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Impact of endoscopy-based research on quality of life in healthy volunteers

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world Journal of Gastroenterology 2010年第4期16卷 467-473页

作者： alexander Link Gerhard Treiber Brigitte peters Thomas wex Peter Malfertheiner Department of Gastroenterology Hepatology and Infectious Diseases Otto-von-Guericke University Leipziger St.44 39120 Magdeburg Germany Department of Internal Medicine Division of Gastroenterology Baylor Research Institute Baylor UniversityMedical Center 3500 Gaston Ave (H-250) Dallas TX 75246United States Department of Gastroenterology Oncology and General Internal Medicine Zollernalb Clinic Tuebinger St.30 72336 Balingen Germany Institute for Biometry and Medical Informatics Otto-von-Guericke University Leipziger St. 44 39120 Magde-burg Germany Department of Gastroenterology Hepatology and Infectious Diseases Otto-von-Guericke University Leipziger St.44 39120 MagdeburgGermany

AIM:To study the impact of an endoscopy-based long-term study on the quality of life in healthy volunteers(HV).METHODS:Ten HV were included into a long-term prospective endoscopy-based placebo-controlled trial with 15 endoscopic examinations per person in 5 different drug *** completed short form-36(SF-36) and visual analog scale-based questionnaires(VAS) for different abdominal symptoms at days 0,7 and 14 of each drug *** wereperformed according to short-and long-term changes and compared to the control ***:All HV completed the study with duration of more than 6 *** quality of life score was comparable to a general *** of the SF-36 questionnaires showed no significant changes in physical,mental and total scores,either in a short-term perspective due to different medications,or to potentially endoscopic procedure-associated long-term cumulative *** to SF-36,VAS revealed no significant changes in total scores for pathological abdominal symptoms and remained unchanged over the time course and when compared to the control ***:This study demonstrates that quality of life in HV is not significantly affected by a longterm endoscopy-based study with multiple endoscopic procedures.

关键词： Endoscopy research Ethics Healthy volunteers Quality of life

Rationally designed mariner vectors for functional genomic analysis of Actinobacillus pleuropneumoniae and other Pasteurellaceae species by transposon-directed insertion-site sequencing (TraDIS)

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Animal Diseases 2021年第4期1卷 249-261页

作者： Janine T.Bossé Yanwen Li Leon G.Leanse Liqing Zhou Roy R.Chaudhuri Sarah E.peters Jinhong wang Gareth A.Maglennon Matthew T.G.Holden Duncan J.Maskell alexander w.Tucker Brendan w.wren Andrew N.Rycroft Paul R.Langford on behalf of the BRaDPT consortium Section of Paediatric Infectious Disease Department of Infectious DiseaseImperial College LondonSt.Mary’s CampusLondonUK wellman Center for Photomedicine Harvard Medical SchoolBostonUSA The Applied Diagnostic Research and Evaluation Unit St George’s University of LondonLondonUK Department of Veterinary Medicine University of CambridgeCambridgeUK Department of Molecular Biology and Biotechnology University of SheffieldSheffieldUK Department of Pathology and Pathogen Biology The Royal Veterinary CollegeHatfieldUK The wellcome Trust Sanger Institute CambridgeUK School of Medicine University of St AndrewsSt AndrewsUK The University of Melbourne ParkvilleVictoriaAustralia s Faculty of Infectious&Tropical Diseases London School of Hygiene&Tropical MedicineLondonUK

Comprehensive identification of conditionally essential genes requires efficient tools for generating high-density transposon libraries that, ideally, can be analysed using next-generation sequencing methods such as Transposon Directed Insertion-site Sequencing (TraDIS). The Himar1 (mariner) transposon is ideal for generating near-saturating mutant libraries, especially in AT-rich chromosomes, as the requirement for integration is a TA dinucleotide, and this transposon has been used for mutagenesis of a wide variety of bacteria. However, plasmids for mariner delivery do not necessarily work well in all bacteria. In particular, there are limited tools for functional genomic analysis of Pasteurellaceae species of major veterinary importance, such as swine and cattle pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida, respectively. Here, we developed plasmids, pTsodCPC9 and pTlacPC9 (differing only in the promoter driving expression of the transposase gene), that allow delivery of mariner into both these pathogens, but which should also be applicable to a wider range of bacteria. Using the pTlacPC9 vector, we have generated, for the first time, saturating mariner mutant libraries in both A. pleuropneumoniae and P. multocida that showed a near random distribution of insertions around the respective chromosomes as detected by TraDIS. A preliminary screen of 5000 mutants each identified 8 and 14 genes, respectively, that are required for growth under anaerobic conditions. Future high-throughput screening of the generated libraries will facilitate identification of mutants required for growth under different conditions, including in vivo, highlighting key virulence factors and pathways that can be exploited for development of novel therapeutics and vaccines.

