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CT-guided high-dose-rate brachytherapy in the interdisciplinary treatment of patients with liver metastases of pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 530-538页

作者： Gero Wieners alexander christian schippers Federico Collettini Dirk Schnapauff Bernd Hamm Peter Wust Hanno Riess Bernhard Gebauer Department of Diagnostic and Interventional Radiology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum Department of Radiation Oncology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum Department of Oncology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum

BACKGROUND： CT-guided high-dose-rate brachytherapy（CT-HDRBT） is an interventional radiologic technique for local ablation of primary and secondary malignomas applying a radiation source through a brachycatheter percutaneously into the targeted lesion. The aim of this study was to assess local tumor control, safety and efficacy of CT-HDRBT in the treatment of liver metastases of pancreatic cancer. METHODS： Twenty consecutive patients with 49 unresectable liver metastases of pancreatic cancer were included in this retrospective trial and treated with CT-HDRBT, applied as a single fraction high-dose irradiation（15-20 Gy） using a 192 Irsource. Primary endpoint was local tumor control and secondary endpoints were complications, progression-free survival and overall ***： The mean tumor diameter was 29 mm（range 10-73）. The mean irradiation time was 20 minutes（range 7-42）. The mean coverage of the clinical target volume was 98%（range 88%-100%）. The mean D100 was 18.1 Gy and the median D100 was 19.78 Gy. Three major complications occurred with post-interventional abscesses, three of which were seen in 15 patients with biliodigestive anastomosis（20%）and overall 15%. The mean follow-up time was 13.7 months（range 1.4-55.0）. The median progression-free survival was 4.9 months（range 1.4-42.9, mean 9.4）. Local recurrence occurred in 5（10%） of 49 metastases treated. The median overall survival after CT-HDRBT was 8.6 months（range 1.5-55.3）. Eleven patients received chemotherapy after ablation with a median progression-free survival of 4.9 months（mean 12.9）. Nine patients did not receive chemotherapy after intervention with a median progression-free survival of 3.2 months（mean 5.0）. The rate of local tumor control was 91% in both groups after 12 ***： CT-HDRBT was safe and effective for the treatment of liver metastases of pancreatic cancer.

关键词： brachytherapy pancreatic cancer liver metastases CT intervention

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Efficient determination of stability lobe diagrams by in-process varying of spindle speed and cutting depth

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Advances in Manufacturing 2018年第3期6卷 272-279页

作者： christian Brecher Prateek Chavan alexander Epple Laboratory for Machine Tools and Production Engineering(WZL) RWTH Aachen University Campus-Boulevard 3052074 Aachen Germany

The experimental determination of stability lobediagrams （SLDs） in milling can be realized by eithercontinuously varying the spindle speed or by varying thedepth of cut. In this paper, a method for combining boththese methods along with an online chatter detectionalgorithm is proposed for efficient determination of *** accomplish this, communication between the machinecontrol and chatter detection algorithm is established, andthe machine axes are controlled to change the spindle speedor depth of cut. The efficiency of the proposed method isanalyzed in this paper.

关键词： Chatter detection Poincaré Cutting depthvariation Spindle speed

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Impact of renewable energies on the operation and economicsituation of coal fired power stations： Actual situation of coalfired power stations in Germany

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Frontiers in Energy 2017年第2期11卷 119-125页

作者： Hans-Joachim KRAUTZ alexander LISK Joachim POSSELT christian KATZER Department for Power Plant Technology Brandenburg University of Technology Cottbus-Senftenberg 03046 Cottbus Gemany

Due to the fluctuating character of the renewable energy sources the demand of conventional power plants for flexibility is increasing. In the recent years, in Germany there has been a fast rise of production capacity of renewable energies, especially from wind turbines, photovoltaic installations, and biomass plants. The installed nominal power of wind turbines is actually (December 2016) 42 GW and of photovoltaic installations 40?GW. The renewable electric energy production in Germany is about 190?TWh/a, which represents a share of 33% of the yearly demand. The increased need for flexibility affects both the power gradients as well as the minimum load of conventional power plants. Due to this flexibility behaviour, conventional power plants are faced with problems concerning the durability of power plant components, corrosion, more maintenance effort and consequently the overall life expectancy. Another consequence of the increasing share of renewable energies is the decreasing full load operating hours, especially of coal fired and gas power plants. Along with decreasing revenues from the energy exchange market, coal fired power plants are faced with new economically challenges.

