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Multi-material additive manufacturing-functionally graded materials by means of laser remelting during laser powder bed fusion

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Frontiers of Mechanical Engineering 2023年第4期18卷 183-193页

作者： alexander SChMIDT Felix JENSCh Sebastian hÄRTEL Chair of hybrid Manufacturing Brandenburg University of TechnologyCottbus 03046Germany

Many processes may be used for manufacturing functionally graded *** them,additive manufacturing seems to be predestined due to near-net shape manufacturing of complex geometries combined with the possibility of applying different materials in one *** adjusting the powder composition of the starting material layer by layer,a macroscopic and step-like gradient can be *** further improve the step-like gradient,an enhancement of the in-situ mixing degree,which is limited according to the state of the art,is *** this paper,a novel technique for an enhancement of the in-situ material mixing degree in the melt pool by applying laser remelting(LR)is *** effect of layer-wise LR on the formation of the interface was investigated using pure copper and low-alloy steel in a laser powder bed fusion *** cross-sectional selective electron microscopic analyses were carried *** applying LR,the mixing degree was enhanced,and the reaction zone thickness between the materials was ***,an additional copper and iron-based phase was formed in the interface,resulting in a smoother gradient of the chemical composition than the case without *** Marangoni convection flow and thermal diffusion are the driving forces for the observed effect.

关键词： multi-material additive manufacturing(MMAM) functionally graded materials(FGMs) laser powder bed fusion(L-PBF) laser remelting(LR) pure copper

Increasingβ-hexosaminidase A activity using genetically modified mesenchymal stem cells

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Neural Regeneration Research 2024年第1期19卷 212-219页

作者： Alisa A.Shaimardanova Daria S.Chulpanova Valeriya V.Solovуeva Shaza S.Issa Aysilu I.Mullagulova Angelina A.Titova Yana O.Mukhamedshina Anna V.Timofeeva alexander M.Aimaletdinov Islam R.Nigmetzyanov Albert A.Rizvanov Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazanRussia Department of histology Cytology and EmbryologyKazan State Medical UniversityKazanRussia

GM2 gangliosidoses are a group of autosomal-recessive lysosomal storage disorde *** diseases result from a deficiency of lysosomal enzymeβ-hexosaminidase A(hexA),which is responsible for GM2 ganglioside *** deficiency causes the accumulation of GM2-gangliosides mainly in the nervous system cells,leading to severe progressive neurodegeneration and *** date,there is no treatment for these ***-mediated gene therapy is considered a promising treatment for GM2 *** study aimed to evaluate the ability of genetically modified mesenchymal stem cells(MSCs-hEXA-hEXB)to restore hexA deficiency in Tay-Sachs disease patient cells,as well as to analyze the functionality and biodistribution of MSCs in *** effectiveness of hexA deficiency cross-correction was shown in mutant MSCs upon intera ction with *** results also showed that the MSCs-hEXA-hEXB express the functionally active hexA enzyme,detectable in vivo,and intravenous injection of the cells does not cause an immune response in *** data suggest that genetically modified mesenchymal stem cells have the potentials to treat GM2 gangliosidoses.

关键词： adeno-associated viral vectors cell therapy cell-mediated gene therapy gene therapy GM2 gangliosidosis Sandhoff disease Tay-Sachs disease β-hexosaminidase

Surgical Treatment of Nephroblastoma in a 4-Year Male Child: A Case Report and Literature Review

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Case Reports in Clinical Medicine 2024年第2期13卷 43-51页

作者： alexander Kofi Egote Samuel Kolonziah Blay Constance Amuzuah Egote Cardinal Kofi Newton Albert Afriyie Akowuah Emmanuel Nana Bosoma Urology Unit Sunyani Teaching Hospital Sunyani Ghana

herein we report a patient with nephroblastoma which was successfully removed at the Sunyani Teaching hospital CJ Oppong theatre in Ghana in sub-Saharan Africa by extended below umbilical incision. Our patient had a family history of Wilms tumour predisposing him to the disease. his main symptoms were haematuria and abdominal mass which was noticed later. Examination and investigation were suggestive of a late-stage unilateral Nephroblastoma resulting in the need for nephrectomy. To reduce the need for such radical surgeries among children at an early stage, there is the need for early screening of children for Wilms tumours especially, those with family predisposition as in our case study. The case report presented here constitutes a rare case of nephroblastoma in the literature.

