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levels of circulating follicular helper T cells,T helper 1 cells,and the prognostic significance of soluble form of CD40 ligand on survival in patients with alcoholic cirrhosis

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liver Research 2018年第1期2卷 52-59页

作者： Kristin Hollister Praveen Kusumanchi Ruth Ann Ross Kristina Chandler AdePeju Oshodi laura Heathers Sean Teagarden li Wang alexander l.dent Suthat liangpunsakul Department of Microbiology and Immunology Indiana University School of MedicineIndianapolisINUSA Division of Gastroenterology and Hepatology Department of MedicineIndiana University School of MedicineIndianapolisINUSA Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisINUSA Department of Physiology and Neurobiology The Institute for Systems GenomicsUniversity of ConnecticutStorrsCTUSA Veterans Affairs Connecticut Healthcare System West HavenCTUSA Department of Internal Medicine Section of Digestive DiseasesYale UniversityNew HavenCTUSA School of Pharmaceutical Sciences Wenzhou Medical UniversityWenzhouZhejiangChina Department of Biochemistry and Molecular Biology Indiana University School of MedicineIndianapolisINUSA Roudebush Veterans Administration Medical Center IndianapolisINUSA

Background:Excessive drinkers(ED)and patients with alcoholic liver disease(AlD)are several times more susceptible to bacterial and viral infections and have a decrease in antibody responses to *** helper T(TFH)cells are essential to select B cells in the germinal center and to produce *** cells express both a membrane-associated and a soluble form of CD40 ligand(sCD40l),in which the latter form is released to circulation upon T cell *** effect of alcohol on TFH cells has not been ***:The goals of this study are to determine the levels of TFH and T helper 1(Th1)cells in ED and those with alcoholic cirrhosis(AC)when compared to healthy controls and to determine the prognostic significance of sCD40l in a cohort of patients with ***:Controls,ED,and those with AC were *** demographic,laboratory tests,and peripheral blood mononuclear cells(PBMCs)were isolated and assessed via flow cytometry for TFH *** vitro study was performed to determine the ability of PBMCs to secrete interferon(IFN)-ɣupon *** sCD40l was also determined and its prognostic significance was tested in a cohort of AC ***:The levels of circulating TFH(cTFH)cells were significantly lower in peripheral blood of subjects with ED and AC compared to controls(Plation was also lower in ED and those with *** sCD40l was significantly lower in ED and AC when compared to that in controls(Plevel was an independent predictor of ***:Patients with AC had significantly lower level of cTFH and *** level of sCD40l was an independent predictor of mortality in these patients.

关键词： Follicular helper T(TFH)cells Circulating follicular helper T(cTFH)cells T helper 1(Th1) Soluble form of CD40 ligand(sCD40l) Alcoholic liver disease(AlD) Alcoholic cirrhosis(AC)

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Development of 3D Scanning System for Robotic Plasma Processing of Medical Products with Complex Geometries

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Journal of Electronic Science and Technology 2020年第3期18卷 212-222页

作者： Darya l.Alontseva Elaheh Ghassemieh alexander l.Krasavin Albina T.Kadyroldina School of Information Technology and Intelligent Systems D.Serikbayev East Kazakhstan State Technical UniversityUst-Kamenogorsk 070004 Wolfson School of Mechanical Electrical and Manufacturing EngineeringLoughborough UniversityLoughborough LE113TU

This paper describes the development of an intelligent automated control system of a robot manipulator for plasma treatment of medical implants with complex *** two-layer coatings from the Ti wire and hydroxyapatite powders are applied on the surface of Ti medical implants by microplasma spraying to increase the biocompatibility of *** coating process requires precise control of a number of parameters,particularly the plasma spray distance and plasma jet traverse ***,the development of the robotic plasma surface treatment involves automated path *** key idea of the proposed intelligent automatic control system is the use of data of preliminary three-dimensional (3D) scanning of the processed implant by the robot *** segmentation algorithm of the point cloud from laser scanning of the surface is *** methodology is suitable for robotic 3D scanning systems with both non-contact laser distance sensors and video cameras,used in additive manufacturing and medicine.

