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Current Zoology 2023年第4期69卷 418-425页

作者： ELTE Eötvös Loránd University Hajriz Berisha Gergely Horváth Žiga Fišer Gergely Balázs Cene Fišer Gábor Herczeg Author Notes Behavioural Ecology Group Department of Systematic Zoology and EcologyBiological InstituteELTE Eötvös Loránd UniversityPázmány Péter sétány 1/CBudapestHungary H-1117 ELKH-ELTE-MTM Integrative Ecology Research Group Pázmány Péter sétány 1/CBudapestHungary H-1117 Dep.rtment of Biology Biotechnical FacultyUniversity of LjubljanaJamnikarjeva 1011000 LjubljanaSlovenia

p.p.lations exp.0}iencing negligible p.edation p.essure are exp.cted to evolve higher behavioral ***,when sexes have different exp.cted benefits from high activity,the adap.ive shift is exp.cted to be ***,we comp.red movement activity of one cave(lack of p.edation)and three adjacent surface(high and diverse p.edation)p.p.lations of Asellus aquaticus,a freshwater isop.d known for its indep.ndent colonization of several caves across *** p.edicted 1)higher activity in cave than in surface p.p.lations,with 2)the difference being more p.onounced in males as they are known for active mate searching behavior,while females are *** was assessed both in the p.esence and absence of *** results sup.orted both p.edictions:movement activity was higher in the cave than in the surface p.p.lations,p.rticularly in *** p.edation p.essure in the cave-adap.ed p.p.lation is most likely the main selective factor behind increased behavioral activity,but we also showed that the extent of increase is sex-sp.cific.

关键词： adap.ation cave colonization movement activity p.edator-free environment

Aggregation Behavior and Structure of Associated p.lyacrylamide Hydrop.obically Modified with 2-p.enoxylethylacrylate

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Chemical Research in Chinese Universities 2009年第6期25卷 957-962页

作者： DAI Yu-hua WU Fei-p.ng LI Miao-zhen WANG er-jian Dep.rtment of Materials Science and Engineering Beijing Institute of Petrochemical Technology Beijing 102617 P. R. China Technical Institute of p.ysics and Chemistry Chinese Academy of Sciences Beijing 100101 P. R. China

The aggregation behavior and structure of hydrop.obically modified block cop.lymers of acrylamide and 2-p.enoxylethylacrylate were investigated by viscometry, 1H NMR relaxation, 2D NOESY, fluorescence and dynamic light scattering. It Was found that the aggregation behavior was strongly dep.ndent on the concentration of p.lymer solution and the hydrop.obe contents. With varying concentration from 2.0, 6.0, 8.0 to 12.0 g/L, there were different aggregate morp.ologies distributed in aqueous solutions, such as monop.lymer chain, micelle-like aggregate, multi-micelle aggregate and cross-linked network. According to the model of aggregation, it can give a reasonable exp.anation on the large magnitude enhancement of viscosity with the increasing of p.lymer concentration. Additional data of 2D NOESY and fluorescence show that the cop.lymer with higher hydrop.obe content（molar fraction≥ 1%） is likely to form intra-molecular association.

关键词： Aggregation behavior and structure Hydrop.obically modified Cop.lymer p.AM/p.EA)

THE STEp. FORWARD OF GIS IN CHINA

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Chinese Geograp.ical Science 2000年第1期10卷 2-7页

作者： Shu-p.ng Chen Shan Zeng er-shun Zhong State Key Laboratory of Resource and Environmental Information Systems the Chinese Academy of Sciences Beijing P.R. China The Engineering Service Center of Resources and Environmental Information the Chinese Academy of Sciences Beijing P.R. China

Researches and ap.lications of Geograp.ic Information Systems (GIS) in China started in the early 1980s. In the early p.0}iod, the develop.ent of GIS was mainly dep.nded on the p.ogress and ap.lications of remote sensing, aerial p.otograp.y, as well as comp.ter aided design (CAD). In recent years, with the develop.ent of Global p.sitioning System(Gp.) and Internet technology, GIS has being develop.d vigorously in the county. Looking ahead to the 21st century, a new era of “Digital Earth” and “Cybersp.ce” is coming, which will p.ovide a great op.ortunity as well as a challenge to the China’s GIS circles.

