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Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

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Matter and Radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová Michal Krupka Zuzana Kuglerová Sushil Kumar Singh Vojtech Vozda Ludek Vysín MichalŠmíd Pablo Perez-Martin Marion Kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann Felix Rosenthal Sam M.Vinko Alessandro Forte thomas Gawne thomas Campbell Shenyuan Ren YuanFeng Shi trevor Hutchinson Oliver Humphries thomas Preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan alexander Köhler Marion Harmand Sven toleikis Katerina falk Libor Juha Department of Radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

Radiotherapy among nonagenarians with anal or rectal carcinoma: should we avoid or adapt treatment?

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Chinese Journal of Cancer 2017年第10期36卷 524-525页

作者： Alexis Vallard Chloé Rancoule Jean-Baptiste Guy Avi Assouline alexander t. falk Pierre Auberdiac Julien Langrand-Escure Cyrus Chargari Nicolas Magné Department of Radiotherapy Lucien Neuwirth Cancer Institute 108 BisAvenue Albert.Raimond BP 60008 42271 Saint.Priest En Jarez France Department of Radiotherapy Porte De Saint Cloud Clinical Centre 92100 Boulogne-Billancourt France Department of Radiation Oncology Antoine Lacassagne Centre 06100 Nice France Department of Radiotherapy Claude Bernard Private Hospital 81000 Albi France Department of Radiotherapy Val-De-Grace Military Hospital 75230 Paris France

Dear editor,Radiotherapy is a cornerstone in the management of anal or rectal cancer. Because elderly patients are often excluded from clinical trials, little is known about radiotherapy’s therapeutic index (efficacy/toxicity ratio) in the geriatric population [1]. Still, the ageing of population imposes the challenge to treat older cancer patients and probably to adjust their treatment [2]. A few studies reported data on radiation-induced toxicities in nonagenarian patients, but data on efficacy are still scarce. For rectal cancer, preoperative radiotherapy programs were suggested to be feasible in elderly patients [3–5], with a preference for short protocols without chemotherapy [4]. For anal cancer, the safety of radiochemotherapy was only reported in limited sets of elderly patients [6]. the objective of the present study was to report efficacy and toxicity data on the radiotherapy treatment of nonagenarian patients with anal or rectal *** analyzed the data of 34 nonagenarian patients with anal or rectal cancers: 27 (79.4%) with a rectal adenocarcinoma and 7 (20.6%) with an anal canal squamous cell carcinoma.

关键词： Radiotherapy feasible in elderly patients

Establishing a breast cancer center in Herat,Afghanistan:an implementation study

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Global Health Journal 2021年第4期5卷 204-208页

作者： Aziz-ur-Rahman Niazi Aziz Ahmad Jami Ahmad Zia Shams Ahmad Saeed Mahmoodi Eckart Krapfl Stephan falk alexander Buia Ernst Hanisch Faculty of Medicine Herat UniversityHeratAfghanistan Afghanistan Surgeons Society-West Andisha buidingEast of Herat Stadium7 Ahmad Shah Bada RoadHeratAfghanistan Kimia Hospital Qomandani Amniya StreetHeratAfghanistan German Cancer Research Center Im Neuenheimer Feld 280Heidelberg 69120Germany Interdisziplinäres Brustzentrum Asklepios Klinik LangenRöntgenstraβe 20Langen 63225Germany Center for Histology Cytology and Molecular Diagnostics TrierMax-Planck-Str.5Trier 54296Germany Department of General Visceral and thoracic Surgery Asklepios Klinik LangenRöntgenstraβe 20Langen 63225Germany

