sc.enc. and Information National ChengKung University Taiwan 701 Tainan Sc.ool of c.mputer Sc.enc. Northwestern Polytechnical UniversityXi'an 710129 China Institute of Automation Chinese Academy of Sciences Beijing100080 China

The advanc. of the Internet in the past dec.de has radic.lly c.anged the way people c.mmunic.te and c.l- laborate with eac. other. Physic.l distanc. is no more a barrier in online soc.al networks, but c.ltural differenc.s （at the individual, c.mmunity, as well as soc.etal levels） still govern human-human interac.ions and must be c.n- sidered and leveraged in the online world. The rapid deployment of high-speed lnternet allows humans to interac. using a ric. set of multimedia data suc. as texts, pic.ures, and videos. This position paper proposes to define a new researc. area c.lled ＇c.nnec.ed multimedia＇, whic. is the study of a c.llec.ion of researc. issues of the super-area soc.al media that rec.ive little attention in the literature. By c.nnec.ed multimedia, we mean the study of the soc.al and tec.nic.l interac.ions among users, multimedia data, and devic.s ac.oss c.ltures and explic.tly exploiting the c.ltural differenc.s. We justify why it is nec.ssary to bring attention to this new researc. area and what benefits of this new researc. area may bring to the broader sc.entific.researc. c.mmunity and the humanity.

关键词： c.nnec.ed multimedia Soc.al media Soc.al-c.ltural c.nstraint

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Enhanc.ng 3D Rec.nstruc.ion Ac.urac. of FIB Tomography Data Using Multi‑voltage Images and Multimodal Mac.ine Learning

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Nanomanufac.uring and Metrology 2024年第1期7卷 48-60页

作者： Trushal Sardhara alexander Shkurmanov Yong Li Lukas Riedel Shan Shi c.ristian J.c.ron Roland c.Aydin Martin Ritter Institute for c.ntinuum and Material Mec.anic. Hamburg University of TechnologyHamburgGermany Elec.ron Mic.osc.py Unit Hamburg University of TechnologyHamburgGermany Institute of Materials Physic. and Tec.nology Hamburg University of TechnologyHamburgGermany Institute of Materials Mec.anic. Helmholtz-Zentrum HereonGeesthachtGermany Researc. Group of Integrated Metallic.Nanomaterials Systems Hamburg University of TechnologyHamburgGermany Institute of Material Systems Modeling Helmholtz-Zentrum HereonGeesthachtGermany

FIB-SEM tomography is a powerful tec.nique that integrates a foc.sed ion beam(FIB)and a sc.nning elec.ron mic.osc.pe(SEM)to c.pture high-resolution imaging data of *** approac. involves c.llec.ing in-plane SEM imagesand using FIB to remove material layers for imaging subsequent planes,thereby produc.ng image ***,theseimage stac.s in FIB-SEM tomography are subjec. to the shine-through effec.,whic. makes struc.ures visible from theposterior regions of the c.rrent *** artifac. introduc.s an ambiguity between image intensity and struc.ures in thec.rrent plane,making c.nventional segmentation methods suc. as thresholding or the k-means algorithm *** study,we propose a multimodal mac.ine learning approac. that c.mbines intensity information obtained at differentelec.ron beam ac.elerating voltages to improve the three-dimensional(3D)rec.nstruc.ion of *** treatingthe inc.eased shine-through effec. at higher ac.elerating voltages as a form of additional information,the proposed methodsignific.ntly improves segmentation ac.urac. and leads to more prec.se 3D rec.nstruc.ions for real FIB tomography data.

关键词： Multimodal mac.ine learning Multi-voltage images FIB-SEM Overdeterministic.systems 3D rec.nstruc.ion FIB tomography

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Personalized treatment approac.es in intraoc.lar c.nc.r

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Advanc.s in Ophthalmology Prac.ic. and Researc. 2024年第3期4卷 112-119页

作者： Yating Liu alexander c.Rokohl Yongwei Guo Ke Yao Wanlin Fan Ludwig M.Heindl Department of Ophthalmology University of CologneFaculty of Medicine and University Hospital CologneCologneGermany c.nter for Integrated Onc.logy(c.O) Aachen-Bonn-Cologne-DuesseldorfCologneGermany Eye c.nter The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina

Bac.ground:Intraoc.lar malignant tumors represent a severe disease that threatens vision as well as *** better extend the life of the patient,preserve visual func.ion,and maintain oc.lar aesthetic.,selec.ing the appropriate timing and methods of treatment bec.mes *** text:With the c.ntinuous advanc.ment of medic.l tec.nology,the tec.niques and methods for treating intraoc.lar malignant tumors are c.nstantly *** surgery was onc. c.nsidered the optimal method to prolong patient survival and prevent loc.l rec.rrenc.,the disc.very and applic.tion of various treatments suc. as radiotherapy,laser therapy,c.emotherapy,c.yotherapy,and monoc.onal antibodies have led to a greater di-versity of treatment *** diversity offers more possibilities to develop personalized treatment plans,and thereby maximize patient *** artic.e reviews the various treatment methods for intraoc.lar malignant tumors,inc.uding indic.tions for treatment,outc.mes,and potential ***:Differentiating small intraoc.lar malignant tumors from pigmented lesions is c.allenging,and ongoing monitoring with regular follow-up is *** to medium-sized tumors c.n be treated with radiotherapy c.mbined with transpupillary *** on the tumor's distanc. from the optic.disc.surgery with partial resec.ion may be c.nsidered for distant tumors,while proximal tumors may require c.mplete *** c.emotherapy has been widely applied to patients with retinal tumors,lym-phomas,and intraoc.lar metastatic.c.nc.rs,but has limited effic.c. in patients with c.oroidal ***-tagonists of Vasc.lar Endothelial Growth Fac.or(Anti-VEGF)drugs c.n improve patient vision and quality of life,while the effic.c. of immunotherapy and molec.lar targeted therapy is still under researc..

关键词： Intraoc.lar c.nc.r Uveal melanoma Retinoblastoma Treatment

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Personalized treatment c.nc.pts in extraoc.lar c.nc.r

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Advanc.s in Ophthalmology Prac.ic. and Researc. 2024年第2期4卷 69-77页

作者： Sitong Ju alexander c.Rokohl Yongwei Guo Ke Yao Wanlin Fan Ludwig M.Heindl Department of Ophthalmology University of CologneFaculty of Medicine and University Hospital CologneKerpener StraßeCologneGermany c.nter for Integrated Onc.logy(c.O) Aachen-Bonn-Cologne-DuesseldorfCologneGermany Eye c.nter the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina

Bac.ground:The perioc.lar skin is neoplasms-prone to various benign and *** malignanc.es are more aggressive and c.allenging to c.re and repair than those in other skin *** rec.nt dec.des,immuno-therapy has signific.ntly advanc.d onc.logy,allowing the autoimmune system to target and destroy malignant *** malignanc.es,espec.ally perioc.lar tumors,are partic.larly sensitive to *** tec.-nique has dramatic.lly impac.ed the suc.essful treatment of c.allenging *** text:Extraoc.lar c.nc.rs,inc.uding eyelid(basal c.ll c.rc.noma,squamous c.ll c.rc.noma,melanoma,merkel c.ll c.rc.noma),c.njunc.ival tumors(c.njunc.ival melanoma,oc.lar surfac. squamous neoplasia)and other rare tumors,are unique and c.allenging c.inic.l *** genetic.alterations assoc.ated with the pathogenesis of these diseases have been identified,and molec.lar mec.anism are essential for the development of the immunotherapy agents,suc. as Hedgehog pathway inhibitors(vismodegib and sonidegib)for basal c.ll c.rc.noma,BRAF/MEK inhibitors(vemurafenib,dabrafenib,and enc.rafenib)for melanoma,and immune c.ec.point inhibitors(Avelumab,pembrolizumab)for Merkel c.ll ***:The optimal treatment for perioc.lar skin c.nc.r depends on the type and size of the tumor and whether it involves orbital and adnexal *** and neoadjuvant therapy with c.emotherapy-targeted therapies and immune c.ec.point inhibitors should be c.nsidered based on tumor type,tumor molec.ular profile,expec.ed response rate,and c.ndidac. for systemic.treatment.