关键词： Mariner Transposon TraDIS Pasteurellaceae Actinobacillus pleuropneumoniae Pasteurella multocida

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非常规资源油气系统模拟理论基础

海洋地质 2013年第1期29卷 20-21页

作者： Kenneth peters Bjorn wYGRALA alexander NEBER

应用地球化学、地质力学和3D石油系统综合建模是成功开发非常规资源的关键。在此过程中，存在以下三个主要影响因素：（1）对地质、地球化学和相关技术的含义（例如，垂向分异性，微震事件对裂隙范围的定义，稳定碳同位素“年龄倒转”... 详细信息

应用地球化学、地质力学和3D石油系统综合建模是成功开发非常规资源的关键。在此过程中，存在以下三个主要影响因素：（1）对地质、地球化学和相关技术的含义（例如，垂向分异性，微震事件对裂隙范围的定义，稳定碳同位素“年龄倒转”）的理解；（2）对油气页岩建模的特殊功能（例如，朗缪尔吸附、孔隙模型和地质力学，包括应力背景和演化史）的了解；（3）如何利用3D模型来确定合适的开发技术（例如，针对高应力地区的相关模型）。

关键词：油气系统模拟理论资源应用地球化学基础地质力学稳定碳同位素 3D模型

低温和酸中毒对人全血凝血功能损害的协同作用

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麻醉与镇痛 2009年第3期5卷 28-34页

作者： Daniel Dirkmann alexander A. Klaus Gorlinger Jurgen peters 张昕(译) Klinik fur Anasthesiologie und Intensivmedizin Universitat Duisburg-Essen Universi~tsklinikum Essen Essen Germany 不详

背景低温和酸中毒对不同临床状态下凝血疾患的影响已有报道。本研究中，我们对全血的凝血功能进行评估，以探讨低温和酸中毒对凝血的影响。方法采自10名健康志愿者（2女，8男）的全血样本（3．000μl），加入40μl摩尔浓度递加的盐酸，... 详细信息

背景低温和酸中毒对不同临床状态下凝血疾患的影响已有报道。本研究中，我们对全血的凝血功能进行评估，以探讨低温和酸中毒对凝血的影响。方法采自10名健康志愿者（2女，8男）的全血样本（3．000μl），加入40μl摩尔浓度递加的盐酸，使血液酸化至pH（α-pH固定计）介于7．0和7．37之间。用内源性（InTEM^TM）和外源性（ExTEM^TM）活化方法孵化30分钟后，再用旋转血栓弹性测定法分析凝血功能。为了评估凝血功能对温度的依赖性，所有试验均在血液／血栓弹性测定仪的温度30、33、36和39℃下分别进行。此外，通过添加细胞松弛素D进行了另一项外源性激活方法，以此来检测在无血小板作用时，血凝块的形成情况。结果正常pH下低温导致了凝血时间延长[ExTEM：65秒±3．6（36℃）vs85±4（30℃），P〈0．001；InTEM：181秒±10（36℃）vs226±9，P〈0．001]，血凝块形成时间延长[ExTEM：105秒±5（36℃）vs 187±6（30℃），P〈0．001；InTEM：101秒±5（36℃）vs175±7，P〈0．001]，并且伴有α角的缩小，[ExTEM：65．6±1．8（36℃）vs 58±1．1，P〈0．01；InTEM：70．5±1．8（36℃）vs 60．2±1．5，P〈0．001]。最大血栓弹力仅在InTEM测定法中显著受损[56．9mm±0．9（36℃）vs 52．7±0．9，P〈0．05]。相反，正常体温下酸中毒本身无明显作用。酸中毒放大了低温的作用，并在内源性和外源性激活实验中，两者对凝血时间、d角、最大血栓弹力的影响有协同作用。用细胞松弛素D消除血小板功能后进行的纤维蛋白凝块形成试验显示，凝血功能并没有受损。血凝块溶解在低温和（或）酸中毒环境下减少，而在体温升高的情况下增加。结论在此体外研究中，血栓弹性测定法显示：酸中毒使低温引起的凝血功能改变恶化，而不伴低温的酸中毒对凝血功能无显著影响。这种情况是由于凝血因子和血小板功能受到抑制引起的。因此，在37℃下进行的血栓弹性测定法高估了低温尤其伴酸中毒时凝血功能的完整性。

关键词：凝血功能改变酸中毒协同作用人全血低温功能损害凝血时间延长细胞松弛素D

Embedding physics domain knowledge into a Bayesian network enables layer-by-layer process innovation for photovoltaics

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npj Computational Materials 2020年第1期6卷 1592-1600页

