检索结果-南通市图书馆

Stable diffusion gradients in microfluidic conduits bounded by fluid walls

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2024年第3期10卷 357-367页

作者： Federico Nebuloni Cyril Deroy Peter r.cook Edmond J.Walsh Department of Engineering Science Osney Thermo-Fluids InstituteUniversity of OxfordOxford OX20ESUK Sir William Dunn School of Pathology University of OxfordOxford OX13REUK

Assays mimicking in vitro the concentration gradients triggering biological responses like those involved in fighting infections and blood clotting are essential for biomedical *** assays prove especially attractive as they allow precise control of gradient shape allied to a reduction in *** microfluidic devices are fabricated using solid plastics that prevent direct access to responding ***-walled microfluidics allows the manufacture of circuits on standard Petri dishes in seconds,coupled to simple operating methods;cell-culture medium sitting in a standard dish is confined to circuits by fluid walls made of an immiscible *** develop and experimentally validate an analytical model of diffusion between two or more aqueous streams flowing at different rates into a fluid-walled conduit with the cross-section of a circular *** solid walls,fluid walls morph during flows as pressures fall,with wall shape changing down the *** model is validated experimentally for Fourier numbersrescein diffusing between laminar *** enables a priori prediction of concentration gradients throughout a conduit,so allowing rapid circuit design as well as providing bioscientists with an accurate way of predicting local concentrations of bioactive molecules around responsive and nonresponsive cells.

关键词： walls diffusion attractive

Stratification of Patients with Diabetes Using Continuous Glucose Monitoring Profiles and Machine Learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health Data Science 2022年第1期2022卷 144-152页

作者： Yinan Mao Kyle Xin Quan Tan Augustin Seng Peter Wong Sue-Anne Toh alex r.cook Saw Swee Hock School of Public Health National University of Singapore and National University Health SystemSingapore Department of Statistics and Data Science National University of SingaporeSingapore NOVI Health Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Duke-NUS Medical School Singapore

*** glucose monitoring(CGM)offers an opportunity for patients with diabetes to modify their lifestyle tobetter manage their condition and for clinicians to provide personalized healthcare and lifestyle ***,analytic toolsare needed to standardize and analyze the rich data that emerge from CGM *** would allow glucotypes of patients tobe identified to aid clinical *** this paper,we develop an analysis pipeline for CGM data and applyit to 148 diabetic patients with a total of 8632 days of follow *** pipeline projects CGM data to a lower-dimensional spaceof features representing centrality,spread,size,and duration of glycemic excursions and the circadian *** then useprincipal components analysis and k-means to cluster patients’records into one of four glucotypes and analyze clustermembership using multinomial logistic *** differ in the degree of control,amount of time spent inrange,and on the presence and timing of hyper-and *** on the program had statistically significantimprovements in their glucose *** pipeline provides a fast automatic function to label raw CGM datawithout manual input.

关键词： Patients Profiles membership

Urban-rural Disparities for COVID-19:Evidence from 10 Countries and Areas in the Western Pacific

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health Data Science 2021年第1期2021卷 60-68页

作者： Minah Park Jue Tao Lim Lin Wang alex r.cook Borame L.Dickens Saw Swee Hock School of Public Health National Health SystemsNational University of SingaporeSingapore Department of Genetics University of CambridgeCambridge CB23EHUK Mathematical Modelling of Infectious Diseases Unit Institut PasteurUMR2000CNRSParis 75015France

*** evidence on the effectiveness of various types of social distancing measures,from voluntary physical distancing to a community-wide quarantine,exists for the Western Pacific region(WPr)which has large urban and rural *** estimated the time-varying reproduction number(rt)in a Bayesian framework using district-level mobility data provided by Facebook(i)to assess how various social distancing policies have contributed to the reduction in transmissibility of SArS-COV-2 and(ii)to examine within-country variations in behavioural responses,quantified by reductions in mobility,for urban and rural *** distancing measures were largely effective in reducing transmissibility,with rt estimates decreased to around the threshold of ***-country analysis showed substantial variation in public compliance across *** in mobility were significantly lower in rural and remote areas than in urban areas and metropolitan cities(prders in *** findings provide empirical evidence that public compliance and consequent intervention effectiveness differ between urban and rural areas in the *** work is required to ascertain the factors affecting these differing behavioural responses,which can assist in policy-making efforts and increase public compliance in rural areas where populations are older and have poorer access to healthcare.

