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Genes & diseases 2024年第4期11卷 106-108页

作者： Gloria Garavito-de Egea alex dominguez-Vargas Jorg e l.Velez Gustavo Aroca Luis Fagng Elkin Navarro-Quiroz Zilac Espitaleta Kenny del Toro-Camargo Leticia Martinez-Ariza Tatiana Gonzalez-Vargas Susana Garcia Mauricio Arcos-Burgos Eduardo Egea Universidad del Norte Division Ciencias de la SaludBarranquillaColombia Universidad Simon Bolivar Facultad de Ciencias de la SaludBarranquillaColombia Clinica de la Costa Grupo de Investigacion en NefrologiaBarranquillaColombia Universidad de Antioquia Grupo de Investigacion en Psiquiatria(GIPSI)Departamento de PsiquiatriaInstituto de Investigaciones MedicasFacultad de MedicinaMedellinColombia

Genome-wide association studies(GWASs)have identified hundreds of loci across the human genome conferring susceptibility to autoimmune diseases(AIds),some of which are shared between more than two ***,this univariate ... 详细信息

关键词： susceptibility diseases diabetes

BMPRⅡ^(+)neural precursor cells isolated and characterized from organotypic neurospheres:an in vitro model of human fetal spinal cord development

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Neural Regeneration Research 2024年第2期19卷 447-457页

作者： Michael W.Weible II Michael d.Lovelace Hamish d.Mundell Tsz Wai Rosita Pang Tailoi Chan-Ling Bosch Institute Discipline of Anatomy and Histology(F13)University of SydneySydneyNSWAustralia School of Environment and Science Griffith UniversityNathanQLDAustralia discipline of Medicine Nepean Clinical SchoolFaculty of Medicine and HealthUniversity of SydneyKingswoodNSWAustralia New South Wales Brain Tissue Resource Centre School of Medical SciencesFaculty of Medicine and HealthUniversity of SydneyCharles Perkins Centre(D17)SydneyNSWAustralia

Roof plate secretion of bone morphogenetic proteins(BMPs)directs the cellular fate of sensory neurons during spinal cord development,including the formation of the ascending sensory columns,though their biology is not well ***-ⅡBMP receptor(BMPRⅡ),the cognate receptor,is expressed by neural precursor cells during embryogenesis;however,an in vitro method of enriching BMPRⅡ^(+)human neural precursor cells(hNPCs)from the fetal spinal cord is *** was undertaken on intact second-trimester human fetal spinal cord using antibodies to BMPRⅡand leukemia inhibitory factor(LIF).Regions of highest BMPRⅡ^(+)immunofluorescence localized to sensory *** and meningeal-associated BMPRⅡ^(+)vascular cells were identified in both intact fetal spinal cord and cortex by co-positivity with vascular lineage markers,Cd34/*** immunostaining identified a population of somas concentrated in dorsal and ventral horn interneurons,mirroring the expression of LIF receptor/Cd118.A combination of LIF supplementation and high-density culture maintained culture growth beyond 10 passages,while synergistically increasing the proportion of neurospheres with a stratified,*** neurospheres were characterized by BMPRⅡ^(+)/MAP2ab^(+/–)/βⅢ-tubulin^(+)/nestin^(–)/vimentin^(–)/GFAP^(–)/NeuN^(–)surface hNPCs surrounding a heterogeneous core ofβⅢ-tubulin^(+)/nestin^(+)/vimentin^(+)/GFAP^(+)/MAP2ab^(–)/NeuN^(–)multipotent *** cultures from tripotential neurospheres contained neuronal(βⅢ-tubulin^(+)),astrocytic(GFAP+),and oligodendrocytic(O4+)lineage ***-activated cell sorting-sorted BMPRⅡ^(+)hNPCs were MAP2ab^(+/–)/βⅢ-tubulin^(+)/GFAP^(–)/O4^(–)in *** is the first isolation of BMPRⅡ^(+)hNPCs identified and characterized in human fetal spinal *** data show that LIF combines synergistically with high-density reaggregate cultures to support the organotypic reorganization of neurospheres,characterize

关键词： BMPRⅡ bone morphogenetic protein histotypic human spinal cord development leukemia inhibitory factor neurosphere organotypic reaggregate sensory columns

development and testing of a high-power S-band klystron at BINP SB RAS

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Nuclear Science and Techniques 2024年第7期35卷 58-67页

作者： A.Levichev A.Barnyakov S.Samoylov d.Nikiforov V.Ivanov M.Arsentyeva d.Chekmenev O.Pavlov I.Pivovarov Budker Institute of Nuclear Physics Lavrentyeva Av.11NovosibirskRussia630090 Novosibirsk State University Pirogova Str.2NovosibirskRussia630090

This paper details the development and testing of the first working prototype of the S-band high-power klystron,accomplished at the Budker Institute of Nuclear Physics,Siberian Branch,Russian Academy of Sciences(BINP SB RAS).Upon testing,the klystron demonstrated the following parameters:an operating frequency of 2856 MHz and a peak power output of 50 *** paper presents the klystron's design,its constituent units,and pertinent processing procedures,along with discussions on the measurement of its parameters.

