检索结果-南通市图书馆

Genome recoding strategies to improve cellular properties: mechanisms and advances

aBIOTECH 2021年第1期2卷 79-95页

作者： Tanya Singh Sudesh Kumar Yadav alexander vainstein Vinay Kumar Department of Botany School of Basic SciencesCentral University of PunjabBathinda 151001India Center of Innovative and Applied Biotechnology Mohali 140306India Institute of Plant Sciences and Genetics in Agriculture The Hebrew University of JerusalemRehovotIsrael

The genetic code,once believed to be universal and immutable,is now known to contain many variations and is not quite *** basis for genome recoding strategy is genetic code variation that can be harnessed to improve cellular ***,genome recoding is a promising strategy for the enhancement of genome flexibility,allowing for novel functions that are not commonly documented in the organism in its natural ***,the basic concept of genetic code and associated mechanisms for the generation of genetic codon variants,including biased codon usage,codon reassignment,and ambiguous decoding,are extensively *** of the concept of natural genetic code expansion is also *** generation of recoded organisms and associated mechanisms with basic targeting components,including aminoacyl-tRNA synthetase–tRNA pairs,elongation factor EF-Tu and ribosomes,are highlighted for a comprehensive understanding of this *** research associated with the generation of diverse recoded organisms is also *** success of genome recoding in diverse multicellular organisms offers a platform for expanding protein chemistry at the biochemical level with non-canonical amino acids,genetically isolating the synthetic organisms from the natural ones,and fighting viruses,including SARS-CoV2,through the creation of attenuated *** conclusion,genome recoding can offer diverse applications for improving cellular properties in the genome-recoded organisms.

关键词： Genetic code Codon usage Protein engineering Attenuated virus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transient Expression of Virally Delivered Meganuclease In Planta Generates Inherited Genomic Deletions

引用

Molecular Plant 2015年第8期8卷 1292-1294页

作者： Arik Honig Ira Marton Michal Rosenthal J. Jeff Smith Michael G. Nicholson Derek Jantz Amir Zuker alexander vainstein Danziger Innovations Ltd. Mishmar Hashiva Village Beit Dagan 50297 Israel Precision Biosciences 302 East Pettigrew Street Dibrell Building Suite A-100 Durham NC 27701 USA Institute of Plant Sciences and Genetics in Agriculture Robert H. Smith Faculty of Agriculture Food and Environment Hebrew University of Jerusalem Rehovot 76100 Israel

Dear Editor The use of sequence-specific nucleases for plant genomic DNA mutagenesis is an exciting and rapidly developing tech- nology （Voytas and Merchant, 2013; Baltes and Voytas, 2014）. To date, most mutated plants have been recovered from transgenic plants stably expressing nucleases. However, transient nuclease delivery by plant DNA- and RNA-based viral vectors followed by regeneration of plantlets from modi- fied tissues has emerged as an alternative, efficient strategy in some plant species （Marton et al., 2010; Baltes et al., 2014）. Delivery of nucleases by plant RNA viruses is particularly attractive because they typically do not integrate into the plant genome, and therefore the mutated plants are not classified as transgenic （Marton et al., 2013; Voytas and Gao, 2014）.

关键词： @@

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：