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Broadband 1-GHz mid-infrared frequency comb

Light(Science & Applications) 2022年第10期11卷 2358-2364页

作者： Nazanin Hoghooghi Sida Xing Peter Chang Daniel Lesko alexander lind Greg Rieker Scott Diddams Precision Laser Diagnostics Laboratory University of ColoradoBoulderCO 80309USA Time and Frequency Division National Institute of Standards and TechnologyBoulderCO 80305USA Department of Physics University of ColoradoBoulderCO 80309USA Department of Chemistry University of ColoradoBoulderCO 80309USA Electrical Computer and Energy Engineering University of ColoradoBoulderCO 80309USA

Mid-infrared(MIR)spectrometers are invaluable tools for molecular fingerprinting and hyper-spectral *** the available spectroscopic approaches,GHz MIR dual-comb absorption spectrometers have the potential to simultaneously combine the high-speed,high spectral resolution,and broad optical bandwidth needed to accurately study complex,transient events in chemistry,combustion,and ***,such a spectrometer has not yet been demonstrated due to the lack of GHz MIR frequency combs with broad and full spectral ***,we introduce the first broadband MIR frequency comb laser platform at 1 GHz repetition rate that achieves spectral coverage from 3 to 13 μ*** frequency comb is based on a commercially available 1.56 μm mode-locked laser,robust all-fiber Er amplifiers and intra-pulse difference frequency generation(IP-DFG)of few-cycle pulses in x(2)nonlinear *** used in a dual comb spectroscopy(DCS)configuration,this source will simultaneously enable measurements with μs time resolution,1 GHz(0.03 cm-1)spectral point spacing and a full bandwidth of>5 THz(>166 cm-1)anywhere within the MIR atmospheric *** represents a unique spectroscopic resource for characterizing fast and non-repetitive events that are currently inaccessible with other sources.

关键词： repetition spacing transient

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Muscle RING-finger protein-1 (MuRFl) functions and cellular localization are regulated by SUMOl post-translational modification

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Journal of Molecular Cell Biology 2019年第5期11卷 356-370页

作者： Gabriel Heras Arvind Venkat Namuduri Leonardo Traini Ganna Shevchenko alexander Falk Sara Bergstrom lind Mi Jia Geng Tian Stefano Gastaldello Department of Physiology and Pharmacology Karolinska Institutet Solnavagen 9 Quarter B5 Stockholm SE-17177 Sweden Department of Chemistry-BMC Analytical Chemistry Uppsala University Box 599 Uppsala SE-75124 Sweden Precision Medicine and Pharmacy Research Center Binzhou Medical University Yantai 264003 China

The muscle RING-finger protein-1 (MuRFl) is an E3 ubiquitin ligase expressed in skeletal and cardiac muscle tissues and it plays important roles in muscle remodeling. Upregulation of MuRFl gene transcription participates in skeletal muscle atrophy, on contrary downregulation of protein expression leads to cardiac hypertrophy. MuRFl gene point mutations have been found to generate protein aggregate myopathies defined as muscle disorder characterized by protein accumulation in muscle fibers. We have discovered that MuRFl turned out to be also a target for a new post-translational modification arbitrated by conjugation of SUM01 and it is mediated by the SUMO ligases E2 UBC9 and the E3 PIASy/4. SUMOylation takes place at lysine 238 localized at the second coiled-coil protein domain that is required for efficient substrate interaction for polyubiquitination. We provided evidence that SUMOylation is essential for MuRFl nuclear translocation and its mitochondria accumulation is enhanced in hyper? glycemic conditions delivering a stabilization of the overall SUMOylated proteins in cultured myocytes. Thus, our findings add this SUM01 post-translational modification as a new concept to understand muscle disorders related to the defect in MuRFl activity.

关键词： TRIM63/MuRFl muscle remodeling SUMO protein degradation hyperglycemia

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哥本哈根Sanders酒店

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现代装饰 2018年第9期 80-85页

作者： Pernille lind Richy Almond 彭佳英国伦敦设计事务所lind+Almond

Sanders酒店的所有者是alexander Klpin,他提出的设计要求虽然简单但却充满了挑战性——打造哥本哈根最好的酒店。设计最关键的目的之一就是为城市生活带来全新的体验,唤起人们对旧时会员俱乐部的记忆,同时为游客和当地的人们营造家... 详细信息

Sanders酒店的所有者是alexander Klpin,他提出的设计要求虽然简单但却充满了挑战性——打造哥本哈根最好的酒店。设计最关键的目的之一就是为城市生活带来全新的体验,唤起人们对旧时会员俱乐部的记忆,同时为游客和当地的人们营造家一般的温馨氛围。设计面临着诸多挑战,例如酒店建筑的老化、家具配饰的陈旧、室内设计与当地环境的不协调等等。

关键词：酒店建筑哥本哈根室内设计城市生活挑战性俱乐部

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