关键词： Klystron Linear accelerator Electron beam

Green building research in South Africa:A scoping review and future roadmaps

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Energy and Built Environment 2024年第2期5卷 316-335页

作者： Favour d.Agbajor Modupe Cecilia Mewomo department of Construction Management and Quantity Surveying Durban University of TechnologySteve Biko CampusDurban4001South Africa

The construction industry is recognised to pose serious environmental threats due to its anthropogenic *** confront this challenge,green building has been famed as an auspicious strategy to alleviate energy-related carbon emissions alongside climate change ***,it has birthed diverse empirical studies and holistic reviews by the research ***,these previous studies have been carried out from a global and continental viewpoint regardless of the green building development specifically in emerging *** present study seeks to fill the sparse research upshots on the synthesis of green building research at the country level with core focus on South *** this light,the current study provides a scoping overview of the intellectual exploration on green building research in the South African *** study’s findings highlight the varying growth regarding the subject matter,the drivers,drawbacks,and socio-economic issues confronting in developing green building projects in the *** optimize the advancement of green building in the region,this study recommends the implementation of financing schemes,utilization of advanced digital technologies,and promotion of green and sustainable building curricula across the institutions as well as post-occupancy-related studies within the green building spectrum towards a safe and salutogenic built-environment in the country.

关键词： Green building Sustainable construction Energy efficiency Review South Africa

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老龄飞机推迟退役对于售后市场的影响

航空维修与工程 2024年第8期 18-20页

作者： alex derber 赵平(译) 不详

根据对全球老龄飞机退役数量的预测,老龄飞机的推迟退役导致飞机、发动机和零部件售后市场中卖方逐渐占主导地位。面对航空公司运力的需求,一方面是新飞机产能不足,一方面是售后市场的航材供应不足。老龄飞机推迟退役不仅进一步减少了... 详细信息

根据对全球老龄飞机退役数量的预测,老龄飞机的推迟退役导致飞机、发动机和零部件售后市场中卖方逐渐占主导地位。面对航空公司运力的需求,一方面是新飞机产能不足,一方面是售后市场的航材供应不足。老龄飞机推迟退役不仅进一步减少了飞机拆解市场中可拆解飞机的数量。

关键词：老龄飞机航材供应退役售后市场卖方航空公司产能不足飞机拆解

Commentary on“The deterministic condition for the ground reaction force acting point on the combined knee valgus and tibial internal rotation moments in the early phase of cutting maneuvers in female athletes”

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Journal of Sport and Health Science 2024年第3期13卷 373-375页

作者： Nathan d.Schilaty Nathaniel A.Bates department of Neurosurgery&Brain Repair University of South FloridaTampaFL 33620USA department of Medical Engineering University of South FloridaTampaFL 33620USA Center for Neuromusculoskeletal Research University of South FloridaTampaFL 33620USA department of Orthopaedics The Ohio State University Wexner Medical CenterColumbusOH 43210USA

*** For decades,substantial disagreement has persisted as to whether dynamic knee valgus is the cause of the majority of anterior cruciate ligament(ACL)injuries or rather the result of the ACL rupture.1 Consequently,great effort and expense has gone into capturing 3-dimensional kinetics and kinematics from live athletes to drive in vitro and in silico models of ACL injury in order to elucidate the actual mechanism of injury,as these factors have been demonstrated to be surrogates of intraarticular structural loading on the ACL.2,3 The elucidation of injury mechanisms for non-contact ACL injuries is of great medical value as such knowledge consequently permits quantified examination and validation of interventions and their respective effectiveness in both prevention and rehabilitation of these traumatic knee injuries.