关键词： COV policy Facebook

The Triple Combination of Meropenem,Avibactam,and a Metallo-b-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different b-Lactamase Producers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2024年第7期38卷 124-132页

作者： Zhuoren Ling Alistair James Macdonald Farley Aditya Lankapalli Yanfang Zhang Shonnette Premchand-Branker Kate cook Andrei Baran Charlotte Gray-Hammerton Claudia Orbegozo rubio Edgars Suna Jordan Mathias Jürgen Brem Kirsty Sands Maria Nieto-rosado Maria Mykolaivna Trush Nadira Naznin rakhi Willames Martins Yuqing Zhou Christopher Joseph Schofield Timothy Walsh Department of Biology&Ineos Oxford Institute for Antimicrobial research University of OxfordOxford OX13REUK Chemistry research Laboratory Department of Chemistry and the Ineos Oxford Institute for Antimicrobial ResearchUniversity of OxfordOxford OX13TAUK Latvian Institute of Organic Synthesis Riga LV-1006Latvia Department of Medical Microbiology Division of Infection and ImmunitySchool of MedicineCardiff UniversityCardiff CF144XNUK Enzymology and Applied Biocatalysis research Center Faculty of Chemistry and Chemical EngineeringBabes-Bolyai UniversityCluj-Napoca 400028Romania

This work explores the potential of a triple combination of meropenem(MEM),a novel metallo-blactamase(MBL)inhibitor(indole-2-carboxylate 58(InC58)),and a serine-b-lactamase(SBL)inhibitor(avibactam(AVI))for broad-spectrum activity against carbapenemase-producing bacteria.A diverse panel comprising MBL-and SBL-producing strains was used for susceptibility testing of the triple combination using the agar dilution *** frequency of resistance(For)to MEM combined with InC58 was *** were sequenced and tested for cross resistance,fitness,and the stability of the resistance *** with the double combinations of MEM plus an SBL or MBL inhibitor,the triple combination extended the spectrum of activity to most of the isolates bearing SBLs(oxacillinase-48(OXA-48)and Klebsiella pneumoniae carbapenemase-2(KPC-2))and MBLs(New Delhi metallo-blactamases(NDMs)),although it was not effective against Verona integron-encoded metallo-blactamase(VIM)-carrying Pseudomonas aeruginosa(***)and OXA-23-carrying Acinetobacter baumannii(***).The For to MEM plus InC58 ranged from 2.22×10^(-7)to 1.13×10^(-6).The resistance correlated with mutations to ompC and comr,affecting porin C and copper permeability,*** mutants manifested a fitness cost,a decreased level of resistance during passage without antibiotic pressure,and cross resistance to another carbapenem(imipenem)and a b-lactamase inhibitor(taniborbactam).In conclusion,compared with the dual combinations,the triple combination of MEM with InC58 and AVI showed a much wider spectrum of activity against different carbapenemaseproducing bacteria,revealing a new strategy to combat b-lactamase-mediated antimicrobial resistance.