关键词： flexible load operation minimal load power gradients power plant maintenance corrosion life expectancy

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Tunable colors and conductivity by electroless growth of Cu/Cu2O particles on sol-gel modified cellulose

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Nano Research 2020年第10期13卷 2658-2664页

作者： Justus Landsiedel Waleri Root christian Schramm alexander Menzel Steffen Witzleben Thomas Bechtold Tung Pham Research Institute for Textile Chemistry and Textile Physics University of Innsbruck6850 DornbirnAustria Department of Physical Chemistry University of Innsbruck6020 InmsbruckAustria Department of Natural Sciences Bonn Rhein sSieg University of Applied Sciences5359 RheinbachGermany

Development of colored surfaces by formation of nano-structured aggregates is a widely used strategy in nature to color lightweight structures (e.g. butterflies) without the use of dye pigments. The deposition of nanoscale particles mimics nature in it’s approach coloring surfaces. This work presents sol-gel modification of cellulose surfaces used to form a template for growth of Cu/Cu2O core–shell particles with defined size-distributions. Besides improving the adhesion of the deposited particulate material, the sol-gel matrix serves as a template for the control of particle sizes of the Cu/Cu2O structures, and as a consequence of particle size variation the surface color is tunable. As an example, red color was achieved with an average particle size of 35 nm, and shifts gradually to blue appearance when particles have grown to 80 nm on the sol-gel modified fabric. The copper concentration on representative fabrics is kept low to avoid modifying the textile characteristics and were all in the range of 150–170 mg per g of cellulose material. As a result of copper deposition on the surface of the material, the cellulose fabric also became electrically conductive. Remarkably, the electrical conductivity was found to be dependent on the average particle sizes of the deposits and thus related to the change in observed color. The generation of color by growth of nano-sized particles on sol-gel templates provides a highly promising approach to stain surfaces by physical effects without use of synthetic colorants, which opens a new strategy to improve environmental profile of coloration.

关键词： electroless copper deposition sol-gel support thin film structural coloration tunable sheet resistance LSPR

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Primary intestinal lymphangiectasia in an adult patient:A case report and review of literature

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World Journal of Gastroenterology 2020年第48期26卷 7707-7718页

作者： Rudolf Huber Georg Semmler alexander Mayr Felix Offner christian Datz Department of Internal Medicine General Hospital OberndorfTeaching Hospital of the Paracelsus Medical University SalzburgOberndorf 5110Austria Department of Pathology General Hospital FeldkirchFeldkirch 6800Austria

BACKGROUND Primary intestinal lymphangiectasia(PIL),first described in 1961,is a rare disorder of unknown etiology resulting in protein-losing *** disease is characterized by dilatation and leakage of intestinal lymph vessels leading to hypoalbuminemia,hypogammaglobulinemia,and *** the severity and location of lymph vessels being affected can vary considerably,the range of associated symptoms is wide from mild lower-limb edema to generalized edema,abdominal and/or pleural effusion,and recurrent diarrhea,among *** usually developing in early childhood,we present the case of a 34-yearold woman with ***,we performed a literature review systematically assessing clinical presentation,and provide a practical approach to facilitate diagnosis and therapy of PIL in *** SUMMARY Our patient presented with unspecific symptoms of abdominal discomfort,fatigue,nausea,and recurrent edema of the lower ***,a striking collinearity of clinical symptoms with female hormone status was ***,polyglobulia,hypoalbuminemia,hypogammaglobulinemia,and transient lymphocytopenia were *** to suspicion of a bone marrow disease,an extensive diagnostic investigation was carried out excluding secondary causes of polyglobulinemia and *** diagnosis of primary intestinal lymphangiectasia was established after 22 wk by histological analysis of biopsy samples obtained via ***,the patient was put on a high-protein and low-fat diet with medium-chain triglycerides supplementation leading to significant improvement of clinical symptoms until 2 years of *** PIL can be the reason for cryptogenic hypoalbuminemia,hypogammaglobulinemia,and lymphopenia in *** to difficulty in correct diagnosis,treatment initiation is often delayed despite being effective and *** leads to a significant disease burden in affected *** is increasingly been

