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Clinical longitudinal evaluation of COVID-19 patients and prediction of organ-specific recovery using artificial intelligence

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Precision Clinical Medicine 2021年第1期4卷 62-69页

作者： Winston T.Wang Charlotte L.Zhang Kang Wei Ye Sang Jun Shen Guangyu Wang alexander x.lozano Department of Materials Science&Engineering Stanford UniversityStanfordCA 94305USA Mayo Clinic Alix school of Medicine ScottsdaleAZ 85259USA Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou 510623China The First College of Clinical Medical Science China Three Gorges UniversityYichang 443000China Department of Radiology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

Within COVID-19 there is an urgent unmet need to predict at the time of hospital admission which COVID-19 patients will recover from the disease,and how fast they recover to deliver personalized treatments and to properly allocate hospital resources so that healthcare systems do not become *** this end,we have combined clinically salient CT imaging data synergistically with laboratory testing data in an integrative machine learning model to predict organ-specific recovery of patients from *** trained and validated our model in 285 patients on each separate major organ system impacted by COVID-19 including the renal,pulmonary,immune,cardiac,and hepatic *** greatly enhance the speed and utility of our model,we applied an artificial intelligence method to segment and classify regions on CT imaging,from which interpretable data could be directly fed into the predictive machine learning model for overall *** all organ systems we achieved validation set area under the receiver operator characteristic curve(AUC)values for organ-specific recovery ranging from 0.80 to 0.89,and significant overall recovery prediction in Kaplan-Meier *** demonstrates that the synergistic use of an artificial intelligence(AI)framework applied to CT lung imaging and a machine learning model that integrates laboratory test data with imaging data can accurately predict the overall recovery of COVID-19 patients from baseline characteristics.

关键词： artificial intelligence medical image COVID-19 longitudinal evaluation

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Adaptive Control for Passive Kinesiotherapy ELLTIO

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Journal of Bionic Engineering 2014年第4期11卷 581-588页

作者： Ricardo López Hipólito Aguilar Sergio Salazar Rogelio lozano Laboratory UMI LAFMIA 3175 CINVESTAV-CNRS Móxico D. F. CNRS Research Director Universitb de Technologie de Compiègne 60200 Compiègne France

Exoskeletons are mechatronic devices used to increase human muscle strength and resistance. In the last decade these devices have become a very useful tool to assist active kinesiotherapy. This paper presents the design of exoskeleton focused on the rehabilitation of ankle and knee for the right leg. The construction of prototype like Exoskeleton for Lower Limb Training with Instrumented Orthoses （ELLTIO） using Series Elastic Actuator （SEA） to reduce the effort in the human joints, and a control law to perform a rehabilitation routine using an adaptive control scheme were first implemented in simulation to verify the control strategy and make a real rehabilitation test. The adaptive control law is proposed with the intention that the exoskeleton can adapt to user parameters at the time when performing the exercise. The results show the parameters estimation and tracking trajectory for the exoskeleton were proposed, and this trajectory could be a routine rehabilitation proposed by the therapist.

关键词： exoskeleton parametric identification rehabilitation robotics adaptive control.

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On Boundary Factors and Traces of Subgroups of Finite Groups

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Communications in Mathematics and Statistics 2014年第3期2卷 349-361页

作者： W.Guo alexander N.Skiba x.Tang School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026People’s Republic of China Department of Mathematics Francisk Skorina Gomel State University246019 GomelBelarus

A subgroup E of a finite group G is called hypercyclically embedded in G if every chief factor of G below E is *** A be a subgroup of a group *** we call any chief factor H/AG of G a G-boundary factor of *** any G-boundary factor H/AG of A,we call the subgroup(A∩H)/AG of G/AG a G-trace of *** the basis of these notions,we give some new characterizations of hypercyclically embedded subgroups.

关键词： Finite group Hypercyclically embedded subgroup G-boundary factor G-trace of subgroup Meet-irreducible subgroup

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Chargino Production via Z^0-Boson Decay in a Strong Electromagnetic Field

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Chinese Physics Letters 2016年第3期33卷 17-19页

作者： alexander Kurilin Moscow Technological Institute on leave from Moscow State Open Pedagogical University

In the framework of MSSM the probability of Z0-boson decay to chaxginos in a strong electromagnetic field, Z x＋x-, is analyzed. The method of calculations employs exact solutions of relativistic wave equations for charginos in a crossed electromagnetic field. Analytic expression for the decay width is obtained at an arbitrary value of the parameter which characterizes the external-field strength Fμv and Z%boson momentum qv. The process Z0→ x＋x- is forbidden in a vacuum for the case of relatively heavy charginos： Mx±mz/2. However, in an intense electromagnetic background this reaction could take place in the region of superstrong fields （x〉1）.