关键词： Carbapenemase Metallo/serine-b-lactamase inhibitor Avibactam Meropenem Antimicrobial resistance

维普期刊数据库

Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Giles T.Hanley-cook Yuri Bastos-Moreira Dries S.Martens Trenton Dailey-Chwalibóg Laeticia Celine Toe Brenda de Kok Lionel Ouédraogo Alemayehu Argaw Kokeb Tesfamariam Patrick Kolsteren Lieven Huybregts Tim S.Nawrot Sarah De Saeger Marthe De Boevre Carl Lachat Department of Food Technology， Safety and Health， Faculty of Bioscience Engineering， Ghent University Center of Excellence in Mycotoxicology and Public Health， MYTOXSOUTH~(?) Coordination Unit， Faculty of Pharmaceutical Sciences， Ghent University Centre for Environmental Sciences， Hasselt University Unité Nutrition et Maladies Métaboliques， Institut de recherche en Sciences de la Santé (IrSS) Centre Muraz Center of Excellence in Mycotoxicology and Public Health， MYTOXSOUTH? Coordination Unit， Faculty of Pharmaceutical Sciences， Ghent University Nutrition， Diets， and Health Unit， Department of Food and Nutrition Policy， International Food Policy research Institute (IFPrI) Department of Public Health & Primary Care， University of Leuven Department of Biotechnology and Food Technology， Faculty of Science， University of Johannesburg， Doornfontein Campus

Background: Evidence regarding the effectiveness of prenatal nutritional supplements has mainly considered anthropometric pregnancy outcomes. The effect on markers of health and disease， such as offspring telomere length (TL) and mitochondrial DNA content (mtDNAc) is unknown. Objectives: We assessed the efficacy of maternal multiple micronutrient (MMN)-fortified balanced-energy protein (BEP) and iron-folic acid (IFA) supplementation on newborn TL as a secondary outcome and mtDNAc as a non-declared outcome. Design: We conducted a randomized controlled trial in rural Burkina Faso， among pregnant females (15-40 years old) enrolled at rs received either MMN-fortified BEP and IFA (intervention) or IFA only (control) throughout pregnancy. Whole arterial blood samples were collected from the umbilical cord of 104 control and 90 intervention group infants， respectively. Average relative TL and mtDNAc were measured using quantitative polymerase chain reaction. Linear regression models were fitted to assess TL and mtDNAc differences across trial arms. results: We found that a combined daily MMN-fortified BEP supplement and IFA tablet did not affect newborn TL [β = -0.010 (95% CI: -0.057， 0.036); P = 0.662] or mtDNAc [β = 0.065 (95% CI: -0.203， 0.073); P = 0.354]， as compared to an IFA tablet alone. These findings were confirmed (P > 0.05) by adjusting the regression models for potential prognostic factors of study outcomes at enrollment. Exploratory analyses indicated higher， but non-significantly different mtDNAc among children born either small-for-gestational age， low birthweight， or preterm. Conclusions: Newborns from mothers who received daily nutritional supplements across gestation did not have different relative TL or mtDNAc.

关键词：

粉末冶金Al-5.6Zn-2Mg合金在热压缩过程中加工硬化特性及本构模型的比较

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Central South University 2024年第2期31卷 346-368页

作者： KATIKA Harikrishna DAMODA r.K. DAVIDSON M.J. SEETHArAM r. KASAGANI Veera Venkata Nagaraju Department of Mechanical Engineering National Institute of TechnologyWarangal 506004India Department of Mechanical Engineering The Indian Institute of Information Technology Design and ManufacturingKurnool 518007India

在300~5000℃、应变速率为0.1~0.0001 s−1的条件下,在万能试验机上对Al-5.6Zn-2Mg铝合金进行热压缩试验,以确定动态再结晶开始时的加工硬化速率曲线σ_(c)(ε_(c))l以及关键特征σ_(c)(ε_(c))l、σ_(p)(ε_(p))和σ_(ss)与Z系数之间的... 详细信息