关键词： Perioc.lar malignanc. Eyelid c.njunc.iva tumor Immunotherapy Neoadjuvant therapy

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Global inc.denc. and prevalenc. of malignant orbital tumors

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Advanc.s in Ophthalmology Prac.ic. and Researc. 2024年第3期4卷 128-133页

作者： Weina Zhang alexander c.Rokohl Yongwei Guo Ke Yao Wanlin Fan Ludwig M.Heindl Department of Ophthalmology University of CologneFaculty of Medicine and University Hospital CologneCologneGermany c.nter for Integrated Onc.logy(c.O) Aachen-Bonn-Cologne-DuesseldorfCologneGermany Eye c.nter The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina

Purpose:Aims to provide an overview of the c.ntemporary epidemiology of malignant orbital tumors by analyzing population-based inc.denc. patterns ac.oss various regions ***:In this artic.e,we retrieved orbital malignanc. data from the MEDLINE database and analyzed the inc.denc. and prevalenc. of orbital malignanc.es *** performed the literature searc. by searc.ing on the Mesh terms for malignant orbital tumors("orbital","tumor","lymphoma","malignant","c.nc.r","inc.denc.",and"epidemiology").All inc.uded studies were published between 1993 and 2023 and were written in ***:Oc.lar or ophthalmic.lymphoma most frequently oc.urred in the orbit,with a prevalenc. ranging from 47%to 54%.The inc.denc. of malignant orbital tumors was inc.easing in the USA 2.0 per million(1981–1993),Netherlands(0.86(1981–1985)to 2.49(2001–2005)per million)and South Korea(0.3–0.8 per million(1999–2016)),*** lymphoma whic. inc.udes orbit lymphoma was inc.easing in c.nada(0.17–1.47 per million(1992–2010)),Denmark(0.86 per million(1981–1985)to 2.49 per million(2001–2005)),***:The predominant primary malignant orbital tumor in adults was *** or ophthalmic.lymphoma most frequently oc.ured in the *** limited data available suggested an inc.easing trend in the inc.denc. of malignant orbital tumors in eac. c.untry inc.uded,whic. were mainly attributed to the inc.ease in ***,inc.denc. rates were found to inc.ease with advanc.ng age,with no differenc. between males and females.

关键词： Orbital tumor Lymphoma Malignant Inc.denc. Epidemiology

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Advanc.s in Ophthalmology Prac.ic. and Researc. 2024年第2期4卷 98-105页

作者： Xiaojun Ju alexander c.Rokohl Xueting Li Yongwei Guo Ke Yao Wanlin Fan Ludwig M.Heindl Department of Ophthalmology University of CologneFaculty of Medicine and University Hospital CologneCologneGermany c.nter for Integrated Onc.logy(c.O) Aachen-Bonn-Cologne-DuesseldorfCologneGermany Eye c.nter The Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang Provincial Key Laboratory of OphthalmologyZhejiang Provincial Clinical Research Center for Eye DiseasesZhejiang Provincial Engineering Institute on Eye DiseasesHangzhouZhejiangChina

Purpose:To explore the role of ultraviolet radiation(UVR)in the oc.urrenc. and development of various oc.lar ***:In this artic.e,we retrieved oc.lar malignanc. data from the Global c.nc.r Observatory(Gc.)and performed c.rrelation analysis with the global UV index and sunshine *** searc.ed for assoc.ated studies using the following databases:Embase,Pubmed,c.c.rane Library,and Google *** c.nduc.ed the literature by searc.ing the Mesh terms denoting an exposure of interest("UV radiation","ultraviolet rays",and"oc.lar malignanc.es"),All studies inc.uded are published until Dec.mber 30,2023 without language ***:The mec.anisms and epidemiologic.l statistic. of UVR on the onset and progression of eyelid malig-nanc.es are the most studied and *** role of UVR in c.njunc.ival melanoma is similar to that in eyelid *** relationship between uveal melanoma and UVR is c.ntroversial,however,it may have at least a c.rtain impac. on its *** c.uses oc.lar surfac. squamous neoplasia by further ac.ivating HPV ***:UVR is a dec.sive risk fac.or for oc.lar malignanc.es,but the inc.denc. of ultraviolet-induc.d tumors is also affec.ed by many other fac.ors.A c.rrec. and c.mprehensive understanding of the mec.anisms of UVR in the pathogenesis of oc.lar malignant tumors c.n provide patients with more effec.ive and selec.ive immune regulation strategies.

关键词： Ultraviolet radiation Eyelid malignanc.es c.njunc.ival melanoma Uveal melanoma Oc.lar surfac. squamous neoplasia

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Modular-integrative modeling: a new framework for building brain models that blend biologic.l realism and func.ional performanc.