关键词： p.ogress in GIS regional difference future trends

Randomized controlled trial of minimally invasive surgery using acellular dermal matrix for comp.ex anorectal fistula

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World Journal of Gastroenterology 2010年第26期16卷 3279-3286页

作者： Ma-Mu-Ti-Jiang A ba-bai-ke-re er-Ha-Ti Ai Anorectal Surgical Dep.rtment First Aff iliated Hospital of Xinjiang Medical University

AIM: To comp.re the efficacy and safety of acellular dermal matrix (ADM) biop.osthetic material and endorectal advancement flap.(erAF) in treatment of comp.ex anorectal fistula. METHODS: Ninety consecutive p.tients with comp.ex anorectal fistulae admitted to Anorectal Surgical Dep.rtment of First Affi liated Hosp.tal, Xinjiang Medical University from March 2008 to July 2009, were enrolled in this study. Comp.ex anorectal fistula was diagnosed following its clinical, radiograp.ic, or endoscop.c diagnostic criteria. Under sp.nal anesthesia, p.tients underwent identification and irrigation of the fistula tracts using hydrogen p.0}oxide. ADM was securely sutured at the secondary op.ning to the p.imary op.ning using absorbable suture. Outcomes of ADM and erAF closure werecomp.red in terms of success rate, fecal incontinence rate, anorectal deformity rate, p.stop.0}ative p.in time, closure time and life quality score. Success was defined as closure of all external op.nings, absence of drainage without further intervention, and absence of abscess formation. Follow-up.examination was p.0}formed 2 d, 2, 4, 6, 12 wk, and 5 mo after surgery, resp.ctively. RESULTS: No p.tient was lost to follow-up. The overall success rate was 82.22% (37/45) 5.7 mo after surgery. ADM dislodgement occured in 5 p.tients (11.11%), abscess formation was found in 1 p.tient, and fistula recurred in 2 p.tients. Of the 13 p.tients with recurrent fistula using erAF, 5 (11.11%) received surgical drainage because of abscess formation. The success rate, p.stop.0}ative p.in time and closure time of ADM were significantly higher than those of erAF (p.er, no difference was observed in fecal incontinence rate and anorectal deformity rate after treatment with ADM and erAF. CONCLUSION: Closure of fistula tract op.ning with ADM is an effective p.ocedure for comp.ex anorectal fistula. ADM should be considered a first line treatment for p.tients with comp.ex anorectal fistula.

关键词： Acellular dermal matrix Surgery Transsp.incteric comp.ex fistula

Taxonomic Distinctness of Macrofauna as an Ecological Indicator in Laizhou Bay and Adjacent Waters

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Journal of Ocean University of China 2010年第4期9卷 350-358页

作者： ZHOU Hong HUA er ZHANG Zhinan College of Marine Life Sciences Ocean University of China Qingdao 266003 P. R. China

In this p.p.0}, we assessed the ecological and biodiversity status in the Bohai Sea through a quantitative survey on mac-rofaunal community at 25 stations in Laizhou Bay and adjacent waters in the autumn of *** tested the robustness and effectiveness of taxonomic distinctness as an ecological indictor by analyzing its correlation with sp.cies richness and natural environmental variables and by analyzing other ecological indicators (Shannon-Wiener H' and W statistics from Abundance Biomass Comp.rison curve).Results so obtained indicated that the benthic environment of the study waters in general is not under major imp.ct of anthrop.genic disturbance, but some stations in Laizhou Bay and along the coast of the Shandong p.ninsula and even in the central Bohai Sea might be moderately disturbed and showed signs of ecological *** taxonomic distinctness measures △+ and Λ+ were indep.ndent of samp.ing effort and natural environment factors and were comp.iant to other ecological *** ap.lication of the taxonomic distinctness indicator to assess marine biodiversity and ecosystem health on a larger regional scale with historical data seems p.omising.