在300~5000℃、应变速率为0.1~0.0001 s−1的条件下,在万能试验机上对Al-5.6Zn-2Mg铝合金进行热压缩试验,以确定动态再结晶开始时的加工硬化速率曲线σ_(c)(ε_(c))l以及关键特征σ_(c)(ε_(c))l、σ_(p)(ε_(p))和σ_(ss)与Z系数之间的相关性。使用了四个本构模型,Arrhenius模型、改进的Johnson-cook模型(MJC)、改进的Zerilli-Armstrong模型(MZA)和开发的人工神经网络(ANN)。结果表明,ANN型模型和Arrhenius模型的相对误差的绝对平均值最低,分别为0.486%和3.36%,MZA型模型和MJC型模型的相对误差的绝对平均值较高,分别为8.84%和3.93%。由于Arrhenius模型能够处理各种因素之间的非线性关系,因此它被认为是最合适的预测模型,但在材料性质未知或实验数据有限的情况下,MJC模型可能是一种更简单的替代方法。MZA模型不适合估计热压缩时的流变应力。此外,训练最好的神经网络模型的预测性能最好,相对误差的绝对平均值为0.486%,r值为0.99。

关键词：加工硬化速率曲线本构建模热压缩 EBSD分析流变曲线

Net zero emission goals demand worldwide cooperation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science review 2023年第11期10卷 93-95页

作者： Shi Xue Dou Wei-Hong Lai Chris cook Institute of Energy Materials Science University of Shanghai for Science and Technology Institute for Superconducting and Electronic Materials University of Wollongong Faculty of Engineering and Information Sciences University of Wollongong

The serious threat of climate change has become a reality of daily life all over the world. There is no priority facing humans at present more urgent than climate change. The goal of achieving net zero emissions (NZEs) within a time frame short enough to avoid catastrophic changes can only be accomplished through worldwide cooperation.

关键词：

Optimized Hot Spot and Directional Distribution Analyses Characterize the Spatiotemporal Variation of Large Wildfires in Washington,USA,1970-2020

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Disaster risk Science 2022年第1期13卷 139-150页

作者： Kevin Zerbe Chris Polit Stacey McClain Tim cook Washington Emergency Management Division Camp MurrayTacomaWA 98430USA

Spatiotemporal analysis of fire activity is vital for determining why wildfires occur where they do,assessing wildfire risks,and developing locally relevant wildfire risk reduction *** various spatial statistical methods,we determined hot spots of large wildfires(>100 acres)in Washington,the United States,and mapped spatiotemporal variations in large wildfire activity from 1970 to *** results found that all hot spots are located east of the crest of the Cascade *** spatiotemporal analysis found that the geographic area wherein most of the state’s acres burned has shrunk considerably since 1970 and has become concentrated over the north-central portion of the state over *** concentration of large wildfire activity in north-central Washington was previously unquantified and may provide important information for hazard mitigation efforts in that *** results highlight the advantages of using spatial statistical methods that could aid the development of natural hazard mitigation plans and risk reduction strategies by characterizing previous hazard occurrences spatially and spatiotemporally.

关键词： Hazard mitigation Natural hazards Spatial statistics Washington state Wildfire

维普期刊数据库

The First Documented Experience of Qi and an Account of Healing Failure:4th-Century BCE

在线全文

学校读者我要写书评

暂无评论

Chinese Medicine and Culture 2023年第2期6卷 139-146页

作者： Constance A.cook Professor&Chair Modern Languages and LiteraturesLehigh UniversityBethlehemPA 18015USA

This essay will review the earliest case that documents a patient’s experience of qi,one found on a bamboo text buried with the patient who died in the 318 *** of the healing encounter and of concepts of illness show how non-transmitted documents hidden from later editors in tombs preserve an older layer of medical understanding than that in transmitted canons,such as the Huang Di Nei Jing(Inner Canon of the Yellow Emperor).The 4th-century BCE case record described below is the longest early medical record concerning the treatment of a specific *** is also an account of failure formally recorded for the sake of the survivors and buried with the dead to be transmitted to the world of the *** essay begins with a reevaluation of ancient concept of qi and then moves on to the individual case record.

关键词： Ancient Divination Heart Magic Manuscript Qi Wu Xing Yin-yang

维普期刊数据库