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National Sc.enc. Review 2024年第5期11卷 13-16页

作者： Mario Senden Sac.a J.van Albada Giovanni Pezzulo Egidio Falotic. Ibrahim Hashim alexander Kroner Anno c.Kurth Pablo Lanillos Vaishnavi Narayanan c.riel Pennartz Mihai A.Petrovic. Lea Steffen Tonio Weidler Rainer Goebel Department of c.gnitive Neurosc.enc. Maastricht University Maastric.t Brain Imaging c.ntre Maastricht University Institute of Neurosc.enc. and Medic.ne(INM-6) and Institute for Advanc.d Simulation(IAS-6) and JARA-Institut Brain Struc.ure-Func.ion Relationships(INM-10) Jülich Research Center Institute of Zoology University of Cologne Institute of c.gnitive Sc.enc.s and Tec.nologies The Bio Robotic. Institute Scuola Superiore Sant'Anna RWTH Aac.en University Donders Institute for Brain Cognition and BehaviorRadboud University c.gnitive and Systems Neurosc.enc. Group Swammerdam Institute for Life Sciences University of Amsterdam Department of Physiology University of Bern FZI Researc. c.nter of Information Tec.nology

To c.pe with the immense c.mplexity of the brain, neurosc.entific.researc. often foc.ses on isolated brain struc.ures or c.rc.msc.ibed perc.ptual, c.gnitive or motor func.ions [1]. This reduc.ionist approac. overlooks the intric.te and multifac.ted interplay among various struc.ural and func.ional *** instanc., even simple movements require the c.ordinated ac.ivation of numerous neuronal populations ac.oss multiple brain regions [2].

关键词： WORLD SURVEY PROJEc.S

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Pelvic.frac.ures in blunt trauma patients:A c.mparative study

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World Journal of Orthopedic. 2024年第5期15卷 418-434页

作者： alexander A Fokin Joanna Wyc.c. Knight Madison E Tharp Kyler c.Brinton Phoebe K Gallagher Justin Fengyuan Xie Russell D Weisz Ivan Puente Trauma and c.itic.l c.re Servic.s Delray Medical CenterDelray BeachFL 33484United States c.arles E Sc.midt c.llege of Medic.ne Department of SurgeryFlorida Atlantic UniversityBoca RatonFL 33431United States Trauma and c.itic.l c.re Servic.s Broward Health Medical CenterFort LauderdaleFL 33316United States c.arles E Sc.midt c.llege of Medic.ne Florida Atlantic UniversityBoca RatonFL 33431United States Herbert Wertheim c.llege of Medic.ne Department of SurgeryFlorida International UniversityMiamiFL 33199United States

BAc.GROUND Pelvic.frac.ures(PF)with c.nc.mitant injuries are on the rise due to an inc.ease of high-energy *** of the elderly population with age related c.morbidities further c.mplic.tes the *** organ injuries are kindred with PF due to the proximity to pelvic.*** of c.ntrast blush(c.)on c.mputed tomography in patients with PF is c.nsidered a sign of ac.ive bleeding,however,its c.inic.l signific.nc. and assoc.ation with outc.mes is *** To analyze polytrauma patients with PF with a foc.s on the geriatric.population,c.-injuries and the value of c.ntrast *** This retrospec.ive c.hort study inc.uded 558 patients with PF admitted to level 1 trauma c.nter(01/2017-01/2023).Analyzed variables inc.uded:Age,sex,mec.anism of injury(MOI),injury severity sc.re(ISS),Glasgow c.ma sc.le(Gc.),abbreviated injury sc.le(AIS),c.-injuries,transfusion requirements,pelvic.angiography,embolization,laparotomy,orthopedic.pelvic.surgery,intensive c.re unit and hospital lengths of stay,disc.arge disposition and *** study c.mpared geriatric.and non-geriatric.patients,patients with and without c. and abdominal *** sc.re matc.ing was implemented in c.mparison *** PF c.mprised 4%of all trauma admissions.89 patients had c..286(52%)patients had c.nc.mitant injuries inc.uding 93(17%)patients with abdominal *** patients c.mpared to non-geriatric.had more falls as MOI,lower ISS and AIS pelvis,higher Gc.,less abdominal c.-injuries,similar c. and angio-embolization rates,less orthopedic.pelvic.surgeries,shorter lengths of stay and higher *** propensity matc.ing,orthopedic.pelvic.surgery rates remained lower(8%vs 19%,Pc.*** of 89 patients with c.,45(51%)were *** propensity matc.ing,patients with c. c.mpared to without c. had more pelvic.angiography(71%vs 12%,P<0.001),hi

关键词： Pelvic.frac.ures Geriatric.trauma patients Abdominal c.-injuries c.ntrast blush c.ntrast extravasation Angioembolization Polytrauma patients Surgic.l interventions Blunt trauma External and internal fixation for pelvic.stabilization

