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World Journal of Gastrointestinal Oncology 2019年第2期11卷 102-116页

作者： alexander jp fulton Angela Lamarca Christina Nuttall Lynne McCallum Rille Pihlak Derek O'Reilly Fiona Lalloo Mairéad G McNamara Richard A Hubner Tara Clancy Juan W Valle Department of Medical Oncology The Christie NHS Foundation Trust Hepato-pancreato-biliary Surgical Department Manchester Royal InfirmaryCentral Manchester University Hospitals NHS Foundation Trust Manchester Centre for Genomic Medicine Central Manchester University Hospitals NHS Foundation Trust Saint Mary's Hospital

BACKGROUND Identification of germ-line mutations in pancreatic ductal adenocarcinoma(PDAC) could impact on patient/*** To assess the referral pathways for genetic consultations in *** Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer(EUROPAC)*** Four-hundred patients were eligible. Of 113 patients(28.3%) meeting EUROPAC criteria, 8.8% were referred for genetic opinion. Germ-line mutations were identified in 0.75% of the whole *** referrals and increased awareness may be able to overcome the low rate of successful genetic appointments.

关键词： Genetic counselling Pancreatic adenocarcinoma Genetic consultation BRCA Germline

Mechanisms of pulmonary endothelial barrier dysfunction in acute lung injury and acute respiratory distress syndrome

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第2期2卷 80-87页

作者： Yunchao Su Rudolf Lucas David J.R.fulton alexander D.Verin Department of Pharmacology&Toxicology Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA Division of Pulmonary and Critical Care Medicine Department of MedicineMedical College of GeorgiaAugusta UniversityAugustaGA 30912USA Vascular Biology Center Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA Research Service Charlie Norwood Veterans Affairs Medical CenterAugustaGA 30912USA

Endothelial cells(ECs)form a semi-permeable barrier between the interior space of blood vessels and the un-derlying *** endothelial barrier integrity is maintained through coordinated cellular processes involving receptors,signaling molecules,junctional complexes,and protein-regulated cytoskeletal *** acute lung injury(ALI)or its more severe form acute respiratory distress syndrome(ARDS),the loss of endothelial barrier integrity secondary to endothelial dysfunction caused by severe pulmonary inflamma-tion and/or infection leads to pulmonary edema and ***-inflammatory agonists such as histamine,thrombin,bradykinin,interleukin 1𝛽,tumor necrosis factor𝛼,vascular endothelial growth factor,angiopoietin-2,and platelet-activating factor,as well as bacterial toxins and reactive oxygen species,cause dynamic changes in cytoskeletal structure,adherens junction disorganization,and detachment of vascular endothelial cadherin(VE-cadherin)from the actin cytoskeleton,leading to an increase in endothelial *** interactions with leukocytes,platelets,and coagulation enhance the inflammatory ***,inflammatory infil-tration and the associated generation of pro-inflammatory cytokines during infection cause EC death,resulting in further compromise of the structural integrity of lung endothelial *** the use of potent antibiotics and aggressive intensive care support,the mortality of ALI is still high,because the mechanisms of pulmonary EC barrier disruption are not fully *** this review,we summarized recent advances in the studies of endothelial cytoskeletal reorganization,inter-endothelial junctions,endothelial inflammation,EC death,and endothelial repair in ALI and ARDS,intending to shed some light on the potential diagnostic and therapeutic targets in the clinical management of the disease.

关键词： Lung Endothelium Pulmonary edema Acute lung injury Acute respiratory distress syndrome

Towards seamless environmental prediction-development of Pan-Eurasian EXperiment(PEEX)modelling platform

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Big Earth Data 2024年第2期8卷 189-230页