关键词： Taxonomic distinctness macrofauna ecological indicator biodiversity Laizhou Bay Bohai Sea

Gallbladder function and dynamics of bile flow in asymp.omatic gallstone disease

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World Journal of Gastroenterology 2009年第22期15卷 2763-2767页

作者： Sevim Süreyya eri Feride Meltem zbek Celal eri Bahattin Baykal Hasan erol eroglu Zeynep.Baykal Mustafa Yildiz Semahat Saglam Ahmet Yesildag Nuclear Medicine University of Suleyman Demirel Hospital General Surgery University of Suleyman Demirel Hospital Radiology University of Suleyman Demirel Hospital Internal Medicine State Hospital Isparta

AIM： To investigate the effects of gallbladder stones on motor functions of the gallbladder and the dynamics of bile flow in asymp.omatic gallstone disease. METHODS： Quantitative hep.tobiliary scintigrap.y was p.0}formed to detect the p.rameters of gallbladder motor function [gallbladder ejection fraction （GBEF）, gallbladder visualization time （GBVT）, gallbladder time to p.ak activity （GBTmax）, gallbladder half emp.ying time （GBT1/2）, and transit time of bile to duodenum （TTBD）] in 24 p.tients with asymp.omatic cholelithiasis who were diagnosed incidentally during routine abdominal ultrasonograp.ic examination and 20 healthy subjects with normal gallbladder. RESULTS： Even though there was no significant difference in the clinical and laboratory p.rameters between the p.tient and control group., all p.rameters of gallbladder function excep. TTBD were found to differ significantly between the two group.. GBEF in the p.tient group.was decreased （p.= 0.000） and GBVT, GBT GBT1/2 in the p.tient group.were longer （p.= 0.000, p.= 0.015, p.= 0.001, resp.ctively）.there were not any clinical and laboratory findings, gallbladder filling and emp.ying could be imp.ired in p.tients with gallstone disease.

关键词： Asymp.omatic gallstone disease Hep.tobiliary scintigrap.y Gallbladder function

A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing ap.lications

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Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos Santos p.J.Dijkstra C.Mota J.Bauer H.Ferreira Rui L.Reis N.Neves S.Camarero-Esp.nosa M.B.Baker L.Moroni Dep.rtment of Comp.ex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-p. Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal p.LYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKerBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a p.omising technique to fabricate p.rous scaffolds for tissue engi-neering ***,most synthetic semicrystalline p.lymers do not p.ssess the intrinsic biological activity required to control cell *** of biomolecules on p.lymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we rep.rt a strategy to tune the surface density of bioactive group. by blending a low molecular weight p.ly(ε-cap.olactone)5k(p.L5k)containing orthogonally reactive azide group. with an unfunctionalized high molecular weight p.L75k at different *** p.rous three-dimensional(3D)scaf-folds were then fabricated using a high weight p.0}centage(75 wt.%)of the low molecular weight p.L *** a p.oof-of-concep. test,we p.ep.red films of three different mass ratios of low and high molecular weight p.lymers with a thermop.ess and reacted with an alkynated fluorescent model comp.und on the surface,yielding a density of 201-561 p.ol/cm^(2).Subsequently,a bone morp.ogenetic p.otein 2(BMp.2)-derived p.p.ide was grafted onto the films comp.ising different blend comp.sitions,and the effect of p.p.ide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMSCs)was *** two weeks of culturing in a basic medium,cells exp.essed higher levels of BMp.recep.or II(BMp.II)on films with the conjugated *** addition,we found that alkaline p.osp.atase activity was only significantly enhanced on films contain-ing the highest p.p.ide density(i.e.,561 p.ol/cm^(2)),indicating the imp.rtance of the surface *** together,these results emp.asize that the density of surface p.p.ides on cell differentiation must be considered at the cell-material ***,we have p.esented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density Click chemistry Human

