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Short-term results of incremental penile girth enhancement using liquid injectable silicone： words of praise for a change

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Asian Journal of Andrology 2007年第3期9卷 408-413页

作者： YacovYacobi alexander tsivian Roman Grinberg Oded Kessler Department of Urologic Surgery E. Wolfson Medical Center Holon 58100 Israel Theomim Clinic Ramat-Gan 52511 Israel

Aim： To report our experience with penile girth augmentation using liquid injectable silicone. Methods： Between August 2003 and July 2006, 324 men （mean age 35 years, range 19-65 years） received a series of liquid silicone subcutaneous injections between the penile skin and the corpora cavernosa on the dorsal and lateral aspects of the penile shaft, under local anesthesia. Digital photographs taken pre- and post-procedure （n = 324）, and penile contour measurements （n = 30） yielded objective results. Subjective results were derived from patient and partner testimony of satisfaction. Follow-up averaged 20 months （range 1-36 months）. Results： Three hundred and twenty-four procedures were primary augmentations. Most men （61%） were married, 7% were accompanied by their partners, and 93% were circumcised. The mean measured penile circumference was 9.5 cm （7.5-11.5 cm） pretreatment and 12.1 cm （10.3-15.3 cm） post-treatment （mean increase of 27% in circumference and 0.84 cm in diameter）. Patient and partner satisfaction was already expressed after the first two treatments. Sexual activity could be resumed after 8 h. Complications （mild bruising） were easily resolved. Conclusion： Penile girth augmentation using liquid injectable silicone yields very satisfactory short-term results with no immediate or short-term complications.

关键词： injectable silicone penile girth augmentation penile contouring

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Castration-resistant prostate cancer： a strategy to enhance response to androgen deprivation

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Asian Journal of Andrology 2013年第6期15卷 709-710页

作者： Yuri Stanevsky alexander tsivian Matvey tsivian Department of Urologic Surgery The E. Wolfson Medical Center Helen and Sackler school of Medicine Tel Aviv University Tel Aviv 53000 Israel Division of Urology Department of Surgery Duke University Medical Center Durham NC 27710 USA

Anew research study evaluated the mechanisms of prostate cancer （PCa）resistance to androgen deprivation therapy （ADT） and progression to castrate-resistant disease. Using a codinical approach, the investigators were able to identify key gen-etic determinants of ADT resistance, gain insight into the molecular pathways that play a key role in this transition and pro-pose a potential management strategy to overcome ADT resistance in select cancers. This represents a step forward towards per-sonalized medicine guided by specific molecular markers of prostate cancer enab-ling more effective therapies targeted towards altered metabolic pathways.

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