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Network-based identification of feedback modules that control RhoA activity and cell migration

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Journal of Molecular Cell Biology 2015年第3期7卷 242-252页

作者： Tae-Hwan Kim Naser Monsefi Je-Hoon Song alex von Kriegsheim Drieke Vandamme Olivier Pertz Boris NKholodenko Walter Kolch Kwang-Hyun Cho Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 305-701Republic of Korea Systems Biology Ireland University College DublinBelfieldDublin 4Ireland Department of Biomedicine University of BaselBaselSwitzerland School of Medicine and Medical Science University College DublinBelfieldDublin 4Ireland Conway Institute of Biomolecular&Biomedical Research University College DublinBelfieldDublin 4Ireland

Cancer cell migration enables metastatic spread causing most cancer ***-family GTPases control cell migration,but being embedded in a highly interconnected feedback network,the control of their dynamical behavior during cell migration remains *** address this question,wereconstructed the Rho-family GTPases signaling network involved in cell migration,and developed a Boolean network model to analyze the different states and emergent rewiring of the Rho-family GTPases signaling network at protrusions and during extracellular matrix-dependent cell *** simulations and experimental validations revealed that the bursts of RhoA activity induced at protrusions by EGFare regulated by a negative-feedback module composed of Src,FAK,and ***,perturbing this module interfered with cyclic Rho activation and extracellular matrix-dependent migration,suggesting that CSK inhibition can be a novel and effective intervention strategy for blocking extracellular matrix-dependent cancer cell migration,while Src inhibition might fail,depending on the genetic background of ***,this study provides new insights into the mechanisms that regulate the intricate activation states of Rho-family GTPases during extracellular matrix-dependent migration,revealing potential new targets for interfering with extracellular matrix-dependent cancer cell migration.

关键词： cell migration Rho-family GTPases signaling network Boolean network model cyclical RhoA bursts

Improvement in potassium ion batteries electrodes: Recent developments and efficient approaches

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Journal of Energy Chemistry 2021年第11期30卷 307-337,I0007页

作者： Syed Musab Ahmed Guoquan Suo Wei alex Wang Kai Xi Saad Bin Iqbal School of Materials Science and Engineering Shaanxi University of Science and TechnologyXi’an 710021ShaanxiChina Beijing Key Laboratory of Bio-inspired Energy Materials and Devices School of Space and EnvironmentBeihang UniversityBeijing 100191China Cambridge Graphene Centre Department of EngineeringUniversity of CambridgeCambridge CB30FAUK Department of Chemical and Energy Engineering Faculty of Process and System EngineeringOtto-von-Guericke UniversitätMagdeburg 39106Germany

Demand for efficient and continuous application for high-grid energy storage systems involves the study towards novel battery technologies. Hence, considering the vast naturally available resources of potassium all over the world and its encouraging intercalation chemistries, it has recently enticed attention in electrochemical energy storage industry in the form of potassium ion batteries (PIBs). The major factor in this K+ based battery, is to develop efficient approaches to manufacture electrode substance to intercalate its big size potassium ions with considerable voltage, kinetics, charge/discharge capacity, capacity retention, cost, etc. This study contributes in the recent developments of anode and cathode materials for PIBs, including several electrode materials in regards to synthesis, structure, electrochemical performance, and K-storage mechanisms. Finally, the review contributes to provide helpful sources for the increasing number of scientists working in this industry regarding its critical issues and challenges and also to indicate the future direction of electrode materials in PIBs.

关键词： Potassium ion batteries Efficient approaches Recent developments

Two-photon emission from a superlattice-based superconducting light-emitting structure

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Light(Science & Applications) 2024年第7期13卷 1331-1340页

作者： Shlomi Bouscher Dmitry Panna Ronen Jacovi Fauzia Jabeen Christian Schneider Sven Höfling alex Hayat Department of Electrical Engineering TechnionHaifa 32000Israel. Technische Physik Universität WürzburgAm HublandD-97074 WürzburgGermany. Institute of Physics Carl von Ossietzky Universität OldenburgD-26111 OldenburgGermany

Superconductor-semiconductor hybrid devices can bridge the gap between solid-state-based and photonics-based quantum systems,enabling new hybrid computing schemes,offering increased scalability and *** example for a hybrid device is the superconducting light-emitting diode(SLED).SLEDs have been theoretically shown to emit polarization-entangled photon pairs by utilizing radiative recombination of Cooper ***,the twophoton nature of the emission has not been shown experimentally *** demonstrate two-photon emission in a GaAs/AlGaAs *** electroluminescence spectra reveal unique two-photon superconducting features below the critical temperature(Tc),while temperature-dependent photon-pair correlation experiments(g(2)(τ,T))demonstrate temperature-dependent time coincidences below Tc between photons emitted from the *** results pave the way for compact and efficient superconducting quantum light sources and open new directions in light-matter interaction studies.