Objective:Breast cancer is the most common cancer in women,causing significant mortality in the world,which contributed 11.7%to the overall cancer-related mortality in *** 2018,3062 new breast cancer cases were reported accounting for 29.7%of all cancers in women in the ***,a comprehensive diagnostic and therapeutic system is lacking in *** this paper,we reported the implementation of a project aiming to establish a comprehensive breast cancer center in Herat province of ***:From July 2017,a two-year-program initiated at Kimia Hospital in *** first free diagnostic and therapeutic breast cancer project planned by the Afghanistan Surgeons Society-West and the Verein für Afghanistan-Förderung e.V.,as well supported by three international *** target populations of this project were women presenting with breast problems at Kimia Hospital in Herat and healthcare staff involved in breast cancer diagnosis and ***:A group of six medical personnel chosen to represent the breast cancer core team for breast cancer diagnosis and management were trained in *** caregivers established the breast cancer service and tumor *** a period of 20 months,a total of 632 women with breast problems presented to Kimia Hospital of whom 44(7.0%)were diagnosed with breast *** was established by a physical examination,ultrasonography,mammography,biopsy and *** included surgery,radiotherapy and *** seminars for 512 healthcare workers,1000 brochures and a movie were prepared for awareness-raising *** continuation of this project,potential resource providers were identified.A database was developed to record project ***:Implementation of this comprehensive breast cancer project resulted in significant achievements in healthcare staff capacity building,diagnosis and management of breast cancer patients in Herat *** obtai

关键词： Breast cancer Implementation Heart Afghanistan

High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy

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World Journal of Gastroenterology 2021年第24期27卷 3630-3642页

作者： Ulrike Bauer Sabine Gerum falk Roeder Stefan Münch Stephanie E Combs alexander B Philipp Enrico N De toni Martha M Kirstein Arndt Vogel Carolin Mogler Bernhard Haller Jens Neumann Rickmer F Braren Marcus R Makowski Philipp Paprottka Markus Guba Fabian Geisler Roland M Schmid Andreas Umgelter Ursula Ehmer Internal Medicine Ⅱ Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of Radiotherapy and Radiation Oncology University of SalzburgSalzburg 5020Austria Department of Radiation Oncology University Hospital of MunichCampus GroßhadernLMU MunichMunich 81377Germany Department of Radiation Oncology Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of Medicine II Liver CentreUniversity HospitalLMU MunichMunich 81377Germany Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany Institute of Pathology Technical University of MunichMunich 81675Germany Institute of Medical Informatics Statistics and EpidemiologyKlinikum rechts der IsarTechnical University of MunichMunich 81675Germany Institute of Pathology Faculty of MedicineUniversity Hospital of MunichMunich 81377Germany Institute of Diagnostic and Interventional Radiology Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Institute of Diagnostic and Interventional Radiology Section for Interventional RadiologyKlinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of General- Visceral-Vascular-and Transplant-SurgeryUniversity hospital of MunichCampus GroßhadernLMU MunichMunich 81377Germany Emergency Department Vivantes hospital groupHumboldt hospitalBerlin 13509Germany

BACKGROUND Liver transplantation(Lt)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation *** to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor *** chemoembolization(tACE)and less commonly stereotactic body radiation therapy(SBRt)or a combination of tACE and SBRt,are used as bridging therapies in ***,it remains unclear if one of those treatment options is *** analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by *** to analyze histopathological response to a combination of tACE and SBRt in HCC in comparison to tACE or SBRt *** In this multicenter retrospective study,27 patients who received liver transplantation for HCC were *** received either tACE or SBRt alone,or a combination of tACE and SBRt as bridging therapy to liver *** explants of all patients who received at least one tACE and/or SBRt were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging *** analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and Mann-Whitney-U *** Fourteen patients received tACE only,four patients SBRt only,and nine patients a combination therapy of tACE and *** were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor ***,analysis of liver explants revealed that almost all patients in the tACE and SBRt combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas tACE or SBRt alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P valueta suggests th

关键词： Hepatocellular carcinoma transarterial chemoembolization Stereotactic body radiation therapy Bridging therapy Liver transplantation

targeting stem cells by radiation: From the biological angle to clinical aspects

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World Journal of Stem Cells 2016年第8期8卷 243-250页