关键词： of on is in Chargino Production via Z~0-Boson Decay in a Strong Electromagnetic Field for

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Comment on“Hole-pinned defect-dipoles induced colossal permittivity in Bi doped SrTiO_(3)ceramics with Sr deficiency”

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Journal of Materials Science & Technology 2021年第6期65卷 151-153页

作者： alexander Tkach Olena Okhay CICECO-Aveiro Institute of Materials Department of Materials and Ceramic EngineeringUniversity ofAveiroAveiro3810-193Portugal Centre for Mechanical Technology and Automation(TEMA) Department of Mechanical EngineeringUniversity of AveiroAveiro3810-193Portugal

With this contribution,as a comment to the publication in Journal of Mate rials Science&Technology 44(2020)54,reporting giant dielectric response,structural characterization and numerical simulations in Sr_(1-1.5 x)Bi_xTiO_(3)ceramics,we show that the re ported results are rather contradicting and not well analysed,while the suggested mechanism for the giant permittivity response is not valid or doubtful and has to be ***,many details and data are missing making impossible not only to call the obtained results very suitable for practical application but even to reproduce them.

关键词： SrTiO_(3)ceramics Doped dielectrics Perovskite structure Giant permittivity

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Geophysical criterion of pre-outburst coal outsqueezing from the face space into the working

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International Journal of Mining Science and Technology 2019年第3期29卷 499-506页

作者： alexander Shadrin Yuliya Diyuk Federal State Budget Scientific Institution The Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences

The initial process of coal and gas sudden outburst is studied in the article when under the influence of rock and gas pressure the part of a coal seam layer(a coal section)is squeezed out from the mouth of the future outburst cavity in a jump-like manner into the ***-mechanical criterion for a part of a coal seam layer outsqueezing in the form of the relation of active(squeezing out)and passive(preventing the outsqueezing)forces is defined in the *** on it,the geophysical criterion is defined by expressing basic physical parameters through geo-physical ones:the current stress is defined by spectral-acoustic method through the ratio of high frequency and low-frequency components of an acoustic signal,which is generated into a face working space by the mining equipment operating in the face;in-situ gas pressure is defined by gas analytical method by the concentration of methane in the atmosphere of the working;the strength of the most broken coal layer is defined by a strength measuring device(a device for measuring the depth of a steal cone punched into the coal by a spring mechanism).This paper studies the influence of acoustic,strength and filtrating and collecting properties of a face working space on the limit value of an obtained geophysical criterion of pre-outburst squeezing of a coal‘‘plug”out of the mouth of the future outburst cavity into the working.

关键词： Block-like structure Criterion of a coal section outsqueezing Spectral-acoustic method Stress condition Coal strength property In-situ gas pressure Aero and gas control equipment Methane concentration

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COMPLExITY AND INTRANSITIVITY IN TECHNOLOGICAL DEVELOPMENT

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Journal of Systems Science and Systems Engineering 2014年第2期23卷 128-152页

作者： alexander Y.KLIMENKO The University of Queensland

This paper investigates the existence of a fundamental link between two disciplines that emerged during last few decades： complexity science and advanced engineering. During this time many industries, especially those related to the high-tech end of technological development, have faced the problem of increasing complexity of design, production and operation. Industrial projects have grown to become multidisciplinary, tightly interconnected, costly and difficult to control and predict. Two trends can be identified in this respect： one is the consistent effort of systems engineering in reducing the uncertainties of complex industrial operations and the other is the effort undertaken in complexity studies to account for uncertainties present in the real world. In this work, we provide a brief overview of recent developments in advanced engineering and give a consistent interpretation of technological evolution from the perspective of complexity science in general and complex competitive systems （CCS） in particular. CCS is a general framework that was recently developed for analysis of complex systems involving competition. Transitivity of the decision-making process and the cyclic nature of technological progress are considered. Correctness of intransitive decisions is inherently relativistic： the same decisions can be seen as correct or incorrect when considered from different perspectives. When treated simplistically, intransitivity may seem to be illogical but, nevertheless, it is common in nature and needs to be studied. CCS provides a formalised scientific framework for analysis of intransitivity and establishes the existence of an important connection linking complexity and uncertainty with intransitivity. Implications of intransitivity for engineering decision-making and strategic planning are considered in the context of CCS. A working example of intransitivity in competition between major car mantifacturers is presented.