关键词： Plasma processing point cloud robot manipulator surface segmentation three-dimensional(3D)scanning

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Update on herbal and dietary supplement-induced liver injury:current gaps and future directions

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 752-755页

作者： Sabine Weber alexander l.Gerbes Department of Medicine II University HospitalLMU MunichMunichGermany

Drug-induced liver injury(DIlI)is a rare but potentially life-threatening condition,which accounts for the majority of acute liver failure cases in the US and *** direct hepatoxicity,which is mainly caused by acetaminophen,idiosyncratic DIlI is unpredictable and occurs unrelated to the dose or frequency of the ***,DIlI cannot only be caused by a large variety of prescription drugs,but also by herbal and dietary supplements(HDS).While HDS-DIlI has already played a role in Asian countries like China or Korea for a long time,there is also an increasing incidence of HDS-DIlI in countries with formerly less HDS-DIlI cases such as the US,presumably due to a rising usage of those remedies(1).

关键词： Herbal and dietary supplements(HDS) liver injury hepatoxicity autoimmune liver diseases

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Parasites of the liver:A global problem?

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World Journal of Gastroenterology 2024年第30期30卷 3554-3559页

作者： Vladislav V Tsukanov alexander V Vasyutin Julia l Tonkikh Clinical Department of the Digestive System Pathology of Adults and Children Federal Research Center“Krasnoyarsk Science Center”of the Siberian Branch of the Russian Academy of SciencesScientific Research Institute of Medical Problems of the NorthKrasnoyarsk 660022Russia

Parasitic liver diseases can be caused by trematodes,cestodes,nematodes,and *** pathology is significant because millions of people in different parts of the world have liver parasites,which can manifest themselves in the development of inflammation,liver cysts,cholecystitis,cholelithiasis,pancreatitis and liver cirrhosis that are often threatening their *** International Agency for Research on Cancer considers three species of trematodes,Schistosoma haematobium,Opisthorchis viverrini and Clonorchis sinensis,to be *** modern examination methods,in some cases including extensive screening of large populations,are required for diagnosing liver *** of parasitic liver diseases is differentiated and can involve a combination of surgical and therapeutic *** is no doubt that the clinical and epidemiological scale allows one to regard parasitic liver diseases as a global healthcare problem.

关键词： liver Parasites Epidemiology Diagnosis Clinics Treatment Echinococcosis Opisthorchiasis Fascioliasis Schistosomiasis

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Phase field modeling with large driving forces

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npj Computational Materials 2023年第1期9卷 623-631页

作者： Jin Zhang alexander F.Chadwick David l.Chopp Peter W.Voorhees Department of Materials Science and Engineering Northwestern UniversityEvanstonIL 60208USA Department of Engineering Sciences and Applied Mathematics Northwestern UniversityEvanstonIL 60208USA

There is growing interest in applying phase field methods as quantitative tools in materials discovery and ***,large driving forces,common in many materials systems,lead to unstable phase field profiles,thus requiring fine spatial and temporal *** demands more computational resources,limits the ability to simulate systems with a suitable size,and deteriorates the capability of quantitative ***,we develop a strategy to map the driving force to a constant perpendicular to the *** with the third-order interpolation function,we find a stable phase field profile that is independent of the magnitude of the driving *** power of this approach is illustrated using three *** demonstrate that by using the driving force extension method,it is possible to employ a grid size orders of magnitude larger than traditional *** approach is general and should apply to many other phase field models.

关键词： forces interpolation apply

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Mitochondrial transplantation strategies as potential therapeutics for central nervous system trauma

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Neural Regeneration Research 2018年第2期13卷 194-197页

作者： Jenna l.Gollihue Samir P.Patel alexander G.Rabchevsky Spinal Cord and Brain Iniury Research Center University of KentuckyLexingtonKYUSA Separtment of Physiology University of KentuckyLexingtonKYUSA

Mitochondria are essential cellular organelles critical for generating adenosine triphosphate for cellular homeostasis, as well as various mechanisms that can lead to both necrosis and apoptosis. The field of ＂mi- tochondrial medicine＂ is emerging in which injury/disease states are targeted therapeutically at the level of the mitochondrion, including specific antioxidants, bioenergetic substrate additions, and membrane uncoupling agents. Consequently, novel mitochondrial transplantation strategies represent a potentially multifactorial therapy leading to increased adenosine triphosphate production, decreased oxidative stress, mitochondrial DNA replacement, improved bioenergetics and tissue sparing. Herein, we describe briefly the history of mitochondrial transplantation and the various techniques used for both in vitro and in vivo delivery, the benefits associated with successful transference into both peripheral and central nervous system tissues, along with caveats and pitfalls that hinder the advancements of this novel therapeutic.