关键词： Nephroblastoma Wilms Tumour Nephrectomy Screening

Lateral femoral neck stress fractures: A case report

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World Journal of Orthopedics 2024年第9期15卷 891-901页

作者： Christiaan AJ Oudmaijer Nuno R Paulino Pereira David Visser alexander M Wakker Wout S Veltman Robbart van Linschoten Department of Surgery Division of Hepatobiliary and Transplantation SurgeryErasmus MC Transplant InstituteRotterdam 3015 GDZuid-HollandNetherlands Princess Maxima Center for Pediatric Oncology Utrecht 3584 CSNetherlands Orthopaedics and Sports Medicine Erasmus MCErasmus University Medical Center RotterdamRotterdam 3015 GDZuid-HollandNetherlands Department of Surgery Division of Trauma SurgeryErasmus MCErasmus University Medical Center RotterdamRotterdam 3015 GDZuid-HollandNetherlands

BACKGROUND Sport-induced injuries particularly affect young,healthy,and active ***,a popular and accessible sport,can cause a wide range of injuries,including stress *** fractures can occur during high-intensity training or competitions,especially among well-trained amateurs and professional *** diagnosis can be complicated by the typically young age,unremarkable medical history,and vital condition of the *** fractures present insidiously,and this is specifically the case with stress fractures of the femoral *** intervention is crucial to prevent progressive displacement,as this can damage the blood supply to the femoral *** SUMMARY A 30-year-old male runner presented to our outpatient clinic with persistent pain 3 weeks after running a marathon.X-ray showed a complete lateral fracture of the left femoral neck,which was treated surgically with a dynamic hip *** It is essential for healthcare providers to be vigilant for the subtle symptoms of stress fractures to ensure timely *** recognition prevents com-plication and leads to a better prognosis.

关键词： Stress fractures Atypical Femoral Neck Marathon Diagnosis Case report

新奥尔良当代艺术中心共享办公室美国新奥尔良

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世界建筑导报 2024年第1期39卷 74-78页

作者：无 Neil alexander(摄影) Sara Essex Bradley(摄影) EDR建筑事务所不详

The Shop是一个综合的联合办公项目,位于新奥尔良市中心,坐落在新奥尔良市当代艺术中心(CAC)的三层和四层。面向科技、艺术和文化事业,The Shop成为发展中的创新工业的创业者中心。这座历史悠久的建筑之前被用做K&B的总部和一个杂货冷饮... 详细信息

The Shop是一个综合的联合办公项目,位于新奥尔良市中心,坐落在新奥尔良市当代艺术中心(CAC)的三层和四层。面向科技、艺术和文化事业,The Shop成为发展中的创新工业的创业者中心。这座历史悠久的建筑之前被用做K&B的总部和一个杂货冷饮店,70年代中期被用作当代艺术中心。顶部两层在过去40年中一直没有被充分利用,The Shop的开发标志着对这一空间的第一次大规模整修。

关键词：联合办公当代艺术中心新奥尔良市美国新奥尔良 Shop 冷饮店办公室杂货

Functional gastrointestinal disorders in inflammatory bowel disease: Time for a paradigm shift?

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World Journal of Gastroenterology 2020年第26期26卷 3712-3719页

作者： Dipesh h Vasant alexander C Ford Gastroenterology Manchester University NHS Foundation TrustWythenshawe HospitalManchester M239LTUnited Kingdom Division of Diabetes Endocrinology and GastroenterologyUniversity of ManchesterManchester M239LTUnited Kingdom Leeds Institute of Medical Research at St.James’s University of LeedsLeeds LS97TFUnited Kingdom Leeds Gastroenterology Institute Leeds Teaching Hospitals NHS TrustLeeds LS97TFUnited Kingdom

Recent advances in biological therapies have revolutionalised and redefined treatment targets in inflammatory bowel disease(IBD).There is now a stronger emphasis on achieving the more stringent therapeutic goals of mucosal and histological healing,rather than clinical remission ***,the treatment of refractory“functional”gastrointestinal symptoms,often attributed as the aftermath of previous inflammation,has recently become more prominent in quiescent *** further expected advances in anti-inflammatory treatments on the horizon,the burden of such symptoms in quiescent disease,which have been relatively neglected,is set to become an even bigger *** this article,we highlight the current state of research and understanding in this field,including recent developments and clinical practice guidelines on the diagnosis and management of functional gastrointestinal symptoms,such as irritable bowel syndrome and functional anorectal and pelvic floor disorders,in patients with quiescent *** disorders are not only highly prevalent in these patients,they are often misdiagnosed,and are difficult to treat,with very few evidence-based ***,they are associated with substantial impairment in quality-of-life,considerable morbidity,and psychological *** is therefore an urgent need for a change in emphasis towards earlier recognition,positive diagnosis,and targeted treatment for patients with ongoing functional gastrointestinal symptoms in the absence of active *** article also highlights the need for further research to develop much needed evidence-based therapies.