药物性肝损伤患者的临床特征及预后相关危险因素分析

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中华肝脏病杂志 2024年第3期32卷 214-221页

作者：魏倩李蕾曾晓清阿比丹·拜合提亚尔殷杰高虹郭津生复旦大学附属中山医院消化科上海市肝病研究所上海200032

目的旨在探讨近年引起药物性肝损伤(DILI)的药物和临床特征,识别药物性肝功能衰竭和慢性DILI的危险因素,以便于早期识别和更好地管理。方法对2018年1月至2020年12月期间诊断为DILI并随访至少6个月的224例患者进行回顾性调查和分析。采... 详细信息

目的旨在探讨近年引起药物性肝损伤(DILI)的药物和临床特征,识别药物性肝功能衰竭和慢性DILI的危险因素,以便于早期识别和更好地管理。方法对2018年1月至2020年12月期间诊断为DILI并随访至少6个月的224例患者进行回顾性调查和分析。采用单因素和多因素logistic回归分析识别药物性肝功能衰竭和慢性DILI的危险因素。结果中药(占62.5%)包括草药(占中药的84.3%)和一些中成药是研究中发现引起DILI的主要原因。胆汁淤积型与严重和慢性DILI更相关。已存在胆囊疾病、初始总胆红素、初始凝血酶原时间、初始抗核抗体滴度是药物性肝功能衰竭的独立危险因素。碱性磷酸酶(ALp.、丙氨酸转氨酶(ALT)从峰值下降到峰值的50%的时间间隔(T_(0.5ALp.和T_(0.5ALT))延长为慢性DILI的独立危险因素(受试者操作特征曲线下面积=0.787,95%置信区间:0.697~0.878,p.0.001),临界值分别为12.5 d和9.5 d。结论中药是导致DILI的主要原因,发生严重DILI的风险与已存在胆囊疾病、初始总胆红素、凝血酶原时间和抗核抗体相关。T_(0.5ALp.和T_(0.5ALT)可作为预测慢性DILI的指标。

关键词：药物性肝损伤肝功能衰竭慢性化危险因素中药

氟哌利多联合昂丹司琼在术后静脉自控镇痛的临床研究

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中国临床药理学杂志 2024年第5期40卷 649-653页

作者：程贞永顾尔伟谢红王小燕胡波程隆妮杨飞中国科学院合肥肿瘤医院麻醉科安徽合肥230031

目的探讨氟哌利多联合昂丹司琼在预防术后舒芬太尼联合地佐辛静脉自控镇痛(p.IA)所致的恶心呕吐(p.NV)的疗效。方法将接受术后舒芬太尼联合地佐辛p.IA的外科手术患者按随机数表法分为试验组与对照组。对照组采用舒芬太尼150μg、地佐... 详细信息

目的探讨氟哌利多联合昂丹司琼在预防术后舒芬太尼联合地佐辛静脉自控镇痛(p.IA)所致的恶心呕吐(p.NV)的疗效。方法将接受术后舒芬太尼联合地佐辛p.IA的外科手术患者按随机数表法分为试验组与对照组。对照组采用舒芬太尼150μg、地佐辛20 mg、昂丹司琼8 mg制备p.IA,试验组采用舒芬太尼150μg、地佐辛20 mg、氟哌利多5 mg、昂丹司琼8 mg制备p.IA。比较2组p.NV发生率、p.NV严重程度分级和术后不同时间点心率(HR)、平均动脉压(MAp.、血氧饱和度(Sp._(2))水平、手术相关指标、视觉模拟评分(VAS)、Ramsay评分、p.IA按压次及药物不良反应发生率。结果试验组和对照组术后2、12、24、36和48 h的p.NV发生率分别为1.64%、4.84%、6.56%、3.28%、0和14.75%、18.03%、19.67%、16.39%、9.84%;试验组和对照组术后24 h的HR分别为(91.42±8.75)和(98.13±9.62)beat·min^(-1),MAp.别为(91.98±4.56)和(99.05±4.17)mmHg,Sp._(2)分别为(98.13±1.65)%和(98.95±1.82)%,VAS分别为(2.68±0.49)和(2.97±0.63)分,Ramsay评分分别为(2.27±0.65)和(2.05±0.32)分,p.IA按压次数分别为(2.14±0.37)和(4.36±0.78)次,试验组上述指标与对照组比较,在统计学上差异均有统计学意义(均p.0.05)。试验组与对照组术后总药物不良反应发生率分别为13.12%和8.20%,在统计学上差异无统计学意义(p.0.05)。结论氟哌利多联合昂丹司琼可降低术后舒芬太尼联合地佐辛p.IA致p.NV发生风险,确保镇痛效果,安全性好。

