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Effects of 2,3,7,8-TCDD and benzo[a]pyrene on modulating vitellogenin expression in primary culture of crucian carp (Carassius auratus) hepatocytes

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Chinese Science Bulletin 2004年第22期49卷 2372-2378页

作者： LIANGYong C.k.C.wong XUYing M.H.wong StatekeyLaboratoryofFreshwaterEcologyandBiotechnology InstituteofHydrobiologyChineseAcademyofSciencesWuhan430072China//GraduateSchoolofChineseAcademyofSciencesBeijing100039China DepartmentofBiology HongKongBaptistUniversityKowloonTongHongKong StatekeyLaboratoryofFreshwaterEcologyandBiotechnology InstituteofHydrobiologyChineseAcademyofSciencesWuhan430072China

Vitellogenin (Vtg) is the precursor of yolk protein. Its expression and secretion are estrogen-regulated and are crucial for oocyte maturation. An in vitro xenoestro- gen screening model was established by measuring Vtg in- duction in cultured primary hepatocytes from crucian carp. Vtg production was detected by biotin-avidin sandwich ELISA method while Vtg and cytochrome P4501A1 (CYP1A1) mRNA induction were measured by semi- quan- titative PCR-primer dropping technique. Vtg and Vtg mRNA were dose-dependently induced by diethylstilbestrol (DES, 0.2—200 ng/mL) in hepatocytes of crucian carp. Co-treatment of the DES-induced hepatocytes with either 2,3,7,8-TCDD (TCDD, 0.1—4 pg/mL) or benzo[a]pyrene (B[a]P, 5—1000 ng/mL) resulted in a reduction of Vtg pro- duction and an increment of CYP1A1 mRNA expression both in a dose dependent manner, indicating the anti-estro- genic effects of the compounds. However, at lower tested concentrations, TCDD (0.1, 0.2 pg/mL), B[a]P (5 ng/mL) seemed to have a potentiating effect on Vtg expression and secretion, although by their own these compounds had no observable estrogenic effect on Vtg induction. Tamoxifen (a selective estrogen receptor modulators, 1 nmol/L—1 μmol/L), and β-naphtho-flavone (β-NF, an aryl hydrocarbon receptor inducing compounds, 2.5—1000 ng/mL) also were employed to study the possible interactions in DES-induced Vtg ex- pression. In co-treatment of the DES-induced hepatocytes with β-NF or tamoxifen, the decrease in Vtg production did parallel induction of CYP1A1 for β-NF, but tamoxifen inhib- ited Vtg induction did not parallel induced CYP1A1 expres- sion in all test concentrations. On the contrary, it was found that in co-treatment of the TCDD-induced hepatocytes with DES, TCDD induced CYP1A1 mRNA production was inhib- ited by DES also. These results implicated a possible cross talk between estrogen receptor- and aryl hydrocarbon re- ceptor-mediated pathways in the hepatocytes.

关键词： 2,3,7,8-TCDD 苯并[a]芘卵黄蛋白原鲫鱼鲤鱼肝细胞 CYP1A1 卵黄蛋白质异种雌激素

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Deep residual learning for denoising Monte Carlo renderings

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Computational Visual Media 2019年第3期5卷 239-255页

作者： kin-Ming wong Tien-Tsin wong Artixels Hong Kong S.A.R.China Department of Computer Science and Engineering the Chinese University of Hong KongHong Kong S.A.R.China

Learning-based techniques have recently been shown to be effective for denoising Monte Carlo rendering methods. However, there remains a quality gap to state-of-the-art handcrafted denoisers. In this paper, we propose a deep residual learning based method that outperforms both state-of-the-art handcrafted denoisers and learning-based *** the indirect nature of existing learning-based methods(which e.g., estimate the parameters and kernel weights of an explicit feature based filter), we directly map the noisy input pixels to the smoothed output. Using this direct mapping formulation, we demonstrate that even a simple-and-standard ResNet and three common auxiliary features(depth, normal,and albedo) are sufficient to achieve high-quality denoising. This minimal requirement on auxiliary data simplifies both training and integration of our method into most production rendering pipelines. We have evaluated our method on unseen images created by a different renderer. Consistently superior quality denoising is obtained in all cases.

关键词： Monte Carlo rendering denoising deep learning deep residual learning filter-free denoising

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Henkel Technologies and Products for China Aerospace

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材料工程 2006年第5期34卷 32-36页

作者： Michael Cichon Helen Wei Li alex wong Stan Lehmann Raymond wong Henkel Corporation Bay Point California 94565 U.S.A.

Epoxy structural adhesives and composites have been in use for many years for the construction of aerospace vehicles. Henkel provides many epoxy products. Many other resin systems have been evaluated and several, such as imide, phenolic and cyanate ester, have also achieved significant use. Henkel’s newly developed “Epsilon” chemistry demonstrates unique features that benefit application in aerospace structure that use adhesives and composites.