关键词： injuries knee prevention

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维修工作选择“就近”还是“求远”需谨慎

航空维修与工程 2024年第6期 21-23页

作者： alex derber 赵平(编译) 不详

过去20年,西方的航空公司看中亚洲和拉美地区的人力成本低的优势,都愿意将维修工作交由亚洲和拉美地区的MRO完成。但最近两年,受疫情、政治环境、供应链等因素的影响,西方的航空公司越来越多地开始考虑就近维修。

关键词：供应链人力成本拉美地区航空公司维修亚洲

Oligodendroctyes:the forgotten players of diabetes pathophysiology

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Neural Regeneration Research 2024年第11期19卷 2349-2350页

作者： Juan Antonio López-Villodres Beatriz García-díaz departamento Fisiología Humana Histología HumanaAnatomía Patológica y Educación Física y DeportivaFacultad de MedicinaUniversidad de MálagaMálagaSpain UGC Neurociencia.Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma Bionand) MálagaSpain

Oligodendrocytes(OLs),glial cells that provide myelin sheaths to axons in the central nervous system(CNS),have a dual ***,this myelin fatty cover around the axons protects the nerves and is crucial for the saltatory propagation of action *** and not less important,OLs provide trophic support to neurons and ***,OL metabolism is important for OL well-being and the proper accomplishment of their functions,and OL metabolism energetics directly affect the energy metabolism of neighboring neurons.

关键词： metabolism nerves myelin

Global patterns and ecological drivers of taxonomic and phylogenetic endemism in angiosperm genera

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Plant diversity 2024年第2期46卷 149-157页

作者： Hong Qian Brent d.Mishler Jian Zhang Shenhua Qian Research and Collections Center Illinois State Museum1011 East Ash StreetSpringfieldIL 62703USA University and Jepson Herbaria Department of Integrative BiologyUniversity of CaliforniaBerkeleyCA 94720-2465USA Center for Global Change and Complex Ecosystems Zhejiang Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment Ministry of EducationChongqing UniversityChongqing 400045China

Endemism of lineages lies at the core of understanding variation in community composition among geographic regions because it reflects how speciation,extinction,and dispersal have influenced current ***,we investigated geographic patterns and ecological drivers of taxonomic and phylogenetic endemism of angiosperm genera across the *** identify centers of paleo-endemism and neo-endemism of angiosperm genera,and show that they are mostly located in the Southern Hemisphere in tropical and subtropical regions,particularly in Asia and *** categories of phylogenetic endemism centers can be differentiated using current climate *** climate,historical climate change,and geographic variables together explained~80%of global variation in taxonomic and phylogenetic endemism,while 42-46%,1%,and 15%were independently explained by these three types of variables,*** our findings show that past climate change,current climate,and geography act together in shaping endemism,which are consistent with the findings of previous studies that higher temperature and topographic heterogeneity promote *** study showed that many centers of phylogenetic endemism of angiosperms,including regions in Amazonia,Venezuela,and west-central tropical Africa that have not previously been identified as biodiversity hotspots,are missed by taxon-based measures of endemism,indicating the importance of including evolutionary history in biodiversity assessment.

关键词： Angiosperm Current climate Endemism Historical climate change Topographic heterogeneity

Advancing Wound Filling Extraction on 3d Faces:An Auto-Segmentation and Wound Face Regeneration Approach

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2197-2214页

作者： duong Q.Nguyen Thinh d.Le Phuong d.Nguyen Nga T.K.Le H.Nguyen-Xuan department of Mathematics and Statistics Quy Nhon UniversityQuy Nhon City55100Viet Nam Applied Research Institute for Science and Technology Quy Nhon UniversityQuy Nhon City55100Viet Nam CIRTECH Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Facial wound segmentation plays a crucial role in preoperative planning and optimizing patient outcomes in various medical *** this paper,we propose an efficient approach for automating 3d facial wound segmentation using a two-stream graph convolutional *** method leverages the Cir3d-FaIR dataset and addresses the challenge of data imbalance through extensive experimentation with different loss *** achieve accurate segmentation,we conducted thorough experiments and selected a high-performing model from the *** selectedmodel demonstrates exceptional segmentation performance for complex 3d facial ***,based on the segmentation model,we propose an improved approach for extracting 3d facial wound fillers and compare it to the results of the previous *** method achieved a remarkable accuracy of 0.9999993% on the test suite,surpassing the performance of the previous *** this result,we use 3d printing technology to illustrate the shape of the wound *** outcomes of this study have significant implications for physicians involved in preoperative planning and intervention *** automating facial wound segmentation and improving the accuracy ofwound-filling extraction,our approach can assist in carefully assessing and optimizing interventions,leading to enhanced patient ***,it contributes to advancing facial reconstruction techniques by utilizing machine learning and 3d bioprinting for printing skin tissue *** source code is available at https://***/SIMOGroup/WoundFilling3d.

关键词： 3d printing technology face reconstruction 3d segmentation 3d printed model