关键词： Irritable bowel syndrome Inflammatory bowel disease Functional gastrointestinal disorders Faecal incontinence Pelvic floor dyssynergia

A system-on-chip microwave photonic processor solves dynamic RF interference in real time with picosecond latency

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Light(Science & Applications) 2024年第1期13卷 91-102页

作者： Weipeng Zhang Joshua C.Lederman Thomas Ferreira de Lima Jiawei Zhang Simon Bilodeau Leila hudson alexander Tait Bhavin J.Shastri Paul R.Prucnal Department of Electrical and Computer Engineering Princeton UniversityPrinceton08544NJUSA NEC Laboratories America Princeton08540NJUSA Department of Electrical and Computer Engineering Queen’s UniversityKingstonK7L 3N6OntarioCanada Department of Physics Engineering Physics and AstronomyQueen’s UniversityKingstonK7L 3N6OntarioCanada

Radio-frequency interference is a growing concern as wireless technology advances,with potentially life-threatening consequences like interference between radar altimeters and 5 G cellular *** transceivers mix signals with varying ratios over time,posing challenges for conventional digital signal processing(DSP)due to its high *** challenges will worsen as future wireless technologies adopt higher carrier frequencies and data ***,conventional DSPs,already on the brink of their clock frequency limit,are expected to offer only marginal speed *** paper introduces a photonic processor to address dynamic interference through blind source separation(BSS).Our system-on-chip processor employs a fully integrated photonic signal pathway in the analogue domain,enabling rapid demixing of received mixtures and recovering the signal-of-interest in under 15 *** reduction in latency surpasses electronic counterparts by more than three orders of *** complement the photonic processor,electronic peripherals based on field-programmable gate array(FPGA)assess the effectiveness of demixing and continuously update demixing weights at a rate of up to 305 *** compact setup features precise dithering weight control,impedance-controlled circuit board and optical fibre packaging,suitable for handheld and mobile *** experimentally demonstrate the processor’s ability to suppress transmission errors and maintain signal-to-noise ratios in two scenarios,radar altimeters and mobile *** work pioneers the real-time adaptability of integrated silicon photonics,enabling online learning and weight adjustments,and showcasing practical operational applications for photonic processing.

关键词： processor mixing dynamic

Evaluation of Serum Anti-Müllerian hormone (AMh) Values for 28,016 Bulgarian Women: Prognostic Statistical Model of Age Specific AMh Declining

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 651-673页

作者： Martin Vladimirov Evan Gatev Desislava Tacheva Aleksandra Kalacheva Milena Bojilova Serpil Izet alexander Angelov Nedyalko Kalatchev Iavor K. Vladimirov Sbalagrm-Sofia Sofia Bulgaria Bulgarian Academy of Science Institute of Molecular Biology Sofia Bulgaria Department of Cytology-histology and Embryology Sofia University &#8220St. Kliment Ohridski&#8221 Sofia Bulgaria Cibalab Boulevard &#8220Akademik Ivan Evstratiev Geshov&#8221 Sofia Bulgaria Synevo Bulgaria Sofia Bulgaria

The present study aims to establish a relationship between serum AMh levels and age in a large group of women living in Bulgaria, as well as to establish reference age-specific AMh levels in women that would serve as an initial estimate of ovarian age. A total of 28,016 women on the territory of the Republic of Bulgaria were tested for serum AMh levels with a median age of 37.0 years (interquartile range 32.0 to 41.0). For women aged 20 - 29 years, the Bulgarian population has relatively high median levels of AMh, similar to women of Asian origin. For women aged 30 - 34 years, our results are comparable to those of women living in Western Europe. For women aged 35 - 39 years, our results are comparable to those of women living in the territory of India and Kenya. For women aged 40 - 44 years, our results were lower than those for women from the Western European and Chinese populations, close to the Indian and higher than Korean and Kenya populations, respectively. Our results for women of Bulgarian origin are also comparable to US Latina women at age 30, 35 and 40 ages. On the base on constructed a statistical model to predicting the decline in AMh levels at different ages, we found non-linear structure of AMh decline for the low AMh 3.5) the dependence of the decline of AMh on age was confirmed as linear. In conclusion, we evaluated the serum level of AMh in Bulgarian women and established age-specific AMh percentile reference values based on a large representative sample. We have developed a prognostic statistical model that can facilitate the application of AMh in clinical practice and the prediction of reproductive capacity and population health.

关键词： Anti-Müllerian hormone Women Age Ovarian Response Ethnicity Prognostic Statistical Model

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就地养老:蒙蒂菲奥里的M养老住宅

当代建筑 2024年第7期 110-117页

作者：无 Brett Boardman(摄影) Justin alexander(摄影) Evan Zell(摄影) 杰克逊蒂斯建筑设计事务所不详

蒙蒂菲奥里的M养老住宅是悉尼市中心一个高品质养老社区中的独立住宅部分,是对原有养老社区的扩建和更新。这两栋新独立住宅楼位于兰德威克国王街,这里曾经是悉尼电车中心的所在地。

关键词：就地养老适应性社会责任