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Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo

Protein & Cell 2011年第4期2卷 333-346页

作者： Sharyn Bayne He Li Margaret E.E.Jones alex r.pinto Michelle van Sinderen Ann Drummond Evan r.Simpson Jun-Ping Liu Department of Immunology Central Eastern Clinical SchoolMonash UniversityVictoria 3800Australia Prince Henry’s Institute of Medical research Clayton VIC 3168Australia Current address:research Services M459The University of Western Australia35 Stirling HighwayCRAWLEY WA 6009Australia Current address:Murdoch Children’s research Institute Royal Children’s HospitalParkvilleVic 3052Australia

Estrogen is implicated as playing an important role in aging and tumorigenesis of estrogen responsive tissues;however the mechanisms underlying the mitogenic actions of estrogen are not fully *** we report that estrogen deficiency in mice caused by targeted disruption of the aromatase gene results in a signi-ficant inhibition of telomerase maintenance of telomeres in mouse ovaries in a tissue-specific *** inhibition entails a significant shortening of telomeres and compromised proliferation in the follicular granulosa cell compartment of *** expression analysis showed decreased levels of proto-oncogene c-Myc and the telomerase catalytic subunit,telomerase reverse transcriptase(TErT),in response to estrogen *** replacement therapy led to increases in TErT gene expression,telomerase activity,telomere length and ovarian tissue growth,thereby reinstating ovary development to normal in four *** data demonstrate for the first time that telomere maintenance is the primary mechanism mediating the mitogenic effect of estrogen on ovarian granulosa cell proliferation by upregulating the genes of c-Myc and TErT in *** deficiency or over-activity may cause ovarian tissue aging or tumorigenesis,respectively,through estrogen regulation of telomere remodeling.

关键词： estrogen telomerase reverse transcriptase(TErT) telomeres ovary mice

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TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence

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Protein & Cell 2017年第1期8卷 39-54页

作者： Lucy Cassar Craig Nicholls alex r. pinto ruping Chen Lihui Wang He Li Jun-Ping Liu Molecular Signaling Laboratory Department of Immunology Central Eastern Clinical School Monash University Prahran VIC 3181 Australia Institute of Aging research Hangzhou Normal University School of Medicine Hangzhou 311121 Zhejiang Province China

Human telomerase reverse transcriptase （hTErT） plays a central role in telomere lengthening for continuous cell proliferation, but it remains unclear how extracellular cues regulate telomerase lengthening of telomeres. Here we report that the cytokine bone morphogenetic protein-7 （BMP7） induces the hTErT gene repression in a BMPrII receptor- and Smad3-dependent manner in human breast cancer cells. Chonic exposure of human breast cancer cells to BMP7 results in short telomeres, cell senescence and apoptosis. Mutation of the BMPrII receptor, but not TGFbrII, ACTrIIA or ACTrIIB receptor, inhibits BMP7-induced repression of the hTErT gene promoter activity, leading to increased telomerase activity, lengthened telomeres and continued cell proliferation. Expression of hTErT prevents BMP7-induced breast cancer cell senescence and apoptosis. Thus, our data suggest that BMP7 induces breast cancer cell aging by a mechanism involving BMPrII receptor- and Smad3-mediated repression of the hTErT gene.

关键词： BMPrII TGFbeta hTErT telomerase telomeres senescence breast cancer cells

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宽窄行栽植下三倍体毛白杨根系生物量分布及其对土壤养分因子的响应

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植物生态学报 2013年第10期37卷 961-971页

作者：邸楠席本野 Jeremiah r.pinto 王烨李广德贾黎明北京林业大学省部共建森林培育与保护教育部重点实验室北京100083 US Department of Agriculture Forest ServiceRocky Mountn Research Station1221 SMain StMoscowID 83843USA 中央广播电视大学农林医药学院北京100039

三倍体毛白杨(triploid Populus tomentosa)是我国华北地区主要纸浆林品种,在该地区多采用宽窄行模式栽植。为基于根系结构特征制定该模式下毛白杨人工林高效水肥管理策略和明确影响其根系空间分布的主要因子,在5年生林分中于8株样树周... 详细信息