关键词： Primary intestinal lymphangiectasia Waldmann´s disease Protein losing enteropathy Hypoproteinemia Case report

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Versatile multiplexed super-resolution imaging of nanostructures by Quencher-Exchange-PAINT

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Nano Research 2018年第12期11卷 6141-6154页

作者： Tobias Lutz alexander H.Clowsley Ruisheng Lin Stefano Pagliara Lorenzo Di Michele christian Soeller Living Systems Institute & Biomedical Physics University of ExeterExeter EX44QDUK Cavendish Laboratory University of CambridgeCambridge CB30HEUK

The optical super-resolution technique DNA-PAINT (Point Accumulation Imaging in Nanoscale Topography) provides a flexible way to achieve imaging of nanoscale structures at ∼10-nanometer resolution. In DNA-PAINT, fluorescently labeled DNA “imager” strands bind transiently and with high specificity to complementary target “docking” strands anchored to the structure of interest. The localization of single binding events enables the assembly of a super-resolution image, and this approach effectively circumvents photobleaching. The solution exchange of imager strands is the basis of Exchange-PAINT, which enables multiplexed imaging that avoids chromatic aberrations. Fluid exchange during imaging typically requires specialized chambers or washes, which can disturb the sample. Additionally, diffusional washout of imager strands is slow in thick samples such as biological tissue slices. Here, we introduce Quencher-Exchange-PAINT—a new approach to Exchange-PAINT in regular open-top imaging chambers—which overcomes the comparatively slow imager strand switching via diffusional imager washout. Quencher-Exchange-PAINT uses “quencher” strands, i.e., oligonucleotides that prevent the imager from binding to the targets, to rapidly reduce unwanted single-stranded imager concentrations to negligible levels, decoupled from the absolute imager concentration. The quencher strands contain an effective dye quencher that reduces the fluorescence of quenched imager strands to negligible levels. We characterized Quencher-Exchange-PAINT when applied to synthetic, cellular, and thick tissue samples. Quencher-Exchange-PAINT opens the way for efficient multiplexed imaging of complex nanostructures, e.g., in thick tissues, without the need for washing steps.

关键词： super-resolution microscopy fluorescence imaging DNA nanotechnology DNA-PAINT fluorescence quencher

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Efficient offline production of freestanding thin plastic foils for laser-driven ion sources

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High Power Laser Science and Engineering 2017年第2期5卷 8-12页

作者： Sebastian Seuferling Matthias alexander Otto Haug Peter Hilz Daniel Haffa christian Kreuzer Jorg Schreiber Fakultat fur Physik Ludwig-Maximilians-Universitat Munchen D-85748 Garching Germany

Modern chirped pulse amplification laser systems with continuously improving controllability and increasing power are about to reach intensities of up to 10^(22) W cm^(-2) and have proven their potential to accelerate ions out of plasma to several tens percent of the speed of light. For enabling application, one important step is to increase the repetition rate at which ion bunches are at the disposal. In particular, techniques used so far for thin foil target production can require several days of preparing reasonable amounts for a single campaign. In this paper we describe the reasonably droplet method which we have tested and improved so that the emerging foils with thicknesses of a few nanometres up to micrometre can be used as targets for laser ion acceleration. Their quality and performance can compete with so far employed techniques thereby enabling the production of hundreds of targets per day.