关键词： Complexity technology strategy systems engineering industrial strategy and decision-making complex competitive systems.

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Hepatoprotective actions of melatonin:Possible mediation by melatonin receptors

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World Journal of Gastroenterology 2010年第48期16卷 6087-6097页

作者： alexander M Mathes Department of Anesthesiology Critical Care and Pain MedicineSaarland University Hospital

Melatonin,the hormone of darkness and messenger of the photoperiod,is also well known to exhibit strong direct and indirect antioxidant properties. Melatonin has previously been demonstrated to be a powerful organ protective substance in numerous models of injury; these beneficial effects have been attributed to the hormone's intense radical scavenging capacity. The present report reviews the hepatoprotective potential of the pineal hormone in various models of oxidative stress in vivo,and summarizes the extensive literature showing that melatonin may be a suitable experimental substance to reduce liver damage after sepsis,hemorrhagic shock,ischemia/reperfusion,and in numerous models of toxic liver injury. Melatonin's influence on hepatic antioxidant enzymes and other potentially relevant pathways,such as nitric oxide signaling,hepatic cytokine and heat shock protein expression,are evaluated. Based on recent literature demonstrating the functional relevance of melatonin receptor activation for hepatic organ protection,this article finally suggests that melatonin receptors could mediate the hepatoprotective actions of melatonin therapy.

关键词： Antioxidant enzymes Hemorrhagic shock Hepatoprotection Ischemia Liver Liver function Melatonin Melatonin receptor Ramelteon Reperfusion Sepsis Toxic liver injury

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Relationship between surface area and crystal size of pure and doped cerium oxides

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Journal of Rare Earths 2010年第5期28卷 647-653页

作者： C. Bueno-Ferrer S. Parres-Esclapez D. lozano-Castelló A. Bueno-López Analytical Chemistry Nutrition & Food Sciences Department Inorganic Chemistry Department University of Alicante Ap. 99 E-03080 Alicante Spain

Pure and Zr, La or Pr-doped cerium oxides were characterised by transmission electron microscopy (TEM), N2 adsorption-desorption at –196 oC and x-ray diffraction (xRD). For crystal sizes calculation, the Scherrer and Williamson-Hall equations were compared, and the relationship between surface area and crystal size was critically discussed. It was demonstrated that the Williamson-Hall equation must be used instead of the Scherrer equation to calculate crystal sizes, since the latter equation underestimated ...

关键词： ceria xRD N2 adsorption crystal size surface area rare earths

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Cancer and neurodegenerative disorders:pathogenic convergence through microRNA regulation

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Journal of Molecular Cell Biology 2011年第3期3卷 176-180页

作者： Liqin Du alexander Pertsemlidis Harold C.Simmons Comprehensive Cancer Center UT Southwestern Medical Center5323 Harry Hines BoulevardDallasTexas 75390USA Eugene McDermott Center for Human Growth and Development UT Southwestern Medical Center5323 Harry Hines BoulevardDallasTexas 75390USA Department of Internal Medicine UT Southwestern Medical Center5323 Harry Hines BoulevardDallasTexas 75390USA

Although cancer and neurodegenerative disease are two distinct pathological disorders,emerging evidence indicates that these two types of disease share common mechanisms of genetic and molecular *** studies show that individual microRNAs(miRNAs)could be involved in the pathology of both diseases,indicating that the mechanisms of these two seemingly dichotomous diseases converge in the dysregulation of gene expression at the post-transcriptional *** the increasing evidence showing that miRNA-based therapeutic strategies that modulate the activity of one or more miRNAs are potentially effective for a wide range of pathological conditions,the involvement of miRNAs in the common pathways of leading both diseases suggests a bright future for developing common therapeutic approaches for both ***,the miRNAs that are dysregulated in both diseases may hold promise as uniquely informative diagnostic ***,we review recent studies on the miRNAs that have been implicated in both cancer and neurodegenerative diseases.

关键词： microRNA cancer neurodegenerative disease

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