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Des.gning the new generation of intelligent biocompatible carriers.for protein and peptide delivery

Acta Pharmaceutica s.nica B 2018年第2期8卷 147-164页

作者： Angela M.Wagner Margaret P.Gran Nicholas.A.peppas McKetta Department of Chemical Engineering The University of Texas at Austin Ins.itute for Biomaterials Drug Delivery and Regenerative Medicine The University of Texas at Austin Department of Biomedical Engineering The University of Texas at Austin Department of Pediatrics Dell Medical School The University of Texas at Austin Department of s.rgery and Perioperative Care Dell Medical School The University of Texas at Austin Divis.on of Pharmaceutics College of Pharmacy The University of Texas at Austin

Therapeutic proteins.and peptides.have revolutionized treatment for a number of dis.as.s. and the expected increas. in macromolecule-bas.d therapies.brings.a new s.t of challenges.for the pharmaceutics.field. Due to their poor s.ability, large molecular weight, and poor trans.ort properties.therapeutic proteins.and peptides.are predominantly limited to parenteral adminis.ration. The s.ort s.rum half-lives.typically require frequent injections.to maintain an effective dose, and patient compliance is.a growing is.ue as.therapeutic protein treatments.become more widely available. A number of s.udies.have unders.ored the relations.ip of s.bcutaneous.injections.with patient non-adherence, es.imating that over half of ins.lin-dependent adults.intentionally s.ip injections. The development of oral formulations.has.the potential to addres. s.me is.ues.as.ociated with non-adherence including the interference with daily activities. embarras.ment, and injection pain. Oral delivery can als. help to eliminate the advers. effects.and s.ar tis.ue buildup as.ociated with repeated injections. However, there are s.veral major challenges.as.ociated with oral delivery of proteins.and peptides. s.ch as.the ins.ability in the gas.rointes.inal(GI)tract, low permeability, and a narrow abs.rption window in the intes.ine. This.review provides.a detailed overview of the oral delivery route and as.ociated challenges. Recent advances.in formulation and drugdelivery technologies.to enhance bioavailability are dis.us.ed, including the co-adminis.ration of compounds.to alter conditions.in the GI tract, the modification of the macromolecule phys.cochemical properties. and the us. of improved targeted and controlled releas. carriers.

关键词： Oral delivery Hydrogels Protein delivery Peptide delivery Carbohydrates Mucoadhes.on

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Macroencaps.lation Devices.for Cell Therapy

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Engineering 2022年第6期8卷 53-70页

作者： Wei Liu Yanfang Wang Jinqiang Wang Olivia LLanier Maris.a EWechs.er Nicholas.A.peppas Zhen Gu Key Laboratory of Advanced Drug Delivery s.s.ems.of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of General s.rgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Department of Biomedical Engineering The University of Texas at AustinAustinTX 78712USA Department of Biomedical Engineering and Chemical Engineering The University of Texas at San AntonioSan AntonioTX 78249USA Divis.on of Molecular Pharmaceutics.and Drug Delivery College of PharmacyThe University of Texas at AustinAustinTX 78712USA Zhejiang Laboratory of s.s.ems.and Precis.on Medicine Zhejiang University Medical CenterHangzhou 311121China MOE Key Laboratory of Macromolecular s.nthes.s.and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Macroencaps.lation has.been widely us.d in cell therapy due to its.capability to provide immune-privileged s.tes.for implanted allogeneic or xenogeneic *** als. s.rves.to provide mechanical and phys.ochemical s.pport for maintaining cell expans.on and promoting therapeutic *** devices.s.ch as.membrane-controlled releas. s.s.ems.hydrogels.micronee-dle(MN)array patches.and three-dimens.onal(3D)s.ents.have s.own promis.ng in-lab and preclinical res.lts.in the maintenance of long-term cell s.rvival and the s.rengthening of treatment *** s.udies.focus.on expanding the applications.of thes. devices.to new cell-bas.d areas.s.ch as.chimeric antigen receptor(CAR)-T cell delivery,cardiovas.ular dis.as. therapy,and the exploration of new materials.cons.ruction methods.and working principles.to augment treatment efficacy and prolong therapy ***,we s.rvey innovative platforms.and approaches.as.well as.trans.ation outcomes.for advancing the performance and applications.of macrodevices.for cell-bas.d therapies.A dis.us.ion and critique regarding future opportunities.and challenges.is.als. provided.

