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Impact of the microenvironment on the pathogenesis of mucosaassociated lymphoid tissue lymphomas

World Journal of Gastrointestinal Oncology 2022年第1期14卷 153-162页

作者： Barbara Uhl Katharina T Prochazka Karoline Fechter Katrin Pansy Hildegard T Greinix Peter Neumeister alexander JA deutsch Division of Hematology Medical University of GrazGraz 8036Austria

Approximately 8%of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphomas of mucosa-associated lymphoid tissue(MALT),also known as MALT *** arise at a wide range of different extranodal sites,with most cases affecting the stomach,the lung,the ocular adnexa and the *** small intestine is involved in a lower percentage of *** growth in the early stages is associated with long-lasting chronic inflammation provoked by bacterial infections(e.g.,Helicobacter pylori or Chlamydia psittaci infections)or autoimmune conditions(e.g.,Sjögren’s syndrome or Hashimoto thyroiditis).While these inflammatory processes trigger lymphoma cell proliferation and/or survival,they also shape the ***,activated immune cells are actively recruited to the lymphoma,resulting in either direct lymphoma cell stimulation via surface receptor interactions and/or indirect lymphoma cell stimulation via secretion of soluble factors like *** addition,chronic inflammatory conditions cause the acquisition of genetic alterations resulting in autonomous lymphoma cell ***,novel agents targeting the microenvironment have been developed and clinically tested in MALT lymphomas as well as other lymphoid *** this review,we aim to describe the composition of the microenvironment of MALT lymphoma,the interaction of activated immune cells with lymphoma cells and novel therapeutic approaches in MALT lymphomas using immunomodulatory and/or microenvironmenttargeting agents.

关键词： Mucosa-associated lymphoid tissue lymphoma Tumor microenvironment Microenvironment Helicobacter pylori Activated immune cells

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MicroRNAs as novel predictive biomarkers and therapeutic targets in colorectal cancer

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World Journal of Gastroenterology 2014年第33期20卷 11727-11735页

作者： Verena Stiegelbauer Samantha Perakis alexander deutsch Hui Ling Armin Gerger Martin Pichler Division of Clinical Oncology Department of Internal Medicine Medical University of Graz 8036 Graz Austria Division of Hematology Department of Internal Medicine Medical University of Graz 8036 Graz Austria Department of Experimental Therapeutics University of Texas MD Anderson Cancer Center Houston TX 77030 United States

Colorectal cancer(CRC) is the third most common cancer in western countries. Despite significant improvement in available treatment options, CRC still remains the second leading cause of cancer-related death. Traditionally, 5-fluorouracil has been used as the main chemotherapy drug for treatment of metastatic CRC(mCRC). However, during the last two decades more effective chemotherapeutic agents such as oxaliplatin, irinotecan and the monoclonal antibodies cetuximab, panitumumab and bevacizumab have been used in clinical practice. More recently, the therapeutic armamentarium has been supplemented by the monoclonal antibodies bevacizumab, cetuximab and panitumumab as well as the protein-trap aflibercept and the smallmolecule multi-kinase inhibitor regorafenib. One of the major problems for the management of CRC is the inherent or acquired resistance to therapeutic approaches. The discovery of microRNAs(miRNAs), a class of small, endogenous, non-coding, single-stranded RNAs that play a role as post-transcriptional regulators, has added new dimensions to the diagnosis and treatment of cancer. Because miRNAs are important regulators of carcinogenesis, progression, invasion, angiogenesis and metastases in CRC, they might serve as potential predictive and prognostic factors and even as therapeutic targets themselves. Several miRNAs are already known to be dysregulated in CRCs and have been linked to biological processes involved in tumor progression and response to anti-cancer therapies. This review summarizes current therapeutic approaches for treating CRC and highlights the role of miRNAs as novel predictive biomarkers and potential drug targets in CRC patients.

关键词： Colorectal cancer MicroRNAs 5-fluorouracil Epiderm

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波皮盖——一个保存完好的特大撞击构造,既是国家宝藏,也是世界地质遗址

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宝石和宝石学杂志 2013年第1期15卷 57-66页

作者： alexander deutsch Victor L. Masaitis Falko Langenhorst Richard A. F. Grieve 梁伟章(翻译) 李志翔(翻译) 丘志力(校对) Institut for Planetologie Westfailische Wilhelms-Universitat Munster Wilhelm-Klemm-Str. 10 D-48149 MOnster Germany Karpinsky Geological Institute Sredny prospekt 74 St. Petersburg 199106 Russia Bayerisches Geoinstitut Universitat BayreuthD-95440 Bayreuth Germany Earth Sciences Sector 601 Booth Street Ottawa Ontario K1A 0E8 Canada 广州出入境检验检疫局化矿鉴定处不详

最近一段时间,Popigai和impact diamond这两个词在地质界和宝石界都掀起了很大的反响,宝石界尤甚。事关这个被俄罗斯重新提起的Siberia撞击构造据说蕴含了可供人类开采3 000年的亿万克拉"金刚石"。此消息被各种媒体沸沸扬扬地"传播"着,... 详细信息

最近一段时间,Popigai和impact diamond这两个词在地质界和宝石界都掀起了很大的反响,宝石界尤甚。事关这个被俄罗斯重新提起的Siberia撞击构造据说蕴含了可供人类开采3 000年的亿万克拉"金刚石"。此消息被各种媒体沸沸扬扬地"传播"着,形成各种效应。例如,有媒体在报道此消息时配上了大颗钻石毛坯的图片,使人遐想联翩,认为佩戴"鸽子蛋"钻石似乎已不再只是富人的梦想了。但是事实和"传说"明显不同,为了让珠宝业的同仁更清晰地了解这个撞击构造,我们选择德国-加拿大-俄罗斯组成的波皮盖联合考察队(IPEX 97)科学家早年撰写的一篇介绍波皮盖的科学文章进行了完整的翻译(翻译此文已征得原作者同意),以使珠宝界能更清晰和完整地认识这个"新发现",文章中提到的Diamond,我们用带引号的"金刚石"进行翻译,事实上这种撞击产物的定名至今还存在争议。

关键词：撞击构造地质保存宝藏遗址世界 impact 金刚石

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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