作者： Alexis Vallard Sophie Espenel Jean-Baptiste Guy Peng Diao Yaoxiong Xia Anis El Meddeb Hamrouni Majed Ben Mrad alexander tuan falk Claire Rodriguez-Lafrasse Chloé Rancoule Nicolas Magné Department of Radiotherapy Lucien Neuwirth Cancer Institute Laboratoire de Radiobiologie Cellulaire et Moléculaire CNRS UMR 5822 Institut de Physique Nucléaire de Lyon Department of Radiation Oncology Sichuan Cancer Hospital Department of Radiotherapy Centre Antoine Lacassagne

Radiotherapy is a cornerstone of anticancer treatment. However in spite of technical evolutions, important rates of failure and of toxicity are still reported. Although numerous pre-clinical data have been published, we address the subject of radiotherapy-stem cells interaction from the clinical efficacy and toxicity perspective. On one side, cancer stem cells(CSCs) have been recently evidenced in most of solid tumor primary locations and are thought to drive radio-resistance phenomena. It is particularly suggested in glioblastoma, where CSCs were showed to be housed in the subventricular zone(SVZ). In recent retrospective studies, the radiation dose to SVZ was identified as an independent factor significantly influencing overall survival. On the other side, healthy tissue stem cells radio-destruction has been recently suggested to cause two of the most quality of life-impacting side effects of radiotherapy, namely memory disorders after brain radiotherapy, and xerostomia after head and neck radiotherapy. Recent publications studying the impact of a radiation dose decrease on healthy brain and salivary stem cells niches suggested significantly reduced long term toxicities. Stem cells comprehension should be a high priority for radiation oncologists, as this particular cell population seems able to widely modulate the efficacy/toxicity ratio of radiotherapy in real life patients.

关键词： Cancer Neoplastic stem cells Radiation therapy Efficacy toxicity

Can patients determine the level of their dysphagia?

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World Journal of Gastroenterology 2017年第6期23卷 1038-1043页

作者： Hafiz Hamad Ashraf Joanne Palmer Harry Richard Dalton Carolyn Waters thomas Luff Madeline Strugnell Iain alexander Murray Departments of Gastroenterology Royal Cornwall Hospital NHS Trust Research and Development Royal Cornwall Hospital NHS Trust Clinical Imaging Royal Cornwall Hospital NHS Trust

to determine if patients can localise dysphagia level determined endoscopically or radiologically and association of gender, age, level and *** review of consecutive patients presenting to dysphagia hotline between March 2004 and March 2015 was carried out. Demographics, clinical history and investigation findings were recorded including patient perception of obstruction level (pharyngeal, mid sternal or low sternal) was documented and the actual level of obstruction found on endoscopic or radiological examination (if any) was noted. All patients with evidence of obstruction including oesophageal carcinoma, peptic stricture, Schatzki ring, oesophageal pouch and cricopharyngeal hypertrophy were included in the study who had given a perceived level of dysphagia. the upper GI endoscopy reports (barium study where upper GI endoscopy was not performed) were reviewed to confirm the distance of obstructing lesion from central incisors. A previously described anatomical classification of oesophagus was used to define the level of obstruction to be upper, middle or lower oesophagus and this was compared with patient perceived *** thousand six hundred and sixty-eight patients were included, 42.0% of who were female, mean age 70.7 ± 12.8 years old. Of those with obstructing lesions, 726 gave a perceived level of dysphagia: 37.2% had oesophageal cancer, 36.0% peptic stricture, 13.1% pharyngeal pouches, 10.3% Schatzki rings and 3.3% achalasia. twenty-seven point five percent of patients reported pharyngeal level (upper) dysphagia, 36.9% mid sternal dysphagia and 25.9% lower sternal dysphagia (9.5% reported multiple levels). the level of obstructing lesion seen on diagnostic testing was upper (17.2%), mid (19.4%) or lower (62.9%) or combined (0.3%). When patients localised their level of dysphagia to a single level, the kappa statistic was 0.245 (P ting fair agreement. 48% of patients reporting a single level of dysphagia

关键词： Deglutition disorders Oesophageal stenosis Oesophageal neoplasm Gastroscopy Fluoroscopy Patient perception Pharyngeal pouch

Muscle RING-finger protein-1 (MuRFl) functions and cellular localization are regulated by SUMOl post-translational modification