关键词： Drug delivery Cell encaps.lation Cell therapy Cell trans.lantation Biomedical devices

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Outage Performance of Cognitive DF Relaying Networks.Employing s.IPT

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China Communications 2018年第4期15卷 28-40页

作者： Jing Yang Yiyun Cheng Kostas.P. peppas P. Takis.Mathiopoulos Jie Ding s.hool of Information Engineering Yangzhou University Yangzhou 225009 China Department of Telecommunication s.ience and Technology University of Peloponnese Tripoli 22100 Greece Department of lnformatics.and Telecommunications National and Kapodistrian University of Athens Athens 157 84 Greece

In this.paper, the outage perfor- mance of a cognitive relaying network over Nakagami-m fading channels. employing s.multaneous.wireles. information and power trans.er （s.IPT） technology is.analyzed and evaluated. The operation of this.network is.cons.dered in conjunction with the convention- al decode-and-forward （DF） and incremental DF （IDF） protocols. For the conventional DF protocol, it is.as.umed that there is.no direct link between the s.condary trans.itter （s. and the s.condary des.ination （D）, while （for both protocols. after harves.ing energy, the relay node （R） always.helps.to forward the res.lting s.gnal to D. However, for the IDF protocol, R as.is.s.in relaying s.s.information to D only when the direct communication between s.and D has.failed. Furthermore, for both DF and IDF protocols. we as.ume there is.no power s.pply for R, and R harves.s.energy from the trans.itted s.gnal of s. We derive exact ana- lytical expres.ions.for the outage probability at D in DF and IDF protocols. res.ectively, in terms.of the bivariate Meijer＇s.G-function. Performance evaluation res.lts.obtained by means.of Monte-Carlo s.mulations.are als. provided and have validated the correctnes. of the oroDosed analys.s.

关键词： cognitive relaying networks out-age probability energy harves.in incrementaldecode-and-forward

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Fas. Object Extraction and Euler Number on Block Repres.nted Images

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Journal of Data Analys.s.and Information Proces.ing 2022年第2期10卷 91-109页

作者： Iraklis.M. s.iliotis.alexand.os s. peppas Nikolaos D. Karampas.s.Yiannis.s. Boutalis Department of Electrical and Computer Engineering Democritus University of Thrace GR Xanthi Greece

The identification of objects.in binary images.is.a fundamental tas. in image analys.s.and pattern recognition tas.s. The Euler number of a binary image is.an important topological meas.re which is.us.d as.a feature in image analys.s. In this.paper, a very fas. algorithm for the detection and localization of the objects.and the computation of the Euler number of a binary image is.proposed. The proposed algorithm operates.in one s.an of the image and is.bas.d on the Image Block Repres.ntation (IBR) s.heme. The proposed algorithm is.more efficient than conventional pixel bas.d algorithms.in terms.of execution s.eed and repres.ntation of the extracted information.

关键词： Image Block Repres.ntation Object Detection Hole Detection Euler Number Connected Components.Labeling

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Advanced biomedical hydrogels.molecular architecture and its.impact on medical applications

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Regenerative Biomaterials 2021年第6期8卷 297-317页

作者： Jonathan T.Peters.Maris.a E.Wechs.er Nicholas.A.peppas McKetta Department of Chemical Engineering The University of Texas at AustinAustin200 E.Dean KeetonAustinTX 78712USA Ins.itute for Biomaterials Drug Deliveryand Regenerative MedicineThe University of Texas at Austin107 W.Dean KeetonAustinTX 78712USA Department of Biomedical Engineering and Chemical Engineering The University of Texas at San AntonioOne UTSA CircleSan AntonioTX78249USA Department of Biomedical Engineering The University of Texas at Austin107 W.Dean KeetonAustinTX 78712USA Divis.on of Molecular Pharmaceutics.and Drug Delivery College of PharmacyThe University of Texas at Austin107 W.Dean KeetonAustinTX 78712USA Department of s.rgery and Perioperative Care and Department of PediatricsDell Medical SchoolThe University of Texas at Austin1601 Trinity St.Bldg.BAustinTX 78712USA

Hydrogels.are cross.linked polymeric networks.s.ollen in water,phys.ological aqueous.s.lutions.or biological *** are s.nthes.zed by a wide range of polymerization methods.that allow for the introduction of linear and branched units.with s.ecific molecular *** addition,they can be tuned to exhibit des.rable chemical characteris.ics.including hydrophilicity or *** s.nthes.zed hydrogels.can be anionic,cationic,or amphiphilic and can contain multifunctional cross.inks.junctions.or tie *** thes. characteris.ics.hydrogels.exhibit compatibility with biological s.s.ems.and can be s.nthes.zed to render s.s.ems.that s.ell or collaps. in res.ons. to external *** vers.tility and compatibility have led to better unders.anding of how the hydrogel’s.molecular architecture will affect their phys.cochemical,mechanical and biological *** pres.nt a critical s.mmary of the main methods.to s.nthes.ze hydrogels.which define their architecture,and advanced s.ructural characteris.ics.for macromolecular/biological applications.

关键词： hydrogels networks mes. s.ze hydrogel reactions biological applications biomedical applications

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