三倍体毛白杨(triploid Populus tomentosa)是我国华北地区主要纸浆林品种,在该地区多采用宽窄行模式栽植。为基于根系结构特征制定该模式下毛白杨人工林高效水肥管理策略和明确影响其根系空间分布的主要因子,在5年生林分中于8株样树周围挖取2 106个土柱,研究该栽植模式下毛白杨根系生物量的空间分布特征,并分析了细根垂直分布对土壤有机质、速效磷和碱解氮等的响应。结果表明,一维垂向上,宽行内细根根重密度(FrBD)在0–30 cm土层中随深度增加而递减,但在30cm以下土层呈均匀分布(p=0.079);窄行内FrBD呈"双峰"分布,即在0–20 cm(22%)和70–110 cm(31%)土层均有较多细根分布;10–150 cm各土层中,窄行FrBD较宽行高17%–148%。宽、窄行内,随深度增加,粗根根重密度(CrBD)均呈先增后减变化,而细根粗根比(F/C)无显著变化(p>0.05),窄行平均F/C较宽行高60%。一维径向上,宽、窄行内FrBD均呈近均匀分布,而CrBD和F/C均随距离增加分别显著递减和增大。二维尺度上,FrBD在窄行内分布相对均匀,但在宽行内主要集中在表土层且随距离增加细根浅层化程度增强;CrBD在树干两侧呈"不对称"分布;垂向0–20 cm、径向160–300 cm范围是宽行内平均FrBD和F/C较高区域,分别为宽行相应指标总平均的2.8和1.1倍。FrBD在0–30 cm土层中随土壤有机质、速效磷和碱解氮含量的增加而逐渐增大,但在30 cm以下土层中无明显变化趋势。研究结果表明,宽、窄行间毛白杨根系分布的差异性主要体现在细根一维垂直分布和细根、粗根二维分布上。土壤有机质、速效磷和碱解氮是0–30 cm土层中毛白杨细根垂直分布的重要影响因子,但对下层土壤中根系分布无影响。对宽窄行栽植的毛白杨林分灌溉时,灌溉水应供给到窄行区域;施肥时,缓释肥和速效肥应分别浅施在宽行中央附近和窄行内。

关键词：根系生物量土壤养分三倍体毛白杨宽窄行栽植模式

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Amplified Fluorescence Quenching and Biosensor Application of a Poly(p-phenylene) Cationic Polyelectrolyte

Amplified Fluorescence Quenching and Biosensor Application o...

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第七届全国磷化学化工暨第四届海峡化学生物学、生物技术与医药发展讨论会

作者： Chunyan Tan Mauricio r.pinto Kirk S．Schanze 清华大学深圳研究生院广东省化学生物学重点实验室 Department of Chemistry University of Florida Department of Chemistry University of Florida

The quenching behavior of a water-soluble cationic poly(para-phenylene) bearing quaternized ammonium side groups (P-NEt3+) was studied. P-NEt3+ is efficiently quenched by sodium anthraquinone-2,6-disulfonate (AQS) and sodium 1,4,5,8-naphthalenediimide-N,N'-bis(methylsulfonate) (NDS) in aqueous solution via a photoinduced electron transfer mechanism. Absorption spectra of the NDS/P-NEt3+ ion-pair complex indicated formation of a stable

关键词： QTL Amplified Fluorescence Quenching and Biosensor Application of a Poly Cationic Polyelectrolyte p-phenylene

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促进慢性阻塞性肺疾病哮喘患者自我监控空气质量的护理干预措施: 整合性综述

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International Journal of Nursing Sciences 2024年第1期11卷 46-56页

作者： Bruna F.Sebastiao raquel M.Hortelao Sara S.Granadas Jose M.Faria Joana r.pinto Helga rafael Henriques Nursing School of Lisbon LisbonPortugal Hospital Center of Central Lisbon Portugal CUF Tejo Hospital LisbonPortugal University Hospital Center of Northern Lisbon LisbonPortugal Nursing research Innovation and Development Centre of Lisbon(CIDNUR)LisbonPortugal

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronie obst ructive pulmonary disease overlap,A-CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通... 详细信息