关键词： adhesive composite epsilon matrix resin structure

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Femtosecond Degenerate Four-Wave-Mixing in ZnO Microcrystallite Thin Films

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Chinese Physics Letters 1999年第6期16卷 418-419页

作者： ZHANG Wei-li WANG Qing-yue CHAI Lu XING Qi-rong k.S.wong H.Wang Z.k.Tang G.k.L.wong R.Jain Ultrafast Laser Laboratory School of Precision Instruments&Optoelectronics Engineeringand Optoelectronic Information Science and Technology LaboratoryTianjin UniversityTianjin 300072 School of Science Tianjin UniversityTianjin 300072 Department of Physics Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong Center for High Technology Materials University of New Mexico1313 Goddard SEAlbuquerqueNM 87106USA

Transient third-order optical nonlinearityχ^(3)of ZnO microcrystallite thin films is measured at various temperatures by using femtosecond degenerate ***-temperature excitonic enhancement of is *** magnitude ofχ^(3)ranges between 10^(-4)to 10^(-6)esu from 4.2k to room *** measuredχ^(3)response time ranging from 200 to 300 fs ultrafast for temperature down to 4.2k.

关键词： temperature. crystallite nonlinearity

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Reshaping the chromatin landscape after spinal cord injury

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Frontiers in Biology 2014年第5期9卷 356-366页

作者： Jamie k. wong Hongyan ZOU Fishberg Department of Neuroscience Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York NY 10029 USA Department of Neurosurgery Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York NY 10029 USA

The pathophysiology underlying spinal cord injury is complex. Mechanistic understanding of the adaptive responses to injury is critical for targeted therapy aimed at reestablishing lost connections between proximal and distal neurons. After injury, cell-type specific gene transcription programs govern distinct cellular behaviors, and chromatin regulators play a central role in shaping the chromatin landscape to adjust transcriptional profiles in a contextdependent manner. In this review, we summarize recent progress on the pleiotropic roles of chromatin regulators in mediating the diverse adaptive behaviors of neurons and glial cells after spinal cord injury, and wherever possible, discuss the underlying mechanisms and genomic targets. We specifically draw attention to the perspective that takes into consideration the impact of epigenetic modulation on axon growth potential, together with its effect on woundhealing properties of glial cells. Epigenetic modulation of chromatin state represents an emerging therapeutic direction to promote neural repair and axon regeneration after spinal cord injury.

关键词： epigenetics chromatin spinal cord injury axon regeneration neural repair

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Estimating Effective Reproduction Number for SIR Compartmental Model:A Stochastic Evolutionary Approach

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Journal of Social Computing 2022年第2期3卷 182-189页

作者： W.k.wong Filbert H.Juwono the Department of Electrical and Computer Engineering Curtin University MalaysiaMiri 98009Malaysia

Compatmental pandemic models have become a significant tool in the battle against disease *** this,pandemic models sometimes require extensive modification to accuately reflect the actual epidemic condition The Susceptble-Infectious-Removed(SIR)model,in particular,contains two primary parameters:the infectious rate parameter ρ and the removal rate parameter r,in addition to additional unknowns such as the initial infectious *** to the complexity,there is an obvious challenge to tack the evolution of these parameters,especially ρ and γ,over time which leads to the estimation of the reproduction number for the paticular time window,^(κ)*** reproduction mumber may provide better understanding on the efectiveness of isolation or control *** changing ^(κ)T values(evolving over time window)will lead to even more possible parameter *** the present Coronavirus Disease 2019(COVID-19)pandemic,a stochastic optimization stategy is proposed to ft the model on the basis of parameter changes over *** are encoded to reflet the changing parameters of Tρ and γT,alwing the changing ^(κ)T to be *** our approach,an Adaptive Differential Evolution(ADE)and Paricle Swam Optimization(PSO)are used to ft the curves into previously recorded *** eliminates the need to tume the parameters of the Differential Evolution(DE)to balance the exploitation and exploration in the solution *** show that the proposed optimized model can generally ft the cuves well albeit high variance in the solutions.

关键词： Susceptible-Infectious-Removed(SIR)model adaptive differential evolution Coronavirus Disease 2019(COVID-19)

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A minimalist approach for detecting sensor abnormality in oil and gas platforms

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Petroleum Research 2022年第2期7卷 177-185页

作者： Pauline wong W.k.wong Filbert H.Juwono Lenin Gopal Mohd Amaluddin Yusoff Curtin Malaysia Digital Innovation(CMDI) Curtin University Malaysia98009MiriSarawakMalaysia Department of Electrical and Computer Engineering Curtin University Malaysia98009MiriSarawakMalaysia