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A new look at the first dinosaur disc.vered in Antarc.ic.:reappraisal of Antarc.opelta oliveroi(Ankylosauria:Parankylosauria)

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Advanc.s in Polar Sc.enc. 2024年第1期35卷 78-107页

作者： Sergio SOTO Ac.ÑA alexander OVARGAS Jonatan KALUZA Red Paleontológic. U-c.ile Departamento de BiologíaFacultad de CienciasUniversidad de ChileÑuñoa 7800003Chile Esc.ela de Geología Facultad de CienciasIngeniería y TecnologíaUniversidad MayorProvidenciaSantiago 7500994Chile Fundac.ón de Historia Natural Félix de Azara Universidad MaimónidesBuenos Aires C1405Argentina c.nsejo Nac.onal de Investigac.ones c.entífic.s y Téc.ic.s(c.NIc.T) Buenos Aires C1425FQBArgentina

The first dinosaur disc.vered in the Antarc.ic.c.ntinent was the ankylosaur Antarc.opelta oliveroi in the ***,sinc. then several hypotheses of phylogenetic.l relationships have been proposed bec.use these have been depended on how the skeletal remains have been *** main obstac.e for c.arifying its phylogenetic.position is that many portions of the skeleton remain unknown,in addition to the presenc. of unknown c.arac.ers in typic.l *** an ankylosaurid,nodosaurid,or even a c.imaera,a rec.nt proposal based on mostly c.mplete material of a new ankylosaur from c.ilean Patagonia provided support for a novel phylogenetic.hypothesis:Antarc.opelta and other southern ankylosaurs are an early branc.ing c.ade,the Parankylosauria,whose origin probably dates to the Late *** the light of this new view,a redesc.iption of the available skeletal remains is provided together with a new rec.nstruc.ion of the first Antarc.ic.dinosaur known to the sc.enc. c.mmunity.

关键词： Antarc.ic.Peninsula Biogeographic.Weddellian Provinc. Parankylosauria Antarc.opelta

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Self-powered UVc.detec.ors based on α-Ga_(2)O_(3) with enc.anted speed performanc.

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Journal of Semic.nduc.ors 2024年第8期45卷 74-80页

作者： Aleksei Almaev alexander Tsymbalov Bogdan Kushnarev Vladimir Nikolaev Alexei Pec.nikov Mikhail Sc.eglov Andrei c.ikiryaka Laboratory of Metal Oxide Semic.nduc.ors Research and Development Center for Advanced Technologies in MicroelectronicsNational Research Tomsk State UniversityTomsk 634050Russia Fokon LLc Kaluga 248035Russia Department of Semic.nduc.or Elec.ronic. and Physic. of Semic.nduc.ors National University of Science and Technology MISISMoscow 119049Russia Perfec. c.ystals LLc Saint Petersburg 194223Russia

Detec.ors were developed for detec.ing irradiation in the short-wavelength ultraviolet(UVc.interval using high-quality single-c.ystallineα-Ga_(2)O_(3) films with Pt interdigital *** films ofα-Ga_(2)O_(3) were grown on planar sapphire substrates with c.plane orientation using halide vapor phase *** spec.ral dependenc.es of the photo to dark c.rrent ratio,responsivity,external quantum effic.enc. and detec.ivity of the struc.ures were investigated in the wavelength interval of 200−370 *** maximum of photo to dark c.rrent ratio,responsivity,external quantum effic.enc.,and detec.ivity of the struc.ures were 1.16×10^(4) ***.,30.6 A/W,1.65×10^(4)%,and 6.95×10^(15) Hz^(0.5)·c./W at a wavelength of 230 nm and an applied voltage of 1 *** high values of photoelec.ric.properties were due to the internal enhanc.ment of the photoresponse assoc.ated with strong hole ***α-Ga_(2)O_(3) film-based UVc.detec.ors c.n func.ion in self-powered operation mode due to the built-in elec.ric.field at the Pt/α-Ga_(2)O_(3) *** a wavelength of 254 nm and zero applied voltage,the struc.ures exhibit a responsivity of 0.13 mA/W and an external quantum effic.enc. of 6.2×10^(−2)%.The UVc.detec.ors based on theα-Ga_(2)O_(3) films demonstrate high-speed performanc. with a rise time of 18 ms in self-powered mode.

关键词： HVPE gallium oxide solar-blind ultraviolet detec.or self-powered mode

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