关键词： photon quantum utilizing

Anemia and long-term outcome in adjuvant and neoadjuvant radiochemotherapy of stage Ⅱ and Ⅲ rectal adenocarcinoma:The Freiburg experience(1989-2002)

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World Journal of Gastroenterology 2006年第12期12卷 1849-1858页

作者： Christian Weissenberger Geissler Michael Otto Florian Barke Annette Henne Karl von Plehn Georg Rein alex Müller Christine Bartelt Susanne Henke Michael Department of Radiotherapy University Hospital of Freiburg79106 FreiburgGermany Department Oncology Gastroenterology and Internal MedicineStidtische Kliniken Esslingen73730 Esslingen a.N.Germany Department of Internal Medicine I Division of OncologyUniversity Hospital of Freiburg79106 FreiburgGermany

AIM： To evaluate the long-term outcome of standard 5-FU based adjuvant or neoadjuvant radiochemotherapy and to identify the predictive factors, especially anemia before and after radiotherapy as well as hemoglobin increase or decrease during radiotherapy. METHODS： Two hundred and eighty-six patients with Union International Contre Cancer （UICC） stage Ⅱ and Ⅲ rectal adenocarcinomas, who underwent resection by conventional surgical techniques （low anterior or abdominoperineal resection）, received either postoperative （n = 233） or preoperative （n = 53） radiochemotherapy from January 1989 until July 2002. Overall survival （OAS）, cancer-specific survival （CSS）, disease-free survival （DFS）, local-relapse-free （LRS） and distant-relapse-free survival （DRS） were evaluated using Kaplan-Meier, Log-rank test and Cox＇s proportional hazards as statistical methods. Multivariate analysis was used to identify prognostic factors. Median follow-up time was 8 years. RESULTS： Anemia before radiochemotherapy was an independent prognostic factor for improved DFS （risk ratio 0.76, P= 0.04） as well as stage, grading, R status （free radial margins）, type of surgery, carcinoembryonic antigen （CEA） levels, and gender. The univariate analysis revealed that anemia was associated with impaired LRS（better local control） but with improved DFS. In contrast, hemoglobin decrease during radiotherapy was an independent risk factor for DFS （risk ratio 1.97, P= 0.04）. During radiotherapy, only 30.8% of R0-resected patients suffered from hemoglobin decrease compared to 55.6% if R1/2 resection was performed （P= 0.04）. The 5-year OAS, CSS, DFS, LRS and DRS were 47.0%, 60.0%, 41.4%, 67.2%, and 84.3%, respectively. Significant differences between preoperative and postoperative radiochemotherapy were not found. CONCLUSION ： Anemia before radiochemotherapy and hemoglobin decrease during radiotherapy have no predictive value for the outcome of rectal cancer. Stage, grading, R status （free radial margins）, t

关键词： Rectal cancer Adjuvant radiotherapy Adjuvant radiochemotherapy Anemia Procjnostic factor

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下肢静脉造影后的全身和局部反应

放射学实践 1986年第3期 124-125页

作者： von U.Borst ,V.Barth ,B.schulze ,窦永充同济医科大学附属同济医院

静脉造影作为放射学的常规检查,在文献中占据篇幅较大.查阅文献发现,关于病人静脉造影后的主观病痛的资料很少,或只有少数病例报道.其原因为病人和放射科医生之间缺少反馈联系. 为了能得到关于这些主观病痛的较详尽资料,两年来每一个在E... 详细信息

静脉造影作为放射学的常规检查,在文献中占据篇幅较大.查阅文献发现,关于病人静脉造影后的主观病痛的资料很少,或只有少数病例报道.其原因为病人和放射科医生之间缺少反馈联系. 为了能得到关于这些主观病痛的较详尽资料,两年来每一个在Esslingen市立医院的放射学中心作了损伤性检查(包括静脉造

关键词：局部反应非离子下肢静脉造影造影剂 X光乳剂

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海地:梦魇的国度

Investigation of Temperature Dependency of Morphological Properties of Thermoplastic Polyurethane using WAXS and SAXS Monitoring

视野 2010年第6期 4-6页

作者： alex von Tunzelmann 小颖凌奥幸

2008年的飓风摧毁了超过70%的农田;超过80%的人每天生活费用不足2英镑;3.8%的人口呈现艾滋病毒阳性;3000名病人共用一名医生;人均预期寿命61岁,1000个新生儿中死亡80个,5岁以下儿童死亡率是12%.