作者： alexander Mahura alexander Baklanov Risto Makkonen Michael Boy Tuukka Petäjä Hanna KLappalainen Roman Nuterman Veli-Matti Kerminen Stephen R.Arnold Markus Jochum Anatoly Shvidenko Igor Esau Mikhail Sofiev Andreas Stohl Tuula Aalto Jianhui Bai Chuchu Chen Yafang Cheng Oxana Drofa Mei Huang Leena Järvi Harri Kokkola Rostislav Kouznetsov Tingting Li Piero Malguzzi Sarah Monks Mads Bruun Poulsen Steffen M.Noe Yuliia Palamarchuk Benjamin Foreback Petri Clusiu Till Andreas Soya Rasmussen Jun She Jens Havskov Sørensen Dominick Spracklen Hang Su Juha Tonttila Siwen Wang Jiandong Wang Tobias Wolf-Grosse Yongqiang Yu Qing Zhang Wei Zhang Wen Zhang Xunhua Zheng Siqi Li Yong Li Putian Zhou Markku Kulmala Faculty of Science Institute for Atmospheric and Earth System Research(INAR)/PhysicsUniversity of Helsinki(UHEL)HelsinkiFinland Science and Innovation Department World Meteorological Organization(WMO)GenevaSwitzerland Niels Bohr Institute University of CopenhagenCopenhagenDenmark Climate System Research Finnish Meteorological Institute(CSR-FMI)HelsinkiFinland School of Engineering Sciences Lappeenranta University of TechnologyLappeenrantaFinland Institute for Climate and Atmospheric Science School of Earth and EnvironmentUniversity of LeedsLeedsUK Biodiversity and Natural Resources Program International Institute for Applied Systems Analysis(IIASA)LaxenburgAustria Department of Physics and Technology UiT-The Arctic University of NorwayTromsoNorway Nansen Environmental and Remote Sensing Center(NERSC) BergenNorway Atmospheric Composition Finnish Meteorological Institute(AC-FMI)HelsinkiFinland Norwegian Institute for Air Research(NILU) KjellerNorway LAGEO Institute of Atmospheric PhysicsChinese Academy of Sciences(IAP-CAS)BeijingChina Max Planck Institute for Chemistry(MPI-Chem) MainzGermany Institute of Atmospheric Sciences and Climate National Research Council of Italy(CNR-15SAC)BolognaItaly Institute of Geographic Sciences and Natural Resources Research(IGSNRR) Chinese Academy of Sciences(CAS)BeijingChina Faculty of Science Helsinki Institute of Sustainability Science(HELSUS)University of Helsinki(UHEL)HelsinkiFinland Atmospheric Research Centre of Eastern Finland Finnish Meteorological Institute(ARCEF-FMI)KuopioFinland Institute of Atmospheric Physics Chinese Academy of Sciences(IAP-CAS)BeijingChina Department of Plant Physiology Estonian University of Life Sciences(EULS)Institute of Agricultural and Environmental Sciences(IAES)TartuEstonia Danish Meteorological Institute(DMI) CopenhagenDenmark State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry LAPC) Institute of Atmospheric Physics(IAP)Chinese Academy of Sciences(CAS)BeijingChina Uni

The Pan-Eurasian Experiment Modelling Platform(PEEX-MP)is one of the key blocks of the PEEX Research *** PEEX MP has more than 30 models and is directed towards seamless envir-onmental *** main focus area is the Arctic-boreal regions and *** models used in PEEX-MP cover several main components of the Earth’s system,such as the atmosphere,hydrosphere,pedosphere and biosphere,and resolve the physicalchemicalbiological processes at different spatial and temporal scales and *** paper introduces and discusses PEEX MP multi-scale modelling concept for the Earth system,online integrated,forward/inverse,and socioeconomical modelling,and other approaches with a particular focus on applications in the PEEX geographical *** employed high-performance com-puting facilities,capabilities,and PEEX dataflow for modelling results are *** virtual research platforms(PEEXView,Virtual Research Environment,Web-based Atlas)for handling PEEX modelling and observational results are *** over-all approach allows us to understand better physical-chemicalbiological processes,Earth’s system interactions and feedbacks and to provide valuable information for assessment studies on evaluating risks,impact,consequences,*** population,envir-onment and climate in the PEEX *** work was also one of the last projects of *** Zilitinkevich,who passed away on 15 February *** the finalization took time,the paper was actually submitted in 2023 and we could not argue that the final paper text was agreed with him.

关键词： Multi-scale and-processes modelling concept seamless coupling high-performance computing data infrastructure virtual research platforms

Sub-chronic exposure to jp-8 jet fuel enhances susceptibility to noise induced hearing loss in rats

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Sub-chronic exposure to jp-8 jet fuel enhances susceptibilit...

Current Status and Future Challenges of Weather Radar Polarimetry: Bridging the Gap between Radar Meteorology/Hydrology/Engineering and Numerical Weather Prediction

Neurotoxicity and Neurodegeneration:Local Effect and Global Impact--13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health

作者： Larry Fechter Caroline Gearhart Sherry fulton Research Service Loma Linda VA Medical CenterLoma LindaCAUSA

Purpose: Both laboratory and occupational epidemiological studies identify specific organic solvents as potential ototoxicants or agents that promote noise-induced hearing *** the presence of several such aromatic hyd... 详细信息

关键词： Sub-chronic exposure to jp-8 jet fuel enhances susceptibility to noise induced hearing loss in rats

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Advances in Atmospheric Sciences 2019年第6期36卷 571-588页

作者： Guifu ZHANG Vivek N.MAHALE Bryan J.PUTNAM Youcun QI Qing CAO ANDrew D.BYRD Petar BUKOVCIC Dusan S.ZRNIC Jidong GAO Ming XUE Youngsun JUNG Heather D.REEVES Pamela L.HEINSELMAN alexander RYZHKOV Robert D.PALMER Pengfei ZHANG Mark WEBER Greg M.MCFARQUHAR Berrien MOORE III Yan ZHANG Jian ZHANG J.VIVEKANANDAN Yasser AL-RASHID Richard L.ICE Daniel S.BERKOWITZ Chong-chi TONG Caleb fulton Richard J.DOVIAK University of Oklahoma NOAA/National Weather Service Enterprise Electronics Corporation NOAA/National Severe Storms Laboratory National Center for Atmospheric Research Raytheon Company Radar Operations Center

