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Parasites of the liver:A global problem?

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World Journal of Gastroenterology 2024年第30期30卷 3554-3559页

作者： vladislav v Tsukanov alexander v vasyutin Julia L Tonkikh Clinical Department of the Digestive System Pathology of Adults and Children Federal Research Center“Krasnoyarsk Science Center”of the Siberian Branch of the Russian Academy of SciencesScientific Research Institute of Medical Problems of the NorthKrasnoyarsk 660022Russia

Parasitic liver diseases can be caused by trematodes,cestodes,nematodes,and *** pathology is significant because millions of people in different parts of the world have liver parasites,which can manifest themselves in the development of inflammation,liver cysts,cholecystitis,cholelithiasis,pancreatitis and liver cirrhosis that are often threatening their *** International Agency for Research on Cancer considers three species of trematodes,Schistosoma haematobium,Opisthorchis viverrini and Clonorchis sinensis,to be *** modern examination methods,in some cases including extensive screening of large populations,are required for diagnosing liver *** of parasitic liver diseases is differentiated and can involve a combination of surgical and therapeutic *** is no doubt that the clinical and epidemiological scale allows one to regard parasitic liver diseases as a global healthcare problem.

关键词： Liver Parasites Epidemiology Diagnosis Clinics Treatment Echinococcosis Opisthorchiasis Fascioliasis Schistosomiasis

Inhibition of M2 tumor-associated macrophages polarization by modulating the Wnt/β-catenin pathway as a possible liver cancer therapy method

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World Journal of Gastroenterology 2024年第40期30卷 4399-4403页

作者： vladislav v Tsukanov Julia L Tonkikh Edward v Kasparov alexander v vasyutin Clinical Department of the Digestive System Pathology of Adults and Children Federal Research Center“Krasnoyarsk Science Center”of the Siberian Branch of the Russian Academy of SciencesScientific Research Institute of Medical Problems of the NorthKrasnoyarsk 660022Russia

The problem of liver cancer is becoming increasingly important due to the epi-demic of metabolic diseases and persistent high alcohol *** deter-mines great attention to the development and improvement of methods for early diagnosis and treatment of liver *** et al presented a study in the World Journal of Gastroenterology,in which they showed that the use of the traditional Chinese medicine Calculus bovis(CB)can suppress tumor growth in mice by inhibiting M2 tumor-associated macrophages(TAM)through modulating the activity of the Wnt/β-catenin *** interaction of CB components with the Wnt/β-catenin pathway,M2 TAM polarization,and tumor dynamics were studied using network pharmacology,transcriptomics,and molecular *** is now generally accepted that the polarization of TAM and the differentiation of the functions of M1 and M2 phagocytes are of great importance for the progression of *** is assumed that M2 TAM promote proliferation and migration of tumor *** to medicinally influence the Wnt/β-catenin pathway in order to modulate phagocyte polarization now belong to one of the most promising areas of immunotherapy of oncological ***,the work of the Chinese authors deserves attention and further development.

关键词： Liver cancer Treatment Calculus bovis Tumor-associated macrophages M2 tumor Macrophage polarization Wnt/β-catenin pathway

Predictive value of the systemic immune inflammation index in recurrence of atrial fibrillation after radiofrequency catheter ablation

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World Journal of Cardiology 2025年第1期17卷 22-27页

作者： alexander E Berezin Department of Internal Medicine-II Paracelsus Medical University SalzburgSalzburg 5020Austria

The recurrence of atrial fibrillation(AF)in patients after successful radiofrequency catheter ablation(RFCA)appears to be an unresolved clinical issue and needs to be clearly *** are many factors associated with AF recurrence,such as duration of AF,male sex,concomitant heart failure,hemodynamic parameters,chronic obstructive pulmonary disease,hypertension,obstructive sleep apnea,hyperthyroidism,smoking and ***,the inflammatory changes are strongly associated with electrical and structural cardiac remodeling,cardiac damage,myocardial fibrotic changes,microvascular dysfunction and altered reparative *** this context,biomarkers reflecting the different stages of AF pathogenesis deserve thorough *** authors of the retrospective study revealed that one-year recurrence rate of non-valvular AF in the high systemic immune inflammation(SII)index group was significantly increased compared to that of the low SII index group and provided additional predictive value to the ***,the authors suggest that this biomarker may help physicians to optimize the selection of AF patients and to develop a personalized treatment *** conclusion,the SII index may serve as a valuable indicator of recurrent AF in patients after RFCA and may be a biomarker with plausible predictive value for poor clinical outcomes.