作者： Zekun Ren Felipe Oviedo Maung Thway Siyu I.P.Tian Yue wang Hansong Xue Jose Dario Perea Mariya Layurova Thomas Heumueller Erik Birgersson Armin G.Aberle Christoph J.Brabec Rolf Stangl Qianxiao Li Shijing Sun Fen Lin Ian Marius peters Tonio Buonassisi Singapore-MIT Alliance for Research and Technology SMART Singapore 138602Singapore Solar Energy Research Institute of Singapore(SERIS) National University of SingaporeSingapore 117574Singapore Massachusetts Institute of Technology CambridgeMA 02139USA Institute of Materials for Electronics and Energy Technology(i-MEET) Friedrich-Alexander University Erlangen-Nürnberg91058 ErlangenGermany Helmholtz Institute HI-ErN Forschungszentrum JülichImmerwahrstrasse 291058 ErlangenGermany National University of Singapore Singapore 119077Singapore

Process optimization of photovoltaic devices is a time-intensive,trial-and-error endeavor,which lacks full transparency of the underlying physics and relies on user-imposed constraints that may or may not lead to a global ***,we demonstrate that embedding physics domain knowledge into a Bayesian network enables an optimization approach for gallium arsenide(GaAs)solar cells that identifies the root cause(s)of underperformance with layer-by-layer resolution and reveals alternative optimal process windows beyond traditional black-box *** Bayesian network approach links a key GaAs process variable(growth temperature)to material descriptors(bulk and interface properties,e.g.,bulk lifetime,doping,and surface recombination)and device performance parameters(e.g.,cell efficiency).For this purpose,we combine a Bayesian inference framework with a neural network surrogate device-physics model that is 100×faster than numerical *** the trained surrogate model and only a small number of experimental samples,our approach reduces significantly the time-consuming intervention and characterization required by the *** a demonstration of our method,in only five metal organic chemical vapor depositions,we identify a superior growth temperature profile for the window,bulk,and back surface field layer of a GaAs solar cell,without any secondary measurements,and demonstrate a 6.5%relative AM1.5G efficiency improvement above traditional grid search methods.

关键词： knowledge network enable

含油气系统模拟在非常规资源勘探中的实际应用

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海洋地质 2013年第1期29卷 21-21页

作者： Bjorn wYGRALA Kenneth peters alexander NEBER

石油系统建模通常使用1D、2D或者最好是3D地质模型来模拟石油生成、排出、运移和损耗的历史。一个常规含油气系统模式为，生成的石油从源岩排出，然后运移，直到它被圈闭在储层中，或从系统中损耗。在一个非传统的体系中，勘探目标往往... 详细信息

石油系统建模通常使用1D、2D或者最好是3D地质模型来模拟石油生成、排出、运移和损耗的历史。一个常规含油气系统模式为，生成的石油从源岩排出，然后运移，直到它被圈闭在储层中，或从系统中损耗。在一个非传统的体系中，勘探目标往往是针对源岩中残留的油气，二者的主控地质过程是相同的，唯一不同的是，前者的目标是排出的油气，而后者的目标是残留的油气。

关键词：含油气系统资源勘探模拟应用石油系统石油生成地质模型勘探目标

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脊髓损伤后残存自主神经功能载录国际标准

中华物理医学与康复杂志 2010年第4期32卷 310-315页

作者： MS alexander AB Jackson w Donovan DE Graves SL Elliott A Krassioukov Aw Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA wuermser J-J wyndaele 周谋望刘楠 S Charlifue University of Alabama BirminghamALUSA Baylor College of Medicine HoustonTXUSA International Collaboration On Repair Discoveries (ICORD) University of British Columbia and Vancouver Coastal HealthVancouverBritish ColumbiaCanada James A Haley VA Hospital TampaFLUSA Shepherd Center AtlantaGAUSA University of Miami MiamiFLUSA McKay Urology Carolinas HealthcareCharlotteNCUSA Sahlgrenska University Hospital GothenburgSweden Rigshospitalet and University of Copenhagen CopenhagenDenmark Aarhus University Hospital AarhusDenmark Kessler Institute for Rehabilitation West OrangeN JUSA Thomas Jefferson University PhiladelphiaPAUSA Imperial College St Mary's HospitalLondonUK Stanford Uni-versity Palo AltoCAUSA James J peters Veterans Affairs Medical Center BronxNYUSA University Hospital Balgrist ZurichSwitzerland Herlev Hospi-tal University of CopenhagenCopenhagenDenmark Veterans Affairs Puget Sound Health Care SeattleWAUSA Case western Re-serve University ClevelandOHUSA Mayo Clinic RochesterMSUSA and University Hospital Antwerp University AntwerpAntwerpBelgium 北京大学第三医院康复医学科 Craig Hospital EnglewoodCOUSA