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronie obst ructive pulmonary disease overlap,A-CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过系统性综述,寻找证据,以指导制订护理干预措施,促进ACO患者对空气质量的自我管理。方法2023年3月 ,系统检索CINAHL、Medline、Academie Search Complete .Scopus、WebofScience、Cochrane图书馆、乔安娜布里格斯研究所(JoannaBriggsInstitute,JBI)循证实践数据库,以及GoogleScholar。对纳人研究进行数据提取和综合,并对护理干预措施进行分类。采用JBI研究质量评估工具进行方法学质量评估。结果共纳入5篇来自不同国家的研究。促进ACO患者自我监控空气质量的干预措施包括:警觉性干预措施(医务人员定期巡诊、进行症状评估),监测干预措施(监测室内外诱发因素) ,教育干预措施(空气质量警报、避免接触过敏原),以及相关政策的影响,如无烟政策和改善空气质量的综合战略。尽管这些研究报告了不同的干预措施,方法质量也存在差异,但这些干预措施显示了预防患者病情恶化、尽量减少急诊就诊和住院治疗的潜力。这些关键点可作为护理干预措施的关键组成部分。结论有必要采取全面措施,让护士参与促进患者自我监控空气质量的多学科团队.提高认识、制订和实施护理干预,从而使ACO患者受益。同时,需要进--步开展研究,以扩大证据基础并完善这些干预措施。

关键词：空气质量哮喘哮喘-慢阻肺重叠慢性病慢性阻塞性肺疾病护理自我管理

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Natural orifice transluminal endoscopy surgery:A review

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World Journal of Gastroenterology 2011年第33期17卷 3795-3801页

作者： Joo Moreira-pinto Estevo Lima Jorge Correia-pinto Carla rolanda Life and Health Sciences research Institute(ICVS) School of Health SciencesUniversity of MinhoBragaPortugal ICVS/3B's-PT Government Associate Labora-tory Braga/GuimaresPortugal Pediatric Surgery division Centro Hospitalar do Porto4099-001 PortoPortugal Department of Urology Hospital de Braga4709-057 BragaPortugal Department of Pediatric Surgery Hospital de Braga4709-057 BragaPortugal Department of Gastroenterology Hospital de Braga4709-057 BragaPortugal

Minimally invasive surgery started spreading worldwide in 1987,when the first laparoscopic cholecystectomy was ***,improvement of endoscopic equipment and instruments allowed gastroenterologists to attempt more aggressive endoluminal interventions,even beyond the wall *** first transgastric peri-toneoscopy,in 2004,brought to light the concept of natural orifice transluminal endoscopic surgery(NOTES).The idea of incisionless surgery is attractive and has become a new goal for both surgeons and other people interested in this field of *** authors present a review of all developments concerning NOTES,including animal studies and human experience.

关键词： Transesophageal Transgastric Transvesical Transvaginal Transcolonic Natural orifice trans-luminal endoscopic surgery Minimally invasive tech-niques

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Variation of Parameters Formula and Gronwall Inequality for Differential Equations with a General Piecewise Constant Argument

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Acta Mathematicae Applicatae Sinica 2011年第4期27卷 561-568页

作者： Kuo-Shou CHIU Manuel pinto Departamento de Matemótica Facultad de Ciencias BósicasUniversidad Metropolitana de Ciencias de la EducacinJ.P.Alessandri 774SantiagoChile Departamento de Matemóticas Facultad de CienciasUniversidad de ChileCasilla 653SantiagoChile

A variation of parameters formula and Gronwall type integral inequality are proved for a differential equation involving general piecewise alternately advanced and retarded argument.

关键词： variation of parameters formula Gronwall integral inequality alternately advanced and retarded argument

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t-SNE:A study on reducing the dimensionality of hyperspectral data for the regression problem of estimating oenological parameters

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Artificial Intelligence in Agriculture 2023年第1期7卷 58-68页

作者： rui Silva Pedro Melo-pinto CITAB-Centre for the research and Technology of Agro-Environmental and Biological Sciences Inov4Agro-Institute for InnovationCapacity Building and Sustainability of Agri-Food ProductionUniversidade de Trás-os-Montes e Alto DouroQuinta dos PradosVila Real 5000-801Portugal Departamento de Engenharias Escola de Ciências e TecnologiaUniversidade de Trás-os-Montes e Alto DouroQuinta dos PradosVila Real 5000-801Portugal