关键词： Systemic immune inflammation index Recurrent atrial fibrillation Radiofrequency catheter ablation Biomarkers APPLE score Prediction

Protective activity of adipose-derived stem cell extracellular vesicles in ischemia and/or reperfusion

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World Journal of Stem Cells 2025年第1期17卷 1-5页

作者： alexander E Berezin Internal Medicine-II Paracelsus Medical University SalzburgSalzburg 5020Austria

Increasing evidence of the significant clinical value of protection against ischemia/reperfusion injury has contributed to the realization of the independent importance of this approach in improving prognosis and reducing cardiovascular *** vesicles(Evs)derived by adipose mesenchymal stem cells may mediate the paracrine effects of stem cells and provide regenerative and anti-inflammatory properties,which are enhanced byγ-aminobutyric *** protective effects on cardiac myocytes may result from the Ev embarked by miR-21-5p,which is a target for thioredoxin-interacting protein,regulating the formation of thioredoxin-interacting protein-thioredoxin complexes and subsequently enhancing the antioxidant activity of *** has been found thatγ-aminobutyric acid governs myocardial bioenergetics through suppressing inflammation and supporting mitochondrial ***,stem cell-based cell-free therapy based on adipose-derived stem cell Evs is considered a promising approach to individualized management of ischemia-induced cardiomyopathy.

关键词： Extracellular vesicles Adipose mesenchymal stem cells MicroRNA-21-5p Cardiac protection Ischemia Reperfusion

Probing multi-mobility edges in quasiperiodic mosaic lattices

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Science Bulletin 2025年第1期70卷 58-63页

作者： Jun Gao Ivan M.Khaymovich Xiao-Wei Wang Ze-Sheng Xu Adrian Iovan Govind Krishna Jiayidaer Jieensi Andrea Cataldo alexander v.Balatsky val Zwiller Ali W.Elshaari Department of Applied Physics KTH Royal Institute of TechnologyAlbanova University CentreStockholm SE-10691Sweden Nordita Stockholm University and KTH Royal Institute of TechnologyStockholm SE-10691Sweden Institute for Physics of Microstructures Russian Academy of SciencesNizhny Novgorod 603950Russia Center for Integrated Quantum Information Technologies(IQIT) School of Physics and Astronomy and State Key Laboratory of Advanced Optical Communication Systems and NetworksShanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of ConnecticutStorrsConnecticut 06269USA

The mobility edge(ME)is a crucial concept in understanding localization physics,marking the critical transition between extended and localized states in the energy *** localization scaling theory predicts the absence of ME in lower dimensional ***,the search for exact MEs,particularly for single particles in lower dimensions,has recently garnered significant interest in both theoretical and experimental studies,resulting in notable ***,several open questions remain,including the possibility of a single system exhibiting multiple MEs and the continual existence of extended states,even within the strong disorder ***,we provide experimental evidence to address these questions by utilizing a quasiperiodic mosaic lattice with meticulously designed nanophotonic *** observations demonstrate the coexistence of both extended and localized states in lattices with broken duality symmetry and varying modulation *** single-site injection and scanning the disorder level,we could approximately probe the ME of the modulated *** results corroborate recent theoretical predictions,introduce a new avenue for investigating ME physics,and offer inspiration for further exploration of ME physics in the quantum regime using hybrid integrated photonic devices.

关键词： Mobility edge Localization physics Mosaic lattice Nanophotonics

Features of Thermocatalytic Cracking of Polypropylene in the Presence of Potassium Polytitanate and Zeolite Catalysts

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Journal of Harbin Institute of Technology(New Series) 2025年第1期32卷 58-66页

作者： Nikita Zherdetsky alexander Gorokhovsky Roman Borisov valentin Atlasov Department of Chemistry and Chemical Technology of Materials Yuri Gagarin Saratov State Technical UniversitySaratov 410054Russian Federation A.v.Topchiev Institute of Petrochemical Synthesis RAS Moscow 119991Russian Federation

A comparative study of products of thermal and thermocatalytic cracking of polypropylene(PP) in the presence of potassium polytitanate(PPT) synthesized by treatment of TiO_(2)(rutile) powder with molten mixture of KOH and KNO_(3) taken in a weight ratio of 30∶30∶40 has been carried *** was shown that the studied type of PPT powder exhibits catalytic properties in the reaction of thermal decomposition of PP,compared to the effect of commercial zeolite catalyst CBv-780 traditionally used for this *** on the analysis performed,the differences in the mechanism of catalytic action of PPT and the zeolite were *** reasons for the observed differences in the composition of PP cracking products and in the rate of coke formation on the surface of studied catalysts were *** the obtained results,it has been proposed that the CBv-780 catalyst promoted more intensive production of the gaseous hydrocarbons compared to PPT,due to higher specific surface area(internal surface) accessible for relatively light and small-sized hydrocarbon products of ***,intensive coke formation on the outer surface of the microporous zeolite contributes to the blocking of transport channels and the rapid loss of catalytic *** the same time,PPT,which initially has a smaller specific surface area,retains its catalytic activity significantly longer due to slit-shaped flat pores and higher transport accessibility of the inner surface.