关键词： oxygen consumption bioenergetics oxidative phosphorylation cellular uptake replacement strategies spinal cord injury mitochondria

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Raman lasing and soliton mode-locking in lithium niobate microresonators

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light(Science & Applications) 2020年第1期9卷 1925-1931页

作者： Mengjie Yu Yoshitomo Okawachi Rebecca Cheng Cheng Wang Mian Zhang alexander l.Gaeta Marko loncar Department John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA Department of Applied Physics and Applied Mathematics Columbia UniversityNew YorkNY 10027USA Department of Electronic Engineering&State Key laboratory of Terahertz and Millimeter Waves City University of Hong KongKowloonHong KongChina Hyperlight Corporation 501 Massachusetts AvenueCambridgeMA 02139USA

The recent advancement in lithium-niobite-on-insulator(lNOI)technology is opening up new opportunities in optoelectronics,as devices with better performance,lower power consumption and a smaller footprint can be realised due to the high optical confinement in the *** lNOI platform offers both largeχ(2)andχ(3)nonlinearities along with the power of dispersion engineering,enabling brand new nonlinear photonic devices and applications for the next generation of integrated photonic ***,Raman scattering and its interaction with other nonlinear processes have not been extensively studied in dispersion-engineered lNOI *** this work,we characterise the Raman radiation spectra in a monolithic lithium niobate(lN)microresonator via selective excitation of Raman-active phonon *** dominant mode for the Raman oscillation is observed in the backward direction for a continuous-wave pump threshold power of 20mW with a high differential quantum efficiency of 46%.We explore the effects of Raman scattering on Kerr optical frequency comb *** achieve mode-locked states in an X-cut lNOI chip through sufficient suppression of the Raman effect via cavity geometry *** analysis of the Raman effect provides guidance for the development of future chip-based photonic devices on the lNOI platform.

关键词： scattering pump lithium

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Neotectonic transpressional intraplate deformation in eastern Eurasia: Insights from active fault systems in the southeastern Korean Peninsula

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Geoscience Frontiers 2023年第4期14卷 123-136页

作者： Namgwon Kim Seung-Ik Park Chang Soo Cho Youngbeom Cheon alexander l.Peace Department of Geology Kyungpook National UniversityDaegu 41566Republic of Korea Earthquake Research Center Korea Institute of Geosciences and Mineral ResourcesDaejeon 34132Republic of Korea Active Tectonics Research Center Korea Institute of Geosciences and Mineral ResourcesDaejeon 34132Republic of Korea School of Earth Environment and SocietyMcMaster UniversityHamiltonON L8S 4K1Canada

Transpression occurs in response to oblique convergence across a deformation zone in intraplate regions and plate *** Korean Peninsula is located at an intraplate region of the eastern Eurasian Plate and has been deformed under the ENE–WSW maximum horizontal compression since the late *** this study,we analyzed short-term instrumental seismic(focal mechanism)and long-term paleoseis-mic(Quaternary fault outcrop)data to decipher the neotectonic crustal deformation pattern in the south-eastern Korean ***(paleo-)seismic data acquired from an NNE–SSW trending deformation zone between the Yangsan and Ulleung fault zones indicate spatial partitioning of crustal deformation by NNW–SSE to NNE–SSW striking reverse faults and NNE–SSW striking strike-slip faults,supporting a strike-slip partitioned transpression *** instantaneous and finite neotectonic strains,estimated from the focal mechanism and Quaternary outcrop data,respectively,show discrepan-cies in their axes,which can be attributed to the switching between extensional and intermediate axes of finite strain during the accumulation of wrench-dominated ***,some major faults,including the Yangsan and Ulsan fault zones,are relatively misoriented to slip under the current stress condition but,paradoxically,have more(paleo-)seismic records indicating their role in accommodating the neotectonic transpressional *** propose that fluids,heat flow,and lithospheric structure are potential factors affecting the reactivation of the relatively misoriented major *** findings provide insights into the accommodation pattern of strain associated with the neotectonic crustal extrusion in an intraplate region of the eastern Eurasian Plate in response to the collision of the Indian Plate and the sub-duction of the Pacific/Philippine Sea Plates.