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Journal of Molecular Cell Biology 2019年第5期11卷 356-370页

作者： Gabriel Heras Arvind Venkat Namuduri Leonardo traini Ganna Shevchenko alexander falk Sara Bergstrom Lind Mi Jia Geng tian Stefano Gastaldello Department of Physiology and Pharmacology Karolinska Institutet Solnavagen 9 Quarter B5 Stockholm SE-17177 Sweden Department of Chemistry-BMC Analytical Chemistry Uppsala University Box 599 Uppsala SE-75124 Sweden Precision Medicine and Pharmacy Research Center Binzhou Medical University Yantai 264003 China

the muscle RING-finger protein-1 (MuRFl) is an E3 ubiquitin ligase expressed in skeletal and cardiac muscle tissues and it plays important roles in muscle remodeling. Upregulation of MuRFl gene transcription participates in skeletal muscle atrophy, on contrary downregulation of protein expression leads to cardiac hypertrophy. MuRFl gene point mutations have been found to generate protein aggregate myopathies defined as muscle disorder characterized by protein accumulation in muscle fibers. We have discovered that MuRFl turned out to be also a target for a new post-translational modification arbitrated by conjugation of SUM01 and it is mediated by the SUMO ligases E2 UBC9 and the E3 PIASy/4. SUMOylation takes place at lysine 238 localized at the second coiled-coil protein domain that is required for efficient substrate interaction for polyubiquitination. We provided evidence that SUMOylation is essential for MuRFl nuclear translocation and its mitochondria accumulation is enhanced in hyper? glycemic conditions delivering a stabilization of the overall SUMOylated proteins in cultured myocytes. thus, our findings add this SUM01 post-translational modification as a new concept to understand muscle disorders related to the defect in MuRFl activity.

关键词： tRIM63/MuRFl muscle remodeling SUMO protein degradation hyperglycemia

Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks

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Signal transduction and targeted therapy 2022年第1期7卷 243-257页

作者： Louisa Ruhl Isabell Pink Jenny F.Kiihne Kerstin Beushausen Jana Keil Stella Christoph Andrea Sauer Lennart Boblitz Julius Schmidt Sascha David Hans-Martin Jack Edith Roth Markus Cornberg thomas F.Schulz tobias Welte Marius M.Hoper Christine S.falk Institute of transplant Immunology MHHDHanoverGermany Department of Pneumology MHHDHanoverGermany Department of Intensive Care Medicine University of ZurichCHZurichSwitzerland Division of Molecular Immunology Internal Medicine IIINikolaus-Fiebiger-Center of Molecular MedicineFriedrich-Alexander University Erlangen-NurnbergDErlangenGermany Department of Gastroenterology Hepatology and Endocrinology MHHDHanoverGermany Center for Individualized Infection Medicine CiiM HanoverGermany lnstitute of Virology MHHDHanoverGermany German Center for Infection Research DZIFTTU-IICHMarburgGermany Excellence Cluster 2155 RESISt MHHHanoverGermany German Center for Lung Diseases DZL/BREAtH MarburgGermany

the systemic processes involved in the manifestation of life・threatening COVID-19 and in disease recovery are still incompletely understood,despite investigations focusing on the dysregulation of immune responses after SARS-CoV-2 *** define hallmarks of severe COVID-19 in acute disease(n=58)and in disease recovery in con valesce nt patie nts(n=28)from Han nover Medical School,we used flow cytometry and proteomics data with unsupervised clustering *** our observational study,we combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and *** patients displayed an altered immune signature with prolonged lymphopenia but the expansion of granulocytes and plasmablasts along with activated and terminally differentiated t and NK cells and high levels of SARS-CoV-2-specific *** core signature of seven plasma proteins revealed a highly inflammatory microenvironment in addition to endothelial injury in severe *** within this sign ature were associated with either disease progression or *** summary,our data suggest that besides a strong inflammatory response,severe COVID-19 is driven by endothelial activation and barrier disruption,whereby recovery depends on the regeneration of the endothelial integrity.

关键词： cytokine networks signature