关键词： target design and fabrication ultra-short pulse laser interaction with matter

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An easy approach to assess the susceptibility of a landslide by utilizing simple raster overlay methods: A case study on Huangtupo landslide(P.R. China)

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Journal of Mountain Science 2016年第10期13卷 1701-1710页

作者： christian DUMPERTH Joachim ROHN alexander FLEER WANG Jin-ge XIANG Wei Karsten ZIMMERMANN University of Erlangen-Nuremberg Department of Geology and Mineralogy Chair of Applied Geology Exploration and Geosurvey DMT Gmb H & Co. KG Department of Geosciences Chair of Soil Science and Geomorphology University of Tübingen Department of Geotechnical Engineering and Engineering Geology China University of GeosciencesWuhan

Semi qualitative index based methods using rankings and ratings are commonly used in susceptibility estimations over a wide area. However, generalized ranking and ratings are not applicable for one single landslide. This paper gives an easy and transferable approach to a susceptibility assessment of Huangtupo landslide(P.R. China), using raster addition without taking account for ranking and ratings. Slope, aspect, curvature, location and drainage buffer distance raster data sets have been obtained out of open source digital elevation models using ESRI's Arc GIS. These conditioning factor raster data sets have been translated into raster data sets including simple yes or no criteria, referring to triggering or not. Subsequently they have been added by raster math to acquire a simple raster overlay *** that this map is compared to initial displacement measurements, obtained by using a ground based synthetic aperture radar device. Acquired data is recalculated to a raster data set using the same spatial extent, to provide the possibility of comparison of the two raster data sets. The results reveal, that 76.35% of all measured movements occur in areas where raster cells include three or more conditioning factors, indicating that easy raster math operations can lead to satisfying results in local scale.

关键词： Landslide susceptibility Geographical Information System(GIS) Raster overlay Huangtupo Radar interferometry

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Current biomarkers for hepatocellular carcinoma: Surveillance, diagnosis and prediction of prognosis

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World Journal of Hepatology 2015年第2期7卷 139-149页

作者： Kerstin Schütte christian Schulz alexander Link Peter Malfertheiner Department of Gastroenterology Hepatology and Infectious Diseases Otto-von-Guericke-University of Magdeburg

Biomarkers for surveillance, diagnosis and prediction of prognosis in patients with hepatocellular carcinoma(HCC) are currently not ready for introduction into clinical practice because of limited sensitivity and specificity. Especially for the early detection of small HCC novel biomarkers are needed to improve the current effectiveness of screening performed byultrasound. The use of high-throughput technologies in hepatocellular research allows to identify molecules involved in the complex pathways in hepatocarcinogenesis. Several invasive and non-invasive biomarkers have been identified already and have been evaluated in different clinical settings. Gene signatures with prognostic potential have been identified by gene expression profiling from tumor tissue. However, a single "all-in-one" biomarker that fits all-surveillance, diagnosis, prediction of prognosis-has not been found so far. The future of biomarkers most probably lies in a combination of non-invasive biomarkers, imaging and clinical parameters in a surveillance setting. Molecular profiling of tumorous and non-tumorous liver tissue may allow a prediction of prognosis for the individual patient and hopefully clear the way for individual treatment approaches. This article gives an overview on current developments in biomarker research in HCC with a focus on currently available and novel biomarkers, in particular on micro RNA.

关键词： Hepatocellular carcinoma Biomarker Diagnosis Prognosis MicroRNA

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Moving-Water Equilibria Preserving HLL-Type Schemes for the Shallow Water Equations

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Communications in Mathematical Research 2020年第3期36卷 247-271页

作者： christian Klingenberg alexander Kurganov Yongle Liu Markus Zenk Institute for Mathematics Wurzburg UniversityWurzburg 97074Germany Department of Mathematics and SUSTech International Center for Mathematics Southern University of Science and TechnologyShenzhen 518055China Department of Mathematics Harbin Institute of TechnologyHarbin 150001China.

We construct new HLL-type moving-water equilibria preserving upwind schemes for the one-dimensional Saint-Venant system of shallow water equations with nonflat bottom *** designed first-and secondorder schemes are tested on a number of numerical examples,in which we verify the well-balanced property as well as the ability of the proposed schemes to accurately capture small perturbations of moving-water steady states.

关键词： Shallow water equations Harten-Lax-Van Leer(HLL)scheme well-balanced method steady-state solutions(equilibria) moving-water and still-water equilibria

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