关键词： Transpression Strike-slip partition Intraplate strain accommodation Fault-slip analysis Slip tendency analysis

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The evolution of refertilized lithospheric mantle beneath the northeastern Siberian craton:links between mantle metasomatism,thermal state and diamond potential

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Geoscience Frontiers 2022年第6期13卷 153-169页

作者： Sergei Skuzovatov Vladislav S.Shatsky Alexey l.Ragozin alexander P.Smelov Vinogradov Institute of Geochemistry Russian Academy of SciencesSiberian Branch1AFavorskogo Str.Irkutsk 664033Russia Sobolev Institute of Geology and Mineralogy Russian Academy of SciencesSiberian Branch3Koptyug Ave.Novosibirsk 630090Russia Geology&Geophysics Department Novosibirsk State University2 Pirogova Str.Novosibirsk 630090Russia Diamond and Precious Metal Geology Institute Russian Academy of SciencesSiberian Branch39Lenina Ave.Yakutsk 677000Russia

Although the diamond potential of cratons is linked mainly to thick and depleted Archean lithospheric keels, there are examples of craton-edge locations and circum-cratonic Proterozoic terranes underlain by diamondiferous mantle. Here, we use the results of comprehensive major and trace-element studies of detrital garnets from diamond-rich late Triassic(Carnian) sedimentary rocks in the northeastern Siberia to constrain the thermal and chemical state of the pre-Triassic mantle and its ability to sustain the diamond storage. The studied detrital mantle-derived garnets are dominated by low-to mediumCr lherzolitic(~45%) and low-Cr megacrystic(~39%) chemistries, with a significant proportion of eclogitic garnets(~11%), and only subordinate contribution from harzburgitic garnets(~5%) with variable CrOcontents(1.2–8.4 wt.%). low-Cr megacrysts display uniform, “normal” rare-earth element(REE)patterns with no Eu/Eu* anomalies, systematic Zr and Ti enrichment(mainly within 2.5–5), which are evidence of their crystallization from deep metasomatic melts. lherzolitic(G9) garnets exhibit normal or humped to MREE-depleted sinusoidal REE patterns and elevated Nd/Y(up to 0.33–0.41) and Zr/Y ratios(up to 7.62). Rare low-to high-Cr harzburgitic(G10) garnets have primarily “depleted”, sinusoidal REEpatterns, low Ti, Y and HREE, but vary significantly in Zr-Hf, Ti and MREE-HREE contents, Nd/Y(within 0.1–2.4) and Zr/Y(1.53–19.9) ratios. The observed trends of chemical enrichment from the most depleted,harzburgitic garnets towards lherzolitic(including high-Ti high-Cr G11-type) garnets and megacrysts result from either voluminous high-temperature metasomatism by plume-derived silicate melts or recurrent mobilization of less voluminous kimberlitic or related carbonated mantle melts, rather than the initially primitive, fertile nature of the Proterozoic SClM. Calculated Ni-in-garnet temperatures(primarily within ~1150–1250 ℃) indicate their derivation from at least ~220 km thick Cr-undersa

关键词： Siberian craton Kimberlite Diamond placers Peridotites Eclogites Megacrysts

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Biological imaging without autofluorescence in the second near-infrared region

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Nano Research 2015年第9期8卷 3027-3034页

作者： Shuo Diao Guosong Hong alexander l. Antaris Jeffrey l. Blackbum Kai Cheng Zhen Cheng Hongjie Dai Department of Chemistry Stanford University Stanford California 94305 USA Chemical and Materials Science Center National Renewable Energy Laboratory Colorado 8040 I USA Molecular Imaging Program at Stanford (MIPS) and Department of Radiology Stanford University California 94305 USA

Fluorescence imaging is capable of acquiring anatomical and functional infor- mation with high spatial and temporal resolution. This imaging technique has been indispensable in biological research and disease detection/diagnosis. Imaging in the visible and to a lesser degree, in the near-infrared （NIR） regions below 900 nm, suffers from autofluorescence arising from endogenous fluorescent molecules in biological tissues. This autofluorescence interferes with fluorescent molecules of interest, causing a high background and low detection sensitivity. Here, we report that fluorescence imaging in the 1,500-1,700-nm region （termed ＂NIR-IIb＂） under 808-nm excitation results in nearly zero tissue autofluorescence, allowing for background-free imaging of fluorescent species in otherwise notoriously autofluorescent biological tissues, including liver. Imaging of the intrinsic fluorescence of individual fluorophores, such as a single carbon nanotube, can be readily achieved with high sensitivity and without autofluorescence background in mouse liver within the 1,500-1,700-nm wavelength region.

关键词： fluorescence imaging,second near-infrared,nanotechnology autofluorescence

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