近年来，脊髓损伤神经学分类园际标准（International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI）被用来记载脊髓损伤后运动和感觉功能的损害，目前该标准已是第六版。1992年第一份国际认可的... 详细信息

近年来，脊髓损伤神经学分类园际标准（International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI）被用来记载脊髓损伤后运动和感觉功能的损害，目前该标准已是第六版。1992年第一份国际认可的标准出版时，曾进行了较大的修订，修订内容包括完全性损伤与不完全性损伤的定义，

关键词：国际标准脊髓损伤自主神经功能不完全性损伤残存修订内容神经学分类 ards

Therapeutic resistance training:proposal for an algorithm-based approach

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Translational Exercise Biomedicine

Translational Exercise Biomedicine 2024年第1期1卷 89-101页

作者： Frank weber Christina Stark wilhelm Bloch Jonas Böcker Michael Drey Sebastian Gehlert Björn Maier Kirsten peters Ludwig Sachs Benedikt Schoser Eckhard Schönau Rolf Schröder Henning wackerhage Peter Young Jörn Rittweger German Air Force Center of Aerospace Medicine CologneGermany Department of Neurology Medical Faculty and University HospitalUniversity of CologneCologneGermany Section Molecular and Cellular Sports Medicine German Sports University CologneCologneGermany Institute of Aerospace Medicine German Aerospace CenterCologneGermanyLinder Höhe51147 Department of Internal Medicine IV Ludwig-Maximilians-University of MunichMunichGermany Department for Biosciences of Sports Institute of Sports ScienceUniversity of HildesheimHildesheimGermany Duale Hochschule Baden württemberg MannheimGermany Rijnstate Hospital Arnhemthe Netherlands Psychotherapie Praxis Sachs Prien a.ChiemseeGermany Friedrich-Baur-Institute Ludwig-Maximilians-UniversityMunichGermany Department of Pediatrics Medical Faculty and University HospitalUniversity of CologneCologneGermanyD-50937 Institute of Neuropathology Friedrich-Alexander UniversityErlangenGermany Department of Sport and Health Sciences Technical University MunichMunichGermany Medical Park Bad Feilnbach Bad FeilnbachGermany

Background Ageing,immobilization,sepsis or cachexia reduce muscle mass and *** age-related loss,***,contributes to frailty and results in a loss of mobility and autonomy in aging and *** individuals are often socially isolated,have a greater risk of metabolic disorders and psychosomatic *** a result,quality of life and life expectancy are *** and lack of adequate stimuli to the skeletal muscle seem to play a central part in these *** overcome them,resistance training(i.e.,weightlifting)is an effective *** of the problem Despite the efficacy of resistance training for increasing muscle mass and function,this treatment is underused in clinical *** argue that this is due to a lack of a generally applicable *** and framework To address this and related problems,we have formed the Network of Expertise for Immobilization-induced Muscle Disorders(KNIMS)to develop a potential algorithm for treating sarcopenia and other immobilization-related muscle *** important aspect of the proposed method is that it is defined as a formal algorithm that consists of two *** A aims to recover bed-ridden patients’ability to stand by applying vibration-tilt table *** B aims at rehabilitating compromised gait,using a combination of squats,lunges and single leg *** is anticipated that this algorithm-based approach will enhance the ability for standardization and documentation,whilst reducing resource efforts at the same time,which will be equally useful to clinical practice and to clinical research.

关键词： muscle training sarcopenia falls mobility immobilization physiotherapy muscle

Author Correction:Embedding physics domain knowledge into a Bayesian network enables layer-by-layer process innovation for photovoltaics

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npj Computational Materials 2020年第1期6卷 955-955页

作者： Zekun Ren Felipe Oviedo Maung Thway Siyu I.P.Tian Yue wang Hansong Xue Jose Dario Perea Mariya Layurova Thomas Heumueller Erik Birgersson Armin G.Aberle Christoph J.Brabec Rolf Stangl Qianxiao Li Shijing Sun Fen Lin Ian Marius peters Tonio Buonassisi Singapore-MIT Alliance for Research and Technology SMART Singapore Singapore Solar Energy Research Institute of Singapore (SERIS) National University of Singapore Singapore Singapore Massachusetts Institute of Technology Cambridge USA Institute of Materials for Electronics and Energy Technology (i-MEET) Friedrich-Alexander University Erlangen-Nürnberg Erlangen Germany Helmholtz Institute HI-ErN Forschungszentrum Jülich Erlangen Germany National University of Singapore Singapore Singapore

In the original version of the published Article,there was ambiguity in Eq.(1).To improve clarity,Eq.(1)has been corrected to the following.

关键词： enable corrected ambiguity