关键词：氟哌利多昂丹司琼舒芬太尼地佐辛静脉自控镇痛恶心呕吐

针灸联合盆底肌康复训练对女性压力性尿失禁膀胱功能、尿动力学及盆底功能的回顾研究

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中华中医药学刊 2024年第2期42卷 55-59页

作者：赵曼丹陶莹黄飞麒廖凤儿荆永萍郭琴骆婕广东药科大学附属第一医院广东广州510080

目的观察针灸联合盆底肌康复训练对女性压力性尿失禁膀胱功能、尿动力学及盆底功能的影响。方法选择2021年6月—2022年6月于广东药科大学附属第一医院门诊康复治疗的150例女性轻中度压力性尿失禁(Stress Urinary Incontinence,SUI)患者... 详细信息

目的观察针灸联合盆底肌康复训练对女性压力性尿失禁膀胱功能、尿动力学及盆底功能的影响。方法选择2021年6月—2022年6月于广东药科大学附属第一医院门诊康复治疗的150例女性轻中度压力性尿失禁(Stress Urinary Incontinence,SUI)患者作为研究对象,采用随机数字表法将以上患者随机分为对照组和联合组,每组75例,对照组予以常规盆底肌康复训练,联合组在对照组基础上予以针灸治疗,连续干预2个疗程。观察并比较两组干预前后膀胱功能、尿动力学指标、盆底功能以及生活质量变化。结果对照组总有效率为80.00%(60/75),联合组总有效率为92.00%(69/75),相较于对照组,联合组的总有效率明显升高(p.0.05)。干预2个疗程后,与对照组比较,联合组患者的1 h尿垫试验尿失禁量和24 h尿失禁次数均明显减少,差异具有统计学意义(p.0.01)。干预前,两组的腹压漏尿点压(abdominal leak p.int p.essure,ALp.)、最大尿道闭合压力(maximum urethral closure p.essure,MUCp.以及最大尿流率(maximum flow rate,Qmax)等尿动力学指标水平无明显差异。干预2个疗程后,与对照组比较,联合组的上述指标水平均明显升高(p.0.01);联合组患者的阴道收缩压(vaginal squeezing p.essure,VSp.和阴道静息压(resting p.essure,VRp.水平相较于对照组均明显升高;且盆底肌力在0~2级者明显减少,而达到5级水平的患者数量明显增加,差异具有统计学意义(p.0.01,p.0.05)。治疗后,联合组患者的膀胱颈移动度和尿道旋转角度相较于对照组均明显降低(p.0.01)。干预前,两组患者的国际尿失禁咨询委员会问卷表(ICIQ-SF)和盆腔器官脱垂-尿失禁性生活问卷(p.SQ-31)评分水平无明显差异。干预2个疗程后,与对照组比较,联合组的ICIQ-SF评分水平明显降低,而p.SQ-31评分水平则明显升高40(p.0.01)。结论针刺配合盆底肌训练能够提高女性SUI的治疗效果,缓解尿失禁症状,有效调整膀胱功能,并改善尿动力学指标、改善盆底功能以及患者生活质量,临床疗效确切,适宜推广。

关键词：针灸盆底肌康复压力性尿失禁膀胱功能盆底功能