Compressors play an important role in day-to-day operation in most oil and gas platforms,especially in the case for maintaining gas pressure in transportation *** complex problem to detect the sensors health and abnormality as the sensor reading would reflect the various states of the *** ideal situation,sensor readings offer vast amounts of information on compressor health and could possibly indicate early fault of ***,due to harsh site and process operating conditions,sensors are often found to have drifted or failed,and there is no standard methodology to predict abnormality apart from applying emerging industrial smart sensor *** this paper,we investigate a minimalist approach for detecting abnormality of compressor's shaft's RPM *** the sensors in the compressor are correlated,we first use the outputs of other sensors to predict the shaft's RPM using regression-based models(neural networks and multiple linear regression).Second,we calculate the histogram of residuals by taking the difference between the predicted sensor value and the actual sensor value plus the abnormality in terms of bias/miscalibration and *** histogram of residuals can be used for sensor abnormality *** general,sensor states can be monitored by observing the shifting of the mean in the histogram of *** sensor readings contaminated with noise can be seen by a shifted mean whose value is between the normal condition mean and the biased condition *** method is compact and would be relevant to monitor irregularity of the sensors.

关键词： Sensor fault detection Multistage turbine air compressor Multiple linear regression Neural network Oil and gas industry

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Biomedical applications of shape-memory polymers:how practically useful are they?

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Science China Chemistry 2014年第4期57卷 476-489页

作者： wong YeeShan kONG JenFong WIDJAJA Leonardus k VENkATRAMAN Subbu S School of Materials Science & Engineering College of Engineering Nanyang Technological University

Shape-memory effect(SME) is the ability of a material to change its dimension in a predefined way in response to an external stimulus. Polymers that exhibit SME are an important class of materials in medicine, especially for minimally invasive deployment of devices. However, the rate of translation of the concept to approved products is extremely low, with mostly nitinolbased devices being approved. In this review, the general aspects of the different types of stimuli that can be used to activate SME are reviewed and sterilization issues of shape-memory polymer(SMP)-based medical devices are addressed. In addition, the general usefulness as well as the limitations of the shape-memory effect for biomedical applications are described.

关键词： shape memory biodegradable sterilization biomedical polymer

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Afteruse development of former landfll sites in Hong kong

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Journal of Rock Mechanics and Geotechnical Engineering 2013年第6期5卷 443-451页

作者： C.T.wong M.k.Leung M.k.wong W.C.Tang Architectural Services Department HKSAR Government

Landfll is one of the major methods in disposing of municipal solid waste(MSW) in Hong kong. There are now 13 closed landfll sites in Hong kong, and a restoration program has been launched since 1999 to transform the closed landfll sites back into recreational area. The MSW underneath these closed landfll sites will biodegrade slowly and gradually, releasing toxic gases and leachate. As there have only been a few afteruse development ever completed in Hong kong, this paper describes the consideration in planning and design of two former landfll sites in Hong kong–Ngau Chi Wan(NCW) and Jordan Valley(JV) landflls, in particular a discussion on the MSW settlement. Various models in predicting the longterm MSW settlement have been available. This paper reviews the applicability of these models to predict MSW settlement. However, as the predicted settlements can be signifcantly in error, they need sitespecifc calibration and validation. This paper therefore presents the settlement monitoring data in these former landfll sites over the last 30 years, and suggests modifying the Bjarngard and Edgers’ method for estimating this long-term settlement as well as the effect of additional surcharge due to afteruse development. Based on the regression of these data, compression indices Cce and C at different stages of the settlement in the modifed method have been calibrated and validated.

关键词： Afteruse development Closed landflls Municipal solid waste(MSW) settlement Modifed Bjarngard and Edgers' method

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Hepatocellular carcinoma in patients with non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第37期22卷 8294-8303页

作者： Carrie R wong Mindie H Nguyen Joseph k Lim Department of Internal Medicine Yale University School of Medicine Division of Gastroenterology and Hepatology Stanford University School of Medicine Yale Liver Center Section of Digestive Diseases Yale University School of Medicine

Nonalcoholic fatty liver disease(NAFLD) is the most common chronic liver disease in the United States and represents an increasingly important etiology of hepatocellular carcinoma(HCC) with annual cumulative incidence rates ranging from 2% to 12% in cohorts of NAFLD cirrhosis. While the risk of progression of NAFLD to HCC remains higher among patients with fibrosis or cirrhosis, an increasing amount of literature describes NAFLD-HCC as a disease that can occur in the absence of cirrhosis. Efforts to characterize the pathogenesis of NAFLD-HCC have suggested mechanisms that strongly associate with states of hyperinsulinemia and chronic inflammation, cellular mechanisms including adaptive immune responses and hepatic progenitor cell populations, and genetic polymorphisms including mutations of PNPLA3. Current literature describes NAFLD-HCC mostly as a disease of late presentation with lower rates of receipt of curative therapy and worse prognosis. However, a growing body of evidence has reported comparable and potentially more favorable disease-free and overall survival rates among patients with NAFLD-HCC after receipt of curative treatment. This review summarizes current evidence of epidemiology, pathophysiology, disease presentation, demand and receipt of curative therapy, post-treatment outcomes, and overall survival of NAFLD-associated HCC.

关键词： Fatty liver Nonalcoholic steatohepatitis Hepatocellular carcinoma Liver cirrhosis Liver cancer

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