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Within-host model of respiratory virus shedding and antibody response to H9N2 avian influenza virus vaccination and infection in chickens

引用

Infectious Disease Modelling 2021年第1期6卷 490-502页

作者： Xiao-Ting Xie alexander yitbarek Jake Astill Shirene Singh Salah Uddin Khan Shayan Sharif Zvonimir Poljak Amy L.Greer Department of Population Medicine University of GuelphONCanada Department of Pathobiology University of GuelphONCanada School of Veterinary Medicine University of the West IndiesSt.AugustineTrinidad and Tobago

Avian influenza virus(AIV)H9N2 subtype is an infectious pathogen that can affect both the respiratory and gastrointestinal systems in chickens and continues to have an important economic impact on the poultry *** the host innate immune response provides control of virus replication in early infection,the adaptive immune response aids to clear infections and prevent future *** virus-innate immune response pathways can improve our understanding of early infection dynamics and help to guide our understanding of virus shedding dynamics that could lead to reduced transmission between *** some countries use vaccines for the prevention of H9N2 AIV in poultry,the virus continues to be endemic in regions of Eurasia and Africa,indicating a need for improved vaccine efficacy or vaccination *** we explored how three type-I interferon(IFN)pathways affect respiratory virus shedding patterns in infected chickens using a within-host ***,prime and boost vaccination strategies for a candidate H9N2 AIV vaccine are assessed for the ability to elicit seroprotective antibody *** model demonstrates that inclusion of virus sensitivity to intracellular type-I IFN pathways results in a shedding pattern most consistent with virus titres observed in infected chickens,and the inclusion of a cellular latent period does not improve model ***,early administration of a booster dose two weeks after the initial vaccine is administered results in seroprotective titres for the greatest length of time for both broilers and *** results demonstrate that type-I IFN intracellular mechanisms are required in a model of respiratory virus shedding in H9N2 AIV infected chickens,and also highlights the need for improved vaccination strategies for laying hens.

关键词： Avian influenza Disease modelling Innate immunity Adaptive immunity Poultry

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