关键词：海地梦魇儿童死亡率预期寿命生活费用艾滋病毒新生儿英镑医生阳性人口农田飓风病人

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Journal of Chemistry and Chemical Engineering 2015年第8期9卷 494-499页

作者： Steffen Thomas Witzleben Katharina Walbrueck Stephanie Elisabeth Klein Margit schulze Department of Natural Sciences Bonn-Rhein-Sieg University of Applied Sciences von-Liebig-Strasse 20 Rheinbach D53359Germany

Polyether and polyether/ester based TPU （thermoplastic polyurethanes） were investigated with wide-angle XRD （X-ray diffraction） and SAXS （small angle X-ray scattering）. Furthermore, SAXS measurements were performed in the temperature range of 30 ℃ to 130 ℃. Polyether based polymers exhibit only one broad diffraction signal in a region of 2 θ 15° to 25°. In case of polyurethanes with ether/ester modification, the broad diffraction signal arises with small sharp diffraction signals. SAXS measurements of polymers reveal the size and shape of the crystalline zones of the polymer. Between 30 ℃ and 130 ℃ the size of the crystalline zone changes significantly. The size decreases in most of investigated TPU. In the case of Desmopan 9365D an increase of the particle size was observed.

关键词： Thermoplastic polyurethanes morphology mechanical properties SAXS WAXS temperature influence crystallinity

Arabidopsis Heterotrimeric G-protein Regulates Cell Wall Defense and Resistance to Necrotrophic Fungi

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Molecular Plant 2012年第1期5卷 98-114页

作者： Magdalena Delgado-Cerezo Clara Sanchez-Rodriguez Viviana Escudero Eva Miedes Paula Virginia Fernandez Lucia Jorda Camilo Hernandez-Blanco Andrea Sanchez-Vallet Pawel Bednarek Paul schulze-Lefert Shauna Somervilleg Jose Manuel Estevez Staffan Persson Antonio Molina Centro de Biotecnologia y Genomica de Plantas （UPM-INIA） Universidad Politecnica de Madrid Campus de Montegancedo E-28223-Pozuelo de Alarcbn （Madrid） Spain Max-Planck-lnstitute fLir Molekulare Pflanzenphysiologie Am MQhlenberg 2 14476 Potsdam Germany Laboratorio de Fisiologia y Biologia Molecular IFIByNE （CONICET） FCEyN-Universidad de Buenos Aires Pab. II Intendente Guiraldes 2160 Buenos Aires C1428EGA Argentina Present address： Laboratory of Phytopathology Wageningen University Droevendaalsesteeg 1 6708 PB Wageningen The Netherlands Max Planck Institut for Zuchtungsforschung Department of Plant Microbe Interactions Carl-von-Linne-Weg 10 D-50829 Koln Germany Institute of Bioorganic Chemistry Polish Academy of Sciences Noskowskiego 12/14 61-704 Poznan Poland Energy Biosciences Institute 130 Calvin Hall University of California at Berkeley Berkeley CA 94720 USA

The Arabidopsis heterotrimeric G-protein controls defense responses to necrotrophic and vascular fungi. The agbl mutant impaired in the Gβ subunit displays enhanced susceptibility to these pathogens. Gβ/AGB1 forms an obligate dimer with either one of the Arabidopsis Gγsubunits （γ1/AGG1 and γ2/AGG2）. Accordingly, we now demonstrate that the aggl agg2 double mutant is as susceptible as agbl plants to the necrotrophic fungus Plectosphaerella cucumerina. To elucidate the molecular basis of heterotrimeric G-protein-mediated resistance, we performed a comparative transcriptomic analysis of agbl-1 mutant and wild-type plants upon inoculation with P cucumerina. This analysis, together with metab- olomic studies, demonstrated that G-protein-mediated resistance was independent of defensive pathways required for resistance to necrotrophic fungi, such as the salicylic acid, jasmonic acid, ethylene, abscisic acid, and tryptophan-derived metabolites signaling, as these pathways were not impaired in agbl and aggl agg2 mutants. Notably, many mis-reguiated genes in agbl plants were related with cell wall functions, which was also the case in aggl agg2 mutant. Biochemical analyses and Fourier Transform InfraRed （FTIR） spectroscopy of cell walls from G-protein mutants revealed that the xylose content was lower in agbl and aggl agg2 mutants than in wild-type plants, and that mutant walls had similar FTIR spec-tratypes, which differed from that of wild-type plants. The data presented here suggest a canonical functionality of the Gβ and Gγ1/γ2 subunits in the control of Arabidopsis immune responses and the regulation of cell wall composition.

关键词： Plant immunity cell wall indole glucosinolates xylose necrotropic fungi G-protein.

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江西茶叶的多元素分析

江西茶叶的多元素分析