After decades of research and development, the WSR-88 D(NEXRAD) network in the United States was upgraded with dual-polarization capability, providing polarimetric radar data(PRD) that have the potential to improve weather observations,quantification, forecasting, and warnings. The weather radar networks in China and other countries are also being upgraded with dual-polarization capability. Now, with radar polarimetry technology having matured, and PRD available both nationally and globally, it is important to understand the current status and future challenges and opportunities. The potential impact of PRD has been limited by their oftentimes subjective and empirical use. More importantly, the community has not begun to regularly derive from PRD the state parameters, such as water mixing ratios and number concentrations, used in numerical weather prediction(NWP) *** this review, we summarize the current status of weather radar polarimetry, discuss the issues and limitations of PRD usage, and explore potential approaches to more efficiently use PRD for quantitative precipitation estimation and forecasting based on statistical retrieval with physical constraints where prior information is used and observation error is included. This approach aligns the observation-based retrievals favored by the radar meteorology community with the model-based analysis of the NWP community. We also examine the challenges and opportunities of polarimetric phased array radar research and development for future weather observation.

关键词： weather radar polarimetry radar meteorology numerical weather prediction data assimilation microphysics parameterization forward operator

Arterial thrombosis in the context of HCV-associated vascular disease can be prevented by protein C

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Cellular & Molecular Immunology 2017年第12期14卷 986-996页

作者： Philipp Blüm Joachim Pircher Monika Merkle Thomas Czermak Andrea Ribeiro Hanna Mannell Florian Krötz alexander Hennrich Michael Spannagl Simone Köppel Erik Gaitzsch Markus Wörnle Medizinische Klinik und Poliklinik IV InnenstadtKlinikum der Universität München80336 MünchenGermany Walter Brendel Centre of Experimental Medicine and Munich Heart Alliance Ludwig Maximilians University München80336 MünchenGermany Medizinische Klinik und Poliklinik I Klinikum der Universität München80336 MünchenGermany Abteilung für Transfusionsmedizin Zelltherapeutika und HämostaseologieKlinikum der Universität München80336 MünchenGermany

Hepatitis C virus(HCV)infection is a major problem *** is not limited to liver disease but is frequently complicated by immune-mediated extrahepatic manifestations such as glomerulonephritis or vasculitis.A fatal complication of HCV-associated vascular disease is ***:polyribocytidylic acid(poly(I:C)),a synthetic analog of viral RNA,induces a Toll-like receptor 3(TLR3)-dependent arteriolar thrombosis without significant thrombus formation in venules in *** procoagulant effects are caused by increased endothelial synthesis of tissue factor and PAI-1 without platelet *** addition to human umbilical endothelial cells(HUVEC),human mesangial cells(HMC)produce procoagulatory factors,cytokines and adhesion molecules after stimulation with poly(I:C)or HCV-containing cryoprecipitates from a patient with a HCV infection as *** protein C(APC)is able to prevent the induction of procoagulatory factors in HUVEC and HMC in vitro and blocks the effects of poly(I:C)and HCV-RNA on the expression of cytokines and adhesion molecules in HMC but not in *** vivo,protein C inhibits poly(I:C)-induced arteriolar ***,endothelial cells are de facto able to actively participate in immune-mediated vascular thrombosis caused by viral ***,we provide evidence for the ability of protein C to inhibit TLR3-mediated arteriolar thrombosis caused by HCV infection.

关键词： hepatitis C thrombosis toll-like receptor 3

Enhancement of pre-pulse and picosecond pedestal contrast of the petawatt J-KAREN-P laser

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High Power Laser Science and Engineering 2021年第4期9卷 192-199页

作者： Hiromitsu Kiriyama Yasuhiro Miyasaka Akira Kon Mamiko Nishiuchi Akito Sagisaka Hajime Sasao alexander S.Pirozhkov Yuji Fukuda Koichi Ogura Kotaro Kondo Nicholas P.Dover Masaki Kando Kansai Photon Science Institute National Institutes for Quantum Science and Technology(QST)Kizugawa 619-0215Japan Naka Fusion Institute National Institutes for Quantum Science and Technology(QST)Naka 311-0193Japan

We have experimentally improved the temporal contrast of the petawatt J-KAREN-P laser *** have investigated how the generation of pre-pulses by post-pulses changes due to the temporal overlap between the stretched pulse and the post-pulse in a chirped-pulse amplification *** have shown that the time at which the pre-pulse is generated by the post-pulse and its shape are related to the time difference between the stretched main pulse and the *** this investigation,we have found and identified the origins of the pre-pulses and have demonstrated the removal of most pre-pulses by eliminating the post-pulse with wedged *** have also demonstrated the impact of stretcher optics on the picosecond *** have realized orders of magnitude enhancement of the pedestal by improving the optical quality of a key component in the stretcher.

关键词： chirped-pulse amplification temporal contrast ultra-high-intensity lasers