关键词： polypropylene catalytic cracking potassium polytitanate zeolite reaction mechanism recycling

Unveiling the atomic-scale transition between light harvesting and photoprotective states in plant photosynthesis

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Science China Chemistry 2024年第5期67卷 1375-1377页

作者： alexander v.Ruban School of Biological and Behavioural Sciences Queen Mary University of LondonLondon E14NSUK

Non-photochemical chlorophyll fluorescence quenching(NPQ) stands as a cornerstone in the realm of photosynthesis research, attracting generations of dedicated scientists in their quest to unravel its mysteries. This mechanism, crucial for safeguarding photosynthesis, plays a pivotal role in regulating light harvesting, particularly in oxygenic photosynthesis where the oxygen-evolving photosystem II (PSII)is susceptible to photodamage [1].

关键词： harvesting protective attracting

Regulation of TRP-like muscarinic cation current in gastrointestinal smooth muscle with special reference to PLC/InsP3/Ca2+ system

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Acta Pharmacologica Sinica 2006年第7期27卷 833-842页

作者： alexander v ZHOLOS Department of Physiology Queen’s University Belfast UK

Acetylcholine,the main enteric excitatory neuromuscular transmitter,evokes mem-brane depolarization and contraction of gastrointestinal smooth muscle cells byactivating G protein-coupled muscarinic *** the cholinergic exci-tation is generally underlined by the multiplicity of ion channel effects,the pri-mary event appears to be the opening of cation-selective channels;among themthe 60 pS channel has been recently identified as the main target for the acetylcho-line action in gastrointestinal *** evoked cation current,termed mICAT,causes either an oscillatory or a more sustained membrane depolarization response,which in turn leads to increases of the open probability of voltage-gated Ca2+channels,thus providing Ca2+entry in parallel with Ca2+release for intracellularCa2+concentration rise and *** recent years there have been severalsignificant developments in our understanding of the signaling processes under-lying *** have revealed important synergistic interactionsbetween M2and M3receptor subtypes,single channel mechanisms,and the in-volvement of TRPC-encoded proteins as essential components of native musca-rinic cation *** review summarizes these recent findings and in par-ticular discusses the roles of the phospholipase C/InsP3/intracellular Ca2+releasesystem in the mICATphysiological regulation.

关键词： smooth muscle muscarinic receptor G protein phospholipase C InsP3 calcium TRP cation channel

vegetation dynamics at the southern edge of the Siberian mountain taiga

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Journal of Mountain Science 2025年第2期22卷 451-465页

作者： IM Sergei T KHARUK viacheslav I PETROv Il'ya A SHUSHPANOv alexander S DvINSKAYA Maria L ONDAR Sergei O v.N.Sukachev Institute of Forest Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of ScienceKrasnoyarsk 660036Russia Institute of Ecology and Geography Institute of Space and Information TechnologiesSiberian Federal UniversityKrasnoyarsk 660041Russia Laboratory of Biodiversity and Ecology Tomsk State UniversityTomsk 634050Russia Institute of Space Research and High Technologies Reshetnev Siberian State University of Science and TechnologyKrasnoyarsk 660014Russia Department of Biology and Ecology Tuvan State UniversityKyzyl 667000Russia

The growth,survival,and mortality of conifer species in response to the hydrothermal regime have received considerable *** is expected that the highest sensitivity of trees to the warming-drying climate will occur mainly at the edges of the species *** focused on the responses to climate change of the drought-resistant larch(Larix sibirica)and the moisture-sensitive Siberian pine(Pinus sibirica)along the elevation gradient in the Tannu-Ola Ridge,the southern margin where those two species coexist in Siberia by using satellite data(MODIS,Landsat,and microwave),the indexes of gross(GPP)and net(NPP)primary productivity,and tree radial growth index(GI).We found that since the warming restart in the 2000s,the area of larch-dominated forests increased by~150%while the area of pine-dominated forests decreased by~10%.The Siberian pine has retreated at low elevations(vations(about+120%).Since 2001,the forested area increased by~5%.A shrubification,i.e.,an increase in the area of shrubs,was observed at high *** uphill rate of timberline and shrubline migration was about 0.3 m/*** the 2000s,vegetation NPP has increased by 13%.A notable correlation between NPP and the GI of larch and pine was found(r=0.5-0.7).At lower elevations,NPP positively correlated with precipitation and soil moisture,while air temperature and vPD(vapor pressure deficit)increase inhibited *** high elevations,the effects of these variables on productivity *** continuous decline of the Siberian pine forest indicates an inevitable retreat of this species at low elevations and its replacement by larch and birch.

关键词： Trees range changes Mountain taiga Siberian larch Siberian pine Timberline Shrubification Tree uphill migration Forest population dynamics Ecological resilience Habitat suitability