In recent years there is a growing importance in using machine learning techniques to improve procedures in precision agriculture:in this work we perform a study on models capable of predicting oenological parameters from hyperspectral images of wine grape berries,a specially relevant topic to boost production tasks for ***,we explore the capabilities of a novel technique mostly used for visualization,t-Distributed Stochastic Neighbor Embedding(t-SNE),for reducing the dimensionality of the highly complex hyperspectral data and compare its performance with Principal Component Analysis(PCA)method,which despite the introduction of many nonlinear dimensionality reduction techniques over the years,had achieved the best results for real-world data across several studies in *** we explore the potential of Kernel t-SNE,an extension to the t-SNE method that allows for the usage of the technique in streaming data or online *** results show that,in a direct comparison,t-SNE achieves better metrics than PCA for most of the data sets in this work and that the regressor(Support Vector regression,SVr)performs better with the t-SNE reduced features as inputs,accomplishing better predictions with lower error *** the results with current literature,our shallow learning model paired with t-SNE achieves either better or on par results than those reported,even competing with more advanced models that use deep learning techniques,which should propel the introduction of t-SNE in more studies that require dimensionality reduction.

关键词： Hyperspectral images Dimensionality reduction regression T-SNE Support vector machines Wine grape berries

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Organic Light Emitting Diodes with Lithium Contained Alq3 as Electron Injection Layer

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Chemical research in Chinese Universities 2002年第2期18卷 121-123页

作者： Zugang Liu J.L.pinto Department of Materials University of OxfordParks RoadOxford OX13PFUK Departamento de Física Universidade de Aveiro3810194 AveiroPortuga

lNovel lithium doped tris 8 hydroxylquinoline aluminium(Alq3:Li) layer is deposited between emission layer and electron injection aluminium electrode as an electron injection assistant layer in different organic light emitting diodes(OLED) to lower the electron injection barrier. In these devices, Alq3 is used as emission layer, and a bilayer film of N,N bis (1 naphhyl) N,N diphenyl 1,1 biphenyle 4,4' diamine(NPB) and 4,4,4' tris(3 methyl phenylphenylamino) triphenylamine( m MTDATA) used as hole transport layer(HTL). The electroluminescent performance of devices with different thicknesses of Alq3∶Li shows that the insertion of the lithium doped Alq3 layer can reduce the turn on voltage by at least 2 volts, and the stability of devices with this lithium doped Alq3 layer is improved too. It can also change the efficiency of devices. Compared with an ultra thin lithium fluoride(LiF) layer, Alq3∶Li sheet gives similar effects but higher efficiency and can be much thicker and hence it is easier to control the deposition.

关键词： Organic light emitting diodes Lithium layer Alq3 EI

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Biotechnology of the multipurpose tree species Arbutus unedo:a review

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Journal of Forestry research 2022年第2期33卷 377-390页

作者： João Martins Glória pinto Jorge Canhoto Centre for Functional Ecology Department of Life SciencesUniversity of CoimbraCoimbraPortugal Centre for Environmental and Marine Studies Department of BiologyUniversity of AveiroAveiroPortugal

Arbutus unedo L.(strawberry tree,Ericaceae)is a woody species with a circum-Mediterranean *** has considerable ecological relevance in southern European forests due to its resilience to abiotic and biotic *** edible red berries are used in the production of traditional products,including an expensive *** compounds extracted from the species have bioactive prop-erties used by the cosmetic and pharmaceutical *** strawberry tree has gone from a neglected species to become a highly valuable crop with large cultivated areas in southern European and North African *** to an increasing demand from farmers for plants with improved features,researchers have been trying to improve this spe-cies through conventional and biotechnological tools,focus-ing mainly on population analysis using molecular markers,in vitro cloning,tolerance to biotic and abiotic stresses,and intraspecific crosses to obtain genotypes with new *** objective of this review is to gather and update information about the species and make it available to researchers and *** research areas that are considered a priority for this species are highlighted.

关键词： Breeding Chemical profiling Ericaceae Microbiome Micropropagation

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